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At least 289 records · Page 16
All sourcesNASA NTRSDOE OSTI
NASA NTRS1999

Novel optical methodologies in studying mechanical signal transduction in mammalian cells

For the last 3 decades evidence has been accumulating that some types of mammalian cells respond to their mechanically active environment by altering their morphology, growth rate, and metabolism. The study of such responses is very important in understanding, physiological and pathological conditions ranging from bone formation to atherosclerosis. Obtaining this knowledge has been the goal for an active research area in bioengineering termed cell mechanotransduction. The advancement of optical methodologies used in cell biology research has given the tools to elucidate cellular mechanisms that would otherwise be impossible to visualize. Combined with molecular biology techniques, they give engineers invaluable tools in understanding the chemical pathways involved in mechanotransduction. Herein we briefly review the current knowledge on mechanical signal transduction in mammalian cells, focusing on the application of novel optical techniques in the ongoing research.

NASA Discipline Cell Biology↗
NASA NTRS1975

Application of Fourier transforms for microwave radiometric inversions

Existing microwave radiometer technology now provides a suitable method for remote determination of the ocean surface's absolute brightness temperature. To extract the brightness temperature of the water from the antenna temperature, an unstable Fredholm integral equation of the first kind is solved. Fourier transform techniques are used to invert the integral after it is placed into a cross correlation form. Application and verification of the methods to a two-dimensional modeling of a laboratory wave tank system are included. The instability of the ill-posed Fredholm equation is examined and a restoration procedure is included which smooths the resulting oscillations. With the recent availability and advances of fast Fourier transform (FFT) techniques, the method presented becomes very attractive in the evaluation of large quantities of data.

Holmes, J. J.↗
NASA NTRS1986

An example of scaling MST Doppler spectra using median spectra, spectral smoothing, and velocity tracing

Although automatic, computer scaling methods appeared at the start of the MST (mesosphere stratosphere troposphere) radar technique, there is a continuing need for scaling algorithms that perform editing functions and increase the sensitivity of radar by post processing. The scaling method presented is an adaptation of the method of scaling MST Doppler spectra presented by Rastogi (1984). A brief overview of this method is as follows: a median spectrum is calculated from several sequential spectra; the median noise value is subtracted from this derived spectrum; the median spectrum is smoothed; the detection/nondetection decision is made by comparing the smoothed spectrum to the variance of the smoothed noise; and if a signal is detected, then the half-power points of the smoothed echo spectrum are used to place limits on the evaluation of the first two moments of the unsmoothed median spectrum. In all of the above steps, the algorithm is guided by tracing the expected velocity range upward from the lowest range as far as possible. The method is discussed in more detail.

Green, J. L.↗
NASA NTRS1986

Combined Devices for Turbulent-Drag Reduction

Aircraft skin-friction drag reduced as much as 15 percent. One effective drag-reduction technique involves use of riblets. Riblets are longitudinal striations or grooves machined on originally smooth surface. Grooves alined with flow. Grooves have depths and spacings on order of turbulent wallstreak and burst dimensions and designed to change near-wall structure of turbulent boundary layer. Another approach, using large-eddy-breakup (LEBU) devices, or turbulence manipulators or ribbons also demonstrated reductions in local skin friction and net drag in air. LEBU device consists of thin, ribbonlike strips or airfoils suspended parallel to test surface and positioned within turbulent boundary layer. Technique potentially reduce net skin-friction drag by at least 15 percent on turbulent boundary layer of aircraft, representing possible annual savings in fuel costs of $300 to $400 million for U.S. commercial fleet. Also applicable to frictionloss reduction inside pipes and ducts, contributing to increased efficiency of pumps, heat exchangers, air conditioners, and other devices involving fluid flow.

Walsh, M. J.↗
NASA NTRS1972

Power spectral density estimation by spline smoothing in the frequency domain

An approach, based on a global averaging procedure, is presented for estimating the power spectrum of a second order stationary zero-mean ergodic stochastic process from a finite length record. This estimate is derived by smoothing, with a cubic smoothing spline, the naive estimate of the spectrum obtained by applying FFT techniques to the raw data. By means of digital computer simulated results, a comparison is made between the features of the present approach and those of more classical techniques of spectral estimation.

Defigueiredo, R. J. P.↗
NASA NTRS1981

Computer prediction of dual reflector antenna radiation properties

A program for calculating radiation patterns for reflector antennas with either smooth analytic surfaces or with surfaces composed of a number of panels. Techniques based on the geometrical optics (GO) approach were used in tracing rays over the following regions: from a feed antenna to the first reflector surface (subreflector); from this reflector to a larger reflector surface (main reflector); and from the main reflector to a mathematical plane (aperture plane) in front of the main reflector. The equations of GO were also used to calculate the reflected field components for each ray making use of the feed radiation pattern and the parameters defining the surfaces of the two reflectors. These resulting fields form an aperture distribution which is integrated numerically to compute the radiation pattern for a specified set of angles.

Christodoulou, C.↗
NASA NTRS1984

LANDSAT-4 image data quality analysis

Methods were developed for estimating point spread functions from image data. Roads and bridges in dark backgrounds are being examined as well as other smoothing methods for reducing noise in the estimated point spread function. Tomographic techniques were used to estimate two dimensional point spread functions. Reformatting software changes were implemented to handle formats for LANDSAT-5 data.

Anuta, P. E.↗
NASA NTRS1985

Crossover Concept for Optical Printed Circuits

It is possible to reduce crosstalk between optical signals in intersecting optical conductors by taking two steps: Minimize amount of light diffracted into wrong conductor by selecting optimum conductor width, and place light traps in each conductor. How well techniques work depends in part on quality of optical conductors (partically surface smoothness) and on how closely optical-signal mode of propagation approaches ideal. Nature of signals also important: With digital signals, less crosstalk attenuation required than for analog signals.

Jamieson, R. S.↗
NASA NTRS1987

An adaptive grid, unsteady model for two-dimensional magnetohydrodynamic (MHD) flow

An adaptive grid finite difference method for solving multi-dimensional, time-dependent, magnetohydrodynamic (MHD) equations is developed. The method is capable of solving problems that include high gradients due to geometry, propagation of shock waves and unsteady boundary conditions. The grid generation technique is based on variational principles with direct control over grid concentration, smoothness and skewness. An example for a two-dimensional MHD simulation of the propagation of a solar-flare-generated shock wave in solar wind flow in the heliographic equatorial plane is selected for illustration of this method.

Panitchob, Supat↗
NASA NTRS1989

A generalized gradient algorithm for dynamic optimization

A gradient algorithm is developed that determines optimal trajectories with path equality constraints and terminal constraints. A generalized gradient is formed which improves both the performance index and the path equality constraints simultaneously. The algorithm is extended to treat terminal constraints by using Bryson's impulse response technique. The main features of this algorithm are its numerical stability and smooth convergence near the optimum.

Zhao, Yiyuan↗
NASA NTRS1993

A multigrid nonoscillatory method for computing high speed flows

A multigrid method using different smoothers has been developed to solve the Euler equations discretized by a nonoscillatory scheme up to fourth order accuracy. The best smoothing property is provided by a five-stage Runge-Kutta technique with optimized coefficients, yet the most efficient smoother is a backward Euler technique in factored and diagonalized form. The singlegrid solution for a hypersonic, viscous conic flow is in excellent agreement with the solution obtained by the third order MUSCL and Roe's method. Mach 8 inviscid flow computations for a complete entry probe have shown that the accuracy is at least as good as the symmetric TVD scheme of Yee and Harten. The implicit multigrid method is four times more efficient than the explicit multigrid technique and 3.5 times faster than the single-grid implicit technique. For a Mach 8.7 inviscid flow over a blunt delta wing at 30 deg incidence, the CPU reduction factor from the three-level multigrid computation is 2.2 on a grid of 37 x 41 x 73 nodes.

Li, C. P.↗
NASA NTRS1990

Constrained optimization using design of experiment surfaces

An algorithm for solving constrained optimization problems is presented. First, design of experiment techniques are used to survey the design space. After evaluating the objective and constraint functions, as specified by Taguchi orthogonal arrays, analytical models of these functions are generated using a least-squares regression analysis. Next, a nonlinear programming package is used to optimize the analytical model. Based on the optimization information, the design space is reduced so as to close in around the minimum, and the entire procedure is repeated until convergence. An important feature of the algorithm is that function gradients are not required; therefore, for problems in which gradients would have to be estimated using finite-differences the number of function evaluations required for the optimization is significantly reduced, when compared with traditional nonlinear programming techniques. In addition, there is no requirement that the gradients must be smooth and continuous.

Bolt, Marvin Vance↗
NASA NTRS1996

A Numerical Simulation of Scattering from One-Dimensional Inhomogeneous Dielectric Random Surfaces

In this paper, an efficient numerical solution for the scattering problem of inhomogeneous dielectric rough surfaces is presented. The inhomogeneous dielectric random surface represents a bare soil surface and is considered to be comprised of a large number of randomly positioned dielectric humps of different sizes, shapes, and dielectric constants above an impedance surface. Clods with nonuniform moisture content and rocks are modeled by inhomogeneous dielectric humps and the underlying smooth wet soil surface is modeled by an impedance surface. In this technique, an efficient numerical solution for the constituent dielectric humps over an impedance surface is obtained using Green's function derived by the exact image theory in conjunction with the method of moments. The scattered field from a sample of the rough surface is obtained by summing the scattered fields from all the individual humps of the surface coherently ignoring the effect of multiple scattering between the humps. The statistical behavior of the scattering coefficient sigma(sup 0) is obtained from the calculation of scattered fields of many different realizations of the surface. Numerical results are presented for several different roughnesses and dielectric constants of the random surfaces. The numerical technique is verified by comparing the numerical solution with the solution based on the small perturbation method and the physical optics model for homogeneous rough surfaces. This technique can be used to study the behavior of scattering coefficient and phase difference statistics of rough soil surfaces for which no analytical solution exists.

Sarabandi, Kamal↗
NASA NTRS1983

Multi-grid solution of Neumann pressure problem for viscous flows using primitive variables

The multi-grid (MG) technique has been advanced for use with the Neumann boundary-value problem in clustered curvilinear orthogonal coordinates. This comprises an important step in the analysis of viscous flows using the velocity-pressure formulation of the Navier-Stokes equations. With successive over-relaxation (SOR) as the smoothing operator and with suitably formulated restriction and coarse-grid-correction operators, a 4-grid procedure enhances the efficiency of fine-grid solutions of the Neumann problem by a factor of 3 to 5, depending on the problem parameters. Thy influence of the smoothing operator is also examined by employing the alternating-direction implicit and the strongly implicit techniques instead of SOR.

Ghia, U.↗
NASA NTRS1982

Development of computer models for the prediction of large distorted antenna characteristics

A program for calculating the radiation patterns of analytic reflector antennas, using geometric optics and aperture plane integration techniques, was modified and extended to include nonanalytic surfaces. The original program, while capable of predicting patterns for a variety of reflectors, both smooth and multipanelled, was subject to the restriction that the surface had to be expressed analytically, i.e., described by a set of mathematical equations. This restriction was removed by adapting a technique which allows the reflector configuration to be interpolated from a finite set of points measured on the surface. Criteria for choosing both the number and distribution of these measured surface points were developed by comparing the predicted antenna radiation patterns with measured laboratory results. Test cases involved relatively smooth as well as grossly distorted arbitrary surfaces. Finally, surface point accuracies were established by applying random error analysis to the measurement process.

Moskowitz, S. M.↗
NASA NTRS1984

Efficient matrix partitioning for optical computing

Techniques for partitioning optical linear algebra problems to make them amenable to solution using optical processors programmed with simple algorithms are explored. Generalized methods for splitting a linear algebra matrix into a series of submatrices are reviewed, showing that simple forms can be pipelined smoothly and that parallel accumulation can be achieved by beam combining on detectors or by summing electronically. The techniques offer simplified bookkeeping, algorithmic independence, and high efficiency. The computational speed will depend on the number of multiplier-accumulators devoted to the task.

Caulfield, H. J.↗
NASA NTRS1977

Inversion of solar extinction data from the Apollo-Soyuz Test Project Stratospheric Aerosol Measurement (ASTP/SAM) experiment

The inversion methods are reported that have been used to determine the vertical profile of the extinction coefficient due to the stratospheric aerosols from data measured during the ASTP/SAM solar occultation experiment. Inversion methods include the onion skin peel technique and methods of solving the Fredholm equation for the problem subject to smoothing constraints. The latter of these approaches involves a double inversion scheme. Comparisons are made between the inverted results from the SAM experiment and near simultaneous measurements made by lidar and balloon born dustsonde. The results are used to demonstrate the assumptions required to perform the inversions for aerosols.

Pepin, T. J.↗