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At least 307 records · Page 17
All sourcesNASA NTRSDOE OSTI
NASA NTRS1980

To develop behavioral tests of vestibular functioning in the Wistar rat

Two tests of vestibular functioning in the rat were developed. The first test was the water maze. In the water maze the rat does not have the normal proprioceptive feedback from its limbs to help it maintain its orientation, and must rely primarily on the sensory input from its visual and vestibular systems. By altering lighting conditions and visual cues the vestibular functioning without visual cues was assessed. Whether there was visual compensation for some vestibular dysfunction was determined. The second test measured vestibular functioning of the rat's behavior on a parallel swing. In this test the rat's postural adjustments while swinging on the swing with the otoliths being stimulated were assessed. Less success was achieved in developing the parallel swing as a test of vestibular functioning than with the water maze. The major problem was incorrect initial assumptions of what the rat's probable behavior on the parallel swing would be.

Nielson, H. C.↗
NASA NTRS1981

Ocular torsion on earth and in weightlessness

Otolith function is studied by means of measurements of ocular torsion under various acceleration environments on earth and in weightlessness. Photographic measurements of ocular torsion as indicated by the rotation of landmarks on the iris with respect to head-fixed fiducial marks were obtained in subjects undergoing horizontal linear acceleration in a ground-based version of the space sled, lateral acceleration from weightlessness during pullout from the free-fall portion of parabolic flight, and optokinetic stimulation about the roll axis in the supine position in the laboratory and during weightlessness. The responses of ocular torsion to horizontal acceleration are in agreement with a simple low-order linear system with a dominant time constant of 0.33 sec, with a transfer function fit by a model with a pure delay of 0 to 400 msec and a first-order lag. In the pullout experiment, torsion was not observed in response to the onset of acceleration in the right-ear-down position, although it was present in response to the lateral stimulus. Results of the roll vection experiments indicate the independence of ocular torsion and visually induced tilt. In addition, an automatic video system using a soft contact lens target is presented which has been developed for ocular torsion measurements.

Young, L. R.↗
NASA NTRS1982

A study in motion sickness - Saccular hair cells in the adult bullfrog

The bullfrog's saccule were examined using light and scanning electron microscopy. No evidence of a striola was found. Type A hair cells were not only distributed peripherally, but also throughout the central macula, though far less frequently than the dominant type D. Two primary hair cell types were distinguished, which corresponded to the ciliary patterns: type A cilia are associated with short, conical hair cells, and type D cilia are associated with long, cylindrical hair cells. Each displays at least one subtype, which may represent developmental precursors. The otolithic membrane is crisscrossed with tunnels and topped with statoconia.

Cohen, G. M.↗
NASA NTRS1982

Measurement of ocular counterrolling /OCR/ by polarized light

The assessment of the activation of the otolith gravitoinertial sensors in the vestibular system of the inner ear may be accomplished by observing the occular counterrolling (OCR) movements which rotate the eyes about the line of sight. A method is presented for the continuous measurement of OCR by means of polarized light, a system of polarizers, and a contact lens. A polarized hard contact lens is placed between two soft lenses before application to the eye, and the measured phase difference between the incident rotating polarized light and the reflected light from this lens provides readings uncontaminated by other eye movement modes.

Kenyon, R. V.↗
NASA NTRS1984

Mammalian gravity receptors: Structure and metabolism

High performance liquid chromatography (HPLC) instrumentation was used for amino acid analysis of rat otoconial complexes. The amino acids of otoconial complexes pooled by origin from only 10 rats were analyzed. It is indicated that it should be possible to analyze complexes from only three rats, and perhaps fewer, which means that the method should be applicable to material from space flow rats. It is suggested that the organic otoconial phase is comparable in its complement of acidic amino acids to other calcium carbonate containing materials such as fish otoliths and certain mollusk shells. The organic material is high in acidic amino acids; and the relative proportions of aspirate, glutamate, threonine and serine appear to be similar to those found in neogastropod shells. Its significance to the evolution of biomineralization processes occurring in the animal kingdom is emphasized.

Ross, M.↗
NASA NTRS1984

Spatial orientation in weightlessness and readaptation to earth's gravity

Unusual vestibular responses to head movements in weightlessness may produce spatial orientation illusions and symptoms of space motion sickness. An integrated set of experiments was performed during Spacelab 1, as well as before and after the flight, to evaluate responses mediated by the otolith organs and semicircular canals. A variety of measurements were used, including eye movements, postural control, perception of orientation, and susceptibility to space sickness.

Young, L. R.↗
NASA NTRS1985

Mammalian Gravity Receptors: Structure and Metabolism

Calcium metabolism in mammalian gravity receptors is examined. To accomplish this objective it is necessary to study both the mineral deposits of the receptors, the otoconia, and the sensory areas themselves, the saccular and utricular maculas. The main focus was to elucidate the natures of the organic and inorganic phases of the crystalline masses, first in rat otoconia but more recently in otoliths and otoconia of a comparative series of vertebrates. Some of the ultrastructural findings in rat maculas, however, have prompted a more thorough study of the organization of the hair cells and innervation patterns in graviceptors.

Ross, M. D.↗
NASA NTRS1985

Space motion sickness preflight adaptation training Preliminary studies with prototype trainers

Based on the otolith tilt-translation reinterpretation hypothesis (Parker et al., 1985), preflight adaptation procedures and several preflight adaptation trainers (PATs) have been developed. Two PAT prototypes, the Miami University Seesaw (MUS) and the Dynamic Environmental Simulator (DES), include a physical room that is moved relative to the restrained subject. Results from the MUS and DES PAT experiments indicate that exposure to the produced sensory rearrangement can change eye movement reflexes. The changes persisted for a period longer than the training exposure period, indicating similarity with the eye-movement reflexes observed immediately postflight in weightlessness-adapted astronauts. It is concluded that the apparatus and procedures to preadapt astronauts to the sensory rearrangement of weightless space flight can be developed on the basis of the reported PATs and procedures. The third PAT prototype tested, which employs a computer-generated scene, failed to produce changes similar to those recorded in the MUS and DES experiments.

Parker, D. E.↗
NASA NTRS1985

Development of otoconia in the embryonic chick (Gallus domesticus)

In the chick (Gallus domesticus) embryo, otoconium formation started first over the macula sacculi around the 4th day of incubation, and a day later over the macula utriculi. It was determined that each otoconium formed as a result of the segmentation of the immature otolithic membrane, and that the calcium responsible for otoconium calcification was incorporated into the organic matrix of each otoconium in the form of small electron-dense granules (20-150 nm in. diameter). The presence of calcium in these granules was confirmed by histochemical staining with osmic-potassium pyroantimonate, by EDTA chelation, and by X-ray micronanalysis under the electron microscope.

Fermin, C. D.↗
NASA NTRS1986

Space motion sickness

Space motion sickness clinical characteristics, time course, prediction of susceptibility, and effectiveness of countermeasures were evaluated. Although there is wide individual variability, there appear to be typical patterns of symptom development. The duration of symptoms ranges from several hours to four days with the majority of individuals being symptom free by the end of third day. The etiology of this malady remains uncertain but evidence points to reinterpretation of otolith inputs as being a key factor in the response of the neurovestibular system. Prediction of susceptibility and severity remains unsatisfactory. Countermeasures tried include medications, preflight adaptation, and autogenic feedback training. No countermeasure is entirely successful in eliminating or alleviating symptoms.

Vanderploeg, J. M.↗
NASA NTRS1987

Role of orientation reference selection in motion sickness

The objectives of this proposal were developed to further explore and quantify the orientation reference selection abilities of subjects and the relation, if any, between motion sickness and orientation reference selection. The overall objectives of this proposal are to determine (1) if motion sickness susceptibility is related to sensory orientation reference selection abilities of subjects, (2) if abnormal vertical canal-otolith function is the source of these abnormal posture control strategies and if it can be quantified by vestibular and oculomotor reflex measurements, and (3) if quantifiable measures of perception of vestibular and visual motion cues can be related to motion sickness susceptibility and to orientation reference selection ability demonstrated by tests which systematically control the sensory imformation available for orientation.

Peterka, Robert J.↗
NASA NTRS1986

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission. I - Sensory adaptation to weightlessness and readaptation to one-g: An overview

Human sensory/motor adaptation to weightlessness and readaptation to earth's gravity are assessed. Preflight and postflight vestibular and visual responses for the crew on the Spacelab-1 mission are studied; the effect of the abnormal pattern of otolith afferent signals caused by weightlessness on the pitch and roll perception and postural adjustments of the subjects are examined. It is observed that body position and postural reactions change due to weightlessness in order to utilize the varied sensory inputs in a manner suited to microgravity conditions. The aspects of reinterpretation include: (1) tilt acceleration reinterpretation, (2) reduced postural response to z-axis linear acceleration, and (3) increased attention to visual cues.

Young, L. R.↗
NASA NTRS1986

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission. II - Visual vestibular tilt interaction in weightlessness

Adaptation to weightlessness includes the substitution of other sensory signals for the no longer appropriate graviceptor information concerning static spatial orientation. Visual-vestibular interaction producing roll circularvection was studied in weightlessness to assess the influence of otolith cues on spatial orientation. Preliminary results from four subjects tested on Spacelab-1 indicate that visual orientation effects were stronger in weightlessness than pre-flight. The rod and frame test of visual field dependence showed a weak post-flight increase in visual influence. Localized tactile cues applied to the feet in space reduced subjective vection strength.

Young, L. R.↗
NASA NTRS1986

M.I.T./Canadian vestibular experiments on the Spacelab-1 mission. VI - Vestibular reactions to lateral acceleration following ten days of weightlessness

The effects of weightlessness on human orientation and balance are investigated. The responses of the Spacelab-1 crew to linear acceleration are measured using a perception of linear motion test, a closed-loop otolith assessment test (CLOAT), a dynamic ocular torsion test, and a lateral eye deviations test. The perception of linear motion tests measures a subject's ability to detect the presence and direction of small changes in linear acceleration; CLOAT assesses a person's ability to use linear acceleration cues to perform a manual control task; and the dynamic ocular torsion test examines the gravitoinertial contribution to dynamic ocular counterrolling. The threshold accelerations, velocity constants, regression coefficients, scalar performance measures, and torsion measurements for the subjects are analyzed and described. It is noted that the data support the tilt-translation reinterpretation hypothesis of Young et al. (1984, 1986).

Arrott, A. P.↗
NASA NTRS1987

Effects of proposed preflight adaptation training on eye movements, self-motion perception, and motion sickness - A progress report

The preflight adaptation trainer (PAT) was designed to produce rearranged relationships between visual and otolith signals analogous to those experienced in space. Investigations have been undertaken with three prototype trainers. The results indicated that exposure to the PAT sensory rearrangement altered self-motion perception, induced motion sickness, and changed the amplitude and phase of the horizontal eye movements evoked by roll stimulation. However, the changes were inconsistent.

Parker, D. E.↗
NASA NTRS1987

Effects of prolonged weightlessness on self-motion perception and eye movements evoked by roll and pitch

Seven astronauts reported translational self-motion during roll simulation 1-3 h after landing following 5-7 d of orbital flight. Two reported strong translational self-motion perception when they performed pitch head motions during entry and while the orbiter was stationary on the runway. One of two astronauts from whom adequate data were collected exhibited a 132-deg shift in the phase angle between roll stimulation and horizontal eye position 2 h after landing. Neither of two from whom adequate data were collected exhibited increased horizontal eye movement amplitude or disturbance of voluntary pitch or roll body motion immediately postflight. These results are generally consistent with an otolith tilt-translation reinterpretation model and are being applied to the development of apparatus and procedures intended to preadapt astronauts to the sensory rearrangement of weightlessness.

Reschke, Millard F.↗
NASA NTRS1988

Preadaptation to the stimulus rearrangement of weightlessness: Preliminary studies and concepts for trainer designs

An effort to develop preflight adaptation training (PAT) apparatus and procedures to adapt astronauts to the stimulus rearrangement of weightless spaceflight is being pursued. Based on the otolith tilt-translation reinterpretation model of sensory adaptation to weightlessness, two prototype preflight adaptation trainers (PAT) have been developed. These trainers couple pitch movement of the subject with translation of the visual surround. Subjects were exposed to this stimulus rearrangement for periods of 30 m. The hypothesis is that exposure to the rearrangement would attenuate vertical eye movements was supported by two experiments using the Miami University Seesaw (MUS) PAT prototype. The Dynamic Environment Simulator (DES) prototype failed to support this hypothesis; this result is attributed to a pecularity of the DES apparatus. A final experiment demonstrated that changes in vertical eye movements were not a consequence of fixation on an external target during exposure to a control condition. Together these experiments support the view that preflight adaptation training can alter eye movements in a manner consistent with adaptation to weightlessness. Following these initial studies, concepts for development of operational preflight trainers were proposed. The trainers are intended to: demonstrate the stimulus rearrangement of weightlessness; allow astronauts to train in altered sensory environment; modify sensory motor reflexes; and reduce/eliminate space motion sickness symptoms.

Parker, D. E.↗
NASA NTRS1990

Visual-vestibular interaction in humans during earth-horizontal axis rotation

Visual-vestibular interaction using 60 percent constant velocity earth horizontal axis yaw rotation, simulating both the horizontal semicircular canals and the otolith organs, was measured in seven human subjects. Subjects were tested with their eyes open in the dark (EOD) while fixating upon a target rotating with them (FIX), and while observing stationary optokinetic stripes (VVR). Resulting nystagmus slow component velocity (SCV) was analyzed for EOD, FIX, and VVR conditions. It is concluded that the visual-vestibular interactions during EHA differ significantly from those during rotation about the vertical; specifically, there is a nonlinear interaction between linear acceleration and optokinetic nystagmus.

Wall, Conrad, III↗