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NASA’s mission-operations paradigm, established during Project Mercury and minimally evolving through the Apollo Program, Space Shuttle Program, and ISS missions, has primarily depended on real-time support from a ground team of experts. This ground team has served as the safety net for crewed spaceflight missions over the past 60 years, managing the combined state of the mission, vehicle, and crew. However, this operational paradigm, which has seen little change in its Human-Systems Integration Architecture (HSIA), will face challenges during long-duration exploration missions beyond low Earth orbit. Lunar missions may experience one-way communication latencies ranging from 3 to 14 seconds, while Mars missions will encounter up to a 44-minute round-trip latency at a maximum distance from Earth. Communication delays negatively impact the behavioral health and performance of individuals and crews operating across the multi-team space-to-ground system. Previous research indicates that increased isolation and the challenges posed by delayed communication lead to heightened stress, frustration, adverse behavioral symptoms, and reduced individual performance. NASA has investigated the nature and effectiveness of managing this shift in complex operations since early 2000, but additional research is necessary to assess the issues associated with communication latencies and identify effective countermeasures. This work aimed to examine the evidence from 20 years of research on comm delays. We systematically reviewed the past 20 years of communication delay literature, focusing on how this research aligns with relevant, high-priority needs in the HSIA, Team, and BMed Risks. This type of panoramic review has not been done since 2013; a current, aggregated picture of what has been studied and how is needed to inform additional studies and mitigation development. Additional perspectives were gained from interviews with the research participants, operations experts, and communication delay researchers. Results from this effort will help characterize the risk posed by communication latency for upcoming Artemis missions and point toward potential mitigations. The final results will be presented. For the literature review, we formed a search term seed set drawing from languages used in two papers representative of the previous state of knowledge and supplemented it with additional search terms. We conducted literature searches on Google Scholar, PubMed, and Web of Science and searched NASA project archives for output from NASA-sponsored research. This search yielded 150 papers, of which 48 were relevant. SME interviews provided perspective on key communication delay issues and concerns and what is being worked on to mitigate those issues. Preliminary results of the literature review have been presented. Final results to be presented include the results of the literature review and findings from the interviews.