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Abstract: Spacecraft thermal design presents unique thermal and fluid challenges caused by a variety of harsh spacecraft thermal environments. In addition, at cryogenic temperatures (i.e., less than 123 K (-150° C), and sometimes as low as 50 milliKelvin), more challenges arise, such as the increasing importance of mitigating thermal radiation, the effects of coefficient of thermal expansion mismatches between different materials, changes in the physics behavior of materials, and increasing thermodynamic difficulty of lifting heat up large temperature gradients. In this talk, Dr. Rueger will present a broad overview of spacecraft thermal environments; cryogenic design practices; components of interest for the Cryogenics and Fluids Branch (e.g., cryocoolers, adiabatic demagnetization refrigerators, heat switches, and superconducting leads); cryogenic considerations in some current NASA mission examples (e.g., the DragonFly mission to Titan and the X-ray Imaging and Spectroscopy Mission); and capabilities of the Cryogenics and Fluids Branch at NASA.