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NASA NTRS1981

A theoretical study of the high-latitude winter F region at solar minimum for low magnetic activity

A simple plasma convection model is combined with an ionospheric-atmospheric composition model in order to study the high-latitude winter F region at the solar minimum for low magnetic activity. The high latitude ionospheric features, such as the main trough, the ionization hole, the tongue of ionization, the aurorally produced ionization peaks, and the universal time effects are a natural consequence of the competition between the various chemical and transport processes known to be operating in the high-latitude ionosphere. In the polar hole, the F region peak electron density is below 300 km, and the dominant process at 300 km for NO(+) ions is diffusion.

Sojka, J. J.↗

NASA NTRS1982

Aging and space travel

The matter of aging and its relation to space vehicle crewmembers undertaking prolonged space missions is addressed. The capabilities of the older space traveler to recover from bone demineralization and muscle atrophy are discussed. Certain advantages of the older person are noted, for example, a greater tolerance of monotony and repetitious activities. Additional parameters are delineated including the cardiovascular system, the reproductive system, ionizing radiation, performance, and group dynamics.

Mohler, S. R.↗

NASA NTRS1995

Faint Object Camera imaging and spectroscopy of NGC 4151

We describe ultraviolet and optical imaging and spectroscopy within the central few arcseconds of the Seyfert galaxy NGC 4151, obtained with the Faint Object Camera on the Hubble Space Telescope. A narrowband image including (O III) lambda(5007) shows a bright nucleus centered on a complex biconical structure having apparent opening angle approximately 65 deg and axis at a position angle along 65 deg-245 deg; images in bands including Lyman-alpha and C IV lambda(1550) and in the optical continuum near 5500 A, show only the bright nucleus. In an off-nuclear optical long-slit spectrum we find a high and a low radial velocity component within the narrow emission lines. We identify the low-velocity component with the bright, extended, knotty structure within the cones, and the high-velocity component with more confined diffuse emission. Also present are strong continuum emission and broad Balmer emission line components, which we attribute to the extended point spread function arising from the intense nuclear emission. Adopting the geometry pointed out by Pedlar et al. (1993) to explain the observed misalignment of the radio jets and the main optical structure we model an ionizing radiation bicone, originating within a galactic disk, with apex at the active nucleus and axis centered on the extended radio jets. We confirm that through density bounding the gross spatial structure of the emission line region can be reproduced with a wide opening angle that includes the line of sight, consistent with the presence of a simple opaque torus allowing direct view of the nucleus. In particular, our modelling reproduces the observed decrease in position angle with distance from the nucleus, progressing initially from the direction of the extended radio jet, through our optical structure, and on to the extended narrow-line region. We explore the kinematics of the narrow-line low- and high-velocity components on the basis of our spectroscopy and adopted model structure.

Boksenberg, A.↗

NASA NTRS1997

Photoionization modeling of the LWS fine-structure lines in IR bright galaxies

The long wavelength spectrometer (LWS) fine structure line spectra from infrared luminous galaxies were modeled using stellar evolutionary synthesis models combined with photoionization and photodissociation region models. The calculations were carried out by using the computational code CLOUDY. Starburst and active galactic nuclei models are presented. The effects of dust in the ionized region are examined.

Satyapal, S.↗

DOE OSTI2020

Internal Fragments Generated by Electron Ionization Dissociation Enhance Protein Top-Down Mass Spectrometry

Top-down proteomics by mass spectrometry (MS) involves the mass measurement of an intact protein followed by subsequent activation of the protein to generate product ions. Electron-based fragmentation methods like electron capture dissociation and electron transfer dissociation are widely used for these types of analyses. Recently, electron ionization dissociation (EID), which utilizes higher energy electrons (>20 eV) has been suggested to be more efficient for top-down protein fragmentation compared to other electron-based dissociation methods. In this paper, we demonstrate that the use of EID enhances protein fragmentation and subsequent detection of protein fragments. Protein product ions can form by either single cleavage events, resulting in terminal fragments containing the C-terminus or N-terminus of the protein, or by multiple cleavage events to give rise to internal fragments that include neither the C-terminus nor the N-terminus of the protein. Conventionally, internal fragments have been disregarded, as reliable assignments of these fragments were limited. Here, we demonstrate that internal fragments generated by EID can account for ~20–40% of the mass spectral signals detected by top-down EID-MS experiments. By including internal fragments, the extent of the protein sequence that can be explained from a single tandem mass spectrum increases from ~50 to ~99% for 29 kDa carbonic anhydrase II and 8.6 kDa ubiquitin. When searching for internal fragments during data analysis, previously unassigned peaks can be readily and accurately assigned to confirm a given protein sequence and to enhance the utility of top-down protein sequencing experiments.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS2014

ALMA Observations of α Centauri First Detection of Main-Sequence Stars at 3 mm Wavelength

The precise mechanisms that provide the non-radiative energy for heating the chromosphere and the corona of the Sun and those of other stars constitute an active field of research. By studying stellar chromospheres one aims at identifying the relevant physical processes. Defining the permittable extent of the parameter space can also serve as a template for the Sun-as-a-star. This feedback will probably also help identify stars that potentially host planetary systems that are reminiscent of our own. Earlier observations with Herschel and APEX have revealed the temperature minimum of Alpha Cen, but these were unable to spatially resolve the binary into individual components. With the data reported in this Letter, we aim at remedying this shortcoming. Furthermore, these earlier data were limited to the wavelength region between 100 and 870 um. In the present context, we intend to extend the spectral mapping (SED) to longer wavelengths, where the contrast between stellar photospheric and chromospheric emission becomes increasingly evident. The Atacama Large Millimeter submillimeter Array (ALMA) is particularly suited to point sources, such as unresolved stars. ALMA provides the means to achieve our objectives with both its high sensitivity of the collecting area for the detection of weak signals and the high spatial resolving power of its adaptable interferometer for imaging close multiple stars. This is the first detection of main-sequence stars at a wavelength of 3 mm. Furthermore, the individual components of the binary Alpha CenAB are clearly detected and spatially well resolved at all ALMA wavelengths. The high signal-to-noise ratios of these data permit accurate determination of their relative flux ratios, i.e., S(sub y(sup B)) / S(sub y(sup A))> = 0.54 +/- 0.04 at 440 μm, = 0.46 +/- 0.01 at 870 μm, and = 0.47 +/- 0.006 at 3.1 mm, respectively.. The previously obtained flux ratio of 0.44+/-0.18, which was based on measurements in the optical and at 70 μm, is consistent with the present ALMA results, albeit with a large error bar. The observed 3.1 mm emission greatly exceeds what is predicted from the stellar photospheres, and undoubtedly arises predominantly as free-free emission in the ionized chromospheric plasmas of both stars. Given the distinct difference in their cyclic activity, the similarity of their submm SEDs appears surprising.

Herschel↗

NASA NTRS2016

BioSentinel: Biosensors for Deep-Space Radiation Study

The BioSentinel mission will be deployed on NASA's Exploration Mission 1 (EM-1) in 2018. We will use the budding yeast, Saccharomyces cerevisiae, as a biosensor to study the effect of deep-space radiation on living cells. The BioSentinel mission will be the first investigation of a biological response to space radiation outside Low Earth Orbit (LEO) in over 40 years. Radiation can cause damage such as double stand breaks (DSBs) on DNA. The yeast cell was chosen for this mission because it is genetically controllable, shares homology with human cells in its DNA repair pathways, and can be stored in a desiccated state for long durations. Three yeast strains will be stored dry in multiple microfluidic cards: a wild type control strain, a mutant defective strain that cannot repair DSBs, and a biosensor strain that can only grow if it gets DSB-and-repair events occurring near a specific gene. Growth and metabolic activity of each strain will be measured by a 3-color LED optical detection system. Parallel experiments will be done on the International Space Station and on Earth so that we can compare the results to that of deep space. One of our main objectives is to characterize the microfluidic card activation sequence before the mission. To increase the sensitivity of yeast cells as biosensors, desiccated yeast in each card will be resuspended in a rehydration buffer. After several weeks, the rehydration buffer will be exchanged with a growth medium in order to measure yeast growth and metabolic activity. We are currently working on a time-course experiment to better understand the effects of the rehydration buffer on the response to ionizing radiation. We will resuspend the dried yeast in our rehydration medium over a period of time; then each week, we will measure the viability and ionizing radiation sensitivity of different yeast strains taken from this rehydration buffer. The data obtained in this study will be useful in finalizing the card activation sequence for this mission.

Yeast↗

NASA NTRS2010

Resolving the xi Boo Binary with Chandra, and Revealing the Spectral Type Dependence of the Coronal "Fip Effect"

On 2008 May 2, Chandra observed the X-ray spectrum of xi Boo (G8 V+K4 V), resolving the binary for the first time in X-rays and allowing the coronae of the two stars to be studied separately. With the contributions of ξ Boo A and B to the system's total X-ray emission now observationally established (88.5% and 11.5% respectively), consideration of mass loss measurements for GK dwarfs of various activity levels (including one for xi Boo) leads to the surprising conclusion that xi Boo B may dominate the wind from the binary, with xi Boo A's wind being very weak despite its active corona. Emission measure (EM) distributions and coronal abundances are computed for both stars and compared with Chandra measurements of other moderately active stars with G8-K5 spectral types, all of which exhibit a narrow peak in EM near log T = 6.6, indicating that the coronal heating process in these stars has a strong preference for this temperature. As is the case for the Sun and many other stars, our sample of stars shows coronal abundance anomalies dependent on the first ionization potential (FIP) of the element. We see no dependence of the degree of FIP effect on activity, but there is a dependence on spectral type, a correlation that becomes more convincing when moderately active main-sequence stars with a broader range of spectral types are considered. This clear dependence of coronal abundances on spectral type weakens if the stellar sample is allowed to be contaminated by evolved stars, interacting binaries or extremely active stars with logLX 29, explaining why this correlation has not been recognized in the past.

CHANDRA↗

NASA NTRS1983

Eclipse-related measurements of middle-atmosphere electrical parameters

Measurements of electrical conductivity and its constituent parameters, charge density and ion mobility, are presented for the solar eclipse rocket campaign conducted at Red Lake, Ontario, Canada. Three parachute-borne probes (two Gerdien condensers and a blunt probe) were flown during the eclipse which occurred on 26 February 1979. Additional payloads launched at other times provided important supplemental background measurements. The entire launch series occurred during aurorally active conditions, as indicated by the probe measurements. Specifically, positive conductivity enhancements above 45 km demonstrate the dominance of auroral ionization as a source for positive ions in the region. Such effects evidenced during the eclipse make it difficult to determine the extent to which the decrease in positive conductivity above 60 km is eclipse-related. The negative conductivity component associated with free electrons displays solar dependence both during the eclipse and for the other measurement periods. In spite of the aurorally active conditions, rapid electron loss was observed during totality, thus indicating the importance of non-ionizing solar effects on electrons in the region.

Mitchell, J. D.↗

NASA NTRS2019

Developing High-Throughput Organ-On-A-Chip Models to Investigate the Effects of Ionizing Radiation on the Central Nervous System

One of the main health risks in human space exploration is central nervous system (CNS) damage by ionizing radiation. Irradiation with simulated GCRs or their components, or high doses of low-LET radiation such as gamma rays, in animal models has been shown to cause neuronal damage together with glial cell activation and neuroinflammation and has been associated with prolonged cognitive and behavioral dysfunction. The extent of CNS damage in response to any insult, including ionizing radiation, is partially regulated by the blood-brain barrier (BBB), which enables immune cells to enter the CNS. The main cellular regulators of BBB permeability are astrocytes, which also modulate neuronal death, immune responses and oxidative stress, and thus could serve as a robust CNS-specific target for countermeasure development. However, studies on BBB permeability and astrocyte functions in regulating CNS responses to ionizing radiation have been limited, especially in human tissue/organ analogs. Therefore, we have established a high throughput 3D organ-on-a-chip system to study human CNS functions in response to ionizing radiation, with the eventual goal of adapting it to spaceflight missions. We utilized commercially available OrganoPlate system (Mimetas, Inc.) seeded with primary or induced pluripotent stem cell-derived human cells for developing 3D neuronal-astrocytic and BBB models. We investigated both immediate and delayed CNS dose responses to 0.5-1 Gy X-rays by measuring BBB permeability and morphology, and astrocyte activation. We have also quantified secreted markers of oxidative stress and cell viability. In the future, we are planning to monitor dendritic, axonal and synaptic changes in neurons, evaluate the combined exposures to simulated microgravity and ionizing radiation, and compare the responses to low and high-LET ionizing radiation. We anticipate these studies could indicate novel cellular and mechanistic targets for countermeasure developments to improve CNS functions in astronauts.

Malkani, Sherina↗

DOE OSTI2022

Cool outflows in MaNGA: a systematic study and comparison to the warm phase

ABSTRACT This paper investigates the neutral gas phase of galactic winds via the Na i Dλλ5890, 5895Å feature within z ∼ 0.04 MaNGA galaxies and directly compares their incidence and strength to the ionized winds detected within the same parent sample. We find evidence for neutral outflows in 127 galaxies (∼5 per cent of the analysed line-emitting sample). ${\rm Na\, \small {\rm I}\ D}$ winds are preferentially seen in galaxies with dustier central regions and both wind phases are more often found in systems with elevated star formation rate (SFR) surface densities, especially when there has been a recent upturn in the star formation activity according to the $\rm SFR_{5 \, Myr}/SFR_{800 \, Myr}$ parameter. We find the ionized outflow kinematics to be in line with what we measure in the neutral phase. This demonstrates that, despite their small contributions to the total outflow mass budget, there is value to collecting empirical measurements of the ionized wind phase to provide information on bulk motion in the outflow. Depending on dust corrections applied to the ionized gas diagnostics, the neutral phase has ∼1.2−1.8 dex higher mass outflow rates ($\dot{M}_{\rm out}$), on average, compared to the ionized phase. We quantify scaling relations between $\dot{M}_{\rm out}$ and the strengths of the physical wind drivers (SFR, LAGN). Using a radial–azimuthal stacking method, and by considering inclination dependencies, we find results consistent with biconical outflows orthogonal to the disc plane. Our work complements other multiphase outflow studies in the literature that consider smaller samples, more extreme objects, or proceed via stacking of larger samples.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2003

Radiation-Related Risk Analysis for Atmospheric Flight Civil Aviation Flight Personnel

Human data on low dose rate radiation exposure and consequent effects are not readily available, and this fact generates groundtruth concerns for all risk assessment techniques for possible health effects induced by the space radiation environment, especially for long term missions like those foreseen now and in the near future. A large amount of such data may be obtained through civil aviation flight personnel cohorts, in the form of epidemiological studies on delayed health effects induced by the cosmic-ray generated atmospheric radiation environment, a high- LET low dose and low dose rate ionizing radiation with its typical neutron component, to which flight personnel are exposed all throughout their work activity. In the perspective of worldwide studies on radiation exposure of the civil aviation flight personnel, all the available results from previous studies on flight personnel radiation exposure have been examined in various ways (i.e. literature review, meta-analysis) to evaluate possible significant associations between atmospheric ionizing radiation environment and health risks, and to assess directions for future investigations. The physical characteristics of the atmospheric ionizing radiation environment make the results obtained for atmospheric flight personnel relevant for space exploration.

DeAngelis, G.↗

DOE OSTI2022

Curcumin Nanodiscs Improve Solubility and Serve as Radiological Protectants against Ionizing Radiation Exposures in a Cell-Cycle Dependent Manner

Curcumin, a natural polyphenol derived from the spice turmeric (Curcuma longa), contains antioxidant, anti-inflammatory, and anti-cancer properties. However, curcumin bioavailability is inherently low due to poor water solubility and rapid metabolism. Here, we further refined for use curcumin incorporated into “biomimetic” nanolipoprotein particles (cNLPs) consisting of a phospholipid bilayer surrounded by apolipoprotein A1 and amphipathic polymer scaffolding moieties. Our cNLP formulation improves the water solubility of curcumin over 30-fold and produces nanoparticles with ~350 µg/mL total loading capacity for downstream in vitro and in vivo applications. We found that cNLPs were well tolerated in AG05965/MRC-5 human primary lung fibroblasts compared to cultures treated with curcumin solubilized in DMSO (curDMSO). Pre-treatment with cNLPs of quiescent G0/G1-phase MRC-5 cultures improved cell survival following 137Cs gamma ray irradiations, although this finding was reversed in asynchronously cycling log-phase cell cultures. These findings may be useful for establishing cNLPs as a method to improve curcumin bioavailability for administration as a radioprotective and/or radiomitigative agent against ionizing radiation (IR) exposures in non-cycling cells or as a radiosensitizing agent for actively dividing cell populations, such as tumors.

36 MATERIALS SCIENCE↗

NASA NTRS1995

Theta(1) and gamma Tauri: Understanding the coronal structure of Hyades giants. EUV spectroscopy of BY Dra systems

These programs involve: (1) analysis and interpretation of EUVE spectrometer observations of the active giant beta Cet in comparison to the Hyades giant theta(1) Tau, and (2) analysis and interpretation of EUVE spectrometer observations of the BY Dra systems FK Aqr, DH Leo, and BH Lyn. EUVE carried out observations of beta Cet, but has yet to perform an observation of theta(1) Tau. In beta Cet, a number of Fe lines from high ionization species were observed, up to Fe XXIV. The spectrum overall resembles that seen in the active binary Capella (alpha Aur). All three BY Dra systems were observed by EUVE, and show evidence of high temperature (approximately 10(exp 7) K) plasma; FK Aqr and DH Leo show significant variability in their Deep Survey lightcurves. In FK Aqr, spectral differences between its 'quiescent' and 'active' states suggest possible differences in the plasma density. In DH Leo, the Deep Survey lightcurve, taken over nearly 8 days, shows a distinct period of approximately 1.05 days, similar to the photometric period. The emission measure distributions of all three systems are rather similar in shape, and can be well-represented by a power law with slope approximately 1.5 from 6.2-7.0 in log T.

Stern, Robert A.↗

NASA NTRS1994

The X-ray and ultraviolet absorbing outflow in 3C 351

3C 351 (z = 0.371), and X-ray-'quiet' quasar, is one of the few quasars showing signs of a 'warm absorber' in its X-ray spectrum; i.e., partially ionized absorbing material in the line of sight whose opacity depends on its ionization structure. The main feature in the X-ray spectrum is a K-edge due to O VII or O VIII. 3C 351 also shows unusually strong, blueshifted, associated, absorption lines in the ultraviolet (Bahcall et al. 1993) including O VI (lambda lambda 1031, 1037). This high ionization state strongly suggests an identification with the X-ray absorber and a site within the active nucleus. In this paper we demonstrate that the X-ray and UV absorption is due to the same material. This is the first confirmed UV/X-ray absorber. Physical conditions of the absorber are determined through the combination of constraints derived from both the X-ray and UV analysis. This highly ionized, outflowing, low-density, high-column density absorber situated outside the broad emission line region (BELR) is a previously unknown component of nuclear material. We rule out the identification of the absorber with a BELR cloud as the physical conditions in the two regions are inconsistent with one another. The effect of the X-ray quietness and IR upturn in the 3C 351 continuum on the BELR is also investigated. The strengths of the high-ionization lines of C IV lambda-1549 and O VI lambda-1034 with respect to Lyman-alpha are systematically lower (up to a factor of 10) in the material ionized by the 3C 351 continuum as compared to those produced by the 'standard' quasar continuum, the strongest effect being on the strength of O VI lambda-1034. We find that for a 3C 351-like continuum, C III) lambda-1909 ceases to be a density indicator.

Mathur, Smita↗

DOE OSTI2023

Synthesis of Mg–K-biochar bimetallic catalyst and its evaluation of glucose isomerization

Highly efficient isomerization of glucose to fructose is essential for valorizing cellulose fraction of biomass to value-added chemicals. This work provided an innovative method for preparing Mg-biochar and Mg–K-biochar catalysts by impregnating either MgCl 2 alone or in combination with different K compounds (Ding et al. in Bioresour Technol 341:125835, 2021, https://doi.org/10.1016/j.biortech.2021.125835 and KHCO 3 ) on cellulose-derived biochar, followed by hydrothermal carbonization and pyrolysis. Single active substance MgO existing in the 10 Mg–C could give better catalytic effect on glucose isomerization than the synergy of MgO and KCl crystalline material present in 10 Mg–KCl–C. But the catalytic effect of 10 Mg–C was decreased when the basic site of MgO was overloaded. Compared to other carbon-based metal catalysts, 10 Mg–KHCO3–C with 10 wt% MgCl 2 loading had excellent catalytic performance, which gave a higher fructose yield (36.7%) and selectivity (74.54%), and catalyzed excellent glucose conversion (53.99%) at 100 °C in 30 min. Scanning electron microscope–energy dispersive spectrometer and X-Ray diffraction revealed that the distribution of Mg 2+ and K+ in 10 Mg–KHCO 3 –C was uniform and the catalytic active substances (MgO, KCl and K2CO 3 ) were more than 10 Mg–C (only MgO). The synergy effects of MgO and K 2 CO 3 active sites enhanced the pH of reaction system and induced H 2 O ionization to form considerable OH– ions, thus easily realizing a deprotonation of glucose and effectively catalyzing the isomerization of glucose. In this study, we developed a highly efficient Mg–K-biochar bimetallic catalyst for glucose isomerization and provided an efficient method for cellulose valorization.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2024

An electrochemical generator for the continual supply of 213 Bi from 225 Ac for use in targeted alpha therapy applications

Bismuth-213 is a radionuclide of interest for targeted alpha therapy and is supplied via a radiochemical generator system through the decay of 225 Ac. Radionuclide generators employ longer lived “parent” radionuclides to routinely supply shorter-lived “daughter” radionuclides. The traditional 225 Ac/ 213 Bi radiochemical generator relies on an organic cation exchange resin where 225 Ac binds to the resin and 213 Bi is routinely eluted. These resins degrade when they absorb large doses of ionizing radiation (>1 × 10 6 Gy/mg), which has been observed when the loading activity of 225 Ac exceeds 2.59*10 9 Bq (70 mCi). Herein we report the development of an electrochemical generator for the supply of 213Bi that has the potential to overcome this limitation. Bismuth-213 spontaneously electrodeposits onto nickel foils in 0.1 M hydrochloric acid at 70 °C. Using this method, we were able to plate an average of 73 ± 4 % of the 213 Bi in solution and obtain a final 213 Bi recovery of 65 ± 8 % in 0.1 M citrate pH 4.5 via reverse electrolysis using titanium as the cathode. The recovered 213Bi had an average radiochemical purity of >99.8 % and was successfully used to radiolabel DOTATATE with an average radiochemical yield of 85.1 % (not optimized).

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2020

Transient work function gating: A new photoemission regime

We present the theoretical basis for a new photoemission regime, transient work function gating (TWFG), which temporally and energetically gates photoemission and produces near-threshold photoelectrons with thermally limited emittance, percent-level quantum efficiency, and control over temporal coherence. The technique consists of actively gating the work function of a generalized photocathode using a non-ionizing long-wavelength optical field to produce an adiabatic modulation of the carrier density at their surface. We examine TWFG as a means to circumvent the long-standing trade-off between low emittance and high quantum efficiency, untethered to particle source or photocathode specifics. TWFG promises new opportunities in photoemission physics for next generation electron and accelerator-based x-ray photon sources.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗