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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 307 records · Page 17
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

New maxillofacial infrared detection technologies

At the dental clinic the infrared range radiation spectrum of tissues was used to study the dynamics of local temperature and structure of the skin, subcutaneous fat, and other tissues of the maxillofacial area in adult healthy volunteers and patients. In particular, we studied the dynamics of local temperature of mucous membranes of the mouth, teeth, and places in the mouth and dental structures in the norm and in various pathological conditions of the lips, gums, teeth, tongue, palate, and cheeks before, during and after chewing food, drinking water, medication, and inhalation of air. High safety and informational content of infrared thermography are prospective for the development of diagnostics in medicine. We have 3 new methods for infrared detection protected by patents in Russia.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Reconstructed lung doses for the million person study cohort of 26,650 Tennessee Eastman corporation workers employed between 1942 and 1947

Abstract Tennessee Eastman Corporation workers were exposed to uranium dust resulting in high-linear energy transfer (LET) irradiation to lung tissue. In this work, radiation lung doses were reconstructed for 26 650 men and women working at the plant between 1942 and 1947. Site air monitoring data of uranium concentrations and payroll records were used to determine the daily inhaled activities and annualized lung doses. Variations in the activity median aerodynamic diameter of the uranium dust, the solubility of particulate matter in the lungs and the sex-specific breathing rate were investigated as part of a sensitivity analysis. Male and female mean lung doses of 18.9 and 32.7 mGy, respectively, from high-LET alpha irradiation, and there was general agreement with evaluations from previously published epidemiological studies. Annual lung dose estimates and sensitivity analysis for the 26 650 workers in the TEC cohort have been archived on the United States Department of Energy Comprehensive Epidemiologic Data Resource.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2022

Alternate Analysis of an In Vitro Solubility Study on the Lung Dissolution Rate of 238PuO2 Material Involved in the 2020 Incident at Los Alamos National Laboratory

Here this work presents an alternate analysis of an in vitro solubility study on the lung dissolution rate of 238 PuO 2 material involved in a recent inhalation incident at Los Alamos National Laboratory (LANL). The original dataset used in this work was retrieved from a recently published report. The present work shows an analysis of the same dataset by modeling the dissolution in separate time intervals rather than modeling the cumulative dissolution.

238Pu↗
DOE OSTI2014

MO-G-18C-03: Evaluation of Deformable Image Registration for Lung Motion Estimation Using Hyperpolarized Gas Tagging MRI

Purpose: Hyperpolarized gas (HP) tagging MRI is a novel imaging technique for direct measurement of lung motion during breathing. This study aims to quantitatively evaluate the accuracy of deformable image registration (DIR) in lung motion estimation using HP tagging MRI as references. Methods: Three healthy subjects were imaged using the HP MR tagging, as well as a high-resolution 3D proton MR sequence (TrueFISP) at the end-of-inhalation (EOI) and the end-of-exhalation (EOE). Ground truth of lung motion and corresponding displacement vector field (tDVF) was derived from HP tagging MRI by manually tracking the displacement of tagging grids between EOI and EOE. Seven different DIR methods were applied to the high-resolution TrueFISP MR images (EOI and EOE) to generate the DIR-based DVFs (dDVF). The DIR methods include Velocity (VEL), MIM, Mirada, multi-grid B-spline from Elastix (MGB) and 3 other algorithms from DIRART toolbox (Double Force Demons (DFD), Improved Lucas-Kanade (ILK), and Iterative Optical Flow (IOF)). All registrations were performed by independent experts. Target registration error (TRE) was calculated as tDVF – dDVF. Analysis was performed for the entire lungs, and separately for the upper and lower lungs. Results: Significant differences between tDVF and dDVF were observed. Besides the DFD and IOF algorithms, all other dDVFs showed similarity in deformation magnitude distribution but away from the ground truth. The average TRE for entire lung ranged 2.5−23.7mm (mean=8.8mm), depending on the DIR method and subject's breathing amplitude. Larger TRE (13.3–23.7mm) was found in subject with larger breathing amplitude of 45.6mm. TRE was greater in lower lung (2.5−33.9 mm, mean=12.4mm) than that in upper lung (2.5−11.9 mm, mean=5.8mm). Conclusion: Significant differences were observed in lung motion estimation between the HP gas tagging MRI method and the DIR methods, especially when lung motion is large. Large variation among different DIR methods was also observed.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2014

Rapid estimation of 4DCT motion-artifact severity based on 1D breathing-surrogate periodicity

Purpose: Motion artifacts are common in patient four-dimensional computed tomography (4DCT) images, leading to an ill-defined tumor volume with large variations for radiotherapy treatment and a poor foundation with low imaging fidelity for studying respiratory motion. The authors developed a method to estimate 4DCT image quality by establishing a correlation between the severity of motion artifacts in 4DCT images and the periodicity of the corresponding 1D respiratory waveform (1DRW) used for phase binning in 4DCT reconstruction. Methods: Discrete Fourier transformation (DFT) was applied to analyze 1DRW periodicity. The breathing periodicity index (BPI) was defined as the sum of the largest five Fourier coefficients, ranging from 0 to 1. Distortional motion artifacts (excluding blurring) of cine-scan 4DCT at the junctions of adjacent couch positions around the diaphragm were classified in three categories: incomplete, overlapping, and duplicate anatomies. To quantify these artifacts, discontinuity of the diaphragm at the junctions was measured in distance and averaged along six directions in three orthogonal views. Artifacts per junction (APJ) across the entire diaphragm were calculated in each breathing phase and phase-averaged APJ{sup ¯}, defined as motion-artifact severity (MAS), was obtained for each patient. To make MAS independent of patient-specific motion amplitude, two new MAS quantities were defined: MAS{sup D} is normalized to the maximum diaphragmatic displacement and MAS{sup V} is normalized to the mean diaphragmatic velocity (the breathing period was obtained from DFT analysis of 1DRW). Twenty-six patients’ free-breathing 4DCT images and corresponding 1DRW data were studied. Results: Higher APJ values were found around midventilation and full inhalation while the lowest APJ values were around full exhalation. The distribution of MAS is close to Poisson distribution with a mean of 2.2 mm. The BPI among the 26 patients was calculated with a value ranging from 0.25 to 0.93. The DFT calculation was within 3 s per 1DRW. Correlations were found between 1DRW periodicity and 4DCT artifact severity: −0.71 for MAS{sup D} and −0.73 for MAS{sup V}. A BPI greater than 0.85 in a 1DRW suggests minimal motion artifacts in the corresponding 4DCT images. Conclusions: The breathing periodicity index and motion-artifact severity index are introduced to assess the relationship between 1DRW and 4DCT. A correlation between 1DRW periodicity and 4DCT artifact severity has been established. The 1DRW periodicity provides a rapid means to estimate 4DCT image quality. The rapid 1DRW analysis and the correlative relationship can be applied prospectively to identify irregular breathers as candidates for breath coaching prior to 4DCT scan and retrospectively to select high-quality 4DCT images for clinical motion-management research.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

SU-E-J-238: First-Order Approximation of Time-Resolved 4DMRI From Cine 2DMRI and Respiratory-Correlated 4DMRI

Purpose: Cine 2DMRI is useful in MR-guided radiotherapy but it lacks volumetric information. We explore the feasibility of estimating timeresolved (TR) 4DMRI based on cine 2DMRI and respiratory-correlated (RC) 4DMRI though simulation. Methods: We hypothesize that a volumetric image during free breathing can be approximated by interpolation among 3DMRI image sets generated from a RC-4DMRI. Two patients’ RC-4DMRI with 4 or 5 phases were used to generate additional 3DMRI by interpolation. For each patient, six libraries were created to have total 5-to-35 3DMRI images by 0–6 equi-spaced tri-linear interpolation between adjacent and full-inhalation/full-exhalation phases. Sagittal cine 2DMRI were generated from reference 3DMRIs created from separate, unique interpolations from the original RC-4DMRI. To test if accurate 3DMRI could be generated through rigid registration of the cine 2DMRI to the 3DMRI libraries, each sagittal 2DMRI was registered to sagittal cuts in the same location in the 3DMRI within each library to identify the two best matches: one with greater lung volume and one with smaller. A final interpolation between the corresponding 3DMRI was then performed to produce the first-order-approximation (FOA) 3DMRI. The quality and performance of the FOA as a function of library size was assessed using both the difference in lung volume and average voxel intensity between the FOA and the reference 3DMRI. Results: The discrepancy between the FOA and reference 3DMRI decreases as the library size increases. The 3D lung volume difference decreases from 5–15% to 1–2% as the library size increases from 5 to 35 image sets. The average difference in lung voxel intensity decreases from 7–8 to 5–6 with the lung intensity being 0–135. Conclusion: This study indicates that the quality of FOA 3DMRI improves with increasing 3DMRI library size. On-going investigations will test this approach using actual cine 2DMRI and introduce a higher order approximation for improvements. This study is in part supported by NIH (U54CA137788 and U54CA132378)

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

SU-E-T-281: Dose Measurements of Modulated Spot-Scanning Particle Beams with Beam-Gating of Respiratory-Phase

Purpose: To present dosimetric variations due to target movements with beam-gating windows of various respiratory-phase in homogeneous phantom irradiated by modulated spot-scanning carbon-ions and protons in Siemens IONTRIS system. Methods: For the safety and efficacy of proton therapy to treat three patients with lung cancer during our clinical trial, residual motion was required within 5mm. To study dosimetric variations due to respiratory movement, a target of 4.0cmx4.0cm with 2cm thick was moved with distances of 3.5mm, 4.4mm, 6.0mm, 8.3mm, and 11.0mm with beam-gating windows between various phases of inhalation or exhalation at a sin-wave breathing pattern. The target was irritated at 110mm depth by modulated carbon-ions with focus sizes of 4.1mm to 4.6mm, and a grid size of 1mm between spots. And, by modulated protons with focus sizes of 11.4mm to 13.6mm, and a grid size of 1.9mm between spots. A 4.0cmx4.0cm field size was used for both beams. EBT3 films was placed at the center of target for measurements. Delivery dose was 5.0 Gy with >1.0% uniformity over target. The uniformity and field size of each measured 2D lateral profiles were extracted. Results: By irradiating films to a doses at linear region of dose response, the uniformity and field size were extracted by measured optical density. The measured deviations from calculated field width and dose increase with increased motion amplitude. Larger non-uniformity was observed for carbonion with smaller focus size in comparing with protons. For movements of 4.4mm and 6.0mm, Optical Density uniformity of 3.80% and 5.66%were observed for carbon beam. But, is 3.46% for protons with 11.4mm movement. Conclusion: Our investigations showed that 5% optical density uniformity for carbon-ions and protons might be acceptable for treatments with 8.3mm movements in homogeneous phantoms. Dose variation introduced in complex anatomy of real patients need further investigation.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

WE-AB-BRA-11: Development of Physiological-Based Virtual Thorax Phantoms for Evaluation of Deformable Image Registration

Purpose: To develop a methodology of constructing physiological-based virtual thorax phantom based on hyperpolarized (HP) gas tagging MRI for evaluating deformable image registration (DIR). Methods: Three healthy subjects were imaged at both the end-of-inhalation (EOI) and the end-of-exhalation (EOE) phases using a high-resolution (2.5mm isovoxel) 3D proton MRI, as well as a hybrid MRI which combines HP gas tagging MRI and a low-resolution (4.5mm isovoxel) proton MRI. A sparse tagging displacement vector field (tDVF) was derived from the HP gas tagging MRI by tracking the displacement of tagging grids between EOI and EOE. Using the tDVF and the high-resolution MR images, we determined the motion model of the entire thorax in the following two steps: 1) the DVF inside of lungs was estimated based on the sparse tDVF using a novel multi-step natural neighbor interpolation method; 2) the DVF outside of lungs was estimated from the DIR between the EOI and EOE images (Velocity AI). The derived motion model was then applied to the high-resolution EOI image to create a deformed EOE image, forming the virtual phantom where the motion model provides the ground truth of deformation. Five DIR methods were evaluated using the developed virtual phantom. Errors in DVF magnitude (Em) and angle (Ea) were determined and compared for each DIR method. Results: Among the five DIR methods, free form deformation produced DVF results that are most closely resembling the ground truth (Em=1.04mm, Ea=6.63°). The two DIR methods based on B-spline produced comparable results (Em=2.04mm, Ea=13.66°; and Em =2.62mm, Ea=17.67°), and the two optical-flow methods produced least accurate results (Em=7.8mm; Ea=53.04°; Em=4.45mm, Ea=31.02°). Conclusion: A methodology for constructing physiological-based virtual thorax phantom based on HP gas tagging MRI has been developed. Initial evaluation demonstrated its potential as an effective tool for robust evaluation of DIR in the lung.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

Lung motion estimation using dynamic point shifting: An innovative model based on a robust point matching algorithm

Purpose: Image-guided radiotherapy is an advanced 4D radiotherapy technique that has been developed in recent years. However, respiratory motion causes significant uncertainties in image-guided radiotherapy procedures. To address these issues, an innovative lung motion estimation model based on a robust point matching is proposed in this paper. Methods: An innovative robust point matching algorithm using dynamic point shifting is proposed to estimate patient-specific lung motion during free breathing from 4D computed tomography data. The correspondence of the landmark points is determined from the Euclidean distance between the landmark points and the similarity between the local images that are centered at points at the same time. To ensure that the points in the source image correspond to the points in the target image during other phases, the virtual target points are first created and shifted based on the similarity between the local image centered at the source point and the local image centered at the virtual target point. Second, the target points are shifted by the constrained inverse function mapping the target points to the virtual target points. The source point set and shifted target point set are used to estimate the transformation function between the source image and target image. Results: The performances of the authors’ method are evaluated on two publicly available DIR-lab and POPI-model lung datasets. For computing target registration errors on 750 landmark points in six phases of the DIR-lab dataset and 37 landmark points in ten phases of the POPI-model dataset, the mean and standard deviation by the authors’ method are 1.11 and 1.11 mm, but they are 2.33 and 2.32 mm without considering image intensity, and 1.17 and 1.19 mm with sliding conditions. For the two phases of maximum inhalation and maximum exhalation in the DIR-lab dataset with 300 landmark points of each case, the mean and standard deviation of target registration errors on the 3000 landmark points of ten cases by the authors’ method are 1.21 and 1.04 mm. In the EMPIRE10 lung registration challenge, the authors’ method ranks 24 of 39. According to the index of the maximum shear stretch, the authors’ method is also efficient to describe the discontinuous motion at the lung boundaries. Conclusions: By establishing the correspondence of the landmark points in the source phase and the other target phases combining shape matching and image intensity matching together, the mismatching issue in the robust point matching algorithm is adequately addressed. The target registration errors are statistically reduced by shifting the virtual target points and target points. The authors’ method with consideration of sliding conditions can effectively estimate the discontinuous motion, and the estimated motion is natural. The primary limitation of the proposed method is that the temporal constraints of the trajectories of voxels are not introduced into the motion model. However, the proposed method provides satisfactory motion information, which results in precise tumor coverage by the radiation dose during radiotherapy.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Project 57 Air Monitoring Report: January 1 through December 31, 2017

On April 24, 1957, the Atomic Energy Commission (AEC) (now the Department of Energy [DOE]) conducted the Project 57 safety experiment in western Emigrant Valley northeast of the Nevada National Security Site (NNSS, formerly the Nevada Test Site) on lands withdrawn by the Department of Defense (DOD) for the Nevada Test and Training Range (NTTR). The test was undertaken to develop (1) a means of estimating plutonium distribution resulting from a non-nuclear detonation; (2) biomedical evaluation techniques for use in plutonium-laden environments; (3) methods of surface decontamination; and (4) instruments and field procedures for prompt estimation of alpha contamination (Shreve, 1958). Although the test did not result in the fission of nuclear materials, it did disseminate plutonium across the land surface. Following the experiment, the AEC fenced the contaminated area and returned control of the surrounding land to the DOD. Various radiological surveys were performed in the area and in 2007, the DOE expanded the demarked Contamination Area (CA) by posting signs 200 to 400 ft (60 to 120 m) outside of the original fence. Plutonium in soil attaches preferentially to smaller particles (Tamura, 1985; Friesen, 1992; Murarik et al., 1992; and Misra et al., 1993). Therefore, redistribution of soil particles by wind (dust) and water are the mechanisms most likely to transport plutonium beyond the boundary of the Project 57 CA. Monitoring was implemented in 2011 by Desert Research Institute (DRI) to determine if radionuclide contamination was detectable in samples of airborne dust and to characterize meteorological and environmental parameters that influence dust transport. Initially, two monitoring stations consisting of radiological, meteorological, and dust sampling equipment were installed near the southeast and northeast corners of the CA. In January 2015, the original monitoring stations were dismantled and moved farther to the west along the CA boundary. This move was made to place the monitoring stations downwind of ground zero and the High Contamination Area (HCA) during the dominant northerly and southerly winds. Samples of particles suspended in the air are collected every two weeks and submitted for laboratory assessments of gross alpha and gross beta radioactivity, and for determinations of gamma-emitting radionuclides. In calendar year (CY) 2017, the mean gross alpha concentration at monitoring station P57-4 was approximately 4.25 times the value at monitoring station P57-3. In CY2015 and CY2016, the difference in mean gross alpha concentration at the two stations was approximately 1.5. The mean gross alpha concentrations at P57-3 and P57-4 were approximately 1.9 and 7.9 times, respectively, the mean gross alpha concentrations at the surrounding Community Environmental Monitoring Program (CEMP) stations. The minimum gross alpha concentrations reported for the Project 57 stations are in the range of the minimum values observed at the CEMP stations. However, maximum gross alpha concentrations are greater than the maximum concentrations observed at the surrounding CEMP stations. Gamma spectroscopy analyses resulted in the detection of seven radionuclides. Except for americium-241 (Am-241), all reported radionuclides occur naturally in the environment. The Am-241 detection by gamma spectroscopy was confirmed by alpha spectroscopy. During each quarter of CY2017, four suspended particulate matter samples were selected for alpha spectroscopy analysis. Two were selected each quarter from the regular biweekly samples collected at each of the two monitoring stations. Of the eight samples from P57-3, one was reported to have plutonium-238 (Pu-238) above the minimum detectable activity (MDA) and five were reported to have plutonium 239/240 (Pu-239/240) above the MDA. Of the eight samples from P57-4, three were reported to have Pu-238 above the MDA and six were reported to have Pu-239/240 above the MDA. Soil material is also transported by saltation, which is a wind driven phenomena that bounces sand-sized soil particles across the land surface because they are too heavy to be suspended in the air. Samples of particles transported by saltation were collected downwind and upwind of the CA at both monitoring stations in May 2017 after a 190-day deployment and again in September 2017 after a 114-day deployment. Mass of the saltation samples was determined after oven drying. The September sample had greater mass than the May sample. The same relationship was observed for the suspended particulate matter samples during periods of saltation sample collection. The difference in the collected mass appears to be because of the amount of soil moisture. Higher soil moisture exerts additional isotopic bonds between soil particles and water molecules, and between water molecules that envelop soil particles, making it more difficult for wind to raise the particles as dust. In general, samples collected from saltation traps facing south contained more material than samples collected from traps facing north. This suggests that although saltation material may have been moving back and forth in conjunction with the two dominant wind directions, there was a net trend for saltation material to be transported toward the north. Radiological analyses of the saltation samples show that the smaller particle size faction (<63 μm) generally produced the highest activity levels of Am-241, Pu-238, and Pu-239/240. In general, the isotope activity levels decreased as the particle size increased. These results are consistent with the expectation that the greatest potential for transport of radiological contamination is with the smaller particles. Thermoluminescent dosimeters (TLDs) indicated that the average annual external radioactivity dose at the monitoring stations is slightly higher than the dose determined at the surrounding CEMP stations, but approximately half of the estimated national average dose received by the general public from exposure to natural sources. The TLDs at the Project 57 monitoring stations are exposed to both natural sources (terrestrial and cosmic) and radioactive releases from the Project 57 CA. Winds in excess of approximately 15 mph (24 km/hr) begin to generate dust movement by saltation or suspension, as determined by the monitoring instruments. Saltated particles, PM10 (i.e., inhalable dust), and PM2.5 (i.e., fine particulate dust) exhibit an approximately exponential increase with increasing wind speed. The greatest concentrations of dust occurred for winds exceeding 20 mph (32 km/hr). When the wind/dust analysis was performed for winds separated into the dominant northerly and southerly wind directions, it was evident that the northerly winds generated the higher PM10 concentrations and had the dominate influence on the PM10 concentration determined for all wind speeds when all wind directions were evaluated together. During the year, winds in excess of 20 mph (32 km/hr) occurred approximately one percent of the time. Although winds sufficient to generate dust occur at the Project 57 site, they are infrequent and of short duration. A preliminary assessment of individual wind events suggests that dust generation in response to specific wind conditions is highly variable. Wind speeds that would be expected to generate noticeable dust may not do so in every instance. Additionally, saltation transport in response to wind conditions was less common than expected. These variations were likely because of the influence of meteorological and environmental parameters other than wind.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2019

Tank 22 Settled Sludge Core Sample Characterization and Testing

The Savannah River National Laboratory (SRNL) was requested by Savannah River Remediation (SRR) Engineering (SRR-E) to provide sample characterization and analyses of Tank 22 settled sludge core sample and the supernatant liquids (supernate) in support of Tank 22 re-baseline data, inhalation dose potential/hydrogen generation and suspension/removal of settled sludge from the bottom of Tank 22. The approximately 9.5 inches of intact Tank 22 core sample from SRR-E, after extrusion in the SRNL Shielded Cells, showed three visually different stratification layers or regions of solids in the extruded core material. Part of the initial physical characterization of these three segments of the Tank 22 core sample included density, weight percent total solids, particle size distribution, X-ray diffractions and scanning electron microscope of each segment material. Given the dissimilarity of the three Tank 22 segment materials after the physical characterization results and the fact that there was no clear line of demarcation to indicate where each segment began and ended across the entire length of the core sample, SRNL in conjunction with the SRR-E customer decided to blend all three segments of the material to form a composite Tank 22 core sample for further analysis and characterization without taking into consideration the proportional weight or mass contribution of each segment. This compositing approach assumes that the errors introduced in any characterization of the Tank 22 core sample will be comparable to the errors when the three segments are separated and combined proportionally by weight to form the composite Tank 22 sample. This compositing approach maximized the quantity of composited Tank 22 material needed for radionuclide and other physical characterizations.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS1994

Microneurographic evidence of sudden sympathetic withdrawal in carotid sinus syncope; treatment with ergotamine

A proportion of patients with carotid sinus syncope (CSS) remain symptomatic even after pacemaker implantation because of persistence of a vasodepressor component. We report a patient with CSS whose syncopal episodes could be reproduced by carotid sinus massage and were due to profound hypotension associated with sudden sympathetic withdrawal, based on direct measurements of sympathetic nerve traffic. A double-blind trial with inhaled ergotamine provided significant symptomatic relief.

Non-NASA Center↗
NASA NTRS2004

Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation

Nanomaterials are part of an industrial revolution to develop lightweight but strong materials for a variety of purposes. Single-wall carbon nanotubes are an important member of this class of materials. They structurally resemble rolled-up graphite sheets, usually with one end capped; individually they are about 1 nm in diameter and several microns long, but they often pack tightly together to form rods or ropes of microscopic sizes. Carbon nanotubes possess unique electrical, mechanical, and thermal properties and have many potential applications in the electronics, computer, and aerospace industries. Unprocessed nanotubes are very light and could become airborne and potentially reach the lungs. Because the toxicity of nanotubes in the lung is not known, their pulmonary toxicity was investigated. The three products studied were made by different methods and contained different types and amounts of residual catalytic metals. Mice were intratracheally instilled with 0, 0.1, or 0.5 mg of carbon nanotubes, a carbon black negative control, or a quartz positive control and euthanized 7 d or 90 d after the single treatment for histopathological study of the lungs. All nanotube products induced dose-dependent epithelioid granulomas and, in some cases, interstitial inflammation in the animals of the 7-d groups. These lesions persisted and were more pronounced in the 90-d groups; the lungs of some animals also revealed peribronchial inflammation and necrosis that had extended into the alveolar septa. The lungs of mice treated with carbon black were normal, whereas those treated with high-dose quartz revealed mild to moderate inflammation. These results show that, for the test conditions described here and on an equal-weight basis, if carbon nanotubes reach the lungs, they are much more toxic than carbon black and can be more toxic than quartz, which is considered a serious occupational health hazard in chronic inhalation exposures.

Nanotubes, Carbon/adverse effects↗
DOE OSTI2017

Exposure Assumptions Underlying Cleanups to Industrial Versus Unrestricted Uses: Comparison of State and Federal Approaches - 17228

The Environmental Protection Agency (EPA) and various states have designated a variety of cleanup levels ranging from restricted (too much residual contamination to allow any use) to unrestricted or residential. Although there are many potential exposure scenarios, the States of Washington and New Jersey identify only two levels for cleanup of chemical contaminants in soil: 'unrestricted' and 'industrial' (Washington) and 'residential' vs 'non-residential' (New Jersey). Other agencies such as EPA and DOE recognize several levels of recreational use, between unrestricted and industrial, and likewise there are several levels of residential use as well. Cleanup criteria may allow or preclude the use of ground water for drinking, swimming pools, gardens, or lawns. Tribal unrestricted scenarios include the use of water (probably surface water in most scenarios) for sweat lodges, and have calculated high level exposure pathways for both dermal and inhalation pathways as well as ingestion. For residential scenarios, inadvertent ingestion of soil, drinking of ground water, and consumption of local foods represent the highest exposure pathways. Intermediate, recreational pathways may be non-consumptive (hiking, bird watching, photography) or consumptive (hunting, fishing, harvesting plants and medicines), the latter entailing much higher potential exposures. For each land-use there is a corresponding exposure scenario, with different assumptions about the maximally exposed individual, their age, and the amounts of air, water, soil, and foods they consume. For each exposure pathway one can compute the ratio between the exposure assumptions for any two scenarios. The product of the ratios comprises a Vulnerability Index. The index is higher for children than adults. For Washington this Index is reflected in the 'industrial' vs 'unrestricted' soil cleanup levels, which are 43.7 times lower for 'unrestricted'. This paper explores the similarities and differences in the exposure scenarios and vulnerability of the maximally exposed individuals and the consequences of a mismatch between current cleanup levels and possible future land uses. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2017

The Port Hope Areas Initiative's Port Granby Project: Radiation Protection Program - 17446

The Port Granby Project is large remediation project currently underway. A comprehensive and effective radiation protection program has been developed and implemented for the Port Granby Project. The potential radiation hazards associated with this project include: external (gamma) radiation, radon, inhalation, contamination and ingestion. Processes to address each of these potential hazards are identified. Measures of the effectiveness of the radiation protection program are also included. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗