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At least 307 records · Page 17

Nutritional Biochemistry of Spaceflight

Adequate nutrition is critical for crew health and safety during spaceflight. To ensure adequate nutrition, the nutrient requirements need to be both accurate and available from the spaceflight food system. The existing nutritional requirements for extended-duration spaceflight have been defined largely by extrapolation from ground-based research. However, nutritional requirements are influenced by most of the physiological consequences of spaceflight, including loss of lean, adipose, and bone tissue; changes in blood composition; and increased risk of renal stone formation. This review focuses on key areas where information has been gained in recent years: dietary intake and energy metabolism, bone health, fluid and electrolyte homeostasis, and hematological changes. Areas in which specific nutrients have the potential to serve as countermeasures to the negative effects of spaceflight are also reviewed. Dietary Intake

Smith, Scott M.↗

High Dietary Iron and Radiation Exposure Increase Biomarkers of Oxidative Stress in Blood and Liver of Rats

Radiation exposure and increased iron (Fe) status independently cause oxidative damage that can result in protein, lipid, and DNA oxidation. During space flight astronauts are exposed to both increased radiation and increased Fe stores. Increased body Fe results from a decrease in red blood cell mass and the typically high Fe content of the food system. In this study we investigated the combined effects of radiation exposure (0.375 Gy of Cs-137 every other day for 16 days for a total of 3 Gy) and high dietary Fe (650 mg Fe/kg diet compared to 45 mg Fe/kg for controls) in Sprague-Dawley rats (n=8/group). Liver and serum Fe were significantly increased in the high dietary Fe groups. Likewise, radiation treatment increased serum ferritin and Fe concentrations. These data indicate that total body Fe stores increase with both radiation exposure and excess dietary Fe. Hematocrit decreased in the group exposed to radiation, providing a possible mechanism for the shift in Fe indices after radiation exposure. Markers of oxidative stress were also affected by both radiation and high dietary Fe, evidenced by increased liver glutathione peroxidase (GPX) and serum catalase as well as decreased serum GPX. We thus found preliminary indications of synergistic effects of radiation exposure and increased dietary Fe, warranting further study. This study was funded by the NASA Human Research Project.

Morgan, Jennifer L. L.↗

Human-in-the-Loop Integrated Life Support Systems Ground Testing

Human exploration missions beyond low earth orbit will be long duration with abort scenarios of days to months. This necessitates provisioning the crew with all the things they will need to sustain themselves while carrying out mission objectives. Systems engineering and integration is critical to the point where extensive integrated testing of life support systems on the ground is required to identify and mitigate risks. Ground test facilities (human-rated altitude chamber) at the Johnson Space Center are being readied to integrate all the systems for a mission along with a human test crew. The relevant environment will include deep space habitat human accommodations, sealed atmosphere of 8 psi total pressure and 32% oxygen concentration, life support systems (food, air, water), communications, crew accommodations, medical, EVA, tools, etc. Testing periods will approximate those of the expected missions (such as a near Earth asteroid, Earth-Moon L2 or L1, the moon). This type of integrated testing is needed for research and technology development as well as later during the mission design, development, test, and evaluation (DDT&E) phases of an approved program. Testing will evolve to be carried out at the mission level fly the mission on the ground . Mission testing will also serve to inform the public and provide the opportunity for active participation by international partners.

Henninger, Donald L.↗

Human Exploration Missions - Maturing Technologies to Sustain Crews

Human exploration missions beyond low earth orbit will be long duration with abort scenarios of days to months. Providing crews with the essentials of life such as clean air and potable water means recycling human metabolic wastes back to useful products. Individual technologies are under development for such things as CO2 scrubbing, recovery of O2 from CO2, turning waste water into potable water, and so on. But in order to fully evaluate and mature technologies fully they must be tested in a relevant, high-functionality environment; a systems environment where technologies are challenged with real human metabolic wastes. It is for this purpose that an integrated systems ground testing capability at the Johnson Space Center is being readied for testing. The relevant environment will include deep space habitat human accommodations, sealed atmosphere of 8 psi total pressure and 32% oxygen concentration, life support systems (food, air, water), communications, crew accommodations, medical, EVA, tools, etc. Testing periods will approximate those of the expected missions (such as a near Earth asteroid, Earth ]Moon L2 or L1, the moon, and Mars). This type of integrated testing is needed not only for research and technology development but later during the mission design, development, test, and evaluation phases of preparing for the mission.

Mukai, Chiaki↗

Human in the Loop Integrated Life Support Systems Ground Testing

Human exploration missions beyond low earth orbit will be long duration with abort scenarios of days to months. This necessitates provisioning the crew with all the things they will need to sustain themselves while carrying out mission objectives. Systems engineering and integration is critical to the point where extensive integrated testing of life support systems on the ground is required to identify and mitigate risks. Ground test facilities (human-rated altitude chambers) at the Johnson Space Center are being readied to integrate all the systems for a mission along with a human test crew. The relevant environment will include deep space habitat human accommodations, sealed atmosphere capable of 14.7 to 8 psi total pressure and 21 to 32% oxygen concentration, life support systems (food, air, and water), communications, crew accommodations, medical, EVA, tools, etc. Testing periods will approximate those of the expected missions (such as a near Earth asteroid, Earth-Moon L2 or L1, the moon, Mars). This type of integrated testing is needed for research and technology development as well as later during the mission design, development, test, and evaluation (DDT&E) phases of an approved program. Testing will evolve to be carried out at the mission level fly the mission on the ground . Mission testing will also serve to inform the public and provide the opportunity for active participation by international, industrial and academic partners.

Henninger, Donald L.↗

An Updated Look at the Pro K Experiment: Urinary Acid Excretion Can Predict Changes in Bone Metabolism During Space Flight

Mitigating space flight-induced bone loss is critical for space exploration, and diet can play a major role in this effort (1). Previous ground-based studies provide evidence that dietary composition can influence bone resorption during bed rest (2). In this study we examined the role of dietary intake patterns as one factor that can influence bone mineral loss in astronauts during space flight. Crew members were asked to consume, for 4 days at a time, prescribed menus with either a low (0.3-0.6 g/mEq) or high (1.0-1.3 g/mEq) ratio of animal protein to potassium (APro:K). Menus were developed for each crewmember, and were designed to meet both crew preferences and study constraints. Intakes of energy, total protein, calcium, and sodium were held relatively constant between the two diets. The order of the menus was randomized, and crews completed each set (low and high) once before and twice during space flight, for a total of 6 controlled diet sessions. One inflight session and three postflight sessions (R+30, R+180, R+365) monitored typical dietary intake. As of this writing, data are available from 14 crew members. Two subject's samples are awaiting return from ISS via Space-X, and the final subject has one more collection session planned in November 2014. On the last day of each of the 4-d controlled diet sessions, 24-h urine samples were collected, along with a fasting blood sample on the morning of the 5th day. Preliminary analyses will show the relationships between diet and flight on markers of bone metabolism. The results from this study, which represent healthy individuals in a unique environment, will be important to better understand diet and bone interrelationships during space flight as well as on Earth. These data will be important as nutritional requirements and food systems are developed for future exploration-class missions. This study was funded by the Human Health Countermeasures Element of NASA Human Research Program.

Zwart, Sara R.↗

The Agricultural Model Intercomparison and Improvement Project: Phase I Activities by a Global Community of Science

The Agricultural Model Intercomparison and Improvement Project (AgMIP) was founded in 2010. Its mission is to improve substantially the characterization of world food security as affected by climate variability and change, and to enhance adaptation capacity in both developing and developed countries. The objectives of AgMIP are to: Incorporate state-of-the-art climate, crop/livestock, and agricultural economic model improvements into coordinated multi-model regional and global assessments of future climate impacts and adaptation and other key aspects of the food system. Utilize multiple models, scenarios, locations, crops/livestock, and participants to explore uncertainty and the impact of data and methodological choices. Collaborate with regional experts in agronomy, animal sciences, economics, and climate to build a strong basis for model applications, addressing key climate related questions and sustainable intensification farming systems. Improve scientific and adaptive capacity in modeling for major agricultural regions in the developing and developed world, with a focus on vulnerable regions. Improve agricultural data and enhance data-sharing based on their intercomparison and evaluation using best scientific practices. Develop modeling frameworks to identify and evaluate promising adaptation technologies and policies and to prioritize strategies.

farm crops↗

Effect of Low Shear Modeled Microgravity (LSMMG) on the Probiotic Lactobacillus Acidophilus ATCC 4356

The introduction of generally recognized as safe (GRAS) probiotic microbes into the spaceflight food system has the potential for use as a safe, non-invasive, daily countermeasure to crew microbiome and immune dysregulation. However, the microgravity effects on the stress tolerances and genetic expression of probiotic bacteria must be determined to confirm translation of strain benefits and to identify potential for optimization of growth, survival, and strain selection for spaceflight. The work presented here demonstrates the translation of characteristics of a GRAS probiotic bacteria to a microgravity analog environment. Lactobacillus acidophilus ATCC 4356 was grown in the low shear modeled microgravity (LSMMG) orientation and the control orientation in the rotating wall vessel (RWV) to determine the effect of LSMMG on the growth, survival through stress challenge, and gene expression of the strain. No differences were observed between the LSMMG and control grown L. acidophilus, suggesting that the strain will behave similarly in spaceflight and may be expected to confer Earth-based benefits.

Stahl, S.↗

Assessing Impacts of Climate Change on Food Security Worldwide

The combination of a warming Earth and an increasing population will likely strain the world's food systems in the coming decades. Experts involved with the Agricultural Model Intercomparison and Improvement Project (AgMIP) focus on quantifying the changes through time. AgMIP, a program begun in 2010, involves about 800 climate scientists, economists, nutritionists, information technology specialists, and crop and livestock experts. In mid-September 2015, the Aspen Global Change Institute convened an AgMIP workshop to draft plans and protocols for assessing global- and regional-scale modeling of crops, livestock, economics, and nutrition across major agricultural regions worldwide. The goal of this Coordinated Global and Regional Integrated Assessments (CGRA) project is to characterize climate effects on large- and small-scale farming systems.

farm crops↗

International Life Sciences Research Announcement 'Pick and Eat' Project Contributions

The International Life Sciences Research Announcement (ILSRA) is a grant which focuses on 'Pick and Eat' salad-crop productivity, nutritional value, and acceptability to supplement the International Space Station (ISS) food system. My contributions into this project were to 1) manage the Veggie chambers to maintain optimal plant growth and attend to any plant needs, 2) analyze data for the VEG-04 Science Verification Test to create a water delivery schedule for the astronauts aboard the ISS, and 3) assume the role as a VEG-04 Experiment Verification Test (EVT) 'pseudonaut' to confirm that all schedules and flight procedures produce quality results. The VEG-04 EVT will continue up until the last day of my internship. Additionally, I'm currently working on two independent research projects, both of which provide insight to potential plant growth hardware options for lunar or Martian surfaces. One of which is a cable culture hydroponics system (favorable in areas with highly limited space), and the other are two aeroponic systems (a subset of hydroponics which uses no media and misting as its delivery for water and nutrients). All independent projects are still being tested and therefore results are not yet established. Lastly, I have been in charge of maintaining the AeroGarden (Registered Trademark), a hydroponic-aeroponic hybrid system which is currently being investigated as a concept to the potential for minimizing human involvement in the process of growing plants. This has the potential to play a major role in future technological project designs for spaceflight hardware. This system is an ongoing project that will continue once my internship ends.

Moore, Jessica↗

Nutrition Requirements, Standards, and Operating Bands for Exploration Missions

The challenge was brought forward in early 2005 to define the nutritional requirements for Exploration missions, and to define the relevant standards and associated operating bands related to nutrition. This document is the result of this charge. An extensive review of existing knowledge was conducted with participation of intramural and extramural experts, and the findings are summarized herein. In short, the approach taken was to define the nutrient intake requirements, that is, the amount of each nutrient expected to be available in the food system. The standards are defined as markers of nutritional status, with optimal (green), sub-optimal (yellow), and critical (red) levels for each. For many of the nutrient requirements, it is not known if they are altered during space flight. Furthermore, in many cases the intake of a nutrient may act as a countermeasure to one or more negative effects of space flight, but these potential countermeasures, too, are not well defined. Thus, we have also documented herein the areas where further research is required. Accordingly, while this document is intended as a comprehensive summary of our knowledge to date, it is expected that this is the first edition of these requirements and standards. As we learn more about space-flight nutrition, and as relationships between disease and nutrients are further defined in Earth-based populations, this document, and the approach to nutrition in the space rogram, will need to be updated accordingly.

Neubek, Deborah J.↗

Nutritional and Organoleptic of Solanaceous Crops

Long-duration missions beyond low-Earth orbit will encounter challenges in maintaining adequate nutrition and acceptability in the food system. In situ production of fresh produce can supplement nutrient deficiencies in the prepackaged diet.

L. E. Spencer↗

Legume Organoleptic and Nutritional Analysis

Long-duration missions beyond low Earth orbit will encounter challenges in maintaining adequate nutrition and acceptability in the food system. In situ production of fresh produce can supplement nutrients deficient in the stored diet. Currently there is a limited number of crops that can be reliably grown for space crop production. Recent challenges with Veggie plant growth technical demonstrations (i.e. Tokyo Bekana Chinese cabbage interveinal chlorosis and necrosis when grown under elevated CO2 (~3000ppm) and narrow-band LED lighting) have highlighted the necessity to conduct rigorous ISS-relevant crop screening on the ground. Additionally, crops must be selected to address specific nutritional deficits as identified by HRP, with an emphasis on having a large diversity of crops available to meet nutritional requirements and crew acceptability. A variety of crop types are necessary to address known nutritional deficits in the stored astronaut diet, to include leafy greens (vitamin C, vitamin K, potassium), tomatoes and peppers (vitamin C, potassium, lycopene), and legumes (vitamin B1).Legumes are being evaluated for biological performance and suitability under ISS-like environmental conditions as well as nutritional content and acceptability. Legumes are one of the few pick and eat crop types that is an excellent source of Vitamin B1.In FY21-22 Biological and Physical Sciences (BPS) is funding screening of 32 legume crop cultivars at KSC, 16 of which will be down-selected based on horticultural performance and informal taste testing for further horticultural assessment and analysis. HRP in FY21-22 is funding organoleptic and nutritional analysis of these 16 down-selected legume cultivars to determine the most promising candidates for future space applications. Nutritional analysis will include full elemental, proximate (fat, protein, calories, carbohydrates, ash), and vitamins B1, C, K. This new work is currently postponed due to Covid-19.

L E Spencer↗

Narrowing Uncertainties in the Effects of Elevated CO2 on Crops

Plant responses to rising atmospheric carbon dioxide (CO2) concentrations, together with projected variations in temperature and precipitation will determine future agricultural production. Estimates of the impacts of climate change on agriculture provide essential information to design effective adaptation strategies, and develop sustainable food systems. Here, we review the current experimental evidence and crop models on the effects of elevated CO2 concentrations. Recent concerted efforts have narrowed the uncertainties in CO2-induced crop responses so that climate change impact simulations omitting CO2 can now be eliminated. To address remaining knowledge gaps and uncertainties in estimating the effects of elevated CO2 and climate change on crops, future research should expand experiments on more crop species under a wider range of growing conditions, improve the representation of responses to climate extremes in crop models, and simulate additional crop physiological processes related to nutritional quality.

carbon dioxide (CO2)↗

Importance of Trade Dependencies for Agricultural Inputs: A Case Study of Finland

Approximately 80% of the world's population lives in countries that are dependent on food imports to sustain an adequate food supply. Besides these food imports, further dependencies also arise due to the requirements for agricultural inputs, including energy, fertilisers, feed and agricultural machinery. While the trade of agricultural inputs is relatively well represented in economic analysis, the quantification is often in terms of monetary values, and thus the assessments of the actual input quantities are very limited. In this paper, we develop a framework for analysis of the traded input quantities at the country-level and demonstrate its utility through an in-depth analysis of Finland's dependency on agricultural inputs. Further, we assess the importance of these inputs for domestic food production from a resilience perspective. We find that Finland, a country with relatively high food self-sufficiency but also a great dependency on imported agricultural inputs, experienced an increase in its dependency over the period 1996-2016. In case of trading partners, the story is more mixed: while trading partners for soybeans increased, those decreased in case of electricity while no significant change was observed in other commodities. In Finland, the rapeseed dependency on imports (ratio of net imports and consumption) grew from around 0% to almost 50% between the years 1987-2013. Changes for electricity remained substantially smaller, with dependency only slightly growing during the study period. Crude oil and soybean supplies are totally dependent on imports as neither is produced in Finland. Interestingly, the highest dependencies for agricultural inputs were on different countries than that for foodstuff imports. Thus, when identifying and assessing approaches to increase resilience to trade-related shocks, it is essential to understand both foodstuff and agricultural input dependencies within the global food system.

trade dependencies↗

Crop Production In Support Of Exploration

The History of Food and Exploration, an Overview of the History of Space Food Systems, the Vision of Space Crop Production and its Role in Exploration, an Overview of Challenges and Knowledge Gaps with Reference to Recent Flight Testing on the International Space Station, Crop Production Challenges Beyond Low Earth Orbit including the Lunar Operations, the Transit Mission to Mars and Mars Surface Operations.

Crop production↗

Extended Duration: The SIRIUS 21 Crew Perspective

The SIRIUS (Scientific International Research In a Unique terrestrial Station) missions represent a collaborative effort between NASA and Russia’s Institute for Biomedical Problems (IBMP) to conduct a series of long duration isolation and confinement spaceflight analog missions. Three missions of 17-day, 4-month, and 8-month duration (SIRIUS 17, 19, and 21) have been completed at IBMP’s Ground-Based Experimental Complex / Nazemnyy eksperimental'nyy kompleks (NEK) in Moscow, Russia. The international SIRIUS 21 crew comprising representatives from the United States, United Arab Emirates and Russia recently completed the 8-month analog lunar mission. The extended duration mission included simulated lunar transit, orbital, and surface operations with corresponding deep space communication delay, during which the crew participated in nearly 70 studies, eight of which were sponsored by NASA’s Human Research Program. The studies examined the effect of isolation and confinement on the behavioral health of research subjects, and investigated medical countermeasures, team performance, crew dynamics, crew autonomy, food system risks, consequences of confinement and associated physiological stressors. SIRIUS 21 crewmembers also participated in operational tasks such as Rover and CubeSat assembly, simulated lunar sample assessment, VR activities, robotic arm training, environmental systems monitoring, exercise, greenhouse maintenance and 3D printing. Communication with Mission Control was limited to 30-minute periods every two hours. Since access to the internet and email was restricted, simulated ground support provided the Crew’s primary source of daily news and mission information. This panel discussion will include presentations from the US SIRIUS 21 crewmembers – William Brown and Ashley Kowalski – about their experience participating in the mission and science. A facilitated question and answer session will follow with attendees encouraged to ask questions and join in discussion with the SIRIUS 21 crewmembers about their experiences. William Brown came to SIRIUS 21 with experience spread across multiple industries, including the military, defense contracting, healthcare consulting, software engineering, and logistics. He has lived in the Middle East, Central Asia, and Russia. A former Boren Scholar, Brown is fluent in Russian. He holds a Master of International Business degree from the University of South Carolina’s Darla Moore School of Business. Prior to that, he earned a bachelor’s degree in Russian language, literature, and culture from the University of South Carolina. There, he also completed additional undergraduate coursework in computer science. Ashley Kowalski is a Project Leader in The Aerospace Corporation’s International Partnerships Department, where she works with, represents, and provides technical support to the the U.S. Space Force Space Systems Command International Affairs (SSC/IA) office. Through her numerous national and international assignments (Russia, China, and Germany), she has worked on topics related to international space systems, national security space systems, civil systems (including human spaceflight and civil launch projects), space policy, satellite industry analysis, and satellite manufacturing start-ups. She is proficient in Russian and German, and fluent in Polish. Kowalski received her Bachelor of Science and Master of Science degrees in mechanical and aerospace engineering from George Washington University in 2011 and 2012, respectively.

S. E. Whiting↗

Accelerating Adoption of Energy-Efficient Technology with the Thermalize Model

The accelerating impacts of climate change destabilize food systems and ecosystems alongside the communities that rely on them. Thus, climate resilience is a health equity issue at both a physical (relating to biological impacts of pollution and environmental degradation) and a cultural level (loss of subsistence lifestyles, languages, etc). With roughly 20% of US energy-related greenhouse gas emissions stemming from heating, cooling, and powering households, accessible energy-efficient home retrofits are a critical element of climate change mitigation strategies. For communities already producing electricity from renewable sources, like Juneau, incentivizing ductless heat pump upgrades and energy efficiency retrofits provides an accessible pathway to transition households away from oil heating and drastically reduce emissions. Thermalize Juneau is a pilot program that will explore a repeatable framework for accelerating the adoption of energy-efficient technology in Alaska communities. This poster will describe Thermalize Juneau's goals and framework, progress through spring 2021, and future plans.

ductless heat pumps↗