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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Behavioral, Brain Imaging, and Genomic Measures to Predict Functional Outcomes After Bed Rest and Spaceflight
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The Benefits of Napping for Safety & How Quickly Can the Brain Wake-Up from Sleep?
Fatigue is a hazard that must be managed within 24-hour safety-critical operations. Napping is the best known countermeasure to fatigue caused by sleep-loss and circadian misalignment. This presentation will: define fatigue; discuss ways to make the most of a nap opportunity; highlight the benefits of napping, including two case studies from workplace settings; outline the challenges in implementing napping in the workplace; and walk through examples to demonstrate that not all naps are equal when it comes to benefits to alertness and performance. The second half of the presentation will focus on sleep inertia, that is, the brief period of impaired alertness and performance experienced after waking from sleep. The factors contributing to and caused by sleep inertia will be discussed, along with countermeasures to reduce the impact of sleep inertia on alertness and performance.
Using a Wearable, Low-Cost Brain Monitoring System During an Ambulatory Virtual Reality EVA Simulation
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The Brain in Space: Implications for Human Explorations of Mars and Human Conditions on Earth
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Electronic Brain Design for Advanced Microspacecraft
A brief history of NASA robotic spacecraft computing architectures is given. Changing needs driving changes in features (10x reduction in cost, various increases in capability, 10x to 100x reduction in power, mass and volume) for spacecraft computing are discussed. A scaleable, parallel/neural computing architecture which addresses these changes is proposed. Evaluation of some of this architecture's components is detailed. Finally, future directions of exploration for this spacecraft computing architecture are considered.
Examining the Effects of 4He Exposure on the Gut-Brain Axis
Beyond low earth orbit, space radiation poses significant risks to astronaut health. Previous studies have shown that the microbial composition of the gastrointestinal (GI) microbiome changes upon exposure to high linear energy transfer radiation. Interestingly, radiation-induced shifts in GI microbiota composition are linked to various neuropsychological disorders. Herein, we aimed to study changes in GI microbiota and behaviors of rats exposed to whole-body radiation (0, 5, or 25 cGy 4 He, 250 MeV/n) at approximately 6 months of age. Fecal samples were collected 24 hours prior to 4 He radiation and 24 hours and 7 days post-exposure for quantitative PCR analyses to assess fecal levels of spore-forming bacteria (SFB), Bifidobacterium, Lactobacillus, and Akkermansia. Rats were also tested in the social odor recognition memory (SORM) test at 7 days following 4 He exposure. A subset of rats was euthanized 90 minutes following completion of the SORM test, and GI tissue from small intestine to colon were prepared for examining overall histological changes and immunohistochemical staining for serotonin (5-HT). No notable pathological changes were observed in GI tissues. Akkermansia spp. and SFB were significantly decreased the 25 cGy group at 24 hours and 7 days post-exposure compared to pre-exposure, respectively. Bifidobacterium and Lactobacillus spp. showed no significant changes. 5-HT production was significantly higher in the proximal small intestine and the cecum in the 25 cGy group compared to the sham group. The 25 cGy group exhibited deficits in recognition in SORM testing at 7 days post-exposure. Taken together, these results suggest a connection between GI microbiome 3 composition, serotonin production, and neurobehavioral performance, and that this connection may be disrupted upon exposure to 25 cGy of 4 He ions
Snapping Shrimp Have Helmets That Protect Their Brains By Dampening Shock Waves
Shock waves are supersonic high-amplitude pressure waves that cause barotrauma when they transfer kinetic energy to the tissues of animals.1–4 Snapping shrimp (Alpheidae) produce shock waves and are exposed to them frequently, so we asked if these animals have evolved mechanisms of physical protection against them. Snapping shrimp generate shock waves by closing their snapping claws rapidly enough to form cavitation bubbles that release energy as an audible ‘‘snap’’ and a shock wave when they collapse.5–8 We tested if snapping shrimp are protected from shock waves by a helmet-like extension of their exoskeleton termed the orbital hood. Using behavioral trials, we found shock wave exposure slowed shelterseeking and caused a loss of motor control in Alpheus heterochaelis from which we had removed orbital hoods but did not significantly affect behavior in shrimp with unaltered orbital hoods. Shock waves thus have the potential to harm snapping shrimp but may not do so under natural conditions because of protection provided to shrimp by their orbital hoods. Using pressure recordings, we discovered the orbital hoods of A. heterochaelis dampen shock waves. Sealing the anterior openings of orbital hoods diminished how much they altered the magnitudes of shock waves, which suggests these helmet-like structures dampen shock waves by trapping and expelling water so that kinetic energy is redirected and released away from the heads of shrimp. Our results indicate orbital hoods mitigate blast-induced neurotrauma in snapping shrimp by dampening shock waves, making them the first biological armor system known to have such a function.
Reactive Oxygen Species in the Brain: The Good, the Bad, and the Ugly
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Plasma and Brain Cytokine Responses to Single and Combinatorial Spaceflight Stressors in Male and Female Mice
Team expertise in immune, neural, cardiovascular, bone, gravitational, radiation, molecular and behavioral biology, sex differences, countermeasures. Part of Virtual NASA Specialized Center of Research (VNSCOR 2) Collective Team of researchers looking to address commonality across research design and queries.
Overview of NASA Human Research Program (HRP) Integrated Research Plan: Implications for Neuromodulation and Brain-Behavior Relationships
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Lighting Up the Right Brain: Flying Safely & Shaping the Future
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Vestibular brain changes within 70 days of head down bed rest
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Effects of Space Flight on Inflammasome Activation in the Brain of Mice
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The Impact of 6 and 12 Months in Space on Human Brain Structure and Intracranial Fluid Shifts
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Effects of Spaceflight Stressors on Brain Volume, Microstructure, and Intracranial Fluid Distribution
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Miniaturized and Wireless Optical Neurotransmitter Sensor for Real-Time Monitoring of Dopamine in the Brain
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Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight
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