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At least 289 records · Page 16

Preservation of auditory and vestibular function after surgical removal of bilateral vestibular schwannomas in a patient with neurofibromatosis type 2

The outcome of acoustic neuroma (vestibular schwannoma) surgery continues to improve rapidly. Advances can be attributed to several fields, but the most important contributions have arisen from the identification of the genes responsible for the dominant inheritance of neurofibromatosis types 1 (NF1) and 2 (NF2) and the development of magnetic resonance imaging with gadolinium enhancement for the early anatomic confirmation of the pathognomonic, bilateral vestibular schwannomas in NF2. These advances enable early diagnosis and treatment when the tumors are small in virtually all subjects at risk for NF2. The authors suggest that advising young NF2 patients to wait until complications develop, especially hearing loss, before diagnosing and operating for bilateral eighth nerve schwannomas may not always be in the best interest of the patient. To the authors' knowledge, this is the first reported case of preservation of both auditory and vestibular function in a patient after bilateral vestibular schwannoma excision.

Case Reports↗

Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells

The effects of chronic, intermittent strain on the mechanosensitive cation (SA-cat) channels in UMR-106.01 osteoblast-like osteosarcoma cells were studied using patch-clamp techniques. Chronically strained cells demonstrated significantly larger increases in whole cell conductance when subjected to additional mechanical strain than nonstrained controls (69.0 +/- 15.1 vs. 14.1 +/- 3.1%; P < 0.001). This increase could be blocked by the SA-cat channel inhibitor, gadolinium, and corresponded to a three- to fivefold increase in SA-cat channel activity. Chronic strain increased the number of open channels in response to stretch and induced spontaneous SA-cat channel activity in 33% of the patches of strained cells. Graded increases in negative patch pressure demonstrated that SA-cat channels in chronically strained cells were activated at significantly lower levels of mechanical perturbation than nonstrained controls. These data suggest that chronic, cyclic strain reduces the activation threshold of the SA-cat channel and further strengthen our hypothesis that this channel may act as a mechanotransducer for the activation of bone remodeling by physical strain.

NASA Discipline Musculoskeletal↗

Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient

Cell death through apoptosis plays a critical role in regulating cellular homeostasis. Whether the disposal of apoptotic cells through phagocytosis can actively induce immune tolerance in vivo, however, remains controversial. Here, we report in a rat model that without using immunosuppressants, transfusion of apoptotic splenocytes from the donor strain prior to transplant dramatically prolonged survival of heart allografts. Histological analysis verified that rejection signs were significantly ameliorated. Splenocytes from rats transfused with donor apoptotic cells showed a dramatically decreased response to donor lymphocyte stimulation. Most importantly, blockade of phagocytosis in vivo, either with gadolinium chloride to disrupt phagocyte function or with annexin V to block binding of exposed phosphotidylserine to its receptor on phagocytes, abolished the beneficial effect of transfused apoptotic cells on heart allograft survival. Our results demonstrate that donor apoptotic cells promote specific allograft acceptance and that phagocytosis of apoptotic cells in vivo plays a crucial role in maintaining immune tolerance.

NASA Discipline Regulatory Physiology↗

A Reversible Thermally Driven Pump for Use in a Sub-Kelvin Magnetic Refrigerator

A document describes a continuous magnetic refrigerator that is suited for cooling astrophysics detectors. This refrigerator has the potential to provide efficient, continuous cooling to temperatures below 50 mK for detectors, and has the benefits over existing magnetic coolers of reduced mass because of faster cycle times, the ability to pump the cooled fluid to remote cooling locations away from the magnetic field created by the superconducting magnet, elimination of the added complexity and mass of heat switches, and elimination of the need for a thermal bus and single crystal paramagnetic materials due to the good thermal contact between the fluid and the paramagnetic material. A reliable, thermodynamically efficient pump that will work at 1.8 K was needed to enable development of the new magnetic refrigerator. The pump consists of two canisters packed with pieces of gadolinium gallium garnet (GGG). The canisters are connected by a superleak (a porous piece of VYCOR glass). A superconducting magnetic coil surrounds each of the canisters. The configuration enables driving of cyclic thermodynamic cycles (such as the sub-Kelvin Active Magnetic Regenerative Refrigerator) without using pistons or moving parts.

Miller, Franklin K.↗

A Superfluid Pulse Tube Refrigerator Without Moving Parts for Sub-Kelvin Cooling

A report describes a pulse tube refrigerator that uses a mixture of He-3 and superfluid He-4 to cool to temperatures below 300 mK, while rejecting heat at temperatures up to 1.7 K. The refrigerator is driven by a novel thermodynamically reversible pump that is capable of pumping the He-3 He-4 mixture without the need for moving parts. The refrigerator consists of a reversible thermal magnetic pump module, two warm heat exchangers, a recuperative heat exchanger, two cold heat exchangers, two pulse tubes, and an orifice. It is two superfluid pulse tubes that run 180 out of phase. All components of this machine except the reversible thermal pump have been demonstrated at least as proof-of-concept physical models in previous superfluid Stirling cycle machines. The pump consists of two canisters packed with pieces of gadolinium gallium garnet (GGG). The canisters are connected by a superleak (a porous piece of VYCOR glass). A superconducting magnetic coil surrounds each of the canisters.

Miller, Franklin K.↗

Micromachined Active Magnetic Regenerator for Low-Temperature Magnetic Coolers

A design of an Active Magnetic Regenerative Refrigeration (AMRR) system has been developed for space applications. It uses an innovative 3He cryogenic circulator to provide continuous remote/distributed cooling at temperatures in the range of 2 K with a heat sink at about 15 K. A critical component technology for this cooling system is a highly efficient active magnetic regenerator, which is a regenerative heat exchanger with its matrix material made of magnetic refrigerant gadolinium gallium garnet (GGG). Creare Inc. is developing a microchannel GGG regenerator with an anisotropic structured bed for high system thermal efficiency. The regenerator core consists of a stack of thin, single-crystal GGG disks alternating with thin polymer insulating layers. The insulating layers help minimize the axial conduction heat leak, since GGG has a very high thermal conductivity in the regenerator s operating temperature range. The GGG disks contain micro channels with width near 100 micrometers, which enhance the heat transfer between the circulating flow and the refrigerant bed. The unique flow configuration of the GGG plates ensures a uniform flow distribution across the plates. The main fabrication challenges for the regenerator are the machining of high-aspect-ratio microchannels in fragile, single-crystal GGG disks and fabrication and assembly of the GGG insulation layers. Feasibility demonstrations to date include use of an ultrashort- pulse laser to machine microchannels without producing unacceptable microcracking or deposition of recast material, as shown in the figure, and attachment of a thin insulation layer to a GGG disk without obstructing the flow paths. At the time of this reporting, efforts were focused on improving the laser machining process to increase machining speed and further reduce microcracking.

Chen, Weibo↗

Implementation of an Ultra-Bright Thermographic Phosphor for Gas Turbine Engine Temperature Measurements

The overall goal of the Aeronautics Research Mission Directorate (ARMD) Seedling Phase II effort was to build on the promising temperature-sensing characteristics of the ultrabright thermographic phosphor Cr-doped gadolinium aluminum perovskite (Cr:GAP) demonstrated in Phase I by transitioning towards an engine environment implementation. The strategy adopted was to take advantage of the unprecedented retention of ultra-bright luminescence from Cr:GAP at temperatures over 1000 C to enable fast 2D temperature mapping of actual component surfaces as well as to utilize inexpensive low-power laser-diode excitation suitable for on-wing diagnostics. A special emphasis was placed on establishing Cr:GAP luminescence-based surface temperature mapping as a new tool for evaluating engine component surface cooling effectiveness.

temperature↗

Temperature and Pressure Sensors Based on Spin-Allowed Broadband Luminescence of Doped Orthorhombic Perovskite Structures

Systems and methods that are capable of measuring pressure or temperature based on luminescence are discussed herein. These systems and methods are based on spin-allowed broadband luminescence of sensors with orthorhombic perovskite structures of rare earth aluminates doped with chromium or similar transition metals, such as chromium-doped gadolinium aluminate. Luminescence from these sensors can be measured to determine at least one of temperature or pressure, based on either the intense luminescence of these sensors, even at high temperatures, or low temperature techniques discussed herein.

Eldridge, Jeffrey I.↗

Fabrication of Lightweight Radiation Shielding Composite Materials by Field Assisted Sintering Technique (FAST)

Advances in radiation shielding technologies are needed to protect humans and electronic components from all threats of space radiation over long durations. In this paper, we report on the use of the innovative and novel fabrication technology known as Field Assisted Sintering Technology (FAST) to fabricate lightweight material with enhanced radiation shielding strength to safeguard humans and electronics suitable for next generation space exploration missions. The base materials we investigated were aluminum (Al), the current standard material for space hardware, and Ultra-High Molecular Weight Polyethylene (UHMWPE), which has high hydrogen content and resistance to nuclear reaction from neutrons, making it a good shielding material for both gamma radiation and particles. UHMWPE also has high resistance to corrosive chemicals, extremely low moisture sensitivity, very low coefficient of friction, and high resistance to abrasion. We reinforced the base materials by adding high density (ie, high atomic weight) metallic material into the composite. These filler materials included: boron carbide (B4C), tungsten (W), tungsten carbide (WC) and gadolinium (Gd).

Prasad, Narasimha↗

Percolation Behaviour in the Magnetic Permeability and Electrical Conductivity in Conducting Magnetic - Insulating Non Magnetic Binary Composites

Experimental results of the complex magnetic permeability (µ) and the electrical conductivity (σ) of a granular paramagnetic Gadolinium Gallium Garnet (GGG: 0.3–26 vol%) and Teflon (PTFE) system are presented and discussed in relation to previously published (conductivity) and unpublished (permeability) studies on granular Fe3O4 – talc and Ni – talc wax systems. In these systems plots of the real conductivity (σ'(sub m)) against the volume fraction (φ) lie on characteristic sigmoid curves that when fitted to the Two Exponent Phenomenological Percolation Equation (TEPPE) confirm the existence of “percolation microstructures” with critical volume fractions (φ(sub c)). The plots of the real and imaginary permeability (µ'(sub m)) and (µ"(sub m)) satisfactorily fit to the TEPPE using the φ(sub c) obtained in each case from the “conductivity” measurements. In all three cases the conductivity results gave the exponent t > 2, and the permeability results gave t < 1.

David S McLachlan↗

Development of a Flight-Worthy 10 to 4 K Continuous Adiabatic Demagnetization Refrigerator

The cryogenics and fluids branch at NASA's Goddard Space Flight Center is currently developing a high-efficiency, vibration-free, flight-worthy Continuous Adiabatic Demagnetization Refrigerator (CADR) that consist of two modular units: one that lifts ~6 microW at 50 mK while rejecting its heat to a 4 K thermal sink, and another unit that provides a constant 4 K cooling stage while rejecting its heat to a thermal sink at 10 K. The two units are linked together via a 4 K common platform. This paper discusses the status report on the thermodynamic performance of the 4 -10 K ADR. This ADR utilizes an Nb3Sn superconducting magnet and Gadolinium Gallium Garnet (GGG) as its refrigerant. Results show that an idealized cycle, one where its hold time at 4 K is equal to the recycle time, can lift 13 mW at 4 K with a hold time of 132 seconds.

CADR↗

Overview of the Recent BWR Burnup Credit Project at Oak Ridge National Laboratory

Oak Ridge National Laboratory (ORNL) and the US Nuclear Regulatory Commission (NRC) have completed a five-year program to investigate burnup credit (BUC) for boiling-water reactor (BWR) spent nuclear fuel (SNF) stored in storage and transportation systems. The project examined both peak reactivity BUC, also sometimes called gadolinium credit, and extended BWR BUC. Here extended refers to credit for burnups beyond that associated with peak reactivity. The findings related to peak reactivity BUC are summarized in NUREG/CR-7194, and four additional NUREG/CR documents present the results of the studies of extended BWR BUC. The first of these documents, NUREG/CR-7224, presents results of investigations to determine the effects of axial moderator density profiles, control blade use, and axial burnup profiles. Studies on the impact of core operating conditions and assembly-specific depletion conditions are addressed in NUREG/CR-7240, validation of depleted SNF isotopic predictions is addressed in NUREG/CR-7251, and validation of keff calculations for extended BWR BUC are discussed in NUREG/CR-7252. A summary of the entire project, including major conclusions regarding each of the studies, is included in this paper.

Marshall, William (B.J.)↗

Iron-based amorphous alloys and methods of synthesizing iron-based amorphous alloys

A method according to one embodiment includes combining an amorphous iron-based alloy and at least one metal selected from a group consisting of molybdenum, chromium, tungsten, boron, gadolinium, nickel phosphorous, yttrium, and alloys thereof to form a mixture, wherein the at least one metal is present in the mixture from about 5 atomic percent (at %) to about 55 at %; and ball milling the mixture at least until an amorphous alloy of the iron-based alloy and the at least one metal is formed. Several amorphous iron-based metal alloys are also presented, including corrosion-resistant amorphous iron-based metal alloys and radiation-shielding amorphous iron-based metal alloys.

36 MATERIALS SCIENCE↗

Detector R&D for ANNIE and Future Neutrino Experiments

The Accelerator Neutrino Neutron Interaction Experiment (ANNIE) is designed to serve as a test bed for new detector technologies in future water and liquid scintillator based neutrino experiments. Located on the Booster Neutrino Beam at Fermilab, ANNIE will be the first gadolinium-loaded water Cherenkov detector on a neutrino beam and will provide high statistics measurements of neutron yields from neutrino interactions in water. It is also the first particle physics application of the new photosensor technology: Large Area Picosecond Photodetectors (LAPPDs). With single photon time resolutions of roughly 50 psec and mm-level imaging capabilities, LAPPDs bring considerable new capabilities for neutrino reconstruction in Cherenkov and scintillator detectors. Leveraging this technology to make detailed neutrino measurements, ANNIE will serve as a first demonstration of their impact on physics. In addition to LAPPDs, the ANNIE R&D program will likely explore other new technologies such as the addition of water-based liquid scintillator. The ANNIE Phase II detector is currently under construction and will start to take data in the summer of 2019. In this talk, I will present on the ANNIE detector R&D program and its relevance to current and future neutrino experiments.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The Accelerator Neutrino Neutron InteractionExperiment: Design, Construction and Preparationfor First Physics

This thesis covers work performed for the Accelerator Neutrino Neutron Interaction Experiment (ANNIE) between 2015 and 2020. ANNIE is a beamline neutrino experiment located at the Fermi National Accelerator Laboratory in Chicago. Its primary physics goals are the measurement of neutrino interaction cross-sections on oxygen, and a measurement of the multiplicity of final state neutrons from these interactions, both as functions of final state kinematics. In order to achieve these goals ANNIE will be pioneering the use of Large Area Picosecond Photodetectors and the use of gadolinium doping to enhance neutron visibility in a water Cherenkov detector. Over the time period of this thesis the ANNIE detector was constructed, an initial 'Phase I' background run was completed, the detector was decommissioned and then substantially upgraded in preparation for the main 'Phase II' physics run. At the time of writing ANNIE is being re-commissioned, with Phase II data taking anticipated to begin in 2021. During this time I spent 21/2 years on-site contributing to almost all aspects of hardware work, while performing software development for the simulation and analysis frameworks. As my first software task I developed Monte Carlo simulations of the detector response, based on the WCSim framework. While thismore » framework provided a starting point for the tank simulation significant modifications were required to implement the complete ANNIE detector system. This included a rewrite of the geometry, along with modifications to the photosensor definitions, hit collections, digitization, triggering, input and output interfaces, etc. To take advantage of improved modelling of neutrons in Geant4.10 the physics lists were also reimplemented in the new version format. As part of this work I determined performance metrics based on the output files, calculating kinematic acceptance, detector efficiency and expected event rates. My contributions on reconstruction focused primarily on the MRD, for which I implemented two track reconstruction algorithms, specialised for high and low energy muons. The high energy algorithm achieves >90% efficiency for tracks with at least 8 hits, and is robust against dead paddles and unrelated hits. The low energy algorithm performs a search in combination with tank information to provide sensitivity down to a single MRD hit. Early data handling work for the Phase I background run included writing the code for handling TDC hits and performing studies on neutron detection without the requirement of multi-hit coincidence. As the collaboration moved to a new framework for the Phase II analysis I performed a substantial amount of work to develop the codebase, implementing tools to perform tasks such as file IO, data parsing, waveform processing, event building, timestamp alignment, time clustering, hit residual calculation, event visualisation etc. I helped develop the python API for integrating multi-language tools, and ported the framework into a Singularity container to provide a self-contained environment that…« less

43 PARTICLE ACCELERATORS↗

Tl+-based and mixed halide A3B2X9-type scintillators

Inorganic halides (e.g., inorganic halide scintillators) of the general formula A3B2X9, including inorganic halides comprising thallium monovalent cations and/or combinations of different halides, are described. Radiation detectors including the inorganic halide scintillators and methods of using the detectors to detect high energy radiation are also described. In some cases, the scintillators can include a gadolinium cation, a boron cation, a lithium cation, a chloride ion, or combinations thereof and the scintillator can be used to detect neutrons.

Rutstrom, Daniel↗

Three-dimensional architectured anode, a direct carbon fuel cell including the three-dimensional architectured anode, and related methods

A method of fabricating a three-dimensional (3D) architectured anode. The method comprises immersing a fabric textile in a precursor solution, the precursor solution comprising a nickel salt and gadolinium doped ceria (GDC). The nickel salt and GDC are absorbed to the fabric textile. The fabric textile comprising the absorbed nickel salt and GDC is removed from the precursor solution and calcined to form a 3D architectured anode comprising nickel oxide and GDC. Additional methods and a direct carbon fuel cell including the 3D architectured anode are also disclosed.

Ding, Dong↗

Towards a neutron multiplicity measurement with the Accelerator Neutrino Neutron Interaction Experiment

The Accelerator Neutrino Neutron Interaction Experiment (ANNIE) is a 26 ton Gadolinium (Gd)-loaded water Cherenkov detector located on the Booster Neutrino Beam line at Fermilab. Its main goals are the measurement of the neutron multiplicity in neutrino-nucleus interactions as well as the cross-section of Charged Current Quasi-Elastic (CCQE) neutrino interactions on water. Besides the physics goals, the experiment also aims to be a testbed for new technologies such as Large Area Picosecond Photodetectors (LAPPDs) and Water-based Liquid Scintillators (WbLS). This thesis presents a preliminary measurement of the neutron multiplicity with {ANNIE}, using an analysis conducted on a fraction of the 2021 beam year. As preparatory measures, the efficiency of ANNIE's Front Muon Veto (FMV) was determined to be {$\bar{\varepsilon}_{\mathrm{FMV}} = (95.6 \pm 1.6)\%$} while the average efficiency for active scintillator paddles in the Muon Range Detector (MRD) was found to be {$\bar{\varepsilon}_ {\mathrm{MRD}} = (92.1 \pm 7.9)\%$}. Furthermore, the simulation framework used for ANNIE was validated and adapted to reproduce the experimental data by comparing the detector response for samples of Michel electrons, Americium Beryllium neutrons, and through-going muons. The analysis finds average neutron yields of {$\bar{n}_{\mathrm{data}} (\mathrm{beam}) = (0.272 \pm 0.010_{\mathrm{stat}})$} for an inclusive set of all identified muon neutrino candidates and {$\bar{n}_{\mathrm{data}} (\mathrm{beam,FV}) = (0.287 \pm 0.044_{\mathrm{stat}})$ for interactions which happened inside of the Fiducial Volume of ANNIE, which was optimized to increase the neutron detection acceptance. The presented neutron multiplicity values represent the number of detected neutrons after all event selection cuts and are not yet corrected for the neutron detection efficiency. An equivalent analysis on a simulated beam sample predicts neutron yields of $\bar{n}_{\mathrm{MC}}(\mathrm{beam}) = (0.515 \pm 0.0 07_{\mathrm{stat}})$ and $\bar{n}_{\mathrm{MC}}(\mathrm{beam,FV}) = (0.627 \pm 0.031_{\mathrm{stat}})$, indicating that the models tend to overpredict the number of neutrons produced in such interactions. Systematic errors have been briefly considered to contribute {$\sigma_{\mathrm{sys,FMV}} \sim 0.01\,$neutrons/$\nu$-interaction} due to the slight FMV inefficiency and {$\sigma_{\mathrm{sys,n}} \sim 0.05\,$neutrons/$\nu$-interaction} due to the neutron detection efficiency. Simulation studies further highlighted the importance of neutron detection in Diffuse Supernova Background (DSNB) searches. A combination of neutron tagging and Convolutional Neural Networks was found to reduce the most relevant Neutral Current Quasi-Elastic (NCQE) interaction background below the signal level, achieving a Signal-to-Background ratio of 4:1. In a further study, we investigated the positive impact of a deployment of a WbLS target on the energy reconstruction in ANNIE. WbLS provides a scintillation signal from hadronic recoils in addition to the charged lepton that can be included in neutrino energy reconstruction. It was found that a deployed WbLS volume in ANNIE improves the neutrino energy reconstruction from 14\% to 12\%, with the potential of going beyond this if more sophisticated reconstruction algorithms are developed in the future.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗