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At least 307 records · Page 17

Endothelium Preserving Microwave Treatment for Atherosclerosis

Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20 C. within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.

Carl, James R.↗

Endothelium Preserving Microwave Treatment for Atherosclerosis

Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20 C. within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed, directable or focussed heating preserves healthy sectors or the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed bean. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.

James R Carl↗

Geophysical Probes of the Icy Satellites of Jupiter

This paper presents a discussion on the structure and dynamic processes of the interiors of the icy satellites of Jupiter. Although such measurements as global gravity and magnetic fields, high precision altimetry and radar sounding can be made from the Jupiter Icy Moons Orbiter (JIMO) satellite, there are certain seismic and heat flow measurements which must be made from the surface to clearly understand the geophysics of a planet such as Jupiter. The possibility of a geophysical probe that can be released into orbit about a satellite to return potential field data for a sufficient period of time is discussed.

Banerdt, W. B.↗

Long-Period Comets and the Oort Cloud

The long-period comets pose a unique problem for the impact hazard problem. Because of their very long orbital period and generally large distances form the Sun, they cannot be surveyed and catalogued in the same manner as the near-Earth asteroids and short-period comets..Improved technologies are needed to detect approaching long-period comets at large heliocentric distances so as to increase the warning time for potential impactors.

long-period comets comets comet impact↗

Ultra Low Temperature Ultra Low Power Instrument Packages for Planetary Surfaces

Achievement of solar system exploration roadmap goals will involve robotic or human deployment and longterm operation of surface science packages remote from human presence, thus requiring autonomous, self-powered operation. The major challenge such packages face will be operating during long periods of darkness in extreme cold potentially without the Pu238 based power and thermal systems available to Apollo era packages (ALSEP). Development of such science payloads will thus require considerable optimization of instrument and subsystem design, packaging and integration for a variety of planetary surface environments in order to support solar system exploration fully. Our work supports this process through the incorporation of low temperature operational components and design strategies which radically minimize power, mass, and cost while maximizing the performance under extreme surface conditions that are in many cases more demanding than those routinely experienced by spacecraft in deep space. Chief instruments/instrument package candidates include those which could provide long-term monitoring of the surface and subsurface environments for fundamental science and human crew safety. The initial attempt to design a 10 instrument environmental monitoring package with a solar/battery based power system led to a package with a unacceptably large mass (500 kg) of which over half was battery mass. In phase 1, a factor of 5 reduction in mass was achieved, first through the introduction of high performance electronics capable of operating at far lower temperature and then through the use of innovative thermal balance strategies involving the use of multi-layer thin materials and gravity-assisted heat pipes. In phase 2, reported here, involves strategies such as universal incorporation of ULT/ULP digital and analog electronics, and distributed or non-conventionally packaged power systems. These strategies will be required to meet the far more challenging thermal requirements of operating through a normal 28 day diurnal cycle. The limited temperature range of efficient battery operation remains the largest obstacle.

Clark, P. E.↗

Discovery of Eclipses from the Accreting Millisecond X-Ray Pulsar Swift J1749.4-2807

We report the discovery of X-ray eclipses in the recently discovered accreting millisecond X-ray pulsar SWIFT J1749.4-2807. This is the first detection of X-ray eclipses in a system of this type and should enable a precise neutron star mass measurement once the companion star is identified and studied. We present a combined pulse and eclipse timing solution that enables tight constraints on the orbital parameters and inclination and shows that the companion mass is in the range 0.6-0.8 solar mass for a likely range of neutron star masses, and that it is larger than a main-sequence star of the same mass. We observed two individual eclipse egresses and a single ingress. Our timing model shows that the eclipse features are symmetric about the time of 90 longitude from the ascending node, as expected. Our eclipse timing solution gives an eclipse duration (from the mid-points of ingress to egress) of 2172+/-13 s. This represents 6.85% of the 8.82 hr orbital period. This system also presents a potential measurement of "Shapiro" delay due to general relativity; through this technique alone, we set an upper limit to the companion mass of 2.2 Solar mass .

Markwardt, C. B.↗

Electromagnetic Flow Meter Having a Driver Circuit Including a Current Transducer

An electromagnetic flow meter (EMFM) accurately measures both the complete flow rate and the dynamically fluctuating flow rate of a fluid by applying a unipolar DC voltage to excitation coils for a predetermined period of time, measuring the electric potential at a pair of electrodes, determining a complete flow rate and independently measuring the dynamic flow rate during the "on" cycle of the DC excitation, and correcting the measurements for errors resulting from galvanic drift and other effects on the electric potential. The EMFM can also correct for effects from the excitation circuit induced during operation of the EMFM.

Karon, David M.↗

Overview of Primitive Object Volatile Explorer (PrOVE) CubeSat or Smallsat Concept

Here we describe the Primitive Object Volatile Explorer (PrOVE), a smallsat mission concept to study the surface structure and volatile inventory of comets in their perihelion passage phase when volatile activity is near peak. CubeSat infrastructure imposes limits on propulsion systems, which are compounded by sensitivity to the spacecraft disposal state from the launch platform and potential launch delays. We propose circumventing launch platform complications by using waypoints in space to park a deep space SmallSat or CubeSat while awaiting the opportunity to enter a trajectory to flyby a suitable target. In our Planetary Science Deep Space SmallSat Studies (PSDS3) project, we investigated scientific goals, waypoint options, potential concept of operations (ConOps) for periodic and new comets, spacecraft bus infrastructure requirements, launch platforms, and mission operations and phases. Our payload would include two low-risk instruments: a visible image (VisCAM) for 5-10 m resolution surface maps; and a highly versatile multispectral Comet CAMera (ComCAM) will measure 1) H2O, CO2, CO, and organics non-thermal fluorescence signatures in the 2-5 μm MWIR, and 2) 7-10 and 8-14 μm thermal (LWIR) emission. This payload would return unique data not obtainable from ground-based telescopes and complement data from Earth-orbiting observatories. Thus, the PrOVE mission would (1) acquire visible surface maps, (2) investigate chemical heterogeneity of a comet nucleus by quantifying volatile species abundance and changes with solar insolation, (3) map the spatial distribution of volatiles and determine any variations, and (4) determine the frequency and distribution of outbursts.

Clark, Pamela S.↗

Stabilization of a Swept-Wing Boundary Layer by Discrete Roughness Elements at High Reynolds Numbers

Direct numerical simulations (DNS) are performed to study potential stabilizing ef- fect of spanwise periodic discrete roughness elements (DREs) on cross ow instabilities in a spatially developing three-dimensional boundary layer over an in nite-swept natural- laminar- ow wing at a freestream Mach number of 0:75 and a chord Reynolds number of approximately 25 million. In the DNS, both the spanwise periodic DREs and distributed roughness in the leading-edge region are implemented to simulate a typical experimen- tal scenario in which multiple steady cross ow modes including the most unstable mode (i.e., the \target" mode) emerge because of the presence of naturally distributed surface roughness in the leading edge region and spanwise periodic control cylinders of subcritical wavelength are used to force small-wavelength disturbances (i.e., the control mode) for damping the target mode. The DNS results show that the e ectiveness of DRE control is sensitive to roughness diameter, height, and chordwise placement. For the DRE parame- ters considered in this study, the stabilizing e ect on the target mode is small within the computational domain that ended at about 35% of the chord.

Nicholson, Gary↗

Impact of Air Traffic Reductions during the COVID-19 Pandemic on Aircraft-induced Clouds and their Radiative Effects

Air travel restrictions due to the novel coronavirus 2019 (COVID-19) pandemic drastically reduced air travel internationally during the spring of 2020. Such an extraordinary disruption of air traffic may have a profound effect on contrail formation that could allow for better quantification and scientific understanding of the radiative impacts of aviation-induced clouds on climate. This investigation synergizes MODIS, CrIS, and GOES-16 satellite analyses with weather analyses, including those from GEOS and MERRA, to compare contrail formation conditions and radiative forcings of linear contrails and thin cirrus detected over the contiguous United States (CONUS) and the North Atlantic for the 2020 air traffic slowdown period with parallel analyses conducted for a baseline period from a previous year with normal air traffic. A consistent analysis system for contrail detection and cloud property retrievals (e.g. optical depth, particle size, and altitude) from satellites, coupled with radiative transfer modeling are applied to characterize and contrast contrail cirrus properties and radiative effects estimated during the pandemic and baseline periods. Temperature and humidity profiles from numerical weather models and hyperspectral infrared measurements are used to estimate the contrail formation potential (CFP) over the study areas in order to help choose the most appropriate baseline period and to account for potential impacts of differences in meteorology on contrail formation and coverage. This study, using NASA satellite data and other assets, is expected to improve our understanding of the relationship between air traffic, contrail cirrus coverage and related impacts in order to better quantify the need for contrail formation mitigation strategies that could reduce aviation effects on climate.

William L Smith↗

Overview of Primitive Volatile Explorer (PrOVE) Cubesat or Smallsat Concept

Here we describe the Primitive Object Volatile Explorer (PrOVE), a smallsat mission concept to study the surface structure and volatile inventory of comets in their perihelion passage phase when volatile activity is near peak. CubeSat infrastructure imposes limits on propulsion systems, which are compounded by sensitivity to the spacecraft disposal state from the launch platform and potential launch delays. We propose circumventing launch platform complications by using waypoints in space to park a deep space SmallSat or CubeSat while awaiting the opportunity to enter a trajectory to flyby a suitable target. In our Planetary Science Deep Space SmallSat Studies (PSDS3) project, we investigated scientific goals, waypoint options, potential concept of operations (ConOps) for periodic and new comets, spacecraft bus infrastructure requirements, launch platforms, and mission operations and phases. Our payload would include two low-risk instruments: a visible image (VisCAM) for 5-10 m resolution surface maps; and a highly versatile multispectral Comet CAMera (ComCAM) will measure 1) H2O, CO2, CO, and organics non-thermal fluorescence signatures in the 2-5 µm MWIR, and 2) 7-10 and 8-14 µm thermal (LWIR) emission. This payload would return unique data not obtainable from ground-based telescopes and complement data from Earth-orbiting observatories. Thus, the PrOVE mission would (1) acquire visible surface maps, (2) investigate chemical heterogeneity of a comet nucleus by quantifying volatile species abundance and changes with solar insolation, (3) map the spatial distribution of volatiles and determine any variations, and (4) determine the frequency and distribution of outbursts.

Zucherman, Aaron↗

Long-Period Comets and the Oort Cloud

The long-period comets pose a unique problem for the impact hazard problem. Because of their very long orbital] periods and generally large distances from the Sun, they cannot be surveyed and catalogued in the same manner as the near-Earth asteroids and short-period comets. They appear at random, uniformly distributed on the celestial sphere. Current technologies can detect long-period comets at distances of approx. 5 AU, giving somewhat less than a one year warning time for potential Earth impactors. The mean impact probability for a long-period comet crossing the Earth's orbit is 2.2 to 2.5 x 10(exp -9) per perihelion passage. The mean impact velocity is approximately 52 km sec-1 but the most probable impact energy is characterized by a velocity of 56 to 58 km/sec. The estimated current impact rate for cometary nuclei large enough to create 10 km diameter (or larger) craters on the Earth is between 5 x 10(exp -7) and 2.8 x 10(exp -6) per year, with a bed estimated value of 1.0 x 10(exp -6) per year. Nuclei large enough to initiate global climatic disturbances strike the Earth on average every 16 Myr. The impact frequency may be increased substantially for brief periods of time during cometary showers, initiated by major perturbations of the Oort cloud. Improved technologies are needed to detect approaching long-period comets at large heliocentric distances so as to increase the warning time for potential impactors.

Weissman, Paul R.↗

Characterization of Rapid Charging Events Due to Sheath Capacitance and Impact on the International Space Station Plasma Hazard Process

During an Extravehicular Activity (EVA), if the Extravehicular Mobility Unit (EMU) makes galvanic contact with the International Space Station (ISS), a negative Floating Potential (FP) can lead to an arcing hazard when it exceeds -45.5 V, and a positive FP can produce a DC current high enough to stimulate the astronaut’s muscles (5 mA), and also cause a hazard. The Boeing Space Environments team developed and utilizes a Plasma Interaction Model (PIM) in order to calculate the ISS FP based on the plasma environment, ISS velocity, geomagnetic field, solar array and ISS orientation, and solar array regulation to support EVA planning operations. Presently, the model excludes the sheath capacitance, resulting in the total potential drop being across the dielectric surface of the vehicle. Data from the Floating Potential Measurement Unit (FPMU) show this assumption to be generally true. However, Rapid Charging Events (RCE) are often observed in the FPMU data at eclipse exit when the electron number density, Ne, is low (less than 5(sub e)10 m (exp-3)). During these events, the FP can rise more than 40 V in one to five seconds. There is then a relaxation phase where the FP drops back to the normal FP values. The PIM model is not capable of producing these RCEs. It was thought that the inclusion of the sheath in PIM could improve the charging predictions, particularly as related to RCEs. A parametric study was performed to determine what portion of the measured FP is across the sheath for a range of Ne experienced by the ISS, and if the inclusion of the sheath in PIM is necessary. Results show that the potential drop across the sheath is negligible at times when the N(sub e) is greater than 1(sub e)11 m-3. However, there appears to be a transitional region between 1(sub e)10 m(exp -3) and 1(sub e)11 m(exp -3) where the sheath capacitance becomes more significant. During those conditions the potential drop across the sheath can be larger than the potential drop across the dielectric for short periods (1-5 seconds). These results agree remarkably well with measurements made by the FPMU. The inclusion of the sheath explains why high charging measurements occur when the Ne is low at eclipse exit and even times when the solar arrays are not a significant driver (i.e., potentials often rise as the ISS flies through spread-F). Results also show that the RCEs are not a safety concern because the potential drop across the dielectric surface does not exceed -45.5 V. In that case, the EMU would not arc. This gives high confidence in the low probability of an arcing hazard occurring.

plasma environment↗

A Comparison of ARTEMIS Observations and Particle-in-cell Modeling of the Lunar Photoelectron Sheath in the Terrestrial Magnetotail

As an airless body in space with no global magnetic field, the Moon is exposed to both solar ultraviolet radiation and ambient plasmas. Photoemission from solar UV radiation and collection of ambient plasma are typically opposing charging currents and simple charging current balance predicts that the lunar dayside surface should charge positively; however, the two ARTEMIS probes have observed energydependent loss cones and high-energy, surface-originating electron beams above the dayside lunar surface for extended periods in the magnetosphere, which are indicative of negative surface potentials. In this paper, we compare observations by the ARTEMIS P1 spacecraft with a one dimensional particle-in-cell simulation and show that the energy-dependent loss cones and electron beams are due to the presence of stable, non-monotonic, negative potentials above the lunar surface. The simulations also show that while the magnitude of the non-monotonic potential is mainly driven by the incoming electron temperature, the incoming ion temperature can alter this magnitude, especially for periods in the plasma sheet when the ion temperature is more than twenty times the electron temperature. Finally, we note several other plasma phenomena associated with these non-monotonic potentials, such as broadband electrostatic noise and electron cyclotron harmonic emissions, and offer possible generation mechanisms for these phenomena.

Lunar↗

Spatial variation in soil microbial processes as a result of woody encroachment depends on shrub size in tallgrass prairie

Aims: As woody plants encroach into grassland ecosystems, we expect that altered plant-soil interactions will lead to changes in the microbial processes that affect carbon storage and nutrient cycling. Specifically, this research aimed to address how (1) soil chemistry, (2) microbial nutrient demand, and (3) the rate and source of potential soil C mineralization vary spatially under individual woody shrubs of varying size within a mesic grassland. Methods: Here, we collected soil samples from the center, the midpoint between the center and edge, the edge, and the shrub-grass ecotone of multiple Cornus drummondii shrubs across a shrub-size gradient in infrequently burned tallgrass prairie. Results: We found total soil carbon and total soil nitrogen increased with shrub size in every location but the edge. Microbial demand for nitrogen also increased as shrubs increased in size. Across all shrub sizes and sampling locations, potential soil carbon mineralization rates were higher when microbes broke down proportionally more shrub-derived (C 3 ) organic matter than grass-derived (C 4 ) organic matter. Conclusions: Our results suggest that the spatio-temporal context of woody encroachment is critical for understanding its impact on belowground microbial processes. In this ecosystem, a longer period of occupancy by woody plants increases potentially mineralizable carbon.

59 BASIC BIOLOGICAL SCIENCES↗

Bacteria detection instrument and method

A method and apparatus for screening a sample fluid for bacterial presence are disclosed wherein the fluid sample is mixed with culture media of sufficient quantity to permit bacterial growth in order to obtain a test solution. The concentration of oxygen dissolved in the test solution is then monitored using the potential difference between a reference electrode and a noble metal electrode which are in contact with the test solution. The change in oxygen concentration which occurs during a period of time as indicated by the electrode potential difference is compared with a detection criterion which exceeds the change which would occur absent bacteria.

Renner, W.↗

Towards A Representation of Vertically Resolved Ozone Changes in Reanalyses

The Solar Backscatter Ultraviolet Radiometer (SBUV) instruments on NASA and NOAA spacecraft provide a long-term record of total-column ozone and deep-layer partial columns since about 1980. These data have been carefully processed to extract long-term trends and offer a valuable resource for ozone monitoring. Studies assimilating limb-sounding observations in the Goddard Earth Observing System (GEOS) data assimilation system (DAS) demonstrate that vertical ozone gradients in the upper troposphere and lower stratosphere (UTLS) are much better represented than with the deep-layer SBUV observations. This is exemplified by the use of retrieved ozone from the EOS Microwave Limb Sounder (EOS-MLS) instrument in the MERRA-2 reanalysis, for the period after 2004. This study examines the potential for extending the use of limb-sounding observations at earlier times and into the future, so that future reanalyses may be more applicable to the study of long-term ozone changes.Historical data are available from NASA instruments: the Limb Infrared Monitor of the Stratosphere (LIMS: 1978-1979); the Upper Atmospheric Research Satellite (UARS: 1991-1995); Sounding of the Atmosphere using Broadband Emission Radiometry (SABER: 2000-onwards). For the post EOS-MLS period, the joint NASA-NOAA Ozone Monitoring and Profiling Suite Limb Profiler (OMPS-LP) instrument was launched on the Suomi-NPP platform in 201x and is planned for future platforms. This study will examine two aspects of these data pertaining to future reanalyses. First, the feasibility of merging the EOS-MLS and OMPS-LP instruments to provide a long-term record that extends beyond the potential lifetime of EOS-MLS. If feasible, this would allow for long-term monitoring of ozone recovery in a three-dimensional reanalysis context. Second, the skill of the GEOS DAS in ingesting historical data types will be investigated. Because these do not overlap with EOS-MLS, use will be made of system statistics and evaluation using independent datasets. Impacts of using a complete ozone chemistry module will also be considered.

ML↗

Ripples in the bottom of the potential energy landscape of metallic glass

Abstract In the absence of periodicity, the structure of glass is ill-defined, and a large number of structural states are found at similar energy levels. However, little is known about how these states are connected to each other in the potential energy landscape. We simulate mechanical relaxation by molecular dynamics for a prototypical $${{{\rm{C}}}}{{{{\rm{u}}}}}_{64.5}{{{\rm{Z}}}}{{{{\rm{r}}}}}_{35.5}$$ C u 64.5 Z r 35.5 metallic glass and follow the mechanical energy loss of each atom to track the change in the state. We find that the energy barriers separating these states are remarkably low, only of the order of 1 meV, implying that even quantum fluctuations can overcome these potential energy barriers. Our observation of numerous small ripples in the bottom of the potential energy landscape puts many assumptions regarding the thermodynamic states of metallic glasses into question and suggests that metallic glasses are not totally frozen at the local atomic level.

36 MATERIALS SCIENCE↗