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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 289 records · Page 16
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

Physiological Maturation of Regenerating Hair Cells

The bullfrog saccule, a sensor of gravity and substrate-borne vibration, is a model system for hair cell transduction. Saccular hair cells also increase in number throughout adult life and rapidly recover after hair cell damage, making this organ an ideal system for studying hair cell development, repair, and regeneration. We have used of hair cell and supporting cell immunocytochemical markers to identify damaged hair cells and hair cell precursors in organotypic cultures of the bullfrog saccule. We then used an innovative combination of confocal, electron, and time-lapse microscopy to study the fate of damaged hair cells and the origin of new hair cells after gentamicin ototoxicity in normal and mitotically blocked saccular cultures. These studies have shown that gentamicin ototoxicity produces both lethal and sublethal hair cell damage. They have also shown that hair cell recovery in this organ takes place by both the repair of sublethally damaged hair cells and by the replacement of lost hair cells by mitotic regeneration. In parallel studies, we have used biophysical and molecular biological techniques to study the differentiation and innervation of developing, repairing, and regenerating hair cells. More specifically, we have used RT-PCR to obtain the bullfrog homologues of L-type voltage- gated calcium (L-VGCC) and large-conductance Ca(2+)-activated potassium (BK) channel genes. We have then obtained probes for these genes and, using in situ hybridization, begun to examine their expression in the bullfrog saccule and amphibian papilla. We have also used fluorescent-labeled channel toxins and channel toxin derivatives to determine the time of appearance of L-type voltage-gated calcium (L-VGCC) and Ca(2+)-activated potassium (BK) channels and to study dynamic changes in the number, distribution, and co-localization of these proteins in developing, repairing, and regenerating hair cells. Using time-lapse microscopy, we are also studying the dynamic relationship between ion channel clustering and synaptic formation in hair cells and afferent neurons. In future studies, we will determine when hair cell precursors acquire electrical tuning, and, using whole-cell patch-clamp techniques, identify and characterize their L-VGCC and BK currents. We will also use biophysical techniques to determine the number of L-VGCC and BK channels and the size and gating kinetics of their underlying L-VGCC and BK conductances, correlating these variables with the amplitude and frequency of membrane oscillations produced by intracellular current steps. We expect these studies to determine how hair cells regulate ion channel expression to achieve specific physiological responses.

Baird, Richard A.↗
NASA NTRSDate not supplied

Inlet Radiated Noise Predictions for the NASA Source Diagnostic Test Fan Using Physics-Based Simulations

Commercial supersonic aircraft are expected to produce considerably more noise during landing and take-off operations than existing subsonic aircraft. Establishing noise regulation is challenging because no examples of this aircraft type are currently flying. Existing aircraft noise prediction tools can be used, but the noise source models for these empirical tools are typically based on data from subsonic aircraft components. The present work documents a procedure for using physics-based computational tools to generate the propagating sound field radiating out the nacelle inlet. Although no analytical source modeling is demonstrated, these tools utilize measured data to compare the complex pressure for various propagating modes. The discrepancies found in applying the propagation tools to the subsonic inlet will be ascribed to calculations of supersonic inlets being used to update current empirical noise prediction tools.

Noise Predictions↗
NASA NTRSDate not supplied

Dose-Response Data Collection Preparation for the NASA Quesst Mission With the X-59

Supersonic flight has the potential to cut travel times in half; however, community annoyance to sonic booms led to the ban on overland commercial supersonic flight by the Federal Aviation Administration in 1973. As part of its Quesst mission, NASA is developing the X-59 aircraft to demonstrate quiet supersonic flight and collect dose-response data to inform regulators in their efforts to establish noise standards to replace the current supersonic speed limit. This talk presents an overview of the NASA Quesst mission and poses some challenges in collecting and analyzing X-59 dose-response data. For the upcoming community flight campaign, the noise dose is the loudness of a supersonic overflight of the X-59 and the perceptual response from participants is captured via surveys after the flyover events. Establishing a relationship between noise dose and perceptual response will be a key product of these efforts.

X-59↗
NASA NTRS1973

Can the ionosphere regulate magnetospheric convection.

A simple model is outlined that relates the dayside magnetopause displacement to the currents feeding the polar cap ionosphere, from which the ionospheric electric field and the flux return rate may be estimated as a function of magnetopause displacement. Then, flux conservation arguments make possible an estimate of the time scale on which convection increases.

Coroniti, F. V.↗
NASA NTRS1975

Neural models on temperature regulation for cold-stressed animals

The present review evaluates several assumptions common to a variety of current models for thermoregulation in cold-stressed animals. Three areas covered by the models are discussed: signals to and from the central nervous system (CNS), portions of the CNS involved, and the arrangement of neurons within networks. Assumptions in each of these categories are considered. The evaluation of the models is based on the experimental foundations of the assumptions. Regions of the nervous system concerned here include the hypothalamus, the skin, the spinal cord, the hippocampus, and the septal area of the brain.

Horowitz, J. M.↗
NASA NTRSDate not supplied

Activities of the NASA Urban Air Mobility Noise Working Group (UNWG)

The NASA-led Urban Air Mobility Noise Working Group was established in 2018 following an exploratory meeting of stakeholders from traditional and emerging aviation sectors across industry, government agencies, academia, and community groups. Its mission is to create and support a diverse community of acoustics experts to identify, discuss, and address noise issues associated with UAM vehicles and their operations. The UNWG is comprised of four subgroups including Tools and Technologies, Ground and Flight Testing, Human Response and Metrics, and Regulation and Policy. In 2020, NASA published the white paper entitled “Urban Air Mobility Noise: Current Practice, Gaps, and Recommendations,” that presents a set of high-level goals and makes recommendations to address gaps in the current practice. This presentation is about recent activities of each of the subgroups to address those recommendations, including work towards establishment of an aeroacoustic test database for model validation, development of a set of measurement guidelines to quantify vehicle acoustic emission, a remotely administered human response study for quantifying annoyance to UAM operations, and status on noise standard, regulation, policy, and community engagement developments.

Urban air mobility↗
NASA NTRS1974

The problem of controlling the directivity of low directivity antennas on spacecraft in flight

Interests exist in the creation of antennas allowing adjustment of the radiation pattern and directivity in flight without using complex switching and matching circuits. Results are presented of certain experimental tests performed with log-periodic conical helical antennas to determine the possibilities of regulation of their radiation patterns without changing the structure of the current-carrying elements, supply connections, etc.

Mashkov, V. I.↗
NASA NTRS1985

Lightweight Regulated Power Supply

Power-supply circuit regulates output voltage by adjusting frequency of chopper circuit according to variations. Currently installed in battery charger for electric wheelchair, circuit is well suited to other uses in which light weight is important - for example, in portable computers, radios, and test instruments.

Mclyman, C. W.↗
NASA NTRS2000

Formation Flying With Decentralized Control in Libration Point Orbits

A decentralized control framework is investigated for applicability of formation flying control in libration orbits. The decentralized approach, being non-hierarchical, processes only direct measurement data, in parallel with the other spacecraft. Control is accomplished via linearization about a reference libration orbit with standard control using a Linear Quadratic Regulator (LQR) or the GSFC control algorithm. Both are linearized about the current state estimate as with the extended Kalman filter. Based on this preliminary work, the decentralized approach appears to be feasible for upcoming libration missions using distributed spacecraft.

Folta, David↗
NASA NTRS2012

Human-Automation Integration: Principle and Method for Design and Evaluation

Future space missions will increasingly depend on integration of complex engineered systems with their human operators. It is important to ensure that the systems that are designed and developed do a good job of supporting the needs of the work domain. Our research investigates methods for needs analysis. We included analysis of work products (plans for regulation of the space station) as well as work processes (tasks using current software), in a case study of Attitude Determination and Control Officers (ADCO) planning work. This allows comparing how well different designs match the structure of the work to be supported. Redesigned planning software that better matches the structure of work was developed and experimentally assessed. The new prototype enabled substantially faster and more accurate performance in plan revision tasks. This success suggests the approach to needs assessment and use in design and evaluation is promising, and merits investigatation in future research.

human-automation integration↗
NASA NTRSDate not supplied

Cumulative Noise Metric Design Considerations for the Nasa Quesst Community Test Campaign With the X-59 Aircraft

The National Aeronautics and Space Administration (NASA) plans to collect X-59 aircraft dose-response data to inform international regulators in their efforts to establish acceptable noise standards to replace the current ban on overland supersonic commercial flight. For this upcoming community test campaign, the sound level from a supersonic overflight of the X-59 constitutes a single-event dose, and an end-of-day survey after multiple flight events constitutes a cumulative response. This study considers how X-59 community tests could be designed to explore the relationship between multiple single events and cumulative annoyance response. Presently, a day-night level summation of single-event doses formulates the cumulative dose; however, a generalization method may improve the understanding of the linkage between multiple single events and cumulative response. This work utilizes an analysis method that employs a parameter to vary the cumulative dose metric such that it can represent the loudest single event, remain as the day-night level summation, or be more responsive to the number of events. The analysis is demonstrated on simulated dose-response datasets derived from previous NASA field studies and from expectations of X-59 community tests. Results demonstrate that certain dose designs are more efficient than others in determining the analysis parameter.

dose-response modeling↗
NASA NTRSDate not supplied

Cumulative Noise Metric Design Considerations for the NASA Quesst Community Test Campaign With the X-59 Aircraft

The National Aeronautics and Space Administration (NASA) plans to collect X-59 aircraft dose-response data to inform international regulators in their efforts to establish acceptable noise standards to replace the current ban on overland supersonic commercial flight. For this upcoming community test campaign, the sound level from a supersonic overflight of the X-59 constitutes a single-event dose, and an end-of-day survey after multiple flight events constitutes a cumulative response. This study considers how X-59 community tests could be designed to explore the relationship between multiple single events and cumulative annoyance response. Presently, a day-night level summation of single-event doses formulates the cumulative dose; however, a generalization method may improve the understanding of the linkage between multiple single events and cumulative response. This work utilizes an analysis method that employs a parameter to vary the cumulative dose metric such that it can represent the loudest single event, remain as the day-night level summation, or be more responsive to the number of events. The analysis is demonstrated on simulated dose-response datasets derived from previous NASA field studies and from expectations of X-59 community tests. Results demonstrate that certain dose designs are more efficient than others in determining the analysis parameter.

dose-response modeling↗
NASA NTRSDate not supplied

Research Needs for Developing Qualification Standards for Flight Simulation Training Devices with Head Mounted Displays

This presentation discusses research needs to support evidence-based qualification standards for Flight Simulation Training Devices (FSTDs) with head mounted displays (HMDs). Currently, the FAA and EASA have no qualification standards specifically for FSTDs using HMDs and extended reality (XR) visuals, and existing qualification standards may not be sufficient. Special Conditions can be prescribed for the evaluation and qualification of individual devices, but these Special Conditions need to be assessed and adjusted on a case-by-case basis resulting in an elaborate process. Furthermore, test tolerances used in Special Conditions are often based on conventional visual systems and may not be adequate. This presentation first identifies gaps in the current knowledge of using HMDs in pilot training, and, more specifically, using HMDs in the training of manual aircraft control with motion cues. Next, research is proposed to help close these gaps, inform the development of qualification criteria and tolerances, and guide efforts to update regulations. The Vertical Motion Simulator (VMS) at NASA Ames Research Center, with its large motion capability, is currently undergoing significant upgrades including a state-of-the-art out-the-window visual system. In addition, an HMD capability will be introduced to use in conjunction with the conventional visual system. With its long history of setting standards in the simulation industry, the VMS is the ultimate tool to conduct research that could help accelerate the development of standards for the use of HMDs in FSTDs. The goal of the talk is ultimately to spark a discussion about the research needs and priorities to best serve the development of new qualification standards.

XR↗
NASA NTRS2002

Efficient Design in a DC to DC Converter Unit

Space Flight hardware requires high power conversion efficiencies due to limited power availability and weight penalties of cooling systems. The International Space Station (ISS) Electric Power System (EPS) DC-DC Converter Unit (DDCU) power converter is no exception. This paper explores the design methods and tradeoffs that were utilized to accomplish high efficiency in the DDCU. An isolating DC to DC converter was selected for the ISS power system because of requirements for separate primary and secondary grounds and for a well-regulated secondary output voltage derived from a widely varying input voltage. A flyback-current-fed push-pull topology or improved Weinberg circuit was chosen for this converter because of its potential for high efficiency and reliability. To enhance efficiency, a non-dissipative snubber circuit for the very-low-Rds-on Field Effect Transistors (FETs) was utilized, redistributing the energy that could be wasted during the switching cycle of the power FETs. A unique, low-impedance connection system was utilized to improve contact resistance over a bolted connection. For improved consistency in performance and to lower internal wiring inductance and losses a planar bus system is employed. All of these choices contributed to the design of a 6.25 KW regulated dc to dc converter that is 95 percent efficient. The methodology used in the design of this DC to DC Converter Unit may be directly applicable to other systems that require a conservative approach to efficient power conversion and distribution.

Bruemmer, Joel E.↗
NASA NTRS2023

Automated Fluidics Device for Extraction and Quantification of miRNA Biomarkers From Blood

Radiation Assessment DuRing Exposure And long-Duration Spaceflight (RADREADS) demonstrates space-compatible point-of-care technology for quantitative biological monitoring of blood miRNA biomarkers in response to long-term low dose radiation exposure. This individualized monitoring approach will inform targeted treatment strategies to maximize medical resource utilization by accounting for individual susceptibility to radiation-related illnesses. As human spaceflight progresses beyond Earth’s magnetic shielding, radiation exposure poses a significant risk to astronaut health and safety. Extended operation in this environment comes with an increased risk of radiation exposure, leading to higher risks of radiation sickness, cancer, central nervous system effects, and degenerative diseases. While conventional physical dosimetry techniques capture radiation dose, individualistic susceptibility to radiation damage is varied. Multiple characteristics, including age, body weight, sex, genetics, and immune status, have been found to influence radiosensitivity (Liu et al. 2011, and Bouffler 2016). This differential response necessitates individualized monitoring and targeted treatment strategies to maximize medical resource utilization; however, a practical diagnostic platform for quantifying long-term, low dose radiation-induced tissue damage does not currently exist. MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression by mediating the degradation of messenger RNA. The levels of particular miRNAs are influenced by biological processes such as inflammation and serve as biomarkers for a variety of conditions including cancer (Singh et al. 2017). MicroRNAs are found in various bodily fluids and are amenable to collection via liquid biopsies, providing a minimally invasive and easily quantifiable readout for a variety of radiosensitive reporters. A preliminary signature of 15 spaceflight sensitive miRNA has been identified in rodent and human studies, including miR-21-5p, miR-24-3p, miR-92a-3p, miR-17-5p, miR-16a-3p, miR-34a-3p, and miR-223-3p. These targets generally increased expression with radiation dose and linear energy transfer, though variation between individuals is not yet described. Current gaps in the field include a lack of understanding of longitudinal biological responses to long-term, low dose radiation exposure and the absence of space-compatible point-of-care technology for quantitative biological monitoring. In this body of work, we aim to develop an automated bleed-to-read system to process whole blood for the detection of miRNA biomarkers in order to monitor individualistic responses to radiation exposure. This will be achieved via separating serum (or plasma) from whole blood, followed by extraction, amplification, and quantification of the miRNA using a RT-qPCR reaction. Previously, the WetLab-2 hardware enabled execution of a RT-qPCR reaction aboard ISS; however, it is a manual system that requires crew manipulation and bulky components (Parra et al. 2017). To address these issues, automated fluid handling hardware was developed for each stage of sample preparation. Extraction of total RNA is achieved by sequentially pumping reagents through an off-the-shelf nucleic acid binding column (miRNeasy Serum/Plasma Advanced Kit, Qiagen). This approach eliminates several manual pipetting and centrifuging steps and limits the use of toxic chemicals commonly found in other sample processing techniques. The resulting elution will then be automatically dispensed for RT-qPCR analysis using a compact rotary qPCR (Mic qPCR Cycler, Bio Molecular Systems) that will improve spaceflight compatibility by removing bubbles from the detection region, another challenge highlighted by WetLab-2 (Parra et al. 2017). Efforts are also being made to simplify the RT-qPCR reaction to a 1-step air-dryable mix to improve long-term reagent stability at room temperature and reduce system complexity. By automating the RT-qPCR processes via microfluidic manipulation, RADREADS will reduce crewmember hands-on time and enable the personalized detection of radiation-induced tissue damage during long duration missions. Minimally invasive, longitudinal monitoring of individual’s response to radiation exposure will inform how the physiological system responds to long-term low dose space radiation and enables development of targeted countermeasures by the medical team. Ultimately, this portable technology will require minimal technical expertise and can also be used to monitor miRNA biomarkers associated with other diseases.

Tristen Head↗
NASA NTRSDate not supplied

Short-Haul Fatigue: Pilot Perspectives & Current Research

Introduction: There are few studies investigating the impact of fatigue in short-haul flight operations conducted under United States (U.S.) Federal Aviation Regulations (FAR) Part 117 flight and duty limitations and rest requirements. In order to understand the fatigue factors unique to short-haul operations, we conducted a series of focus groups across four major commercial passenger airlines in the US. The outcomes of this study were intended to inform the scope of a larger study of fatigue in short-haul operations. Methods: Ninety short-haul pilots were recruited through emails distributed by airline safety teams and labor representatives. Fourteen focus groups were conducted via an online conferencing platform in which participants were asked to identify, specific to short-haul: a) schedules and operations that lead to elevated fatigue; b) schedules and operations that are not fatiguing, and c) important fatigue factors to study. Data were collected anonymously and coded using conventional qualitative content analysis, with axial coding and summative analysis used to identify main themes and over-arching categories. Results: Participants had an average of 12,348 (6,483) lifetime flying hours with 71 (14.5) hours of monthly flying. Forty-six percent of participants were captains. The six fatigue factor categories identified were: circadian disruption (e.g., circadian switches, redeyes), high workload (e.g., hassle factors, number of flights per duty), inadequate rest opportunity (e.g., minimum rest layovers, quality of rest facilities), schedule changes (e.g., unpredictability), regulation and policy issues (e.g., scheduling up to FAR 117 limits), and long sits (e.g., long wait times between flights). Discussion: A field study informed by these results and designed to investigate the prevalence and impact of these factors in US short-haul operations is currently underway.

pilots↗
NASA NTRS1976

Study of small turbofan engines applicable to single-engine light airplanes

The design, efficiency and cost factors are investigated for application of turbofan propulsion engines to single engine, general aviation light airplanes. A companion study of a hypothetical engine family of a thrust range suitable to such aircraft and having a high degree of commonality of design features and parts is presented. Future turbofan powered light airplanes can have a lower fuel consumption, lower weight, reduced airframe maintenance requirements and improved engine overhaul periods as compared to current piston engined powered airplanes. Achievement of compliance with noise and chemical emission regulations is expected without impairing performance, operating cost or safety.

Merrill, G. L.↗