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At least 289 records · Page 16
All sourcesNASA NTRSDOE OSTI
NASA NTRS1998

High sustained +Gz acceleration: physiological adaptation to high-G tolerance

Since the early 1940s, a significant volume of research has been conducted in an effort to describe the impact of acute exposures to high-G acceleration on cardiovascular mechanisms responsible to maintaining cerebral perfusion and conscious in high performance aircraft pilots during aerial combat maneuvers. The value of understanding hemodynamic characteristics that underlie G-induced loss of consciousness has been instrumental in the evolution of optimal technology development (e.g., G-suits, positive pressure breathing, COMBAT EDGE, etc.) and pilot training (e.g., anti-G straining maneuvers). Although the emphasis of research has been placed on the development of protection against acute high +Gz acceleration effects, recent observations suggest that adaptation of cardiovascular mechanism associated with blood pressure regulation may contribute to a protective 'G-training' effect. Regular training at high G enhances G tolerance in humans, rats, guinea pigs, and dogs while prolonged layoff from exposure in high G profiles (G-layoff) can result in reduced G endurance. It seems probable that adaptations in physiological functions following chronically-repeated high G exposure (G training) or G-layoff could have significant impacts on performance during sustained high-G acceleration since protective technology such as G-suits and anit-G straining maneuvers are applied consistently during these periods of training. The purpose of this paper is to present a review of new data from three experiments that support the notion that repeated exposure on a regular basis to high sustained +Gz acceleration induces significant physiological adaptations which are associated with improved blood pressure regulation and subsequent protection of cerebral perfusion during orthostatic challenges.

Review, Tutorial↗
NASA NTRS1997

Effect of fluid ingestion on orthostatic responses following acute exercise

Orthostatic tolerance is impaired following an acute bout of exercise. This study examined the effect of fluid ingestion following treadmill exercise in restoring the cardiovascular responses to an orthostatic stress. Five men (age, 29.6 +/- 3.4 yrs) were exposed to a graded lower body negative (LBNP) pressure protocol (0 to -50 mmHg) during euhydration without exercise (C), 20 minutes after exercise dehydration (D), 20 minutes after exercise and fluid ingestion (FI20), and 60 minutes after exercise and fluid ingestion (FI60). Fluid ingestion (mean +/- SE) consisted of water-ingestion equivalent to 50% of the body weight lost during exercise (520 +/- 15 ml). Exercise dehydration resulted in significantly higher heart rates (119 +/- 8 vs 82 +/- 7 bpm), lower systolic blood pressures (95 +/- 1.7 vs 108 +/- 2.3 mmHg), a smaller increase in leg circumference (3.7 +/- 4 vs 6.9 +/- 1.0 mm), and an attenuated increase in total peripheral resistance (2.58 +/- 1.2 vs 4.28 +/- 0.9 mmHg/L/min) at -50 mmHg LBNP compared to the C condition. Fluid ingestion (both 20 and 60), partially restored the heart rate, systolic blood pressure, and total peripheral resistance responses to LBNP, but did not influence the change in leg circumference during LBNP (4 +/- 0.3 for R20 and 2.8 +/- 0.4 mm for R60). These data illustrate the effectiveness of fluid ingestion on improving orthostatic responses following exercise, and suggest that dehydration is a contributing factor to orthostatic intolerance following exercise.

NASA Center JSC↗
NASA NTRS1998

Insight into mechanisms of reduced orthostatic performance after exposure to microgravity: comparison of ground-based and space flight data

Since the beginning of human spaceflight, the value of understanding mechanisms of physiological adaptation to microgravity became apparent to life scientists who were interested in maintining crew health and developing countermeasures agains adverse effects of the mission. However, several characteristics associated the the logistics of spaceflight presented significant limitations to the scientific study of human adaptation to microgravity. Because space missions are so infrequent and involve minimal numbers of crewmembers, meaninful statistical analysis of data are limited. Reproducibility of results from spaceflight experiments is difficult to assess since there are few repeated space missions involving the same crewmembers. Since the emphasis of space missions is placed on operations, experiments are compromised without adequate control over various factors (e.g., time, diet, physical activities, etc.) that can impact measured responses. With the mimimal opportunity to collect spaceflight data, there is a high risk of experiments that simultaneously interfere with other experiments by the increasing demand on the crewmembers to participate in mumerous experiments proposed by multiple investigators. The technology and ability to measure physiological functions necessary to test specific hypotheses can be severely limited by physical space and power constraints of the space enviroment. Finally, technical and logistical aspects of space missions such as launch delays, extended missions, and inflight operational emergencies can significantly compromise the timing and control of experiments. These limitations have stimulated scientists to develop ground-based analogs of microgravity in an effort to investigate the effects of spaceflight on physiological function in a controlled experimental setting. The purpose of this paper is to provide a selected comparison of data collected from ground-based experiments with those obtained from spaceflight in an effort to assess the adequacy of ground analogs of actual flight for the study of human physiological adaptation to microgravity. Specifically, results from ground and spaceflight will be used to provide insight into mechanisms underlying adaptations of blood pressure regulation and reduced orthostatic performance to the microgravity environment.

Non-NASA Center↗
NASA NTRS2002

Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space

Astronauts returning from space have reduced red blood cell masses, hypovolaemia and orthostatic intolerance, marked by greater cardio-acceleration during standing than before spaceflight, and in some, orthostatic hypotension and presyncope. Adaptation of the sympathetic nervous system occurring during spaceflight may be responsible for these postflight alterations. We tested the hypotheses that exposure to microgravity reduces sympathetic neural outflow and impairs sympathetic neural responses to orthostatic stress. We measured heart rate, photoplethysmographic finger arterial pressure, peroneal nerve muscle sympathetic activity and plasma noradrenaline spillover and clearance, in male astronauts before, during (flight day 12 or 13) and after the 16 day Neurolab space shuttle mission. Measurements were made during supine rest and orthostatic stress, as simulated on Earth and in space by 7 min periods of 15 and 30 mmHg lower body suction. Mean (+/- S.E.M.) heart rates before lower body suction were similar pre-flight and in flight. Heart rate responses to -30 mmHg were greater in flight (from 56 +/- 4 to 72 +/- 4 beats min(-1)) than pre-flight (from 56 +/- 4 at rest to 62 +/- 4 beats min(-1), P < 0.05). Noradrenaline spillover and clearance were increased from pre-flight levels during baseline periods and during lower body suction, both in flight (n = 3) and on post-flight days 1 or 2 (n = 5, P < 0.05). In-flight baseline sympathetic nerve activity was increased above pre-flight levels (by 10-33 %) in the same three subjects in whom noradrenaline spillover and clearance were increased. The sympathetic response to 30 mmHg lower body suction was at pre-flight levels or higher in each subject (35 pre-flight vs. 40 bursts min(-1) in flight). No astronaut experienced presyncope during lower body suction in space (or during upright tilt following the Neurolab mission). We conclude that in space, baseline sympathetic neural outflow is increased moderately and sympathetic responses to lower body suction are exaggerated. Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels.

STS-90 Shuttle Project↗
NASA NTRS2002

Aging attenuates the vestibulosympathetic reflex in humans

BACKGROUND: The vestibular system contributes to sympathetic activation by engagement of the otolith organs. However, there is a significant loss of vestibular function with aging. Therefore, the purpose of the present study was to determine if young and older individuals differ in their cardiovascular and sympathetic responses to otolithic stimulation (ie, head-down rotation, HDR). We hypothesized that responses to otolithic stimulation would be attenuated in older adults because of morphological and physiological alterations that occur in the vestibular system with aging. METHODS AND RESULTS: Arterial blood pressure, heart rate, muscle sympathetic nerve activity (MSNA), and head rotation were measured during HDR in 11 young (26 +/- 1 years) and 11 older (64 +/- 1 years) subjects in the prone posture. Five older subjects performed head rotation (chin to chest) in the lateral decubitus position, which simulates HDR but does not alter afferent inputs from the vestibular system. MSNA responses to HDR were significantly attenuated in older as compared with young subjects (P<0.01). MSNA increased in the older subjects by only 12 +/- 5% as compared with 85 +/- 16% in the young. Furthermore, HDR elicited significant reductions in mean arterial blood pressure in older (Delta-6 +/- 1 mm Hg; P<0.01) but not young subjects (Delta1 +/- 1 mm Hg). In contrast to HDR, head rotation performed in the lateral decubitus position did not elicit hypotension. MSNA responses to baroreceptor unloading and the cold pressor test were not different between the age groups. CONCLUSIONS: These data indicate that aging attenuates the vestibulosympathetic reflex in humans and may contribute to the increased prevalence of orthostatic hypotension with age.

NASA Discipline Neuroscience↗
NASA NTRS1994

The effect of dDAVP with saline loading on fluid balance during LBNP and standing after 24-hr head-down bedrest

Shuttle astronauts currently drink approximately a quart of water with eight salt tablets before reentry to restore lost body fluid and thereby reduce the likelihood of cardiovascular instability and syncope during reentry and after landing. However, the saline loading countermeasure is not entirely effective in restoring orthostatic tolerance to preflight levels. We tested the hypothesis that the effectiveness of this countermeasure could be improved with the use of a vasopressin analog, 1-deamino-8-D-arginine vasopressin (dDAVP). The rationale for this approach is that reducing urine formation with exogenous vasopressin should increase the magnitude and duration of the vascular volume expansion produced by the saline load, and in so doing improve orthostatic tolerance during reentry and postflight.

NASA Discipline Number 14-10↗
NASA NTRS1988

Assessment of the efficacy of medical countermeasures in space flight

Changes in body fluids, electrolytes, and muscle mass are manifestations of adaptation to space flight and readaptation to the 1-g environment. The purposes of this paper are to review the current knowledge of biomedical responses to short- and long-duration space missions and to assess the efficacy of countermeasures to 1-g conditioning. Exercise protocols, fluid hydration, dietary and potential pharmacologic measures are evaluated, and directions for future research activities are recommended.

NASA Discipline General Space Life Sciences↗
NASA NTRS1994

Self-generating oscillating pressure exercise device

An exercise device, especially suitable for zero gravity workouts, has a collapsible chamber which generates negative pressure on the lower portion of a body situated therein. The negative pressure is generated by virtue of leg, hand and shoulder interaction which contracts and expands the chamber about the person and by virtue of air flow regulation by valve action.

Watenpaugh, Donald E.↗
NASA NTRS1975

Means and methods of physical conditioning of man in long space flights

Methods of prophylaxis for disorders caused predominantly by reduction or absence of hydrostatic blood pressure in weightlessness and in experimental stimulation of it (readjustment of the watersalt metabolism, relative dehydration, disruption of competence of the cardiovascular system with respect to orthostatic loads, etc.), are adequately substantiated. Two theoretically possible approaches to prophylaxis of this type of disorder are examined: The use of methods of simulation of the effect of hydrostatic blood pressure in flight and the decrease in the gravitational redistribution of blood to the lower part of the body in the postflight period. In particular, the method of negative pressure in the lower region of the body gave favorable results. A significant decrease in orthostatic disorders after completion of such experiments was achieved by use of g-suits or other types of special clothing.

Stepantsov, V. I.↗
NASA NTRS1974

Pressure distribution on a vectored-thrust V/STOL fighter in the transition-speed range

A wind-tunnel investigation has been conducted in the Langley V/STOL tunnel with a vectored-thrust V/STOL fighter configuration to obtain detailed pressure measurements on the body and on the wing in the transition-speed range. The vectored-thrust jet exhaust induced a region of negative pressure coefficients on the lower surface of the wing and on the bottom of the fuselage. The location of the jet exhaust relative to the wing was a major factor in determining the extent of the region of negative pressure coefficients.

Mineck, R. E.↗
NASA NTRS2016

Bringing Gravity to Space

This panel will present NASA's plans for ongoing and future research to define the requirements for Artificial Gravity (AG) as a countermeasure against the negative health effects of long-duration weightlessness. AG could mitigate the gravity-sensitive effects of spaceflight across a host of physiological systems. Bringing gravity to space could mitigate the sensorimotor and neuro-vestibular disturbances induced by G-transitions upon reaching a planetary body, and the cardiovascular deconditioning and musculoskeletal weakness induced by weightlessness. Of particular interest for AG during deep-space missions is mitigation of the Visual Impairment Intracranial Pressure (VIIP) syndrome that the majority of astronauts exhibit in space to varying degrees, and which presumably is associated with weightlessness-induced fluid shift from lower to upper body segments. AG could be very effective for reversing the fluid shift and thus help prevent VIIP. The first presentation by Dr. Charles will summarize some of the ground-based and (very little) space-based research that has been conducted on AG by the various space programs. Dr. Paloski will address the use of AG during deep-space exploration-class missions and describe the different AG scenarios such as intra-vehicular, part-of-vehicle, or whole-vehicle centrifugations. Dr. Clement will discuss currently planned NASA research as well as how to coordinate future activities among NASA's international partners. Dr. Barr will describe some possible future plans for using space- and ground-based partial-G analogs to define the relationship between physiological responses and G levels between 0 and 1. Finally, Dr. Stenger will summarize how the human cardiovascular system could benefit from intermittent short-radius centrifugations during long-duration missions.

Norsk, P.↗
NASA NTRS1995

Pros and Cons of Using Water Immersion to Simulate Physiological Responses to Microgravity

Head-out water immersion (HOI) has been employed as a remedial treatment for various ills and ailments for many millennia, and total body immersion even longer as protective encapsulation for the mammalian fetus. Two discrete differences between stimuli induced by true microgravity (10(exp -4) g) and HOI are readily apparent. External water pressure on the skin and accompanying negative pressure breathing cause blood to shift headward. Secondly, the gravitational force is ever present during immersion and microgravity, but its effect is essentially neutralized during Earth orbital flight. Thus, the physiological responses to immersion should not be expected to match those during microgravity. Immersion has been used mainly to study and understand kidney function and associated cardiovascular responses for control of body fluid volume and osmotic content, with some application to and simulation of microgravity responses. There is a plethora of data from human HOI studies, but relatively few controlled data from microgravity studies. In general, it appears that physiological responses occur more quickly with water immersion than in microgravity, but this may be due to less rigorous control (voluntary and involuntary) of the preflight state of crew members. The central venous pressure-vasopressin (Gauer-Henry) reflex control for fluid balance may not be of prime importance in microgravity. Gross functions such as reduced body weight and water, level of hypovolemia, decreased isokinetic strength, and lower nitrogen balance found during immersion are qualitatively similar in microgravity, but the mechanisms controlling these and other functions are, for the most part, unclear. Only acquisition of data from well-controlled microgravity experiments will resolve this discrepancy.

Greenleaf, J. E.↗
NASA NTRS2018

The Effects of Background Pressure on SPT-140 Thruster Performance at Multiple Power Levels

NASA's planned Psyche mission is scheduled to launch in 2022 and begin a 3.5-year cruise to the metallic asteroid Psyche, where it would examine this unique body. The baseline spacecraft design is a hybrid of JPL's deep-space heritage subsystems with commercial partner SSL's power, structure, and SPT-140 electric propulsion subsystems. Since the deep-space implementation of the SPT-140 differs from the commercial implementation, primarily in the need for deep power throttling, characterization of the system at lower powers is necessary. One specific area of interest is the sensitivity of thruster performance to background pressure in ground-based test facilities, which can have an impact on the prediction of in-space performance. Measurements of this pressure dependence were performed on a qualification-model SPT-140 thruster over the 0.9-4.5 kW range of interest for the Psyche mission. Thrust sensitivity to pressure, in an absolute sense, was largest at 4.5 kW and decreased with power until there was little-to-no measurable effect at 0.9 kW. In a relative sense, thrust sensitivity was similar at all powers above 0.9 kW with about 2-4% higher thrust measured at 10 μTorr than at the lowest operating pressure. Thruster stability margin, examined as a function of magnet current, did not have a strong dependence on facility pressure. Finally, an investigation of low-power operation at the lowest facility pressure showed that a combination of added cathode keeper current and additional cathode propellant flow significantly mitigated the larger negative cathode-to-ground voltages that were observed. These test results, combined with thruster life test results, inform the selection of proper low-power operating conditions for Psyche.

Snyder, John S.↗
NASA NTRS2018

The Effects of Background Pressure on SPT-140 Hall Thruster Performance

NASA’s planned Psyche mission is scheduled to launch in 2022 and begin a 3.5-year cruise to the metallic asteroid Psyche, where it would examine this unique body. The baseline spacecraft design is a hybrid of JPL’s deep-space heritage subsystems with commercial partner SSL’s power, structure, and SPT-140 electric propulsion subsystems. Since the deepspace implementation of the SPT-140 differs from the commercial implementation, primarily in the need for deep power throttling, characterization of the system at lower powers is necessary. One specific area of interest is the sensitivity of thruster performance to background pressure in ground-based test facilities, which can have an impact on the prediction of in-space performance. Measurements of this pressure dependence were performed on a qualification-model SPT-140 thruster over the 0.9-4.5 kW range of interest for the Psyche mission. Thrust sensitivity to pressure, in an absolute sense, was largest at 4.5 kW and decreased with power until there was little-to-no measurable effect at 0.9 kW. In a relative sense, thrust sensitivity was similar at all powers above 0.9 kW with about 2-4% higher thrust measured at 10 µ µTorr than at the lowest operating pressure. Thruster magnetic field sensitivity, examined as a function of magnet current, did not have a strong dependence on facility pressure. Finally, an investigation of low-power operation at the lowest facility pressure showed that a combination of added cathode keeper current and additional cathode propellant flow significantly mitigated the larger negative cathode-to-ground voltages that were observed. These test results, combined with thruster life test results, inform the selection of proper low-power operating conditions for Psyche.

Mackey, Jonathan A.↗
NASA NTRS2016

Experimental Evaluation of the Scale Model Method to Simulate Lunar Vehicle Dynamics

As compared to driving on Earth, the presence of lower gravity and uneven terrain on planetary bodies makes high speed driving difficult. In order to maintain ground contact and control vehicles need to be designed with special attention to dynamic response. The challenge of maintaining control on the Moon was evident during high speed operations of the Lunar Roving Vehicle (LRV) on Apollo 16, as at one point all four tires were off the ground; this event has been referred to as the Lunar Grand Prix. Ultimately, computer simulation should be used to examine these phenomena during the vehicle design process; however, experimental techniques are required for the validation and elucidation of key issues. The objectives of this study were to evaluate the methodology for developing a scale model of a lunar vehicle using similitude relationships and to test how vehicle configuration, six or eight wheel pods, and local tire compliance, soft or stiff, affect the vehicles dynamic performance. A wheel pod consists of a drive and steering transmission and wheel. The Lunar Electric Rover (LER), a human driven vehicle with a pressurized cabin, was selected as an example for which a scale model was built. The scaled vehicle was driven over an obstacle and the dynamic response was observed and then scaled to represent the full-size vehicle in lunar gravity. Loss of ground contact, in terms of vehicle travel distance with tires off the ground, was examined. As expected, local tire compliance allowed ground contact to be maintained over a greater distance. However, switching from a six-tire configuration to an eight-tire configuration with reduced suspension stiffness had a negative effect on ground contact. It is hypothesized that this was due to the increased number or frequency of impacts. The development and testing of this scale model provided practical lessons for future low-gravity vehicle development.

Moon↗
DOE OSTI2023

Contrasting the characteristics of atmospheric pressure plasma jets operated with single and double dielectric material: physicochemical characteristics and application to bacterial killing

Abstract This study reports an experimental comparison of two types of atmospheric pressure plasma jets in terms of their fundamental plasma characteristics and efficacy in bacterial sterilization. The plasma jets are fabricated by inserting a high voltage electrode inside a one-end closed (double DBD plasma jet) or both ends open (single DBD plasma jet) quartz tubes which are further enclosed inside a second quartz tube containing a ground electrode. Both plasma jets are operated in contact with water surface by using a unipolar pulsed DC power supply with helium as the working gas. Results from electrical and time-resolved imaging show that the single DBD configuration induces 3–4 times higher accumulation of charges onto the water surface with significantly faster propagation of plasma bullets. These results are accompanied by the higher discharge intensity as well as stronger emissions from short-lived reactive species which were analyzed through optical emission spectroscopy at the plasma-water interface. The rotational temperature for the single DBD configuration was observed to be higher making it unsafe for direct treatments of sensitive biological targets. These characteristics of the single DBD configuration result in the production of more than two times higher concentration of H 2 O 2 in plasma activated water. Shielding of the HV electrode reduces the plasma potential which in turn reduces the electric field & electron energy at the plasma-water interface. The reduced electric field for the double DBD configuration was lower by ≈463 Td than the single DBD configuration. The bactericidal efficacy of the two configurations of the plasma jets were tested against Escherichia coli , a well studied Gram-negative bacterium that can be commensal and pathogenic in human body. Our results demonstrate that although single DBD plasma jet result in stronger antibacterial effects, the double DBD configuration could be safer.

Physics↗
NASA NTRSDate not supplied

Testing of Two Mars Powered Descent Vehicle Concepts in the Langley Unitary Plan Wind Tunnel

Testing was conducted in the NASA Langley Unitary Plan Wind Tunnel in order to investigate the aerodynamic interference of sub-scale versions of two Mars powered descent vehicle concepts at supersonic Mach numbers (2.4 and 3.5): a model based on a blunt hypersonic inflatable aerodynamic decelerator (HIAD) and the second representing a more slender rigid vehicle with body flaps (CobraMRV). Each model was designed to accommodate up to eight nozzles, with the HIAD model having five different nozzle configurations to investigate the effects of nozzle location, cant angle, and area ratio. The models were tested with high pressure air as the nozzle plume gas, and included the following instrumentation: high-speed video, discrete steady state and high-frequency pressure, pressure sensitive paint, and a new flow-through force and moment balance for the HIAD model. The high-speed imagery showed the overall expected growth of the shock layer to increasing thrust levels. The discrete stagnation pressure data on the HIAD model with four and eight blowing nozzles was sensitive to thrust coefficient with the nozzles canted at 0 degrees, whereas having nozzles canted outward 20 degrees and/or being located closer to the heatshield shoulder largely removed that sensitivity. The CobraMRV model stagnation pressure was more sensitive to tunnel Mach number and sideslip angle, due to the nozzle arrangement and plume interference. Pressure sensitive paint data quality was compromised by paint damage from frequent model changes, especially for the HIAD model. However, pressure coefficient data on the CobraMRV model showed the same trends as the discrete pressure measurements, as well as a sensitivity to non-zero sideslip angles. The aerodynamic force coefficients were derived from the pressure sensitive paint data. On the HIAD models, the primary force coefficient decreased with increasing thrust due to the nozzle plumes blocking flow to the heatshield area surrounding the nozzle exist. On the CobraMRV model, the force coefficient was relatively insensitive to thrust coefficient at the lower Mach number when sideslip angle was 0 degrees The force coefficient decreases with increasing thrust coefficient when the sideslip angle is 10 degrees. Balance data quality was negatively impacted by thermal drift issues that were not apparent in pre-test calibration measurements, thus preventing usable test data. Results and lessons learned will be used to take further technology development steps, including more advanced ground test techniques and flight testing.

Karl T Edquist↗