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At least 307 records · Page 17

Design and integrated operation of an innovative thermodynamic vent system concept

A unique zero-g thermodynamic vent system (TVS) is being developed by NASA's Marshall Space Flight Center (MSFC) and Rockwell International to meet cryogenic propellant management requirements for future space missions. The design is highly innovative in that it integrates the functions of a spray-bar tank mixer and a TVS. This concept not only satisfies the requirement for efficient tank mixing and zero-g venting but also accommodates thermal conditioning requirements for other components (e.g., engine feed lines, turbopumps, and liquid acquisition devices). In addition, operations can be extended to accomplish tank chill-down, no-vent fill, and emergency venting during zero-g propellant transfer. This paper describes the system performance characterization and future test activities that are part of MSFC's Multipurpose Hydrogen Test Bed (MHTB) program. The testing will demonstrate the feasibility and merit of the design, and serve as a proof-of-concept development activity.

Fazah, Michel M.↗

Boosting Thermoelectric Performance in Nanocrystalline Ternary Skutterudite Thin Films through Metallic CoTe 2 Integration

Metal–semiconductor nanocomposites have emerged as a viable strategy for concurrently tailoring both thermal and electronic transport properties of established thermoelectric materials, ultimately achieving synergistic performance. In this investigation, a series of nanocomposite thin films were synthesized, embedding metallic cobalt telluride (CoTe 2 ) nanophase within the nanocrystalline ternary skutterudite (Co(Ge 1.22 Sb 0.22 )Te 1.58 or CGST) matrix. Our approach harnessed composition fluctuation-induced phase separation and in situ growth during thermal annealing to seamlessly integrate the metallic phase. The distinctive band structures of both materials have developed an ohmic-type contact characteristic at the interface, which raised carrier density considerably yet negligibly affected the mobility counterpart, leading to a substantial improvement in electrical conductivity. The intricate balance in transport properties is further influenced by the metallic CoTe 2 phase’s role in diminishing lattice thermal conductivity. The presence of the metallic phase instigates enhanced phonon scattering at the interface boundaries. Consequently, a 2-fold enhancement in the thermoelectric figure of merit (zT ~ 1.30) is attained with CGST-7 wt. % CoTe 2 nanocomposite film at 655 K compared to that of pristine CGST.

36 MATERIALS SCIENCE↗

A transcriptomic atlas of acute stress response to low pH in multiple Issatchenkia orientalis strains

Because of its natural stress tolerance to low pH, Issatchenkia orientalis (a.k.a. Pichia kudriavzevii) is a promising non-model yeast for bio-based production of organic acids. Yet, this organism is relatively unstudied, and specific mechanisms of its tolerance to low pH are poorly understood, limiting commercial use. In this study, we selected 12 I. orientalis strains with varying acid stress tolerance (six tolerant and six susceptible) and profiled their transcriptomes in different pH conditions to study potential mechanisms of pH tolerance in this species. We identified hundreds of genes whose expression response is shared by tolerant strains but not by susceptible strains, or vice versa, as well as genes whose responses are reversed between tolerant and susceptible strains. We mapped regulatory mechanisms of transcriptomic responses via motif analysis as well as differential network reconstruction, identifying several transcription factors, including Stb5, Mac1, and Rtg1/Rtg3, some of which are known for their roles in acid response in Saccharomyces cerevisiae. Functional genomics analysis of short-listed genes and transcription factors suggested significant roles for energy metabolism and translation-related processes, as well as the cell wall integrity pathway and RTG-dependent retrograde signaling pathway. Finally, we conducted additional experiments for two organic acids, 3-hydroxypropionate and citramalate, to eliminate acid-specific effects and found potential roles for glycolysis and trehalose biosynthesis specifically for response to low pH. In summary, our approach of comparative transcriptomics and phenotypic contrasting, along with a multi-pronged bioinformatics analysis, suggests specific mechanisms of tolerance to low pH in I. orientalis that merit further validation through experimental perturbation and engineering.

59 BASIC BIOLOGICAL SCIENCES↗

Data for A Transcriptomic Atlas of Acute Stress Response to Low pH in Multiple Issatchenkia orientalis Strains

Because of its natural stress tolerance to low pH, Issatchenkia orientalis (a.k.a. Pichia kudriavzevii ) is a promising non-model yeast for bio-based production of organic acids. Yet, this organism is relatively unstudied, and specific mechanisms of its tolerance to low pH are poorly understood, limiting commercial use. In this study, we selected 12 I. orientalis strains with varying acid stress tolerance (six tolerant and six susceptible) and profiled their transcriptomes in different pH conditions to study potential mechanisms of pH tolerance in this species. We identified hundreds of genes whose expression response is shared by tolerant strains but not by susceptible strains, or vice versa, as well as genes whose responses are reversed between tolerant and susceptible strains. We mapped regulatory mechanisms of transcriptomic responses via motif analysis as well as differential network reconstruction, identifying several transcription factors, including Stb5, Mac1, and Rtg1/Rtg3, some of which are known for their roles in acid response in Saccharomyces cerevisiae . Functional genomics analysis of short-listed genes and transcription factors suggested significant roles for energy metabolism and translation-related processes, as well as the cell wall integrity pathway and RTG-dependent retrograde signaling pathway. Finally, we conducted additional experiments for two organic acids, 3-hydroxypropionate and citramalate, to eliminate acid-specific effects and found potential roles for glycolysis and trehalose biosynthesis specifically for response to low pH. In summary, our approach of comparative transcriptomics and phenotypic contrasting, along with a multi-pronged bioinformatics analysis, suggests specific mechanisms of tolerance to low pH in I. orientalis that merit further validation through experimental perturbation and engineering.

Conversion↗

The Sizes of z ∼ 9−10 Galaxies Identified in the Brightest of Reionizing Galaxies (BoRG) Survey

Redshift z = 9–10 object selection is the effective limit of Hubble Space Telescope (HST) imaging capability, even when confirmed with Spitzer. If only a few photometry data points are available, it becomes attractive to add criteria based on their morphology in these J- and H-band images. One could do so through visual inspection, a size criterion, or alternate morphometrics. We explore a vetted sample of Brightest of Reionizing Galaxies (BoRG) z ∼ 9 and z ∼ 10 candidate galaxies and the object rejected by Morishita+ to explore the utility of a size criterion in z = 9–10 candidate selection. A stringent, point-spread function (PSF)-corrected effective radius criterion ([[Formula]]) would result in the rejection of 65%–70% of the interlopers visually rejected by Morishita et al. It may also remove up to ∼20% of bona fide brightest (L≫L{sup ∗}) z = 9 or 10 candidates from a BoRG selected sample based on the Mason et al. luminosity functions, assuming the Holwerda et al. z∼9 size–luminosity relation. We argue that including a size constraint in lieu of a visual inspection may serve in wide-field searches for these objects in, e.g., Euclid or HST archival imaging with the understanding that some brightest (L≫L{sup ∗}) candidates may be missed. The sizes of the candidates found by Morishita et al. follow the expected size distribution of z ∼ 9 for bright galaxies, consistent with the log normal in Shibuya et al. and single objects. Two candidates show high star formation surface density (Σ{sub SFR}>25M{sub ⊙} kpc{sup −2}) and all merit further investigation and follow-up observations.

79 ASTRONOMY AND ASTROPHYSICS↗

Figure of merit for direct-detection optical channels

The capacity and sensitivity of a direct-detection optical channel are calculated and compared to those of a white Gaussian noise channel. Unlike Gaussian channels in which the receiver performance can be characterized using the noise temperature, the performance of the direct-detection channel depends on both signal and background noise, as well as the ratio of peak to average signal power. Because of the signal-power dependence of the optical channel, actual performance of the channel can be evaluated only by considering both transmit and receive ends of the systems. Given the background noise power and the modulation bandwidth, however, the theoretically optimum receiver sensitivity can be calculated. This optimum receiver sensitivity can be used to define the equivalent receiver noise temperature and calculate the corresponding G/T product. It should be pointed out, however, that the receiver sensitivity is a function of signal power, and care must be taken to avoid deriving erroneous projections of the direct-detection channel performance.

Chen, C.-C.↗

Neutron stars and white dwarfs in galactic halos

The possibility that galactic halos are composed of stellar remnants such as neutron stars and white dwarfs is discussed. On the basis of a simple model for the evolution of galactic halos, researchers follow the history of halo matter, luminosity, and metal and helium abundances. They assume conventional yields for helium and the heavier elements. By comparing with the observational constraints, which may be considered as fairly conservative, it is found that, for an exponentially decreasing star formation rate (SFR) with e-folding time tau, only values between 6 x 10(8) less than similar to tau less than similar to 2 x 10(9) years are allowed together with a very limited range of masses for the initial mass function (IMF). Star formation is allowed for 2 solar mass less than similar to m less than similar to 8 solar mass if tau = 2 x 10(9) years, and for 4 solar mass less than similar to m less than similar to 6 solar mass if tau = 10(9) years. For tau = 6 x 10(8) years, the lower and upper mass limits merge to similar to 5 solar mass. Researchers conclude that, even though the possibility of neutron stars as halo matter may be ruled out, that of white dwarfs may still be a viable hypothesis, though with very stringent constraints on allowed parameters, that merits further consideration.

Ryu, Dongsu↗

Neutron stars and white dwarfs in galactic halos?

The possibility that galactic halos are composed of stellar remnants such as neutron stars and white dwarfs is discussed. On the basis of a simple model for the evolution of galactic halos, researchers follow the history of halo matter, luminosity, and metal and helium abundances. They assume conventional yields for helium and the heavier elements. By comparing with the observational constraints, which may be considered as fairly conservative, it is found that, for an exponentially decreasing star formation rate (SFR) with e-folding time tau, only values between 6 x 10(8) less than similar to tau less than similar to 2 x 10(9) years are allowed together with a very limited range of masses for the initial mass function (IMF). Star formation is allowed for 2 solar mass less than similar to m less than similar to 8 solar mass if tau = 2 x 10(9) years, and for 4 solar mass less than similar to m less than similar to 6 solar mass if tau = 10(9) years. For tau = 6 x 10(8) years, the lower and upper mass limits merge to similar to 5 solar mass. Researchers conclude that, even though the possibility of neutron stars as halo matter may be ruled out, that of white dwarfs may still be a viable hypothesis, though with very stringent constraints on allowed parameters, that merits further consideration.

Ryu, Dongsu↗

Solid structure of Li 2 BeF 4 (FLiBe) from room temperature to melting studied by neutron and X-ray diffraction

Molten fluoride salts such as Li 2 BeF 4 (FLiBe) are used in molten salt reactors, fluoride-salt-cooled high-temperature reactors and fusion reactors as a fuel solvent, coolant and/or tritium breeding medium. In engineered systems that use molten salt, solid-state material will be present during melting and freezing scenarios, and therefore the temperature-dependent properties of the solid and solid/liquid phase transition merit investigation. To observe the behavior of the solid state of Li 2 BeF 4 from room temperature to melting, this work used neutron and X-ray diffraction to measure the changes in the lattice parameters and volume of the crystalline unit cell and compared the results with prior low-temperature data for solid Li 2 BeF 4 . From neutron diffraction data it is also possible to identify anisotropy: centimetre-scaled crystals align preferentially with the a axes parallel to the direction of freezing front propagation, and the c axes expand 54% more than the a axes. This work provides the lattice constants as a function of temperature, quantifies the thermal expansion, and determines the equation describing the change in density for solid Li 2 BeF 4 from room temperature to 459°C to be ρ solid (kg m −3 ) = 2182 (3) − 0.115 (2) T (°C) and the volume expansion upon melting to be less than 5%. This density changes depending on molecular weight and enrichment.

36 MATERIALS SCIENCE↗

Variable-beamwidth monopulse antennas

The merits of nine methods for zooming microwave amplitude-sensing monopulse antenna patterns are discussed. Of these, six are directly related to the TDRSS (Tracking Data Relay Satellite System) and are compatible with a deployable-mesh pseudo-paraboloidal main reflector. The remaining three methods utilize radically different geometrical configurations that depart considerably from the TDRSS parameters existing at this time. Preservation of the monopulse postulates is considered to be of prime importance for any variable-beamwidth candidate, however, it is allowed that approximate satisfaction of the postulates should be accepted for practical reasons. All of the methods discussed admit free choice of the polarization state, and the zooming function is never predicated on polarization. Exploration of the zooming techniques was carried out almost entirely by means of the Kirchhoff-Kottler vector diffraction program. The program generates electric and magnetic field intensity, associated phase, and time-average Poynting vector power flow in the intermediate near-field and far-field zones in both receive and transmit modes of operation. A few of the concepts have been verified experimentally with excellent agreement between theory and practice.

Schmidt, R. F.↗

Dark Energy Survey year 3 results: covariance modelling and its impact on parameter estimation and quality of fit

ABSTRACT We describe and test the fiducial covariance matrix model for the combined two-point function analysis of the Dark Energy Survey Year 3 (DES-Y3) data set. Using a variety of new ansatzes for covariance modelling and testing, we validate the assumptions and approximations of this model. These include the assumption of Gaussian likelihood, the trispectrum contribution to the covariance, the impact of evaluating the model at a wrong set of parameters, the impact of masking and survey geometry, deviations from Poissonian shot noise, galaxy weighting schemes, and other sub-dominant effects. We find that our covariance model is robust and that its approximations have little impact on goodness of fit and parameter estimation. The largest impact on best-fitting figure-of-merit arises from the so-called fsky approximation for dealing with finite survey area, which on average increases the χ2 between maximum posterior model and measurement by $3.7{{\ \rm per\ cent}}$ (Δχ2 ≈ 18.9). Standard methods to go beyond this approximation fail for DES-Y3, but we derive an approximate scheme to deal with these features. For parameter estimation, our ignorance of the exact parameters at which to evaluate our covariance model causes the dominant effect. We find that it increases the scatter of maximum posterior values for Ωm and σ8 by about $3{{\ \rm per\ cent}}$ and for the dark energy equation-of-state parameter by about $5{{\ \rm per\ cent}}$.

79 ASTRONOMY AND ASTROPHYSICS↗

Dark Energy Survey Year 3 results: Optimizing the lens sample in a combined galaxy clustering and galaxy-galaxy lensing analysis

We investigate potential gains in cosmological constraints from the combination of galaxy clustering and galaxy-galaxy lensing by optimizing the lens galaxy sample selection using information from Dark Energy Survey (DES) Year 3 data and assuming the DES Year 1 metacalibration sample for the sources. We explore easily reproducible selections based on magnitude cuts in i-band as a function of (photometric) redshift, zphot, and benchmark the potential gains against those using the well-established redMaGiC [E. Rozo et al., Mon. Not. R. Astron. Soc. 461, 1431 (2016)MNRAA40035-871110.1093/mnras/stw1281] sample. We focus on the balance between density and photometric redshift accuracy, while marginalizing over a realistic set of cosmological and systematic parameters. Our optimal selection, the MagLim sample, satisfies i<4zphot+18 and has ∼30% wider redshift distributions but ∼3.5 times more galaxies than redMaGiC. Assuming a wCDM model (i.e. with a free parameter for the dark energy equation of state) and equivalent scale cuts to mitigate nonlinear effects, this leads to 40% increase in the figure of merit for the pair combinations of Ωm, w, and σ8, and gains of 16% in σ8, 10% in Ωm, and 12% in w. Similarly, in ΛCDM, we find an improvement of 19% and 27% on σ8 and Ωm, respectively. We also explore flux-limited samples with a flat magnitude cut finding that the optimal selection, i<22.2, has ∼7 times more galaxies and ∼20% wider redshift distributions compared to MagLim, but slightly worse constraints. We show that our results are robust with respect to the assumed galaxy bias and photometric redshift uncertainties with only moderate further gains from increased number of tomographic bins or the inclusion of bin cross-correlations, except in the case of the flux-limited sample, for which these gains are more significant.

79 ASTRONOMY AND ASTROPHYSICS↗

Development of a figure-of-merit for space missions

The concept of a quantitative figure-of-merit (FOM) to evaluate different and competing options for space missions is further developed. Over six hundred individual factors are considered. These range from mission orbital mechanics to in-situ resource utilization (ISRU/ISMU) plants. The program utilizes a commercial software package for synthesis and visual display; the details are completely developed in-house. Historical FOM's are derived for successful space missions such as the Surveyor, Voyager, Apollo, etc. A cost FOM is also mentioned. The bulk of this work is devoted to one specific example of Mars Sample Return (MSR). The program is flexible enough to accommodate a variety of evolving technologies. Initial results show that the FOM for sample return is a function of the mass returned to LEO, and that missions utilizing ISRU/ISMU are far more cost effective than those that rely on all earth-transported resources.

Preiss, Bruce↗

Protein remote homology detection and structural alignment using deep learning

Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence similarity to previously annotated proteins. We develop two deep learning methods to address this gap, TM-Vec and DeepBLAST. TM-Vec allows searching for structure–structure similarities in large sequence databases. It is trained to accurately predict TM-scores as a metric of structural similarity directly from sequence pairs without the need for intermediate computation or solution of structures. Once structurally similar proteins have been identified, DeepBLAST can structurally align proteins using only sequence information by identifying structurally homologous regions between proteins. It outperforms traditional sequence alignment methods and performs similarly to structure-based alignment methods. We show the merits of TM-Vec and DeepBLAST on a variety of datasets, including better identification of remotely homologous proteins compared with state-of-the-art sequence alignment and structure prediction methods.

59 BASIC BIOLOGICAL SCIENCES↗

CRCNS US-France Research Proposal: Collaborative Research: Encoding reward expectation in Drosophilia

The fruit fly Drosophila melanogaster has been a valuable model for investigating the genetic and neural bases that underlie learning and memory. Early and most current studies use basic behavior conditioning protocols to study learning in controlled laboratory settings. More recently, the ability to transgenically manipulate many of the brain neurons in the fruit fly with exquisite specificity, and the recent knowledge of the synaptic ‘connectome’ of the fruit fly brain, makes these animals almost unique as a comprehensive model for studies of learning, memory and motivated behavior. In fact, the connectome has revealed many types of new connections that had until now been overlooked. Within this context, the thesis of this proposal is that studies of learning and memory will be greatly enhanced by using more sophisticated means for evaluating memory representations, such as have been developed in vertebrates, and combining those studies with information from the connectome guided by computational modelling. We propose to push beyond the boundaries of existing conditioning protocols for fruit flies to investigate more complex memory representations. In particular, we will investigate the function of reinforcement pathways in relation to the absence of expected reinforcement. More specifically, we propose a series of experiments designed to investigate the memory representations in fruit flies when an expected consequence of a Conditioned Stimulus (CS) fails to occur. Although studies have evaluated how this failure can establish extinction memory for the CS, our studies will go beyond studying extinction. Specifically, we predict that in Drosophila when a CS is associated with a failed expectation of an appetitive food reinforcement it will acquire aversive value, and vice versa for a failed expectation of an aversive reinforcer. We combine these studies with manipulations of reinforcement pathways in the CNS inspired from the connectome, iteratively knitted in with established computational models. Intellectual Merit: The concept of reinforcement expectation and incentive contrast have been influential in the development of studies of associative learning in mammals. These questions are particularly challenging to answer in vertebrates because they require exquisite cellular, temporal, and genetic specificity of experimental manipulations. The recent development of work with identified neurons and their connectomes makes the larval and adult fly brains ripe as models for pushing our understanding of neural bases for these higher- order conditioning phenomena. Broader Impacts: Public health: These analyses and the conceptual framework of prediction error processing underlying them have a profound impact on our understanding of reinforcement-related behavior in humans, including monetary rewards and the mnemonic consequences of traumatic experiences, and for pathologies of the dopamine reinforcement system. Educational: This project will provide interdisciplinary training for postdoctoral researchers, Ph.D. and undergraduate students. The PIs will act as co-supervisors or mentors of students working in the different labs via face-to-face and internet-based technologies. We will also work with ASU’s award-winning Ask- A-Biologist program. This is an online science program designed to enrich the learning experiences of students of all ages and to provide classroom material for use by K-12 teachers. We will develop an extension of a game developed under a prior NSF award, and the new game will include modules to teach K-12 students about how insects learn. We will also integrate into the AAB site a program developed by a collaborator (B Gerber) at the Leibniz Institut für Neurobiologie, Magdeburg, and now in use in schools in Germany, to teach K-12 students how to train animals using the fruit fly larval learning paradigm. Underrepresented groups: All PIs will work with their university offices of Academic Diversity and Equal Opportunity for reaching underrepresented students.

59 BASIC BIOLOGICAL SCIENCES↗

Hybrid X-ray telescope systems

It has been known for some time that glancing incidence X-ray optics have sharply peaked point response functions. The spatial resolution of Wolter X-ray telescope systems is frequently limited by the performance characteristics of the X-ray detector rather than by the optics, even when high resolution detectors such as photographic emulsions are used. This problem becomes even more severe when it is desirable to take advantage of the high sensitivity and broad wavelength response afforded by modern solid state detectors such as charge coupled devices or multi-anode microchannel arrays. Results of theoretical investigations of methods for increasing the telescope plate scale by the use of glancing incidence hyperboloid/ellipsoid X-ray microscope optics and normal incidence contoured layered synthetic microstructure optics for coupling the Wolter mirrors to the detector are reported. The relative merits of the different hybrid X-ray telescope systems which result will be discussed. Considerations will be made concerning applications of these systems to high resolution imagery and spectroscopy of astronomical X-ray/XUV sources.

Shealy, David L.↗

The effect of elastic boundary conditions on the dynamic response of rectangular plates

Natural frequencies and forced steady-state harmonic response for the vibration of uniform rectangular plates with edges elastically restrained against rotation and transverse translation are addressed. A single mode Rayleigh-Ritz solution is derived using functions that describe the normal modes of vibration of a beam whose ends are elastically restrained. The finite element solution is obtained for comparison. MACSYMA symbolic manipulation system is implemented as an aid to the mathematical rigor of the Ritz approach, and NASTRAN finite element code is used to model the mechanical system. Comparisons are made to published results and the solutions of this study are found to give lower frequencies for some values of boundary restraint. Steady-state harmonic amplitudes of displacement and acceleration are found to agree favorably for the two solutions. Low predictions of steady-state strain from NASTRAN result in some cases when compared to the Ritz values. Finally, a subjective assessment is made about the merit of using MACSYMA and NASTRAN.

Brewer, Terry K.↗