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At least 307 records · Page 17

A limited-angle intrafraction verification (LIVE) system for radiation therapy

Purpose: Currently, no 3D or 4D volumetric x-ray imaging techniques are available for intrafraction verification of target position during actual treatment delivery or in-between treatment beams, which is critical for stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) treatments. This study aims to develop a limited-angle intrafraction verification (LIVE) system to use prior information, deformation models, and limited angle kV-MV projections to verify target position intrafractionally. Methods: The LIVE system acquires limited-angle kV projections simultaneously during arc treatment delivery or in-between static 3D/IMRT treatment beams as the gantry moves from one beam to the next. Orthogonal limited-angle MV projections are acquired from the beam's eye view (BEV) exit fluence of arc treatment beam or in-between static beams to provide additional anatomical information. MV projections are converted to kV projections using a linear conversion function. Patient prior planning CT at one phase is used as the prior information, and the on-board patient volume is considered as a deformation of the prior images. The deformation field is solved using the data fidelity constraint, a breathing motion model extracted from the planning 4D-CT based on principal component analysis (PCA) and a free-form deformation (FD) model. LIVE was evaluated using a 4D digital extended cardiac torso phantom (XCAT) and a CIRS 008A dynamic thoracic phantom. In the XCAT study, patient breathing pattern and tumor size changes were simulated from CT to treatment position. In the CIRS phantom study, the artificial target in the lung region experienced both size change and position shift from CT to treatment position. Varian Truebeam research mode was used to acquire kV and MV projections simultaneously during the delivery of a dynamic conformal arc plan. The reconstruction accuracy was evaluated by calculating the 3D volume percentage difference (VPD) and the center of mass (COM) difference of the tumor in the true on-board images and reconstructed images. Results: In both simulation and phantom studies, LIVE achieved substantially better reconstruction accuracy than reconstruction using PCA or FD deformation model alone. In the XCAT study, the average VPD and COM differences among different patient scenarios for LIVE system using orthogonal 30° scan angles were 4.3% and 0.3 mm when using kV+BEV MV. Reducing scan angle to 15° increased the average VPD and COM differences to 15.1% and 1.7 mm. In the CIRS phantom study, the VPD and COM differences for the LIVE system using orthogonal 30° scan angles were 6.4% and 1.4 mm. Reducing scan angle to 15° increased the VPD and COM differences to 51.9% and 3.8 mm. Conclusions: The LIVE system has the potential to substantially improve intrafraction target localization accuracy by providing volumetric verification of tumor position simultaneously during arc treatment delivery or in-between static treatment beams. With this improvement, LIVE opens up a new avenue for margin reduction and dose escalation in both fractionated treatments and SRS and SBRT treatments.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria

ABSTRACT Brucella abortus σ E1 is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model. A putative ATP-binding cassette transporter operon, bab1_0223-bab1_0226 , is among the most highly activated gene sets in the σ E1 regulon. The proteins encoded by the operon resemble quaternary ammonium-compatible solute importers but are most similar in sequence to the broadly conserved YehZYXW system, which remains largely uncharacterized. Transcription of yehZYXW is activated by the general stress sigma factor σ S in Enterobacteriaceae , which suggests a functional role for this transport system in bacterial stress response across the classes Alphaproteobacteria and Gammaproteobacteria . We present evidence that B. abortus YehZYXW does not function as an importer of known compatible solutes under physiological conditions and does not contribute to the virulence defect of a σ E1 -null strain. The sole in vitro phenotype associated with genetic disruption of this putative transport system is reduced growth in the presence of high Li + ion concentrations. A crystal structure of B. abortus YehZ revealed a class II periplasmic binding protein fold with significant structural homology to Archaeoglobus fulgidus ProX, which binds glycine betaine. However, the structure of the YehZ ligand-binding pocket is incompatible with high-affinity binding to glycine betaine. This is consistent with weak measured binding of YehZ to glycine betaine and related compatible solutes. We conclude that YehZYXW is a conserved, stress-regulated transport system that is phylogenetically and functionally distinct from quaternary ammonium-compatible solute importers. IMPORTANCE Brucella abortus σ E1 regulates transcription in response to stressors encountered in its mammalian host and is necessary for maintenance of chronic infection in a mouse model. The functions of the majority of genes regulated by σ E1 remain undefined. We present a functional/structural analysis of a conserved putative membrane transport system (YehZYXW) whose expression is strongly activated by σ E1 . Though annotated as a quaternary ammonium osmolyte uptake system, experimental physiological studies and measured ligand-binding properties of the periplasmic binding protein (PBP), YehZ, are inconsistent with this function. A crystal structure of B. abortus YehZ provides molecular insight into differences between bona fide quaternary ammonium osmolyte importers and YehZ-related proteins, which form a distinct phylogenetic and functional group of PBPs.

ABC transporter↗

Quantitative adaptation analytics for assessing dynamic systems of systems: LDRD Final Report

Our society is increasingly reliant on systems and interoperating collections of systems, known as systems of systems (SoS). These SoS are often subject to changing missions (e.g., nation- building, arms-control treaties), threats (e.g., asymmetric warfare, terrorism), natural environments (e.g., climate, weather, natural disasters) and budgets. How well can SoS adapt to these types of dynamic conditions? This report details the results of a three year Laboratory Directed Research and Development (LDRD) project aimed at developing metrics and methodologies for quantifying the adaptability of systems and SoS. Work products include: derivation of a set of adaptability metrics, a method for combining the metrics into a system of systems adaptability index (SoSAI) used to compare adaptability of SoS designs, development of a prototype dynamic SoS (proto-dSoS) simulation environment which provides the ability to investigate the validity of the adaptability metric set, and two test cases that evaluate the usefulness of a subset of the adaptability metrics and SoSAI for distinguishing good from poor adaptability in a SoS. Intellectual property results include three patents pending: A Method For Quantifying Relative System Adaptability, Method for Evaluating System Performance, and A Method for Determining Systems Re-Tasking.

99 GENERAL AND MISCELLANEOUS↗

What Questions Would a Systems Engineer Ask to Assess Systems Engineering Models as Credible

Digital Systems Engineering strategies typically call for digital Systems Engineering models to be retained in repositories and certified as an authoritative source of truth (enabling model reuse, qualification, and collaboration). In order for digital Systems Engineering models to be certified as authoritative (credible), they need to be assessed - verified and validated - and with the amount of uncertainty in the model quantified (consider reusing someone else's model without knowing the author). Due to this increasing model complexity, the authors assert that traditional human-based methods for validating, verifying, and uncertainty quantification - such as human-based peer-review sessions - cannot sufficiently establish that a digital Systems Engineering model of a complex system is credible. Digital Systems Engineering models of complex systems can contain millions of nodes and edges. The authors assert that this level of detail is beyond the ability of any group of humans - even working for weeks at a time - to discern and catch every minor model infraction. In contrast, computers are highly effective at discerning infractions with massive amounts of information. The authors suggest that a better approach might be to focus the humans at what model patterns should be assessed and enable the computer to assess the massive details in accordance with those patterns - by running through perhaps 100,000 test loops. In anticipation of future projects to implement and automate the assessment of models at Sandia National Laboratories, a study was initiated to elicit input from a group of 25 Systems Engineering experts. The authors positioning query began with - 'What questions would a Systems Engineer ask to assess Systems Engineering models for credibility?" This report documents the results of that survey.

42 ENGINEERING↗

Communication System Modeling in Transactive Systems

Transactive energy systems almost always rely on communication systems for proper operation but most analysis of transactive systems do not model the communication system. Often these analysis are performed by those without a communication system modeling or simulation background and the difficulty of implementing such models in the analysis environment is prohibitive. Without this model, an understanding of the communication system requirements to successfully implement a transactive energy system can not be comprehended. This report details a capability of auto-generating communication system models from an electrical distribution system model, discusses the need for such models, discusses the method by which these models were developed in this project, and demonstrates the impact on the performance of a load management system when using such models. This capability has been incorporated into Pacific Northwest National Laboratory’s (PNNL) Transactive Energy Simulation Platform (TESP).

24 POWER TRANSMISSION AND DISTRIBUTION↗

Modeling District Heating and Cooling Systems with URBANopt, GeoJSON to Modelica Translator, and the Modelica Buildings Library

The URBANopt project has successfully leveraged OpenStudio/EnergyPlus to model buildings and electrical systems at an urban scale; however, URBANopt has lacked the ability to model district thermal energy systems until recently. This paper will present the modeling infrastructure that was developed specifically for the analysis of district heating and cooling systems, and how it is integrated into the existing URBANopt framework. The paper also discusses the development of new models added to the Modelica Buildings Library to model various district energy system components including loads, energy transfer stations (ETS), distribution networks, and central plants. The paper describes how different building loads can be modeled including time series, TEASER reduced-order models, or Spawn of EnergyPlus models. URBANopt District Energy Systems allows the user to switch between the various configurations.

district heating and cooling↗

Integrated Transmission-and-Distribution System Modeling of Power Systems: State-of-the-Art and Future Research Directions

Integrated transmission-and-distribution (T&D) modeling is a new and developing method for simulating power systems. Interest in integrated T&D modeling is driven by the changes taking place in power systems worldwide that are resulting in more decentralized power systems with increasingly high levels of distributed energy resources. Additionally, the increasing role of the hitherto passive energy consumer in the management and operation of power systems requires more capable and detailed integrated T&D modeling to understand the interactions between T&D systems. Although integrated T&D modeling has not yet found widespread commercial application, its potential for changing the decades-old power system modeling approaches has led to several research efforts in the last few years that tried to (i) develop algorithms and software for steady-state and dynamic modeling of power systems and (ii) demonstrate the advantages of this modeling approach compared with traditional, separated T&D system modeling. In this paper, we provide a review of integrated T&D modeling research efforts and the methods employed for steady-state and dynamic modeling of power systems. We also discuss our current research in integrated T&D modeling and the potential directions for future research. This paper should be useful for power systems researchers and industry members because it will provide them with a critical summary of current research efforts and the potential topics where research efforts are needed to further advance and demonstrate the utility of integrated T&D modeling.

24 POWER TRANSMISSION AND DISTRIBUTION↗

OBSERVATION AND CONFIRMATION OF SIX STRONG-LENSING SYSTEMS IN THE DARK ENERGY SURVEY SCIENCE VERIFICATION DATA

We report the observation and confirmation of the first group- and cluster-scale strong gravitational lensing systems found in Dark Energy Survey data. Through visual inspection of data from the Science Verification season, we identified 53 candidate systems. We then obtained spectroscopic follow-up of 21 candidates using the Gemini Multi-object Spectrograph at the Gemini South telescope and the Inamori-Magellan Areal Camera and Spectrograph at the Magellan/Baade telescope. With this follow-up, we confirmed six candidates as gravitational lenses: three of the systems are newly discovered, and the remaining three were previously known. Of the 21 observed candidates, the remaining 15 either were not detected in spectroscopic observations, were observed and did not exhibit continuum emission (or spectral features), or were ruled out as lensing systems. The confirmed sample consists of one group-scale and five galaxy-cluster-scale lenses. The lensed sources range in redshift z ∼ 0.80–3.2 and in i -band surface brightness i {sub SB} ∼ 23–25 mag arcsec{sup −2} (2″ aperture). For each of the six systems, we estimate the Einstein radius θ {sub E} and the enclosed mass M {sub enc}, which have ranges θ {sub E} ∼ 5″–9″ and M {sub enc} ∼ 8 × 10{sup 12} to 6 × 10{sup 13} M {sub ⊙}, respectively.

79 ASTRONOMY AND ASTROPHYSICS↗

Heat recovery subsystem and overall system integration of fuel cell on-site integrated energy systems

The best HVAC (heating, ventilating and air conditioning) subsystem to interface with the Engelhard fuel cell system for application in commercial buildings was determined. To accomplish this objective, the effects of several system and site specific parameters on the economic feasibility of fuel cell/HVAC systems were investigated. An energy flow diagram of a fuel cell/HVAC system is shown. The fuel cell system provides electricity for an electric water chiller and for domestic electric needs. Supplemental electricity is purchased from the utility if needed. An excess of electricity generated by the fuel cell system can be sold to the utility. The fuel cell system also provides thermal energy which can be used for absorption cooling, space heating and domestic hot water. Thermal storage can be incorporated into the system. Thermal energy is also provided by an auxiliary boiler if needed to supplement the fuel cell system output. Fuel cell/HVAC systems were analyzed with the TRACE computer program.

Mougin, L. J.↗

Small space reactor power systems for unmanned solar system exploration missions

A preliminary feasibility study of the application of small nuclear reactor space power systems to the Mariner Mark II Cassini spacecraft/mission was conducted. The purpose of the study was to identify and assess the technology and performance issues associated with the reactor power system/spacecraft/mission integration. The Cassini mission was selected because study of the Saturn system was identified as a high priority outer planet exploration objective. Reactor power systems applied to this mission were evaluated for two different uses. First, a very small 1 kWe reactor power system was used as an RTG replacement for the nominal spacecraft mission science payload power requirements while still retaining the spacecraft's usual bipropellant chemical propulsion system. The second use of reactor power involved the additional replacement of the chemical propulsion system with a small reactor power system and an electric propulsion system. The study also provides an examination of potential applications for the additional power available for scientific data collection. The reactor power system characteristics utilized in the study were based on a parametric mass model that was developed specifically for these low power applications. The model was generated following a neutronic safety and operational feasibility assessment of six small reactor concepts solicited from U.S. industry. This assessment provided the validation of reactor safety for all mission phases and generatad the reactor mass and dimensional data needed for the system mass model.

Bloomfield, Harvey S.↗

A system management methodology for building successful resource management systems

This paper presents a system management methodology for building successful resource management systems that possess lifecycle effectiveness. This methodology is based on an analysis of the traditional practice of Systems Engineering Management as it applies to the development of resource management systems. The analysis produced fifteen significant findings presented as recommended adaptations to the traditional practice of Systems Engineering Management to accommodate system development when the requirements are incomplete, unquantifiable, ambiguous and dynamic. Ten recommended adaptations to achieve operational effectiveness when requirements are incomplete, unquantifiable or ambiguous are presented and discussed. Five recommended adaptations to achieve system extensibility when requirements are dynamic are also presented and discussed. The authors conclude that the recommended adaptations to the traditional practice of Systems Engineering Management should be implemented for future resource management systems and that the technology exists to build these systems extensibly.

Hornstein, Rhoda Shaller↗

Power system monitoring and source control of the Space Station Freedom DC power system testbed

Unlike a terrestrial electric utility which can purchase power from a neighboring utility, the Space Station Freedom (SSF) has strictly limited energy resources; as a result, source control, system monitoring, system protection, and load management are essential to the safe and efficient operation of the SSF Electric Power System (EPS). These functions are being evaluated in the DC Power Management and Distribution (PMAD) Testbed which NASA LeRC has developed at the Power System Facility (PSF) located in Cleveland, Ohio. The testbed is an ideal platform to develop, integrate, and verify power system monitoring and control algorithms. State Estimation (SE) is a monitoring tool used extensively in terrestrial electric utilities to ensure safe power system operation. It uses redundant system information to calculate the actual state of the EPS, to isolate faulty sensors, to determine source operating points, to verify faults detected by subsidiary controllers, and to identify high impedance faults. Source control and monitoring safeguard the power generation and storage subsystems and ensure that the power system operates within safe limits while satisfying user demands with minimal interruptions. System monitoring functions, in coordination with hardware implemented schemes, provide for a complete fault protection system. The objective of this paper is to overview the development and integration of the state estimator and the source control algorithms.

Kimnach, Greg L.↗

An expert system shell for inferring vegetation characteristics: The learning system (tasks C and D)

This report describes the implementation of a learning system that uses a data base of historical cover type reflectance data taken at different solar zenith angles and wavelengths to learn class descriptions of classes of cover types. It has been integrated with the VEG system and requires that the VEG system be loaded to operate. VEG is the NASA VEGetation workbench - an expert system for inferring vegetation characteristics from reflectance data. The learning system provides three basic options. Using option one, the system learns class descriptions of one or more classes. Using option two, the system learns class descriptions of one or more classes and then uses the learned classes to classify an unknown sample. Using option three, the user can test the system's classification performance. The learning system can also be run in an automatic mode. In this mode, options two and three are executed on each sample from an input file. The system was developed using KEE. It is menu driven and contains a sophisticated window and mouse driven interface which guides the user through various computations. Input and output file management and data formatting facilities are also provided.

Harrison, P. Ann↗

Power system monitoring and source control of the Space Station Freedom dc-power system testbed

Unlike a terrestrial electric utility which can purchase power from a neighboring utility, the Space Station Freedom (SSF) has strictly limited energy resources; as a result, source control, system monitoring, system protection, and load management are essential to the safe and efficient operation of the SSF Electric Power System (EPS). These functions are being evaluated in the dc Power Management and Distribution (PMAD) Testbed which NASA LeRC has developed at the Power System Facility (PSF) located in Cleveland, Ohio. The testbed is an ideal platform to develop, integrate, and verify power system monitoring and control algorithms. State Estimation (SE) is a monitoring tool used extensively in terrestrial electric utilities to ensure safe power system operation. It uses redundant system information to calculate the actual state of the EPS, to isolate faulty sensors, to determine source operating points, to verify faults detected by subsidiary controllers, and to identify high impedance faults. Source control and monitoring safeguard the power generation and storage subsystems and ensure that the power system operates within safe limits while satisfying user demands with minimal interruptions. System monitoring functions, in coordination with hardware implemented schemes, provide for a complete fault protection system. The objective of this paper is to overview the development and integration of the state estimator and the source control algorithms.

Kimnach, Greg L.↗

NASA Electronic Library System (NELS): The system impact of security

This paper discusses security issues as they relate to the NASA Electronic Library System which is currently in use as the repository system for AdaNET System Version 3 (ASV3) being operated by MountainNET, Inc. NELS was originally designed to provide for public, development, and secure collections and objects. The secure feature for collections and objects was deferred in the initial system for implementation at a later date. The NELS system is now 9 months old and many lessons have been learned about the use and maintenance of library systems. MountainNET has 9 months of experience in operating the system and gathering feedback from the ASV3 user community. The user community has expressed an interest in seeing security features implemented in the current system. The time has come to take another look at the whole issue of security for the NELS system. Two requirements involving security have been put forth by MountainNET for the ASV3 system. The first is to incorporate at the collection level a security scheme to allow restricted access to collections. This should be invisible to end users and be controlled by librarians. The second is to allow inclusion of applications which can be executed only by a controlled group of users; for example, an application which can be executed by librarians only. The requirements provide a broad framework in which to work. These requirements raise more questions than answers. To explore the impact of these requirements a top down approach will be used.

Mcgregor, Terry L.↗

A review of wiring system safety in space power systems

Wiring system failures have resulted from arc propagation in the wiring harnesses of current aerospace vehicles. These failures occur when the insulation becomes conductive upon the initiation of an arc. In some cases, the conductive path of the carbon arc track displays a high enough resistance such that the current is limited, and therefore may be difficult to detect using conventional circuit protection. Often, such wiring failures are not simply the result of insulation failure, but are due to a combination of wiring system factors. Inadequate circuit protection, unforgiving system designs, and careless maintenance procedures can contribute to a wiring system failure. This paper approaches the problem with respect to the overall wiring system, in order to determine what steps can be taken to improve the reliability, maintainability, and safety of space power systems. Power system technologies, system designs, and maintenance procedures which have led to past wiring system failures will be discussed. New technologies, design processes, and management techniques which may lead to improved wiring system safety will be introduced.

Stavnes, Mark W.↗

Performance of the engineering analysis and data system 2 common file system

The Engineering Analysis and Data System (EADS) was used from April 1986 to July 1993 to support large scale scientific and engineering computation (e.g. computational fluid dynamics) at Marshall Space Flight Center. The need for an updated system resulted in a RFP in June 1991, after which a contract was awarded to Cray Grumman. EADS II was installed in February 1993, and by July 1993 most users were migrated. EADS II is a network of heterogeneous computer systems supporting scientific and engineering applications. The Common File System (CFS) is a key component of this system. The CFS provides a seamless, integrated environment to the users of EADS II including both disk and tape storage. UniTree software is used to implement this hierarchical storage management system. The performance of the CFS suffered during the early months of the production system. Several of the performance problems were traced to software bugs which have been corrected. Other problems were associated with hardware. However, the use of NFS in UniTree UCFM software limits the performance of the system. The performance issues related to the CFS have led to a need to develop a greater understanding of the CFS organization. This paper will first describe the EADS II with emphasis on the CFS. Then, a discussion of mass storage systems will be presented, and methods of measuring the performance of the Common File System will be outlined. Finally, areas for further study will be identified and conclusions will be drawn.

Debrunner, Linda S.↗

An overview of the EOSDIS V0 information management system: Lessons learned from the implementation of a distributed data system

The EOSDIS Version 0 system, released in July, 1994, is a working prototype of a distributed data system. One of the purposes of the V0 project is to take several existing data systems and coordinate them into one system while maintaining the independent nature of the original systems. The project is a learning experience and the lessons are being passed on to the architects of the system which will distribute the data received from the planned EOS satellites. In the V0 system, the data resides on heterogeneous systems across the globe but users are presented with a single, integrated interface. This interface allows users to query the participating data centers based on a wide set of criteria. Because this system is a prototype, we used many novel approaches in trying to connect a diverse group of users with the huge amount of available data. Some of these methods worked and others did not. Now that V0 has been released to the public, we can look back at the design and implementation of the system and also consider some possible future directions for the next generation of EOSDIS.

Ryan, Patrick M.↗