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At least 307 records · Page 17

The Importance of the International Space Station for Life Sciences Research: Past and Future

The International Space Station (ISS) celebrates ten years of operations in 2008. While the station did not support permanent human crews during the first two years of operations, it hosted a few early science experiments months before the first international crew took up residence in November 2000. Since that time, science returns from the ISS have been growing at a steady pace. To date, early utilization of the U.S. Operating Segment of ISS has fielded nearly 200 experiments for hundreds of ground-based investigators supporting U.S. and international partner research. This paper will summarize the life science accomplishments of early research aboard the ISS both applied human research for exploration, and research on the effects of microgravity on life. At the 10-year point, the scientific returns from ISS should increase at a rapid pace. During the 2008 calendar year, the laboratory space and research facilities (both pressurized and external) will be tripled, with multiple scientific modules that support a wide variety of research racks and science and technology experiments conducted by all of the International Partners. A milestone was reached in February 2008 with the launch and commissioning of ESA s Columbus module and in March of 2008 with the first of three components of the Japanese Kibo laboratory. Although challenges lie ahead, the realization of the international scientific partnership provides new opportunities for scientific collaboration and broadens the research disciplines engaged on ISS. As the ISS nears completion of assembly in 2010, we come to full international utilization of the facilities for research. Using the past as an indicator, we are now able to envision the multidisciplinary contributions to improving life on Earth that the ISS can make as a platform for life sciences research.

Robinson, Julie A.↗

Mission X: Train Like an Astronaut. International Fitness Challenge

The Mission X, Train like an Astronaut, pilot project was a 2-year effort directed by the International Life Science Working Group. The pilot was funded by the Human Research Program and was lead by the Human Research Program Education and Outreach (HRPEO) project and supported by a group of space agencies providing in-kind resources. The aim was to identify an international educational outreach concept that would promote a life science topic utilizing the education and outreach expertise of the various space agencies working on the utilization of the International Space Station. This in turn serves as an inspiration for the younger generation to aspire to go further in school, and provides insight into the capability of a participating country to ensure the effort provided value for their communities and children. The pilot project developed the necessary tools to promote communications between the partners and to use materials and expertise from all the countries? space agencies. The Mission X Website (trainlikeanastronaut.org) provided a single repository for the educational activities as well as a place for the Challenge Teams to provide their progress in the international fitness challenge. It also added to the International flavor as different countries were able to share and learn about what was happening with all those involved in the 6-week challenge period. A point system was utilized to promote constructive, cooperative competition in which 4164 students participated. The points were used to help FitKid, Astro Charlie, "Walk-To-The-Moon". The 18 physical and educational Mission X activities were made available on the Mission X website in seven languages. The Mission X pilot project was considered a success in 1) the design, development, and implementation of the multi-language website, 2) the expansion of healthy lifestyle awareness, and 3) the concept for drawing an international educational community together to highlight global topics in association with human space exploration. Metrics (70 post-event surveys) and lessons learned were collated and assessed. Key Lessons Learned were 1) foster and strengthen partnerships at all levels, 2) enhance and standardize MX Training, and 3) further expansion of activities and methods to teach the importance of fitness and nutrition. Methods used to teach the importance of nutrition and fitness are provided in the report.

Lloyd, Charles↗

International Space Education Outreach: Taking Exploration to the Global Classroom

With the development of the International Space Station and the need for international collaboration for returning to the moon and developing a mission to Mars, NASA has embarked on developing international educational programs related to space exploration. In addition, with the explosion of educational technology, linking students on a global basis is more easily accomplished. This technology is bringing national and international issues into the classroom, including global environmental issues, the global marketplace, and global collaboration in space. We present the successes and lessons learned concerning international educational and public outreach programs that we have been involved in for NASA as well as the importance of sustaining these international peer collaborative programs for the future generations. These programs will undoubtedly be critical in enhancing the classroom environment and will affect the achievements in and attitudes towards science, technology, engineering and mathematics.

Dreschel, T. W.↗

International Human Mission to Mars: Analyzing A Conceptual Launch and Assembly Campaign

In July of 2013, U.S. Congressman Kennedy (D-Mass.) successfully offered an amendment to H.R. 2687, the National Aeronautics and Space Administration Authorization Act of 2013. "International Participation—The President should invite the United States partners in the International Space Station program and other nations, as appropriate, to participate in an international initiative under the leadership of the United States to achieve the goal of successfully conducting a crewed mission to the surface of Mars." This paper presents a concept for an international campaign to launch and assemble a crewed Mars Transfer Vehicle. NASA’s “Human Exploration of Mars: Design Reference Architecture 5.0” (DRA 5.0) was used as the point of departure for this concept. DRA 5.0 assumed that the launch and assembly campaign would be conducted using NASA launch vehicles. The concept presented utilizes a mixed fleet of NASA Space Launch System (SLS), U.S. commercial and international launch vehicles to accomplish the launch and assembly campaign. This concept has the benefit of potentially reducing the campaign duration. However, the additional complexity of the campaign must also be considered. The reliability of the launch and assembly campaign utilizing SLS launches augmented with commercial and international launch vehicles is analyzed and compared using discrete event simulation.

Cates, Grant↗

Using an Altimeter-Derived Internal Tide Model to Remove Tides from in Situ Data

Internal waves at tidal frequencies, i.e., the internal tides, are a prominent source of variability in the ocean associated with significant vertical isopycnal displacements and currents. Because the isopycnal displacements are caused by ageostrophic dynamics, they contribute uncertainty to geostrophic transport inferred from vertical profiles in the ocean. Here it is demonstrated that a newly developed model of the main semidiurnal (M2) internal tide derived from satellite altimetry may be used to partially remove the tide from vertical profile data, as measured by the reduction of steric height variance inferred from the profiles. It is further demonstrated that the internal tide model can account for a component of the near-surface velocity as measured by drogued drifters. These comparisons represent a validation of the internal tide model using independent data and highlight its potential use in removing internal tide signals from in situ observations.

Zaron, Edward D.↗

The U.S. DOE-EM international program - 15026

The U.S. Department of Energy (DOE) Office of Environmental Management (EM) conducts international collaboration activities in support of U.S. policies and objectives regarding the accelerated risk reduction and remediation of the environmental cleanup legacy resulting from the nations' nuclear weapons program and government sponsored nuclear energy research. The EM International Program, supported out of the EM Office of the Associate Principal Deputy Assistant Secretary pursues collaborations with foreign government organizations, educational institutions and private industry to assist in identifying technologies and promote international collaborations that leverage resources and link international experience and expertise. The primary objective of the International Program is to work closely with the various technical program offices within EM (e.g., tank waste and nuclear materials management, groundwater and soil remediation, deactivation and decommissioning) to identify collaborative opportunities related to innovative technologies, as well as best management practices, that support successful completion of the EM mission. This objective is directly aligned with the current DOE Strategic Plan 2014 - 2018, issued in April 2014. In mid-fiscal year (FY) 2014, the International Program awarded several collaborative projects for work scope spanning waste management, tank waste management, groundwater and soil remediation, deactivation and decommissioning (D and D), disposal operations, and nuclear materials disposition initiatives to nine foreign organizations. These projects include both technical and non-technical activities, with opportunities for continuation into FY 2015 and beyond. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

The U.S. Nuclear Waste Technical Review Board Intern Program: Developing Next Generation Nuclear Waste Professionals - 16102

The U.S. Nuclear Waste Technical Review Board (Board) created an internship program in the fall of 2013 for undergraduate and graduate students interested in management and disposal of spent nuclear fuel and high-level radioactive waste. Interns must select a project topic in a technical area related to the Board's mission and prepare a well-supported briefing for the agency. The ability to review technical and scientific information in a critical and unbiased manner is essential for completion of the intern's project and this is a particular focus of the interaction between the mentor and the intern. The interns from 2014 and 2015 selected and reviewed topics related to the areas of commingling waste forms for disposal and deep borehole disposal. In addition to the technical project, interns acquire a broad perspective of the federal agencies involved in managing and disposing of radioactive waste while participating in inter-agency networking opportunities. In this review of the Board internship experience, two past interns discuss the personal impact of the program and how they believe the experience prepared them to face the challenges of a career in management and disposal of spent nuclear fuel and high-level radioactive waste. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Estimates of Internal Dose Resulting from I-131 Patients in Hotels - Paper 147

U.S. Nuclear Regulatory Commission Regulatory Guide 8.39 provides the following estimate to the maximum internal committed effective dose, CED{sub i}, to an individual from a released patient having received radionuclide therapy: CED{sub i} = 10{sup -5} Q{sub adm} DCF where Q{sub adm} = activity administered to the patient (Bq), DCF = ingestion dose coefficient (Sv/Bq). Since many released patients stay in a hotel for a day or two after administration of the I-131, an effort was made to provide reasonable estimates of internal committed effective dose to a housekeeper at a hotel. Reasonable exposure scenarios are presented herein with the resulting doses. The value 10{sup -6} from a health physics 'rule of thumb' for intake in workplace environments, and explored by Brodsky, was multiplied by a factor of 10 to account for the most highly exposed individual and to add a degree of conservatism to the evaluation. The ingestion dose coefficient was used since it was felt that the maximum internal intake would either be via the skin or mouth. The scenarios investigated to date and presented herein show rather low potential doses of hotel housekeepers due to internal contamination. The internal doses are conservative since they assume the immediate release and placement of the patient in the hotel or household. The existing Reg. Guide 8.39 internal dose estimate appears to be very conservative and are very low in comparison to external gamma ray dose due to released patients. (authors)

61 RADIATION PROTECTION AND DOSIMETRY↗

On the validity and limitations of 1D model for heat and mass transfer performance evaluation in a multilayer binder-free desiccant dehumidifier: isothermal dehumidification with internal cooling

Efficient humidity control is essential for maintaining indoor thermal comfort, yet conventional vapor-compression-based dehumidifiers are energy-intensive. Employing separate sensible and latent cooling through desiccant-coated heat exchangers (DCHEs) combined with evaporative coolers offers energy savings of up to 80 % compared to conventional systems. However, the dehumidification performance of DCHEs remains limited due to the use of polymer binders for coating desiccant materials onto heat exchange surfaces. In our previous study, we developed a multilayer fixed-bed binder-free desiccant dehumidifier (MFBDD) that demonstrated high dehumidification capacity and low pressure drop compared to rotary desiccant wheels. Nevertheless, its potential for further enhancement through internal cooling and the use of step-shaped adsorption isotherms has not been explored. In this study, a physics-based one-dimensional (1D) transient model is developed and validated to capture the coupled heat and mass transfer processes in the MFBDD and extended to simulate internal cooling using a high-capacity composite metal–organic framework, MIL-101/GO-6 (water uptake ≈1.6 g/g within 35–47 % RH). The model enables detailed analysis of local air and bed temperature dynamics and quantifies how internal cooling affects the dehumidification performance under a wide range of operating conditions. Results show that integrating internal cooling and using MIL-101/GO-6 enhance mass adsorbed, moisture removal capacity, and dehumidification effectiveness by 50 %–99 % compared with the M.S. Gel baseline. The study further reveals that achieving near-isothermal operation requires simultaneous enhancement of the convective heat transfer coefficient and heat exchange surface area. In conclusion, this work provides the first detailed physical insight into the interplay between internal cooling and step-shaped isotherms in a binder-free desiccant device and establishes a validated modeling framework for scaling up and system-level performance evaluation of next-generation energy-efficient dehumidification systems.

Heat and mass transfer↗

Public Health Response and Medical Management of Internal Contamination in Past Radiological or Nuclear Incidents: A Review

Following a radiological or nuclear emergency, workers, responders and the public may be internally contaminated with radionuclides. Screening, monitoring and assessing any internal contamination and providing necessary medical treatment, especially when a large number of individuals are involved, is challenging. Experience gained and lessons learned from the management of previous incidents would help to identify gaps in knowledge and capabilities on preparedness for and response to radiation emergencies. In this paper, eight largescale and five workplace radiological and nuclear incidents are reviewed cross 14 technical areas, under the broader topics of emergency preparedness, emergency response and recovery processes. The review findings suggest that 1) new strategies, algorithms and technologies are explored for rapid screening of large populations; 2) exposure assessment and dose estimation in emergency response and dose reconstruction in recovery process are supported by complementary sources of information, including ‘citizen science’; 3) surge capacity for monitoring and dose assessment is coordinated through national and international laboratory networks; 4) evidence-based guidelines for medical management and follow-up of internal contamination are urgently needed; 5) mechanisms for international and regional access to medical countermeasures are investigated and implemented; 6) long-term health and medical follow up programs are designed and justified; and 7) capabilities and capacity developed for emergency response are sustained through adequate resource allocation, routine nonemergency use of technical skills in regular exercises, training, and continuous improvement.

61 RADIATION PROTECTION AND DOSIMETRY↗

Internal defect detection and characterization of samarium-cobalt sintered magnets by ultrasonic testing technique

Excessive quantities of samarium-cobalt (Sm-Co) magnet material are being scrapped needlessly due to a lack of understanding of inhomogeneity distribution and unacceptable internal defects. If there is a way to identify, locate, characterize and when needed separate the defective portions of magnet material, utilization can be increased and product quality improved. Further, the magnets’ magnetic and mechanical performance can be improved by reducing the occurrence of internal defects. This paper reports on a cost-effective and efficient nondestructive evaluation method based on an ultrasonic testing (UT) technique applied for detecting and characterizing internal defects in Sm-Co sintered magnets. Applying the UT technique will allow users to comprehensively analyze internal defects, such as inclusions, porosity, microcracks, and other structural irregularities, check for homogeneity and anomalous regions and give the locations of these internal anomalies and defects within the Sm-Co sintered magnets. The UT technique can also be applied to other rare-earth permanent magnets, such as sintered or die-upset neodymium-iron-boron (Nd-Fe-B) magnets. The UT technique can effectively guide quality control and acceptable product selection, in addition to optimizing the magnet alloy design and production processes. Therefore, it can facilitate the improvement of magnet manufacturing efficiency and machinability, reduce scrap, prolong service life, increase the use of what would be post-production waste, and enhance product reuse and recycling at end-of-life disposition.

36 MATERIALS SCIENCE↗

A high accuracy/resolution spectral element/Fourier–Galerkin method for the simulation of shoaling non-linear internal waves and turbulence in long domains with variable bathymetry

A high-order hybrid continuous-Galerkin numerical method, designed for the simulation of non-linear, non -hydrostatic internal waves and turbulence in long computational domains with complex bathymetry, is presented. The spatial discretization in the non-periodic wave-propagating directions, utilizes the nodal spectral element method. Such a high-order element-based discretization allows the highly accurate representation of complex domain geometry along with the flexibility of concentrating resolution in areas of interest. Under the assumption of the normal-to-isobath propagation of non-linear internal waves, a third periodic direction is incorporated via a Fourier-Galerkin discretization. The distinct non-hydrostatic nature of non-linear internal waves and, any instabilities and turbulence therein, necessitates the numerically challenging solution of the pressure Poisson problem. A defining feature of this work is the application of a domain decomposition approach, combined with block-Jacobi/deflation-based preconditioning to the pressure Poisson problem. Such a combined approach is particularly suitable for the long high aspect-ratio complex domains of interest and enables the efficient high-accuracy reproduction of the non-hydrostatic dynamics of non-linear internal waves. Implementation details are also described in the context of the stability of the solver and its parallelization strategy. A series of benchmarks of increasing complexity demonstrate the robustness of the flow solver. The benchmarks culminate with the three-dimensional simulation of a convectively breaking mode-one non-linear internal wave over a realistic South-China-Sea bathymetric transect and background current/stratification profiles.

Deflation↗

Underestimating Internal Variability Leads to Narrow Estimates of Climate System Properties

Probabilistic estimates of climate system properties often rely on the comparison of model simulations to observed temperature records and an estimate of the internal climate variability. In this study, we investigate the sensitivity of probability distributions for climate system properties in the Massachusetts Institute of Technology Earth System Model to the internal variability estimate. In particular, we derive probability distributions using the internal variability extracted from 25 different Coupled Model Intercomparison Project Phase 5 models. We further test the sensitivity by pooling variability estimates from models with similar characteristics. We find the distributions to be highly sensitive when estimating the internal variability from a single model. When merging the variability estimates across multiple models, the distributions tend to converge to a wider distribution for all properties. This suggests that using a single model to approximate the internal climate variability produces distributions that are too narrow and do not fully represent the uncertainty in the climate system property estimates.

58 GEOSCIENCES↗

NREL/NASA Internal Short-Circuit Instigator in Lithium Ion Cells

NREL has developed a device to test one of the most challenging failure mechanisms of lithium-ion (Li-ion) batteries -- a battery internal short circuit. Many members of the technical community believe that this type of failure is caused by a latent flaw that results in a short circuit between electrodes during use. As electric car manufacturers turn to Li-ion batteries for energy storage, solving the short circuit problem becomes more important. To date, no reliable and practical method exists to create on-demand internal shorts in Li-ion cells that produce a response that is relevant to the ones produced by field failures. NREL and NASA have worked to establish an improved ISC cell-level test method that simulates an emergent internal short circuit, is capable of triggering the four types of cell internal shorts, and produces consistent and reproducible results. Internal short circuit device design is small, low-profile and implantable into Li-ion cells, preferably during assembly. The key component is an electrolyte-compatible phase change material (PCM). The ISC is triggered by heating the cell above PCM melting temperature (presently 40 degrees C -- 60 degrees C). In laboratory testing, the activated device can handle currents in excess of 300 A to simulate hard shorts (< 2 mohms). Phase change from non-conducting to conducting has been 100 percent successful during trigger tests.

25 ENERGY STORAGE↗

Radiological Characterization for Decommissioning: International Good Practice and Experience - 18396

The 'Task Group on Radiological Characterization for Decommissioning (TGRCD)' functions under the umbrella of the Nuclear Energy Agency' (NEA) 'Working Party on Decommissioning and Dismantling (WPDD),' which is currently reporting to NEA Radioactive Waste Management Committee (RWMC). The TGRCD task group, which is composed of international experts, has been working since 2014 on a commitment to provide a high-level guidance for characterization practitioners working in nuclear decommissioning. The work has focused on facility characterization from a waste and materials perspective. Radiological characterization is a key activity enabling planning and implementation of decommissioning of nuclear facilities. Effective characterization allows the extent, location and nature of contamination to be determined providing crucial information to facilitate facility dismantling, the management of material and arising waste, protection of workers, the public, the environment and associated cost estimation. The report is written for characterization practitioners who carry out the tactical planning, preparation, optimization and implementation of characterization to support the decommissioning of nuclear facilities and the management of associated materials and waste. It compiles recent experience of NEA member countries in radiological characterization, including the experience of international experts and practitioners; the learning from international case studies and international conferences; and national approaches to the application of international and national regulations, standards and guidance documents. Using this comprehensive approach and evaluation studies, the report identifies relevant good practices and sets out set out practical guidance covering all stages of the characterization process as related to decommissioning. This paper provides a summary of the work conducted and the main findings from the detailed report. (authors)

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Stochastic Parameterization for Light Absorption by Internally Mixed BC/dust in Snow Grains for Application to Climate Models

A stochastic approach to model the positions of BC/dust internally mixed with two snow-grain types has been developed, including hexagonal plate/column (convex) and Koch snowflake (concave). Subsequently, light absorption and scattering analysis can be followed by means of an improved geometric-optics approach coupled with Monte Carlo photon tracing to determine their single-scattering properties. For a given shape (plate, Koch snowflake, spheroid, or sphere), internal mixing absorbs more light than external mixing. The snow-grain shape effect on absorption is relatively small, but its effect on the asymmetry factor is substantial. Due to a greater probability of intercepting photons, multiple inclusions of BC/dust exhibit a larger absorption than an equal-volume single inclusion. The spectral absorption (0.2 – 5 um) for snow grains internally mixed with BC/dust is confined to wavelengths shorter than about 1.4 um, beyond which ice absorption predominates. Based on the single-scattering properties determined from stochastic and light absorption parameterizations and using the adding/doubling method for spectral radiative transfer, we find that internal mixing reduces snow albedo more than external mixing and that the snow-grain shape plays a critical role in snow albedo calculations through the asymmetry factor. Also, snow albedo reduces more in the case of multiple inclusion of BC/dust compared to that of an equal-volume single sphere. For application to land/snow models, we propose a two-layer spectral snow parameterization containing contaminated fresh snow on top of old snow for investigating and understanding the climatic impact of multiple BC/dust internal mixing associated with snow grain metamorphism, particularly over mountains/snow topography.

climate models↗

Dose‐response relationships between internally‐deposited uranium and select health outcomes in gaseous diffusion plant workers, 1948‐2011

Objective To examine dose‐response relationships between internal uranium exposures and select outcomes among a cohort of uranium enrichment workers. Methods Cox regression was conducted to examine associations between selected health outcomes and cumulative internal uranium with consideration for external ionizing radiation, work‐related medical X‐rays and contaminant radionuclides technetium ( 99 Tc) and plutonium ( 239 Pu) as potential confounders. Results Elevated and monotonically increasing mortality risks were observed for kidney cancer, chronic renal diseases, and multiple myeloma, and the association with internal uranium absorbed organ dose was statistically significant for multiple myeloma. Adjustment for potential confounders had minimal impact on the risk estimates. Conclusion Kidney cancer, chronic renal disease, and multiple myeloma mortality risks were elevated with increasing internal uranium absorbed organ dose. The findings add to evidence of an association between internal exposure to uranium and cancer. Future investigation includes a study of cancer incidence in this cohort.

Yiin, James H.↗

Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure

When considering the safety of ingested nanomaterials, it is important to quantitate their transfer across intestinal cells; however, little information exists about the effects of nanomaterial size or exposure side (apical versus basolateral epithelial surface) on nanomaterial transfer. Here, we examined cellular internalization and transcellular transport, and the effects of nanomaterials on Caco-2 monolayers after apical or basolateral exposure to Ag or Au nanoparticles with various sizes. After apical treatment, both internalization and transfer to the basolateral side of the monolayers were greater for smaller Ag nanoparticles than for larger Ag nanoparticles. In contrast, after basolateral treatment, larger Ag nanoparticles were more internalized than smaller Ag nanoparticles, but the transfer to the apical side was greater for smaller Ag nanoparticles. Au nanoparticles showed different rules of internalization and transcellular transport compared with Ag nanoparticles. Furthermore, the paracellular permeability of the Caco-2 monolayers was temporarily increased by Ag nanoparticles (5 μg/mL; diameters, ≤10 nm) following basolateral but not apical exposure. We conclude that the internalization, transfer, and effects of nanomaterials in epithelial cell monolayers depend on the size and composition of nanomaterials, and the exposure side. - Highlights: • Ag and Au nanoparticles can transfer across Caco-2 monolayers. • Cellular uptake of nanoparticles change between apical and basolateral exposure. • Basolateral Ag nanoparticle exposure increases the permeability of Caco-2 monolayers.

77 NANOSCIENCE AND NANOTECHNOLOGY↗