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Mortality of older construction and craft workers employed at Department of Energy (DOE) nuclear sites: Follow‐up through 2021

Background To determine if construction and trades workers formerly employed at US Department of Energy (DOE) nuclear weapons sites are at significant risk for occupational diseases, we studied the mortality experience of participants in the Building Trades National Medical Screening Program (BTMed). Methods The cohort included 26,922 participants enrolled between 1998 and 2021 and 8367 deaths. Standardized mortality ratios were calculated based on US death rates. Cox models compared construction workers (n = 22,747; 7487 deaths) to two nonconstruction subpopulations: administrative, scientific and security workers (n = 1894; 330 deaths), and all other nonconstruction workers (n = 2218; 550 deaths). Results Mortality was elevated for all causes, all cancers, cancers of the trachea, bronchus, lung, kidneys, and lymphatic and hematopoietic system, mesothelioma, chronic obstructive pulmonary disease (COPD), asbestosis, transportation injuries, and other injuries, particularly accidental poisonings. There were 167 deaths from coronavirus disease 2019 (COVID-19), which was lower than expected using US death rates. Overall cause-specific mortality was significantly higher among construction workers than for internal comparison groups. Conclusions Construction workers employed at DOE sites have a significantly increased risk for occupational illnesses. Apart from COVID-19 deaths, this update: (1) found that mortality among construction workers is significantly elevated compared to the US population and significantly higher than in the internal comparison populations, and (2) confirmed excess risk for these workers for first employment after 1990. Cancer mortality risks are similar to the cancers identified for DOE compensation from radiation exposures. In conclusion, the high lung cancer risk supports the value of early lung cancer detection. Continued medical surveillance is important.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗

Pando

SAND2025-02006O Pando is a distributed data analysis software tool. It is designed to handle large-scale graph analysis problems, often with a specific focus on blockchain/cryptocurrency data. Pando handles scalability by running on a distributed cluster of servers. Users can customize the output using the program’s plugin/extension design methodology. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology & Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-NA0003525.

Gabert, Kasimir↗

Supramolecular assembly of polycation/mRNA nanoparticles and in vivo monocyte programming

Size-dependent phagocytosis is a well-characterized phenomenon in monocytes and macrophages. However, this size effect for preferential gene delivery to these important cell targets has not been fully exploited because commonly adopted stabilization methods for electrostatically complexed nucleic acid nanoparticles, such as PEGylation and charge repulsion, typically arrest the vehicle size below 200 nm. Here, we bridge the technical gap in scalable synthesis of larger submicron gene delivery vehicles by electrostatic self-assembly of charged nanoparticles, facilitated by a polymer structurally designed to modulate internanoparticle Coulombic and van der Waals forces. Specifically, our strategy permits controlled assembly of small poly(β-amino ester)/messenger ribonucleic acid (mRNA) nanoparticles into particles with a size that is kinetically tunable between 200 and 1,000 nm with high colloidal stability in physiological media. We found that assembled particles with an average size of 400 nm safely and most efficiently transfect monocytes following intravenous administration and mediate their differentiation into macrophages in the periphery. When a CpG adjuvant is co-loaded into the particles with an antigen mRNA, the monocytes differentiate into inflammatory dendritic cells and prime adaptive anticancer immunity in the tumor-draining lymph node. This platform technology offers a unique ligand-independent, particle-size-mediated strategy for preferential mRNA delivery and enables therapeutic paradigmsviamonocyte programming.

Science & Technology - Other Topics↗

CTGAN-TVAE

SAND2026-18914O CTGAN-TVAE (Conditional Tabular Generative Adversarial Networks-Tabular Variational Autoencoders) generates extensive sets of variable generation data through a hybrid framework. It enhances latent space representation by combining TVAE's robust feature-embedding with CTGAN's ability to condition categorical variables such as time. CTGAN-TVAE employs a fully connected neural network within a conditional generative adversarial network framework to manage continuous and categorical data effectively, capturing complex feature interactions without needing sequential modeling. This was developed as part of NNSA-MSIPP: Minority Serving Institution Partnership Program, Grant Number DE-NA0004016. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology & Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.

Newlun, Cody [Sandia National Lab. (SNL-CA), Liver↗

Savannah River National Laboratory (FY2021 LDRD Annual Report)

Research efforts to build upon the unique knowledge base of the Savannah River National Laboratory (SRNL) are funded through the Laboratory Directed Research and Development (LDRD) Program. The program yields foundational scientific research and development (R&D) essential to SRNL’s core business areas, while aligning optimally and continuously with SRNL’s Strategic Plan to provide long-term benefits to the Department of Energy (DOE), the National Nuclear Security Administration (NNSA), and other customers and stakeholders.

99 GENERAL AND MISCELLANEOUS↗

Annual Site Environmental Report (2019)

Los Alamos National Laboratory’s (the Laboratory’s) annual site environmental reports are prepared by the Laboratory’s environmental organizations, as required by U.S. Department of Energy Order 231.1B, Administrative Change 1, Environment, Safety, and Health Reporting, and Order 458.1, Administrative Change 3, Radiation Protection of the Public and the Environment. The following chapters in this report discuss our success in complying with environmental laws, regulations, and orders (Chapter 2, Compliance Summary); how we manage the Laboratory’s environmental performance (Chapter 3, Environmental Programs); how we monitor for air emissions of radioactive materials and climate conditions (Chapter 4, Air Quality); how we monitor for effects of Laboratory operations on groundwater quality (Chapter 5, Groundwater Protection); how we monitor the movement of chemicals and radionuclides by storm water runoff and the levels of chemicals and radionuclides in deposited sediment (Chapter 6, Watershed Quality); how we monitor for the presence, levels, and effects of chemicals and radionuclides in plants, animals, and soil (Chapter 7, Ecosystem Health); and finally, what radionuclide dose or risk from chemical exposure members of the public may experience as a result of Laboratory operations (Chapter 8, Public Dose and Risk Assessment).

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

ASER Annual Site Environmental Report 2020

Los Alamos National Laboratory’s (the Laboratory’s) annual site environmental reports are prepared each year by the Laboratory’s environmental organizations, as required by U.S. Department of Energy Order 231.1B, Administrative Change 1, Environment, Safety, and Health Reporting, and Order 458.1, Administrative Change 4, Radiation Protection of the Public and the Environment. The following chapters in this report discuss our success in complying with environmental laws, regulations, and orders (Chapter 2, Compliance Summary); how we manage the Laboratory’s environmental performance (Chapter 3, Environmental Programs and Analytical Data Quality); how we monitor for air emissions of radioactive materials and climate conditions (Chapter 4, Air Quality); how we monitor for effects of Laboratory operations on groundwater quality (Chapter 5, Groundwater Protection); how we monitor the movement of chemicals and radionuclides by storm water runoff and the levels of chemicals and radionuclides in deposited sediment (Chapter 6, Watershed Quality); how we monitor for the presence, levels, and effects of chemicals and radionuclides in plants, animals, soil, and vegetation (Chapter 7, Ecosystem Health); and finally, what radionuclide dose or risk from chemical exposure members of the public may experience as a result of Laboratory operations (Chapter 8, Public Dose and Risk Assessment).

54 ENVIRONMENTAL SCIENCES↗

Nuclear Safety [Vol. 32, No. 1, January-March 1991]

Nuclear Safety is a review journal that covers significant developments in the field of nuclear safety. Its scope includes the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials, and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated. Table of Contents for this issue follows. GENERAL SAFETY CONSIDERATIONS: 1 The Safety Review and Approval Process for Space Nuclear Power Sources, G. L. Bennett; 19 Report on the American Nuclear Society International Topical Meeting: "The Safety, Status, and Future of Non-Commercial Reactors and Irradiation Facilities", E. G. Silver; 35 Book Review: Fission Product Transport Processes in Reactor Accidents, Proceedings to the International Centre tor Heat and Mass Processes T. S. Kress; 38 Fast Reactor Technology in the 1990s: A Summary of the 1990 International Fast Reactor Safety Meeting, A. E. Levin; ACCIDENT ANALYSIS: 56 Effects of Chemical Phenomena on LWR Severe Accident Fission Product Behavior, A. P. Malinauskas and T. S. Kress; CONTROL AND INSTRUMENTATION: 65 Technical Note: Safety Parameter Display Systems—10 Years Later, R. J. Eckenrode; 68 Potential Application of Neural Networks to the Operation of Nuclear Power Plants, R. E. Uhrig; DESIGN FEATURES: 80 Twenty-First DOE/NRC Nuclear Air-Cleaning Conference, R. R. Bellamy, D. W. Moeller, and M. W. First; 91 Impact of an Apparent Radiation Embrittlement Rate on the Life Expectancy of PWR Vessel Supports, R. D. Cheverton, G. C. Robinson, W. E. Pennell, and R. K. Nanstad; ENVIRONMENTAL EFFECTS: 103 Technical Note: The Impact of Offsite Factors on the Safety Performance of Small Nuclear Power Plants, Yu. D. Baranaev and A. N. Viktorov; WASTE AND SPENT FUEL MANAGEMENT: 109 Activities Related to Waste Management, Compiled by E. G. Silver; OPERATING EXPERIENCES: 118 Reactor Shutdown Experience, Compiled by J. W. Cletcher; 121 Selected Safety-Related Events, Compiled by G. A. Murphy; 123 Operating U.S. Power Reactors, Compiled by E. G. Silver; RECENT DEVELOPMENTS: 140 General Administrative Activities, Compiled by E. G. Silver; 150 Reports, Standards, and Safety Guides, D. S. Queener; 155 Status of Power-Reactor Licensing Activities, Compiled by E. G. Silver; 157 Proposed Rule Changes as of Sept. 30, 1990; ANNOUNCEMENTS: 79 MIT Offers Summer Program on Nuclear Power Reactor Safety; 108 Harvard School of Public Health Offers Several Short Courses; 139 Short Course and Workshop on Nuclear Criticality Safety at University of New Mexico; 160 SCK/CEN Announces Training Course on Emergency Planning and Response; 161 The Authors; 164 Indexes to Nuclear Safety, Volume 31

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Summary of Analytical Services for the Hanford Site Radionuclide NESHAP Program

This document is a summary of the point source analytical requirements used to demonstrate compliance for the Department of Energy (DOE) Hanford Site operations with 40 Code of Federal Regulations (CFR) Part 61, “National Emission Standards for Hazardous Air Pollutants,” (NESHAP) Subpart H, “National Emission Standards for Emissions of Radionuclides Other Than Radon From Department of Energy Facilities,” and the Washington Administrative Code (WAC) 246-247, “Radiation Protection – Air Emissions.” This reference collects information from multiple source documents and is not intended to create, supersede, replace or over-ride any existing contractual, DOE, federal or state statutes, regulations, compliance agreements, orders, permits, licenses or other requirements. The requirement source document governs where any difference may exist. The Hanford Mission Integration Solutions (HMIS) Environmental organization has been contracted by DOE to manage and report data collected from the sampling and monitoring of radioactive air emissions point sources, colloquially called stacks. The Environmental organization coordinates the analyses and reporting of samples collected at various facilities across the Hanford Site. These facilities operate approximately 52 stacks that require sampling, monitoring or estimating radioactive air emissions. The stacks are operated by Bechtel National, Inc. (BNI), Central Plateau Cleanup Company (CPCCo), Hanford Tank Waste Operations & Closure (H2C), Hanford Laboratory Management and Integration (HLMI), and Pacific Northwest National Laboratory (PNNL). Stack samples from CPCCo, HLMI and H2C facilities are collected by the operating contractor staff, delivered to HMIS, and then shipped to an offsite contracted laboratory for analyses. The field and laboratory sample data uploaded into the Sample Management and Analytical Results Tracking (SMART) database are used to calculate sample volumes and concentrations. Sample concentrations are evaluated for compliance with federal and state regulations, permits, and license requirements. The SMART database also calculates total curies released for sampled point sources and stacks. Point source effluent concentrations and releases are published annually in publicly available reports. The BNI and PNNL operate several DOE-Hanford Field Office (HFO) stacks subject to the requirements of 40 CFR 61, Subpart H and WAC 246-247. The concentrations, curies released and dose modeling evaluation for these stacks are included in the DOE-HFO annual radionuclide NESHAP report. The sample collection, analyses and emissions estimates for these stacks are outside the scope of HMIS contracted responsibilities and not addressed further in this document.

54 ENVIRONMENTAL SCIENCES↗

Federal Workplace Charging Program Guide

This report serves as a program guide to support federal agencies in developing their own policy documents for workplace charging. It provides suggested language that agencies can incorporate into their own policies to define requirements for charging privately owned vehicles (POVs) on government-owned or leased property. The Fixing America's Surface Transportation Act authorizes the U.S. General Services Administration (GSA) and other federal agencies to install, operate, and maintain electric vehicle supply equipment (EVSE) for POVs in parking areas used by federal employees and authorized users, and it requires the collection of fees to recover the costs of installing, operating, and maintaining this equipment. This guide offers details for agency facility managers, transportation personnel, employees, and vendors regarding the charging of electric vehicles (EVs) for use by employees and personnel at government-owned and leased buildings. This guide describes the requirements associated with federal agencies providing EV charging in publicly accessible sites. The policy also describes when and how fees may be imposed to cover costs of electricity, as well as EVSE units and installations in various scenarios.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Impala

SAND2025-07450O Impala is a software tool that performs Bayesian model calibration for emulator-based models. The program uses R code to perform the calculations. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology & Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-NA0003525.

Tucker, James [Sandia National Lab. (SNL-CA), Live↗

2009 National Household Travel Survey - California Add-On

The California add-on survey supplements the 2009 National Household Travel Survey (NHTS) with additional household samples and detailed travel behavior for an assigned travel day. The NHTS was conducted by the Federal Highway Administration, which collected data on the demographic and socioeconomic composition of households, as well as detailed information on travel behavior nationwide. State transportation departments and metropolitan planning agencies had the opportunity to purchase extra household samples as part of the NHTS add-on program. These additional samples, along with national samples collected in the add-on areas, are compiled for use in transportation planning, forecasting, and research. The California Department of Transportation participated in the NHTS add-on program and received a total of 21,225 household samples in California, from March 2008 through May 2009.

1Hz data↗

2017 National Household Travel Survey - California Add-On

The California add-on survey supplements the 2017 National Household Travel Survey (NHTS) with additional household samples and detailed travel behavior for an assigned travel day. The NHTS was conducted by the Federal Highway Administration, which collected data on the demographic and socioeconomic composition of households, as well as detailed information on travel behavior nationwide. State transportation departments and metropolitan planning agencies had the opportunity to purchase extra household samples as part of the NHTS add-on program. These additional samples, along with national samples collected in the add-on areas, are compiled for use in transportation planning, forecasting, and research. The California Department of Transportation participated in the NHTS add-on program and received a total of 26,095 household samples in California, from April 2016 through April 2017.

1Hz data↗

Sandia National Laboratories Annual Site Environmental Report, 2019: Tonopah Test Range, Nevada and Kaua'i Test Facility, Hawai'i

Sandia National Laboratories is a multimission laboratory managed and operated by National Technology & Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the United States Department of Energy (DOE) National Nuclear Security Administration. The National Nuclear Security Administration’s Sandia Field Office administers the contract and oversees contractor operations at Sandia National Laboratories, Tonopah Test Range (SNL/TTR) in Nevada and Sandia National Laboratories, Kaua‘i Test Facility (SNL/KTF) in Hawai‘i. Activities at SNL/TTR are conducted in support of DOE weapons programs and have operated at the site since 1957. SNL/KTF has operated as a rocket preparation launching and tracking facility since 1962. DOE and its management and operating contractor are committed to safeguarding the environment, assessing sustainability practices, and ensuring the validity and accuracy of the monitoring data presented in this Annual Site Environmental Report. This report summarizes the environmental protection, restoration, and monitoring programs in place at SNL/TTR and SNL/KTF during calendar year 2019. Environmental topics include air quality, ecology, environmental restoration, oil storage, site sustainability, terrestrial surveillance, waste management, water quality, and implementation of the National Environmental Policy Act. This report is prepared in accordance with and as required by DOE O 231.1B, Admin Change 1, Environment, Safety, and Health Reporting, and has been approved for public distribution.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

PV System Owner's Guide to Identifying, Assessing, and Addressing Weather Vulnerabilities, Risks, and Impacts

The report is designed to help federal facility managers, engineers, contractors, and consultants identify the most common PV system vulnerabilities that could lead from mild to catastrophic loss of PV systems during severe weather events. The guide helps users understand the type and severity of severe weather that can occur at any given location, and provides pre- and post-storm operations and maintenance (O&M) measures that can reduce the potential for damage to a PV system during a severe weather event and help speed the recovery of a PV system damaged during a storm. The guide emphasizes safety in responding to damage from severe weather events.

14 SOLAR ENERGY↗

It's All About the Envelope: Prioritizing Envelope Upgrades for Electrification of Cold Climate Homes

Building decarbonization via electrification on a clean grid is the most promising climate solution proposed to date for the building sector. In cold climate zones, building electrification will be driven in large part by moving from natural gas space heating to cold climate heat pumps (CCHPs). CCHPs are commercially available today, including economical cold climate air source heat pumps (ccASHPs). But there's one big problem - wide-scale adoption of ccASHPs will dramatically increase winter peak electricity demand, even with the highest efficiency ccASHP products. Furthermore, cold climate space heating loads will drive unprecedented electric system peaks during the lowest periods of renewable generation and are likely to overwhelm existing distribution systems. This scenario is avoidable by coupling electrification with building envelope upgrades to reduce peak heating loads. This paper presents a model, built from home energy audit and research data sets, that quantifies the above challenges. Results demonstrate how weatherization efforts coupled with additional high-performance envelope upgrade measures can prepare the building stock for electrification and show the benefit these measures can bring to future utility operations. Much of this envelope upgrade work is cost-effective, according to conservative cost-benefit testing and program successes to date, and is coupled with substantial non-energy benefits. However, persistent market barriers have made scaling of envelope retrofit work challenging for decades, suggesting additional policy support is required. Lessons learned from previous policy experience, combined with new technology and administrative support, create exciting potential for this decarbonization climate solution.

air sealing↗

X-Ray Imaging and Spectroscopy Mission

The X-Ray Imaging and Spectroscopy Mission (XRISM) is a joint mission between the Japan Aerospace Exploration Agency (JAXA) and the National Aeronautics and Space Administration (NASA) in collaboration with the European Space Agency (ESA). In addition to the three space agencies, universities and research institutes from Japan, North America, and Europe have joined to contribute to developing satellite and onboard instruments, data-processing software, and the scientific observation program. XRISM is the successor to the ASTRO-H (Hitomi) mission, which ended prematurely in 2016. Its primary science goal is to examine astrophysical problems with precise, high-resolution X-ray spectroscopy. XRISM promises to discover new horizons in X-ray astronomy. It carries a 6 × 6 pixelized X-ray microcalorimeter on the focal plane of an X-ray mirror assembly (Resolve) and a co-aligned X-ray CCD camera (Xtend) that covers the same energy band over a large field of view. XRISM utilizes the Hitomi heritage, but all designs were reviewed. The attitude and orbit control system was improved in hardware and software. The spacecraft was launched from the JAXA Tanegashima Space Center on 2023 September 6 (UTC). During the in-orbit commissioning phase, the onboard components were activated. Although the gate valve protecting the Resolve sensor with a thin beryllium X-ray entrance window was not yet opened, scientific observation started in 2024 February with the planned performance verification observation program. The nominal observation program commenced with the following guest observation program beginning in 2024 September.

Astronomy and AstroPhysics↗