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NASA NTRS1990

Speculation on a Solar Chronometer for Climate

Solar activity has been correlated to climatic fluctuations and has been postulated as a major factor in quasi-periodic global climatic change. However, correlations are not explanations of physical mechanisms and do not couple cause with effect. A mechanism for a chronometer for solar output variability is proposed based on relations between properties of thermonuclear fusion, nuclear magnetic moment, and nuclear magnetic resonance. A fundamental oscillation of a nucleus with a net nuclear magnetic moment (NMM) is the precession of its axis of rotation when subjected to a magnetic field. Nuclear magnetic resonance (NMR) is the preferred frequency of precession for a nucleus of a particular isotope when placed in a magnetic field of specific intensity. The NMM for those isotopes involved in the proton-proton (p-p) chain pathway for solar fusion varies from strong positive to strong negative. Individual fusion events, for hydrogen and helium isotopes which release varying amounts of energy, may be controlled by NMR frequencies. The pulses of energy from fusion events occurring at NMR frequencies in the solar interior may be transformed into pressure or gravity waves that emerge as gravity or acoustic waves at the surface. Dictated by spherical harmonics, certain wavelengths may be reinforced and reenter the solar interior to modulate the fusion process. Qualitative analysis of solar and climatic data support the interaction of the three basic components of the chronometer, magnetic activity, oscillation frequency, and solar energy output.

Perry, Charles A.↗

NASA NTRS2016

The Impacts of Dry Dynamic Cores on Asymmetric Hurricane Intensification

The fundamental pathways for tropical cyclone (TC) intensification are explored by considering axisymmetric and asymmetric impulsive thermal perturbations to balanced, TC-like vortices using the dynamic cores of three different nonlinear numerical models. Attempts at reproducing the results of previous work, which used the community WRF Model, revealed a discrepancy with the impacts of purely asymmetric thermal forcing. The current study finds that thermal asymmetries can have an important, largely positive role on the vortex intensification, whereas other studies find that asymmetric impacts are negligible. Analysis of the spectral energetics of each numerical model indicates that the vortex response to asymmetric thermal perturbations is significantly damped in WRF relative to the other models. Spectral kinetic energy budgets show that this anomalous damping is primarily due to the increased removal of kinetic energy from the vertical divergence of the vertical pressure flux, which is related to the flux of inertia-gravity wave energy. The increased kinetic energy in the other two models is shown to originate around the scales of the heating and propagate upscale with time from nonlinear effects. For very large thermal amplitudes (50 K), the anomalous removal of kinetic energy due to inertia-gravity wave activity is much smaller, resulting in good agreement between models. The results of this paper indicate that the numerical treatment of small-scale processes that project strongly onto inertia-gravity wave energy can lead to significant differences in asymmetric TC intensification. Sensitivity tests with different time integration schemes suggest that diffusion entering into the implicit solution procedure is partly responsible for the anomalous damping of energy.

Guimond, Stephen R.↗

NASA NTRS2019

Evaluating Effects of Altered Gravity on the Nervous System Using D. melanogaster

A comprehensive understanding of the effects of spaceflight and altered gravity on human physiology is necessary for continued human space exploration and long-term space habitation. The oxidative stress response has been identified in astronauts exposed to short- and long-term space missions that are exposed to the multitude of stress factors of spaceflight, including altered gravity and radiation exposure. Reactive oxygen species (ROS) are byproducts of homeostatic cellular metabolism, yet when overproduced the oxidative stress response ensues, rendering molecules destructive causing cell death and inflammation. Controlling aberrant ROS production is necessary to prevent pathological consequences, in particular within the nervous system, since neurons are extremely sensitive overexpressed ROS insults. We hypothesize that exposure to altered gravity triggers the oxidative stress response, leading to impairments in the nervous system. In this study, we used a well-established spaceflight model organism, Drosophila melanogaster, to assess altered gravity associated changes in the nervous system using a ground-based hypergravity model. Acute hypergravity resulted in an induction of oxidative stress-related genes with an increase in reactive oxygen species (ROS) in fly brains (p<0.001). Also, qPCR analysis shows that parkin gene expression is significantly reduced in these fly brains(p<0.05). Additionally, chronic hypergravity resulted in depressed locomotor phenotype in these flies (p<0.05) in conjunction to decreased dopaminergic neuron counts (p<0.0001) and increased apoptosis in these fly brains (p<0.0001). Further, assessment of neurological changes, including the neuronal architecture, synaptic integrity and genetic regulation caused by hypergravity conditions were noted. Overall, our results validate chronic hypergravity simulation as a behavioral model to study spaceflight effects, and oxidative stress pathway as a potential avenue for countermeasure development for astronauts undergoing short- and long-term missions and for neurodegenerative research on Earth.

Mhatre, Siddhita↗

NASA NTRS2001

Hormonal modulation of food intake in response to low leptin levels induced by hypergravity

A loss in fat mass is a common response to centrifugation and it results in low circulating leptin concentrations. However, rats adapted to hypergravity are euphagic. The focus of this study was to examine leptin and other peripheral signals of energy balance in the presence of a hypergravity-induced loss of fat mass and euphagia. Male Sprague-Dawley rats were centrifuged for 14 days at gravity levels of 1.25, 1.5, or 2 G, or they remained stationary at 1 G. Urinary catecholamines, urinary corticosterone, food intake, and body mass were measured on Days 11 to 14. Plasma hormones and epididymal fat pad mass were measured on Day 14. Mean body mass of the 1.25, 1.5, and 2 G groups were significantly (P < 0.05) lower than controls, and no differences were found in food intake (g/day/100 g body mass) between the hypergravity groups and controls. Epididymal fat mass was 14%, 14%, and 21% lower than controls in the 1.25, 1.5, and 2.0 G groups, respectively. Plasma leptin was significantly reduced from controls by 46%, 45%, and 65% in the 1.25, 1.5, and 2 G groups, respectively. Plasma insulin was significantly lower in the 1.25, 1.5, and 2.0 G groups than controls by 35%, 38%, and 33%. No differences were found between controls and hypergravity groups in urinary corticosterone. Mean urinary epinephrine was significantly higher in the 1.5 and 2.0 G groups than in controls. Mean urinary norepinephrine was significantly higher in the 1.25, 1.5 and 2.0 G groups than in controls. Significant correlations were found between G load and body mass, fat mass, leptin, urinary epinephrine, and norepinephrine. During hypergravity exposure, maintenance of food intake is the result of a complex relationship between multiple pathways, which abates the importance of leptin as a primary signal.

NASA Discipline Regulatory Physiology↗

NASA NTRS1997

Redox Energy and Sulfur Chemistry in Prebiotic Polymer Synthesis and Replication

In the past year we have made significant progress in three research areas: (1) Most importantly, we discovered a new pathway of prebiotic amino acid synthesis in which formaldehyde and glycolaldehyde (substrates of the formose reaction) react with ammonia yielding alanine and homoserine in the presence of thiol catalysts. This thiol-dependent synthesis of amino acids undoubtedly occurs via amino acid thioester intermediates capable of forming peptides. This 'one-pot' reaction system operates under mild aqueous conditions, and like modern amino acid biosynthesis, uses sugar intermediates which are converted to amino acids by energy-yielding redox disproportionation. (2) Finally, in preparation for the analysis of Martian meteorite samples, we upgraded our HPLC system and developed an improved method capable of detecting a I femtomole of amino acid enantiomers. (3) We completed our analysis of the energetics of metabolism that revealed that life depends on biosynthetic processes driven by chemical energy made available by the redox disproportionation of carbon groups of sugars. We established that the favorable energy of redox disproportionation is based on the universal reduction potentials of carbon groups. We concluded that it is hard to imagine any other organic molecule besides sugars (formaldehyde oligomers) having the energy and reactivity needed to drive either modem biosynthesis or the chemical processes behind its origin.

Weber, Arthur L.↗

NASA NTRS2019

Thermochemical Modelling of Fluid-Rock Reactions in Vera Rubin Ridge, Galecrater, Mars

Vera Rubin Ridge (VRR) in Gale Crater, Mars, is a ~200 m wide ~6.5 km long northeast- southwest resistant geomorphological feature on the northern slopes of Aeolis Mons (Mt. Sharp). Analysis of Compact Reconnaissance Imaging Spectrometer for Mars (CRISM) orbital data showed that VRR has strong hematite spectral signatures. Hematite was confirmed in-situ at VRR with the Curiosity rover and has been shown to be present throughout the Mur- ray formation. VRR is stratigraphically continu-ous with the underlying Murray formation. Previous thermochemical modelling showed how hematite at VRR could have formed as the result of open-system weathering at high water/rock ratios. Here we use thermochemical modelling to investigate possible reaction pathways for the hematite-clay- bearing assemblage observed at VRR, starting from an identified least-altered (minimum clay content) Murray composition, and a Mars basal brine.

Turner, S. M. R.↗

NASA NTRS2001

Optimizing Orbit-Instrument Configuration for Global Precipitation Mission (GPM) Satellite Fleet

Following the scientific success of the Tropical Rainfall Measuring Mission (TRMM) spearheaded by a group of NASA and NASDA scientists, their external scientific collaborators, and additional investigators within the European Union's TRMM Research Program (EUROTRMM), there has been substantial progress towards the development of a new internationally organized, global scale, and satellite-based precipitation measuring mission. The highlights of this newly developing mission are a greatly expanded scope of measuring capability and a more diversified set of science objectives. The mission is called the Global Precipitation Mission (GPM). Notionally, GPM will be a constellation-type mission involving a fleet of nine satellites. In this fleet, one member is referred to as the "core" spacecraft flown in an approximately 70 degree inclined non-sun-synchronous orbit, somewhat similar to TRMM in that it carries both a multi-channel polarized passive microwave radiometer (PMW) and a radar system, but in this case it will be a dual frequency Ku-Ka band radar system enabling explicit measurements of microphysical DSD properties. The remainder of fleet members are eight orbit-synchronized, sun-synchronous "constellation" spacecraft each carrying some type of multi-channel PMW radiometer, enabling no worse than 3-hour diurnal sampling over the entire globe. In this configuration the "core" spacecraft serves as a high quality reference platform for training and calibrating the PMW rain retrieval algorithms used with the "constellation" radiometers. Within NASA, GPM has advanced to the pre-formulation phase which has enabled the initiation of a set of science and technology studies which will help lead to the final mission design some time in the 2003 period. This presentation first provides an overview of the notional GPM program and mission design, including its organizational and programmatic concepts, scientific agenda, expected instrument package, and basic flight architecture. Following this introduction, we focus specifically on the last topic, that being an analysis which leads to an optimal flight architecture dictated in part by science requirements but constrained by allowable orbital mechanics, instrument scan patterns, and antenna aperture properties. Because the optimal architecture involves an interplay between orbit mechanics and instrument specifications, it is important to recognize that in attempting to serve various scientific themes, the final optimal architecture will represent a compromise concerning dynamic range, spatial resolution, sampling interval, pointing, beam coincidence, and measurement uncertainty. Moreover, cost becomes a major factor in seeking the optimal architecture through the pathways of antenna and instrument scan designs, as well as propulsion requirements associated with the orbit heights of various "constellation" members. Although the results presented at the IGARSS-2001 meeting will likely not be the fully refined flight architecture specifications, they are expected to be nearly complete.

Smith, Eric A.↗

NASA NTRS1999

Human Mars Mission: SEP Architecture, Crew Taxi Propulsion Stage Study and Design and Technology for Reaction and Control System

The Mars exploration is a candidate pathway to expand human presence and useful activities in the solar system. There are several propulsion system options being considered to place the Mars payload on its interplanetary transfer trajectory. One propulsion option is the use of Solar Electric Propulsion (SEP) to spiral out with the Mars payload from an initial Low Earth Orbit (LEO) to an elliptical High Earth Orbit (HEO). This report, presented in annotated facing page format, describes the work completed on the design of a crew taxi propulsion stage used in conjunction with the SEP. Transportation system/mission analysis topics covered in this report include sub-system analysis, trajectory profile description, mass performance and crew taxi stage sizing, stage configuration, stage cost, and Trans-Mars Injection (TMI) launch window. The high efficiency of SEP is used to provide the major part of the TMI propulsion maneuver. Orbital energy is continuously added over a period of approximately twelve months. The SEP and Mars payload follow a spiral trajectory from an initial LEO to a final elliptical HEO. A small chemical stage is then used to provide the final part of the TMI. The now unloaded SEP returns to LEO to repeat another spiral trajectory with payload to HEO. The spiral phase of the SEP's trajectory takes several months to reach HEO, thus significantly increasing the exposure time of the crew to zero-gravity. In order to minimize the long zero-gravity effects, a high thrust chemical stage delivers the crew to the SEP's HEO. The crew rendezvous with the Mars payload in HEO. After a checkout period the Mars payload with the crew is injected onto a Trans-Mars Trajectory by a small chemical stage.

Young, Archie↗

NASA NTRSDate not supplied

Quantative Measurements of Trace Elements and Three-Dimensional Atomic Scale Characterisation of Presolar O-rich Oxides and Silicates: An Atom Probe Tomography Approach

Presolar grains are recordsof a single moment in stellar evolution which have survived nebula and parent body processingwithin our Solar System. These grains condensed within a range of stellar envi-ronments including asymptotic giant branch stars, red giant branch stars, nova, supernova (SN) and hydrogen burning electron capture supernova(ECSN)[1,2]. Iso-topic and chemical compositions can be used to unravel details about environmental conditions at the time of their condensation and physical and chemical processes occurring at the time. For example,nucleosynthesis, stellar evolution, physical properties of stellar atmos-pheres, mixing from inner core to outer envelope, galac-tic chemical evolution, interstellar medium and parent body processing.NanoSIMS enables detailed characterisation of iso-topic compositions and rapid in situidentification of O-rich presolar oxides and silicates using their character-istic 17O/16O and 18O/16O isotopic ratios.Spectroscopic techniques e.g., auger spectroscopyand transmission electron microscopy, have provided additional details on major and minor chemical signatures. However, due tospatial resolution limitations,interaction volumes and interferencesfrom surrounding grains for in situtech-niques, attaining quantative characterisation of trace el-ements,hasproved challenging[1,3]. As the most sensitive geochemical tracers of envi-ronmental changes, trace elements are essential to un-ravelling the geochemical record of their parent stellar environments and evolutionary pathways[4].We car-ried out correlated in situisotopic and chemical analyses of 13 presolar grains to better understand stellar evolu-tion. In this work, we achieved this using a custom ap-proach, coordinating NanoSIMS, Scanning Electron Microscopy Energy Dispersive X-Ray Spectroscopy (SEM-EDX)and Atom Probe Tomography(APT).Our objective was to develop an approach which could ena-ble precise targeting of presolar grains for atom probe tomography and successfully execute atomic scale anal-yses of presolar oxides and silicates, to achieve quantative analysis of their trace elements for the first time.We also aimed to test the capability for Atom Probe tomography to measure isotopic compositions and stoichiometries of presolar oxide and silicate grains.

N D Nevill↗

NASA NTRSDate not supplied

Strong Thermoset Regolith UV-Curable Composite Technology (STRUCT) Overview

Future lunar surface missions require construction materials that can be manufactured in situ using lo-cal resources while operating under extreme environmental conditions. Many Lunar material demands can be solved solely with regolith by compacting or sintering. And yet past Lunar missions rely on polymeric materials, and sustained Lunar missions must reduce Earth-supplied polymers dependence. Dual-cure (Ultraviolet (UV) and thermal) polymer-regolith composites offer a promising pathway by leveraging solar UV radiation, moderate thermal in-put, and regolith. Mission mass limits, power availability and energy constraints on the lunar surface further motivate low-energy processing and curing strategies for surface construction materials. The Strong Thermoset Regolith UV-Curable Composite Technology (STRUCT) project has successfully synthesized and demonstrated dual-cure photopolymer resins derivable from in-situ resources [3]. Morphological, thermal, and mechanical characterization show that the newly formulated UV curable resin systems integrates well with lunar regolith simulants. Processing and chemistry changes, and computational analysis advanced the composite design. X-ray CT scanned and computational analysis demonstrate that resin, regolith and additives are well incorporated. The large fraction of regolith, 95% by mass, large char yield (82% mass), low thermal conductivity (0.26 W/m/K), confirm this material as a promising high-performance thermal and structural material.

thermal conductivity↗

NASA NTRS1997

Study of the solid-phase thermal decomposition of NTO using Simultaneous Thermogravimetric Modulated Beam Mass Spectrometry (STMBMS)

The solid phase thermal reaction chemistry of NTO between 190 and 250 C is presently being evaluated by utilizing STMBMS, a technique that enables the authors to measure the vapor pressure of NTO and to explore the reaction mechanisms and chemical kinetics associated with the NTO thermal decomposition process. The vapor pressure of NTO is expressed as Log(sub 10) p(torr) = 12.5137 + 6,296.553(1/t(k)) and the Delta-H(sub subl) = 28.71 +/- 0.07 kcal/mol (120.01 +/- 0.29 kJ/mol). The pyrolysis of NTO results in the formation of gaseous products and a condensed-phase residue. The identity of the major gaseous products and their origin from within the NTO molecules are determined based on the results from pyrolysis of NTO, NTO-3-C-13, NTO-1,2- (15)N2 and NTO-(2)H2. Identification of the products show the major gaseous products to be N2, CO2, NO, HNCO, H2O and some N2O, CO, HCN and NH3. The N2 is mostly derived from the N-1 and N-2 positions with some being from the N-4 and N-1 or N-2 positions. The CO2 is derived from both carbons in the NTO molecule in comparable amounts. The residue has an elemental formula of C(2.1)H(.26)N(2.9)O and FTIR analysis suggests that the residue is polyurea- and polycarbamate- like in nature. The temporal behaviors of the rates of formation of the gaseous products indicate that the overall thermal decomposition of NTO in the temperature range evaluated involves four major processes: (1) NTO sublimation; (2) an apparent solid-solid phase transition between 190 and 195 C; (3) a decomposition regime induced by the presence of exogenous H2O at the onset of decomposition; and (4) a decomposition regime that occurs at the onset of decomposition and continues until the depletion of NTO. Decomposition pathways that are consistent with the data are presented.

Minier, L.↗

NASA NTRS1999

Human Mars Mission: SEP Architecture Crew Taxi Propulsion Stage Study and Design and Technology for Reaction and Control System

The Mars exploration is a candidate pathway to expand human presence and useful activities in the solar system. There are several propulsion system options being considered to place the Mars payload on its inter-planetary transfer trajectory. One propulsion option is the use of Solar Electric Propulsion (SEP) to spiral out with the Mars payload from an initial Low Earth Orbit (LEO) to an elliptical High Earth Orbit (HEO). This report, presented in annotated facing page format, describes the work completed on the design of a crew taxi propulsion stage used in conjunction with the SEP. Transportation system/mission analysis topics covered in this report include sub-system analysis, trajectory profile description, mass performance and crew taxi stage sizing, stage configuration, stage cost, and Trans-Mars Injection (TMI) launch window. The high efficiency of SEP is used to provide the major part of the TMI propulsion maneuver. Orbital energy is continuously added over a period of approximately twelve months. The SEP and Mars payload follow a spiral trajectory from an initial LEO to a final elliptical HEO. A small chemical stage is then used to provide the final part of the TMI. The now unloaded SEP returns to LEO to repeat another spiral trajectory with payload to HEO. The spiral phase of the SEP's trajectory takes several months to reach HEO, thus significantly increasing the exposure time of the crew to zero-gravity. In order to minimize the long zero-gravity effects, a high thrust chemical stage delivers the crew to the SEP's HEO. The crew rendezvous with the Mars payload in HEO. After a checkout period the Mars payload with the crew is injected onto a Trans-Mars Trajectory by a small chemical stage.

Young, Archie↗

NASA NTRS2018

Carbon-Nitrogen Coupling Under Three Schemes of Model Representation: A Traceability Analysis

The interaction between terrestrial carbon (C) and nitrogen (N) cycles has been incorporated into more and more land surface models. However, the scheme of C-N coupling differs greatly among models, and how these diverse representations of C-N interactions will affect C-cycle modeling remains unclear. In this study, we explored how the simulated ecosystem C storage capacity in the terrestrial ecosystem (TECO) model varied with three different commonly used schemes of C-N coupling. The three schemes (SM1, SM2, and SM3) have been used in three different coupled C-N models (i.e., TECO-CN, CLM 4.5, and O-CN, respectively). They differ mainly in the stoichiometry of C and N in vegetation and soils, plant N uptake strategies, down regulation of photosynthesis, and the pathways of N import. We incorporated the three C-N coupling schemes into the C-only version of the TECO model and evaluated their impacts on the C cycle with a traceability framework. Our results showed that all three of the C-N schemes caused significant reductions in steady-state C storage capacity compared with the C-only version with magnitudes of −23%, −30%, and −54% for SM1, SM2, and SM3, respectively. This reduced C storage capacity was mainly derived from the combined effects of decreases in net primary productivity (NPP; −29%, −15%, and −45%) and changes in mean C residence time (MRT; 9%, −17%, and −17%) for SM1, SM2, and SM3, respectively. The differences in NPP are mainly attributed to the different assumptions on plant N uptake, plant tissue C : N ratio, down regulation of photosynthesis, and biological N fixation. In comparison, the alternative representations of the plant vs. microbe competition strategy and the plant N uptake, combined with the flexible C : N ratio in vegetation and soils, led to a notable spread in MRT. These results highlight the fact that the diverse assumptions on N processes represented by different C-N coupled models could cause additional uncertainty for land surface models. Understanding their difference can help us improve the capability of models to predict future biogeochemical cycles of terrestrial ecosystems.

Du, Zhenggang↗

NASA NTRS1991

Measurement and modification of the EEG and related behavior

Electrophysiological changes in the sensorimotor pathways were found to accompany the effect of rhythmic EEG patterns in the sensorimotor cortex. Additionally, several striking behavioral changes were seen, including in particular an enhancement of sleep and an elevation of seizure threshold to epileptogenic agents. This raised the possibility that human seizure disorders might be influenced therapeutically by similar training. Our objective in human EEG feedback training became not only the facilitation of normal rhythmic patterns, but also the suppression of abnormal activity, thus requiring complex contingencies directed to the normalization of the sensorimotor EEG. To achieve this, a multicomponent frequency analysis was developed to extract and separate normal and abnormal elements of the EEG signal. Each of these elements was transduced to a specific component of a visual display system, and these were combined through logic circuits to present the subject with a symbolic display. Variable criteria provided for the gradual shaping of EEG elements towards the desired normal pattern. Some 50-70% of patients with poorly controlled seizure disorders experienced therapeutic benefits from this approach in our laboratory, and subsequently in many others. A more recent application of this approach to the modification of human brain function in our lab has been directed to the dichotomous problems of task overload and underload in the contemporary aviation environment. At least 70% of all aviation accidents have been attributed to the impact of these kinds of problems on crew performance. The use of EEG in this context has required many technical innovations and the application of the latest advances in EEG signal analysis. Our first goal has been the identification of relevant EEG characteristics. Additionally, we have developed a portable recording and analysis system for application in this context. Findings from laboratory and in-flight studies suggest that we will be able to detect appropriate changes in brain function, and feed this information to on-board computers for modification of mission requirements and/or crew status.

Sterman, M. B.↗

NASA NTRS2021

Asymmetry in Subseasonal Surface Air Temperature Forecast Error with Respect to Soil Moisture Initialization

Soil moisture (W) helps control evapotranspiration (ET), and ET variations can in turn have a distinct impact on 2-m air temperature (T2M), given that increases in evaporative cooling encourage reduced temperatures. Soil moisture is accordingly linked to T2M, and realistic soil moisture initialization has, in previous studies, been shown to improve the skill of subseasonal T2M forecasts. The relationship between soil moisture and evapotranspiration, however, is distinctly nonlinear, with ET tending to increase with soil moisture in drier conditions and to be insensitive to soil moisture variations in wetter conditions. Here, through an extensive analysis of subseasonal forecasts produced with a state-of-the-art seasonal forecast system, this nonlinearity is shown to imprint itself on T2M forecast error in the conterminous United States in two unique ways: (i) the T2M forecast bias (relative to independent observations) induced by a negative precipitation bias tends to be larger for dry initializations, and (ii) on average, the unbiased root-mean-square error (ubRMSE) tends to be larger for dry initializations. Such findings can aid in the identification of forecasts of opportunity; taken a step further, they suggest a pathway for improving bias correction and uncertainty estimation in subseasonal T2M forecasts by conditioning each on initial soil moisture state.

Air Temperature↗

NASA NTRSDate not supplied

T2M Forecasts at Subseasonal Leads: Do Different Soil Moisture Initial States Have Different Impacts?

2-meter Temperature↗

NASA NTRS2015

Expression of Genes Involved in Drosophila Wing Morphogenesis and Vein Patterning Are Altered by Spaceflight

Imaginal wing discs of Drosophila melanogaster (fruit fly) defined during embryogenesis ultimately result in mature wings of stereotyped (specific) venation patterning. Major regulators of wing disc development are the epidermal growth factor receptor (EGF), Notch, Hedgehog (Hh), Wingless (Wg), and Dpp signaling pathways. Highly stereotyped vascular patterning is also characteristic of tissues in other organisms flown in space such as the mouse retina and leaves of Arabidopsis thaliana. Genetic and other adaptations of vascular patterning to space environmental factors have not yet been systematically quantified, despite widespread recognition of their critical importance for terrestrial and microgravity applications. Here we report changes in gene expression with space flight related to Drosophila wing morphogenesis and vein patterning. In addition, genetically modified phenotypes of increasingly abnormal ectopic wing venation in the Drosophila wing1 were analyzed by NASA's VESsel GENeration Analysis (VESGEN) software2. Our goal is to further develop insightful vascular mappings associated with bioinformatic dimensions of genetic or other molecular phenotypes for correlation with genetic and other molecular profiling relevant to NASA's GeneLab and other Space Biology exploration initiatives.

venation↗

NASA NTRS2010

Lessons Learned on Implementing Fault Detection, Isolation, and Recovery (FDIR) in a Ground Launch Environment

This paper's main purpose is to detail issues and lessons learned regarding designing, integrating, and implementing Fault Detection Isolation and Recovery (FDIR) for Constellation Exploration Program (CxP) Ground Operations at Kennedy Space Center (KSC). Part of the0 overall implementation of National Aeronautics and Space Administration's (NASA's) CxP, FDIR is being implemented in three main components of the program (Ares, Orion, and Ground Operations/Processing). While not initially part of the design baseline for the CxP Ground Operations, NASA felt that FDIR is important enough to develop, that NASA's Exploration Systems Mission Directorate's (ESMD's) Exploration Technology Development Program (ETDP) initiated a task for it under their Integrated System Health Management (ISHM) research area. This task, referred to as the FDIIR project, is a multi-year multi-center effort. The primary purpose of the FDIR project is to develop a prototype and pathway upon which Fault Detection and Isolation (FDI) may be transitioned into the Ground Operations baseline. Currently, Qualtech Systems Inc (QSI) Commercial Off The Shelf (COTS) software products Testability Engineering and Maintenance System (TEAMS) Designer and TEAMS RDS/RT are being utilized in the implementation of FDI within the FDIR project. The TEAMS Designer COTS software product is being utilized to model the system with Functional Fault Models (FFMs). A limited set of systems in Ground Operations are being modeled by the FDIR project, and the entire Ares Launch Vehicle is being modeled under the Functional Fault Analysis (FFA) project at Marshall Space Flight Center (MSFC). Integration of the Ares FFMs and the Ground Processing FFMs is being done under the FDIR project also utilizing the TEAMS Designer COTS software product. One of the most significant challenges related to integration is to ensure that FFMs developed by different organizations can be integrated easily and without errors. Software Interface Control Documents (ICDs) for the FFMs and their usage will be addressed as the solution to this issue. In particular, the advantages and disadvantages of these ICDs across physically separate development groups will be delineated.

Ferrell, Bob A.↗