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At least 289 records · Page 16

GraphAide: Advanced Graph-Assisted Query and Reasoning System

Curating knowledge from multiple siloed sources that contain both structured and unstructured data is a major challenge in many real-world applications. Pattern matching and querying represent fundamental tasks in modern data analytics that leverage this curated knowledge. The development of such applications necessitates overcoming several research challenges, including data extraction, named entity recognition, data modeling, and designing query interfaces. Moreover, the explainability of these functionalities is critical for their broader adoption. The emergence of Large Language Models (LLMs) has accelerated the development lifecycle of new capabilities. Nonetheless, there is an ongoing need for domain-specific tools tailored to user activities. The creation of digital assistants has gained considerable traction in recent years, with LLMs offering a promising avenue to develop such assistants utilizing domain-specific knowledge and assumptions. In this context, we introduce an advanced query and reasoning system, GraphAide, which constructs a knowledge graph (KG) from diverse sources and allows to query and reason over the resulting KG. GraphAide harnesses both the KG and LLMs to rapidly develop domain-specific digital assistants. It integrates design patterns from retrieval augmented generation (RAG) and the semantic web to create an agentic LLM application. GraphAide underscores the potential for streamlined and efficient development of specialized digital assistants, thereby enhancing their applicability across various domains.

Purohit, Sumit [BATTELLE (PACIFIC NW LAB)] (ORCID:↗

A metric framework for evaluating the resilience contribution of hydropower to the grid

This paper will describe a proposed framework for expressing the resilience of hydropower generation and provide initial case studies for three classes of hydropower, run-of-river hydropower, hydropower with reservoirs, and pumped storage hydropower. Hydropower has great flexibility to provide support during and after natural and man-made events that can disrupt critical infrastructure functionality. The concept of the framework provides for consideration of policy and rules, constraints of the water shed and other allocations of water, storage and plant capabilities to produce real and reactive power, and the strength of the delivery network. The paper details a resilience response metric that has inputs of state of storage and plant level constraints on real and reactive power production. Using the definition of resilience, based on maintaining a minimally normal operations, we provide a qualitative assessment of hydropower’s ability to address the various time scales comprising the “R”s of resilience.

13 HYDRO ENERGY↗

The role of CenKR in the coordination of Rhodobacter sphaeroides cell elongation and division

ABSTRACT Cell elongation and division are essential aspects of the bacterial life cycle that must be coordinated for viability and replication. The impact of misregulation of these processes is not well understood as these systems are often not amenable to traditional genetic manipulation. Recently, we reported on the CenKR two-component system (TCS) in the Gram-negative bacterium Rhodobacter sphaeroides that is genetically tractable, widely conserved in α-proteobacteria, and directly regulates the expression of components crucial for cell elongation and division, including genes encoding subunit of the Tol-Pal complex. In this work, we show that overexpression of cenK results in cell filamentation and chaining. Using cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET), we generated high-resolution two-dimensional (2D) images and three-dimensional (3D) volumes of the cell envelope and division septum of wild-type cells and a cenK overexpression strain finding that these morphological changes stem from defects in outer membrane (OM) and peptidoglycan (PG) constriction. By monitoring the localization of Pal, PG biosynthesis, and the bacterial cytoskeletal proteins MreB and FtsZ, we developed a model for how increased CenKR activity leads to changes in cell elongation and division. This model predicts that increased CenKR activity decreases the mobility of Pal, delaying OM constriction, and ultimately disrupting the midcell positioning of MreB and FtsZ and interfering with the spatial regulation of PG synthesis and remodeling. IMPORTANCE By coordinating cell elongation and division, bacteria maintain their shape, support critical envelope functions, and orchestrate division. Regulatory and assembly systems have been implicated in these processes in some well-studied Gram-negative bacteria. However, we lack information on these processes and their conservation across the bacterial phylogeny. In R. sphaeroides and other α-proteobacteria, CenKR is an essential two-component system (TCS) that regulates the expression of genes known or predicted to function in cell envelope biosynthesis, elongation, and/or division. Here, we leverage unique features of CenKR to understand how increasing its activity impacts cell elongation/division and use antibiotics to identify how modulating the activity of this TCS leads to changes in cell morphology. Our results provide new insight into how CenKR activity controls the structure and function of the bacterial envelope, the localization of cell elongation and division machinery, and cellular processes in organisms with importance in health, host-microbe interactions, and biotechnology.

59 BASIC BIOLOGICAL SCIENCES↗

A Viral Ecogenomics Framework To Uncover the Secrets of Nature’s “Microbe Whisperers”

Microbes drive critical ecosystem functions and affect global nutrient cycling along with human health and disease. They do so under strong constraints exerted by viruses, which shape microbial communities’ structure and shift host cell metabolism during infection. While the majority of viruses and their associated impacts remain poorly characterized, a number of mechanisms by which viruses alter microbial cells and ecosystems have already been revealed. Here I outline how a comprehensive host-resolved mapping of viral sequence space will enable a thorough characterization of virus-encoded mechanisms for microbial manipulation. With soon-to-be millions of virus genomes obtained from metagenomes, one of the major challenges resides in the development of methods for high-throughput and high-resolution virus-host pairing, before multi-omics approaches can be leveraged to fully decipher virus-host dynamics in nature. Beyond novel fundamental biological knowledge, these studies will likely provide new molecular tools enabling a precise engineering of microbial cells and communities.

59 BASIC BIOLOGICAL SCIENCES↗

G2Aero: A Python package for separable shape tensors

G2Aero is a Python package for the design and deformation of discrete planar curves and tubular surfaces using a geometric data-driven approach. G2Aero utilizes a topology of product manifolds: the Grassmannian, $\mathcal{G}$($\mathcal{n}$, 2) - the set of 2-dimensional subspaces in $\mathbb{R}$ $\mathcal{n}$ - and the symmetric positive-definite (SPD) manifold, $\mathcal{S}^{2}_{++}$ - the set of 2x2 SPD matrices. The package provides a novel framework for representing separable deformations to shapes, which consist of stretching, scaling, rotating, and translating - also known as affine deformations - and a set of complementary deformations - which we refer to as undulation-type deformations. We focus on airfoil and blade design applications to emphasize the utility of the methods in an environment where the separation of affine and undulation-type deformations is critical. Notable functionalities of the framework for blade design include: 1) generating novel 2D (airfoil) shapes informed by a database of physically relevant airfoils, 2) building 3D blades by interpolating sequences of 2D airfoil cross-sections, and 3) generating blades with consistent perturbations along the blade span. We discuss the framework and provide examples in the context of wind energy applications, specifically wind turbine blade design. Figure 1 shows the wire frame obtained by interpolating airfoils defining the IEA 15-MW wind turbine blade and applying affine transformations corresponding to twist, chordal scaling, and bending. This, and all other figures in the paper, can be reproduced following examples and referencing supporting documentation provided in the G2Aero package.

97 MATHEMATICS AND COMPUTING↗

National Grid Deep Energy Retrofit Pilot

Through discussion of five case studies (test homes), this project evaluates strategies to elevate the performance of existing homes to a level commensurate with best-in-class implementation of high-performance new construction homes. The test homes featured in this research activity participated in Deep Energy Retrofit (DER) Pilot Program sponsored by the electric and gas utility National Gridin Massachusetts and Rhode Island. Building enclosure retrofit strategies are evaluated for impact on durability and indoor air quality in addition to energy performance. Evaluation of strategies is structured around the critical control functions of water, airflow, vapor flow, and thermal control. The aim of the research project is to develop guidance that could serve as a foundation for wideradoption of high performance, 'deep' retrofit work. The project will identify risk factors endemic to advanced retrofit in the context of the general building type, configuration and vintage encountered in the National Grid DER Pilot. Results for the test homes are based on observation and performance testing of recently completed projects. Additional observation would be needed to fully gaugelong-term energy performance, durability, and occupant comfort.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Evaluating the Effects of the Kingston Fly Ash Release on Fish Reproduction: Spring 2009 – 2010 Studies

On December 22, 2008, a dike containing fly ash and bottom ash at the Tennessee Valley Authority's (TVA) Kingston Fossil Plant in East Tennessee failed and released a large quantity of ash into the adjacent Emory River. Ash deposits from the spill extended 4 miles upstream of the facility to Emory River mile 6 and downstream to Tennessee River mile 564 ({approx}8.5 miles downstream of the confluence of the Emory River with the Clinch River, and {approx}4 miles downstream of the confluence of the Clinch River with the Tennessee River). A byproduct of coal combustion, fly ash contains a variety of metals and other elements which, at sufficient concentrations and in specific forms, can be harmful to biological systems. The ecological effects of fly ash contamination on exposed fish populations depend on the magnitude and duration of exposure, with the most significant risk considered to come from elevated levels of certain metals in the ash, particularly selenium, on fish reproduction and fish early life stages (Lemly 1993; Besser and others 1996). The ovaries of adult female fish in a lake contaminated by coal ash were reported to have an increased frequency of atretic oocytes (dead or damaged immature eggs) and reductions in the overall numbers of developing oocytes (Sorensen 1988) associated with elevated body burdens of selenium. Larval fish exposed to selenium through maternal transfer of contaminants to developing eggs in either contaminated bodies of water (Lemly 1999) or in experimental laboratory exposures (Woock and others 1987, Jezierska and others 2009) have significantly increased incidences of developmental abnormalities. Contact of fertilized eggs and developing embryos to ash in water and sediments may also pose an additional risk to the early life stages of exposed fish populations through direct uptake of metals and other ash constituents (Jezierska and others 2009). The establishment and maintenance of fish populations is intimately associated with the ability of individuals within a population to reproduce. Reproduction is thus generally considered to be the most critical life function affected by environmental contamination. From a regulatory perspective, the issue of potential contaminant-related effects on fish reproduction from the Kingston fly ash spill has particular significance because the growth and propagation of fish and other aquatic life is a specific classified use of the affected river systems. To address the potential effects of fly ash from the Kingston spill on the reproductive health of exposed fish populations, ORNL has undertaken a series of studies in collaboration with TVA that include: (1) a combined field study of metal bioaccumulation in ovaries and other fish tissues (Adams and others 2012) and the reproductive condition of sentinel fish species in reaches of the Emory and Clinch Rivers affected by the fly ash spill (the current report); (2) laboratory tests of the potential toxicity of fly ash from the spill area on fish embryonic and larval development (Greeley and others 2012); (3) additional laboratory experimentation focused on the potential effects of long-term exposures to fly ash on fish survival and reproductive competence (unpublished); and (4) a combined field and laboratory study examining the in vitro developmental success of embryos and larvae obtained from fish exposed in vivo for over two years to fly ash in the Emory and Clinch Rivers (unpublished). The current report focuses on the reproductive condition of adult female fish in reaches of the Emory and Clinch Rivers influenced by the fly ash spill at the beginning of the spring 2009 breeding season - the first breeding season immediately following the fly ash release - and during the subsequent spring 2010 breeding season. Data generated from this and related reproductive/early life stage studies provide direct input to ecological risk assessment efforts and complement and support other phases of the overall biomonitoring program associated with the fly ash spill.

01 COAL, LIGNITE, AND PEAT↗

Directional Charge Separation in Isolated Organic Semiconductor Crystalline Nanowires

This research program was focused on development of new material platforms and analytical spectroscopy methodologies for probing inter- and intra-molecular electronic processes in conjugated nanomaterials. A detailed understanding of the connection between molecular architecture, supramolecular/polymer assembly, and optoelectronic function is critical to the improvement in polymer-based optoelectronics, yet many questions remain outstanding as to how to ‘program’ specific inter-molecular couplings via molecular structure in order to achieve desired device performance (photostability, chargeseparation and charge-transport efficiency). We combine single-molecule spectroscopy tools and new synthetic methodologies to probe intra- and inter-molecular coupling in small-molecule, oligomeric complex structures and crystalline nanoscale supramolecular assemblies in order to understand in detail, the structure-excitonic property relations and elucidate molecular design rules (distances, angles, etc) for improved performance in organic optoelectronics.

36 MATERIALS SCIENCE↗

Portable Sample Preparation For Chemical and Biological Analysis

Preparing samples for chemical or biological analysis is often time consuming and a critical step function to assure an accurate analysis. This invention provides an automated, hands-free, highly accurate device to prepare industrial, chemical, or biological samples for instrumental analysis methods.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Evaluation of Joint Cyber/Safety Risk in Nuclear Power Systems

This report presents an analysis of the Emergency Core Cooling System (ECCS) for a generic Boiling Water Reactor (BWR)-4 NPP. The Electric Power Research Institute (EPRI) developed Hazards and Consequences Analysis for Digital Systems (HAZCADS) process is applied to the ECCS and its subsystems to identify unsafe control actions (UCAs) which act as possible cyber events of concern. The analysis is performed for two design basis events: Small-break Loss of Coolant Accident (SLOCA) and general transients (TRANS), such as unintended reactor trip. In previous work, HAZCADS UCAs were combined with other cyber-attack analysis to develop a risk-informed approach; however, this was for a single system. This report explores advanced systems engineering modeling approaches to model the interactions between digital assets across multiple systems which may be targeted by cyber adversaries. The complex and interdependent design of digital systems has the potential to introduce emergent cyber properties that are generally not covered by hazard analyses nor formal nuclear Probabilistic Risk Assessment (PRA). The R&D and supporting analysis presented here explores approaches to predict and manage how interdependent system properties effect risk. To show the potential impact of a successful cyber-attack to formal PRA event tree probabilities, HAZCADS analysis was also used. HAZCADS was also used to model the automatic depressurization system (ADS) automatic actuation. This analysis extended to an integrated system analysis for common-cause failure (CCF). In this aspect, the HAZCADS analysis continued by analyzing plant design details for system connectivity in support of critical plant functions. A dependency matrix was developed to depict the integrated functionality of the interconnected systems. Areas of potential CCF are indicated. Future work could include adversary attack development to show how CCF could be caused, resulting in PRA events. Across the multiple systems that comprise the ECCS, the analysis shows that the change in such probabilities was very different between systems. This indicates that some systems have a larger potential risk impact from successful cyber-attack or digital failure, which indicates a need for these systems to have a higher priority for design and defensive measures. Furthermore, we were able to establish that a risk analysis using any arbitrary threat model establishes an ordering of components with regard to cyber-risk. This ordering can be used to influence the overall system design with an eye to lowering risk, or as a way to understand real-time risk to operational systems based on a current threat landscape. Expert knowledge of both the analysis process and the system being analyzed is required to perform a HAZCADS analysis. The need for a tiered risk analysis is demonstrated by the results of this report.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Autonomous System Inference, Trojan, and Adversarial Reprogramming Attack and Defense (Final)

In the world of ever-advancing technology, Autonomous Systems (AS) find extensive application, bolstering functionalities of critical infrastructures such as nuclear power plants. These systems, however, are increasingly becoming a target for nefarious activities, namely through inference attacks, trojan attacks, and adversarial reprogramming. This paper delves into a comprehensive exploration of machine learning (ML)-driven autonomous control systems within advanced nuclear reactor designs, revealing the vulnerabilities and proposing strategies for defense against potential cyber-attacks. Advanced cyber-attacks against critical infrastructure and the energy sector are becoming more common. With the invention of autonomous control systems (ACS) within advanced nuclear reactor designs, system designers, reactor operators, and regulators must consider cybersecurity during the design and operational phases. This article provides a cyber threat assessment of machine learning (ML)- based digital twinning (DT) technologies in the context of advanced reactor ACS. A cyber-physical testbed was created to emulate nuclear reactor digital instrumentation and controls (I&C) and act as a basis for the ACS. The ACS was designed as two plant-level DTs predicting reactor malfunctions and determining control actions and two component-level DTs responsible for classifying component states and forecasting component inputs and outputs (I/O). Two duplicate ACS designs– one using a traditional ML framework and one using an automated ML (AutoML) framework– were created and tested against cyber-attacks on training data, real-time process data, and ML model architectures to determine their respective qualitative cyber-risk in terms of likelihood and impact. Both frameworks showed similar cyber-resilience against training, real-time, and ML architecture attacks, proving that neither is inherently more secure. Recommended safeguard and security measures are posed to system designers, reactor operators, and regulators to maintain the cybersecurity of ML-based DT technologies such as ACS, prompting a holistic view of shared responsibility for maintaining cyber-secure ML-based systems. As global reliance on generation III reactors begins to be critically assessed, the evolution towards advanced reactor systems utilizing digital instrumentation and controls (I&C) becomes not merely preferable, but essential. The integration of semi and fully autonomous control systems (ACS), powered by digital I&C and machine learning (ML)-based digital twinning (DT) technologies, emerges as a potent strategy to mitigate operations and maintenance costs, thereby enhancing the economic feasibility of novel reactor designs. However, with a staggering 500% and 380% increase in cyber-attacks reported against the energy sector by the United States Department of Energy (DoE) and the European Union respectively, a surge in cyber vulnerabilities specifically targeting the nuclear industry has been 2 markedly observed. Notable incidents, such as the W32.Ramnit spyware infiltration at the Gundremmingen nuclear power plant in Germany and the Dtrack spyware intrusion at the Kudankulam nuclear power plant in India, while not directly compromising core industrial control systems (ICS), underscore a compelling necessity to fortify cybersecurity protocols in safeguarding reactor systems against increasingly adept digital adversaries. In light of this, our investigation extends beyond conventional cybersecurity parameters, diving into the intricate web of potential vulnerabilities woven into ML-based DTs and ACS in advanced reactor systems. A crafted cyber-physical testbed and preliminary ACS were devised to act as a mirror, reflecting potential configurations of advanced reactor control designs. Moreover, this study is intertwined with a scrutinization of ML models, developed either through conventional, manually tuned methodologies or via automated means through AutoML, probing into their cyber-risk profiles within operational technology (OT) environments. Expanding on this, two distinct ACS blueprints were forged – one navigating through the corridors of traditional ML and the other traversing the path of AutoML – in an effort to holistically encapsulate the considerations pivotal to ML-based DT control system design. Employing the SANS Institute Industrial Control System (ICS) Kill Chain and the MITRE ATT&CK Tactics, Techniques, and Procedures (TTP) framework, a structured analysis was conducted, launching three targeted attacks against the training dataset, real-time dataset, and ML models, therein dissecting the potential cyber-attack implications against both ML frameworks within an ACS milieu. It is essential to note that three distinct categories of attacks were conducted against both ACS configurations, each encompassing three distinct ML-based DTs, cumulating in a total of 18 varied attacks. This exploration extends into the realms of Autonomous System Inference, Trojan, and Adversarial Reprogramming Attack and Defense, unraveling vulnerabilities, and opportunities for fortified defenses against such intrusions, particularly where ML-driven technologies, and by extension, ACS, are deployed. Final recommendations, articulated through a lens of security, safeguard, and implementation considerations, are presented for both traditional and AutoML models, anchoring upon the existing knowledge landscape and ML-based DT modeling for ACS, and are offered as a beacon to guide the nuclear industry through the intricate cybersecurity challenges that lie ahead.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Chlorine Isotope Separations using Thermal Diffusion

As of the close of 2023 a thermal diffusion isotope separations (TDIS) apparatus was constructed, successful shakedown testing was achieved and enrichments of isotopic concentrations relative to natural abundance 35/37 Cl were collected. Further, the model for these enrichment experiments drove the timing for sampling and other critical, extrapolated functions that are discussed herein. Our decision to move forward in 2024 with the installation of a larger set of separation tubes and associated equipment was based on the successful development of the predictive model. The Chlorine Isotopes Project Team at PNNL is prepared to claim that the installation and hence its separative power is restricted only by the spatial limitations of the laboratory, and this at present appears to be the limiting feature to first pass high enriched 37 Cl.

07 ISOTOPE AND RADIATION SOURCES↗

Lightweight Embedded Controller in Advanced FPGA SoC for Radar Signal Processing [Poster]

The objective of the project is to demonstrate that critical control functions can be implemented using little resources in modern microelectronics. A finite state machine (Figure 1) is implemented onto a field programmable gate array (FPGA). The functionality of the system is demonstrated by sending binary instructions to the controller. The controller transmits patterns through an LED, controls an electromechanical device, and uses pulse-width modulation (PWM) for radar functions.

42 ENGINEERING↗

Designing open quantum systems with known steady states: Davies generators and beyond

We provide a systematic framework for constructing generic models of nonequilibrium quantum dynamics with a target stationary (mixed) state. Our framework identifies (almost) all combinations of Hamiltonian and dissipative dynamics that relax to a steady state of interest, generalizing the Davies’ generator for dissipative relaxation at finite temperature to nonequilibrium dynamics targeting arbitrary stationary states. We focus on Gibbs states of stabilizer Hamiltonians, identifying local Lindbladians compatible therewith by constraining the rates of dissipative and unitary processes. Moreover, given terms in the Lindbladian not compatible with the target state, our formalism identifies the operations – including syndrome measurements and local feedback – one must apply to correct these errors. Our methods also reveal new models of quantum dynamics: for example, we provide a “measurement-induced phase transition” in which measurable two-point functions exhibit critical (power-law) scaling with distance at a critical ratio of the transverse field and rate of measurement and feedback. Time-reversal symmetry – defined naturally within our formalism – can be broken both in effectively classical and intrinsically quantum ways. Our framework provides a systematic starting point for exploring the landscape of dynamical universality classes in open quantum systems, as well as identifying new protocols for quantum error correction.

Guo, Jinkang [Department of Physics and Center for↗

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Diterpenoids form a diverse class of small molecule natural products that are widely distributed across the kingdoms of life and have critical biological functions in developmental processes, interorganismal interactions, and environmental adaptation. Due to these various bioactivities, many diterpenoids are also of economic importance as pharmaceuticals, food additives, biofuels, and other bioproducts. Advanced genomics and biochemical approaches have enabled a rapid increase in the knowledge of diterpenoid-metabolic genes, enzymes, and pathways. However, the structural complexity of diterpenoids and the narrow taxonomic distribution of individual compounds in often only a single species remain constraining factors for their efficient production. Availability of a broader range of metabolic enzymes now provide resources for producing diterpenoids in sufficient titers and purity to facilitate a deeper investigation of this important metabolite group. Drawing on established tools for microbial and plant-based enzyme co-expression, we present an easily operated and customizable protocol for the enzymatic production of diterpenoids in either Escherichia coli or Nicotiana benthamiana, and the purification of desired products via silica chromatography and semi-preparative HPLC. Using the group of maize (Zea mays) dolabralexin diterpenoids as an example, we highlight how modular combinations of diterpene synthase (diTPS) and cytochrome P450 monooxygenase (P450) enzymes can be used to generate different diterpenoid scaffolds. Purified compounds can be used in various downstream applications, such as metabolite structural analyses, enzyme structure-function studies, and in vitro and in planta bioactivity experiments.

09 BIOMASS FUELS↗

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein remodelers NSF and p97, while its overall hexameric architecture and likely structural mechanism bear close similarities to the bacterial protein unfoldase ClpX. We find that TRIP13, aided by the adapter protein p31(comet), converts the HORMA-family spindle checkpoint protein MAD2 from a signaling-active ‘closed’ conformer to an inactive ‘open’ conformer. We propose that TRIP13 and p31(comet) collaborate to inactivate the spindle assembly checkpoint through MAD2 conformational conversion and disassembly of mitotic checkpoint complexes. A parallel HORMA protein disassembly activity likely underlies TRIP13's critical regulatory functions in meiotic chromosome structure and recombination.

59 BASIC BIOLOGICAL SCIENCES↗

Somatic Mutations in PI3Kalpha: Structural Basis for Enzyme Activation and Drug Design

The PI3K pathway is a communication hub coordinating critical cell functions including cell survival, cell growth, proliferation, motility and metabolism. Because PI3K{alpha} harbors recurrent somatic mutations resulting in gains of function in human cancers, it has emerged as an important drug target for many types of solid tumors. Various PI3K isoforms are also being evaluated as potential therapeutic targets for inflammation, heart disease, and hematological malignancies. Structural biology is providing insights into the flexibility of the PI3Ks, and providing basis for understanding the effects of mutations, drug resistance and specificity.

60 APPLIED LIFE SCIENCES↗

CANE FIBERBOARD DEGRADATION WITHIN THE 9975 SHIPPING PACKAGE DURING LONG-TERM STORAGE APPLICATION

The 9975 shipping package is used as part of the configuration for long-term storage of special nuclear materials in the K Area Complex at the Savannah River Site. The cane fiberboard overpack in the 9975 package provides thermal insulation, impact absorption and criticality control functions relevant to this application. The Savannah River National Laboratory has conducted physical, mechanical and thermal tests on aged fiberboard samples to identify degradation rates and support the development of aging models and service life predictions in a storage environment. This paper reviews the data generated to date, and preliminary models describing degradation rates of cane fiberboard in elevated temperature – elevated humidity environments.

36 MATERIALS SCIENCE↗