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At least 289 records · Page 16
All sourcesNASA NTRSDOE OSTI
NASA NTRS2018

Radiation and the Immune System

Radiation has profound effects on the immune system. This makes it particularly important to study in order to protect astronauts venturing into deep space and cancer patients considering radiotherapy treatments. Beyond the Earth's magentic field lies galactic cosmic radiation, which contains heavy ion based rays. Immune alterations in response to radiation depends on factors such as the type and amount of radiation, and potentially even the genes of the individual being exposed. In order to study the effects of cosmic radiation on the immune system, we are exposing primary human immune cells to various types and amounts of radiation. To measure sensitivity to radiation, we are quantifying the DNA damage within the cells before irradiation, 4 hours after irradiation, and 24 hours after irradiation. DNA damage is visualized by fluorescently staining for known DNA repair proteins, which get recruited to the site of damage within a cell. These results will be analyzed to search for correlations between immune cell responses and the type of radiation, amount of radiation, or any genetic markers present in the human blood donors. We will also be attempting to determine which specific immune cells are most suspectible to radiation damage. These correlations and discoveries will contribute to making long duration human deep space exploration a possibility, and can even be used to design more personalized and effective radiation treatments for cancer patients.

Malkani, Sherina S.↗
NASA NTRS2011

A Hypothesis on Biological Protection from Space Radiation Through the Use of New Therapeutic Gases

Radiation exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts for protective shielding also pose a technically challenging issue due to the nature of cosmic radiation and current mass and power constraints with modern exploration technology. The concern regarding exposure to cosmic radiation is the biological damage it induces. As damage is associated with increased oxidative stress, it is important and would be enabling to mitigate and/or prevent oxidative stress prior to the development of clinical symptoms and disease. This paper hypothesizes a "systems biology" approach in which a combination of chemical and biological mitigation techniques are used conjunctively. It proposes using new, therapeutic, medical gases as both chemical radioprotectors for radical scavenging and biological signaling molecules for management of the body s response to exposure. From reviewing radiochemistry of water, biological effects of CO, H2, NO, and H2S gas, and mechanisms of radiation biology, it is concluded that this approach may have great therapeutic potential for radiation exposure. Furthermore, it also appears to have similar potential for curtailing the pathogenesis of other diseases in which oxidative stress has been implicated including, cardiovascular disease, cancer, chronic inflammatory disease, hypertension, ischemia/reperfusion injury, acute respiratory distress syndrome, parkinson s and alzheimer s disease, cataracts, and aging

Schoenfeld, Michael P.↗
NASA NTRS2012

A Hypothesis on Biological Protection from Space Radiation Through the Use of New Therapeutic Gases as Medical Counter Measures

Radiation exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts for protective shielding also pose a technically challenging issue due to the nature of cosmic radiation and current mass and power constraints with modern exploration technology. The concern regarding exposure to cosmic radiation is the biological damage it induces. As damage is associated with increased oxidative stress, it is important and would be enabling to mitigate and/or prevent oxidative stress prior to the development of clinical symptoms and disease. This paper hypothesizes a "systems biology" approach in which a combination of chemical and biological mitigation techniques are used conjunctively. It proposes using new, therapeutic, medical gases as both chemical radioprotectors for radical scavenging and biological signaling molecules for management of the body s response to exposure. From reviewing radiochemistry of water, biological effects of CO, H2, NO, and H2S gas, and mechanisms of radiation biology, it is concluded that this approach may have great therapeutic potential for radiation exposure. Furthermore, it also appears to have similar potential for curtailing the pathogenesis of other diseases in which oxidative stress has been implicated including cardiovascular disease, cancer, chronic inflammatory disease, hypertension, ischemia/reperfusion injury, acute respiratory distress syndrome, Parkinson s and Alzheimer s disease, cataracts, and aging.

Schoenfeld, Michael P.↗
NASA NTRS2011

A Hypothesis on Biological Protection from Space Radiation Through the Use of New Therapeutic Gases

Radiation exposure to astronauts could be a significant obstacle for long duration manned space exploration because of current uncertainties regarding the extent of biological effects. Furthermore, concepts for protective shielding also pose a technically challenging issue due to the nature of cosmic radiation and current mass and power constraints with modern exploration technology. The concern regarding exposure to cosmic radiation is the biological damage it induces. As damage is associated with increased oxidative stress, it is important and would be enabling to mitigate and/or prevent oxidative stress prior to the development of clinical symptoms and disease. This paper hypothesizes a "systems biology" approach in which a combination of chemical and biological mitigation techniques are used conjunctively. It proposes using new, therapeutic, medical gases as both chemical radioprotectors for radical scavenging and biological signaling molecules for management of the body s response to exposure. From reviewing radiochemistry of water, biological effects of CO, H2, NO, and H2S gas, and mechanisms of radiation biology, it is concluded that this approach may have great therapeutic potential for radiation exposure. Furthermore, it also appears to have similar potential for curtailing the pathogenesis of other diseases in which oxidative stress has been implicated including cardiovascular disease, cancer, chronic inflammatory disease, hypertension, ischemia/reperfusion injury, acute respiratory distress syndrome, Parkinson s and Alzheimer s disease, cataracts, and aging.

Schoenfeld, Michael P.↗
NASA NTRS1974

Radiation effects

The effects of cosmic radiation and radiation from solar flares on space probe functions are investigated. Long life batteries for probe use were also investigated.

Thayne, L.↗
NASA NTRS1977

Cosmic ray measurements on board Helios 1 from December 1974 to September 1975 Quiet time spectra, radial gradients, and solar events

The considered time period is characterized by a general decrease in solar activity towards a minimum which occurred in July 1976. The relatively quiet solar conditions facilitate the separation of the gradually varying galactic cosmic radiation from superimposed events of different characteristics. The inspection of neutron monitor data shows that the period is characterized by a slow increase of the high energy galactic cosmic radiation at a relatively constant rate. Attention is given to the instrumentation employed, intensity time profiles and preliminary radial gradients, and quiet time energy spectra. The solar particle events discussed include the January 5, 1976 event, the March 3, 1975 event, and the March 19/20, 1975 event.

Kunow, H.↗
NASA NTRS2006

Single Event Transient Analysis of an SOI Operational Amplifier for Use in Low-Temperature Martian Exploration

The next generation of Martian rover#s to be launched by JPL are to examine polar regions where temperatures are extremely low and the absence of an earth-like atmosphere results in high levels of cosmic radiation at ground level. Cosmic rays lead to a plethora of radiation effects including Single Event Transients (SET) which can severely degrade microelectronic functionality. As such, a radiation-hardened, temperature compensated CMOS Single-On-Insulator (SOI) Operational Amplifier has been designed for JPL by the University of Tennessee and fabricated by Honeywell using the SOI V process. SOI technology has been shownto be far less sensitive to transient effects than both bulk and epilayer Si. Broad beam heavy-ion tests at the University of Texas A&M using Kr and Xebeams of energy 25MeV/amu were performed to ascertain the duration and severity of the SET for the op-amp configured for a low and high gain application. However, some ambiguity regarding the location of transient formation required the use of a focused MeV ion microbeam. A 36MeV O6(+) microbeam. the Sandia National Laboratory (SNL) was used to image and verify regions of particular concern. This is a viewgraph presentation

operational amplifier↗
NASA NTRS1994

Very high energy gamma rays from active galactic nuclei: Cascading on the cosmic background radiation fields and the formation of pair halos

Recent high-energy gamma-ray observations (E(sub gamma) greater than 100 MeV) of blazar Active Galactic Nuclei (AGNs) show emission spectra with no clear upper energy cutoff. AGNs, considered to be possible sources for the observed flux of cosmic rays beyond 10(exp 19) eV, may well have emission extending into the very high energy (VHE), (E(sub gamma) greater than 100 GeV) domain. Because VHE gamma-rays are absorbed by pair production on the intergalactic background radiation fields, much of this emission may not be directly visible. The electromagnetic cascades initiated by absorbed VHE gamma-rays, however, may be observable. Since, most probably, the velocities of (e(+), e(-)) pairs produced in a cascade are quickly isotropized by an ambient random magnetic field, extended 'halos' (R greater than 1 Mpc) of pairs will be formed around AGNs with VHE emission. The cascade radiation from these pair halos is emitted isotropically and should be observable at energies below a few TeV. The halo radiation can be distinguished by its characteristic variation in spectrum and intensity with angular distance from the central source. This variation depends weakly on the details of the central source model, e.g., the orientation and beaming/opening angle of an emitting jet. Limiting or determining the intensity of the pair halo can thus serve as a model-independent bound on or measure of the VHE power of AGNs. Next-generation Cherenkov telescopes may be able to image a pair halo.

Aharonian, F. A.↗
NASA NTRS2003

Measurement of Electron Spectrum to High Energies with the BESS-1999 Experiment

We present our preliminary electron spectra (e(-)). The data were obtained with the BESS instrument during a balloon flight from Canada in 1999. Electrons constitute less than 1% of the total cosmic radiation. However, due to their small mass they suffer severe energy loss through Bremsstrahlung radiation with the interstellar gas and, synchrotron and inverse Compton processes in galactic magnetic and radiation fields, respectively. As a result, their spectral shape is modified differently than that of nuclei during propagation. Thus, by studying the electron component one can gain additional information on the cosmic ray transport in the Galaxy. The Balloon-borne Experiment with Superconducting Spectrometer (BESS) is designed as a high-resolution spectrometer with a large geometry factor to provide accurate measurements of the galactic cosmic radiation (/Z/ is less than 3).

Hams, T.↗
DOE OSTI2020

Effects of Six Sequential Charged Particle Beams on Behavioral and Cognitive Performance in B6D2F1 Female and Male Mice

The radiation environment astronauts are exposed to in deep space includes galactic cosmic radiation (GCR) with different proportions of all naturally occurring ions. To assist NASA with assessment of risk to the brain following exposure to a mixture of ions broadly representative of the GCR, we assessed the behavioral and cognitive performance of female and male C57BL/6J × DBA2/J F1 (B6D2F1) mice two months following rapidly delivered, sequential 6 beam irradiation with protons (1 GeV, LET = 0.24 keV, 50%), 4 He ions (250 MeV/n, LET = 1.6 keV/μm, 20%), 16 O ions (250 MeV/n, LET = 25 keV/μm 7.5%), 28 Si ions (263 MeV/n, LET = 78 keV/μm, 7.5%), 48Ti ions (1 GeV/n, LET = 107 keV/μm, 7.5%), and 56 Fe ions (1 GeV/n, LET = 151 keV/μm, 7.5%) at 0, 25, 50, or 200 cGy) at 4–6 months of age. When the activity over 3 days of open field habituation was analyzed in female mice, those irradiated with 50 cGy moved less and spent less time in the center than sham-irradiated mice. Sham-irradiated female mice and those irradiated with 25 cGy showed object recognition. However, female mice exposed to 50 or 200 cGy did not show object recognition. When fear memory was assessed in passive avoidance tests, sham-irradiated mice and mice irradiated with 25 cGy showed memory retention while mice exposed to 50 or 200 cGy did not. The effects of radiation passive avoidance memory retention were not sex-dependent. There was no effect of radiation on depressive-like behavior in the forced swim test. There was a trend toward an effect of radiation on BDNF levels in the cortex of males, but not for females, with higher levels in male mice irradiated with 50 cGy than sham-irradiated. Finally, sequential 6-ion irradiation impacted the composition of the gut microbiome in a sex-dependent fashion. Taxa were uncovered whose relative abundance in the gut was associated with the radiation dose received. Thus, exposure to sequential six-beam irradiation significantly affects behavioral and cognitive performance and the gut microbiome.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2000

A comparison of depth dependence of dose and linear energy transfer spectra in aluminum and polyethylene

A set of four tissue-equivalent proportional counters (TEPCs), with their detector heads at the centers of 0 (bare), 3, 7 and 9-inch-diameter aluminum spheres, were flown on Shuttle flight STS-89. Five such detectors at the centers of polyethylene spheres were flown 1 year earlier on STS-81. The results of dose-depth dependence for the two materials convincingly show the merits of using material rich in hydrogen to decrease the radiation exposure to the crew. A comparison of the calculated galactic cosmic radiation (GCR) absorbed dose and dose-equivalent rates using the radiation transport code HZETRN with nuclear fragmentation model NUCFRG2 and the measured GCR absorbed dose rates and dose-equivalent rates shows that they agree within root mean square (rms) error of 12.5 and 8.2%, respectively. However, there are significant depth-dependent differences in the linear energy transfer (LET) spectra. A comparison for trapped protons using the proton transport code BRYNTRN and the AP-8 MIN trapped-proton model shows a systematic bias, with the model underpredicting dose and dose-equivalent rates. These results show the need for improvements in the radiation transport and/or fragmentation models.

manned↗
DOE OSTI2014

PQ-symmetry for a small Dirac neutrino mass, dark radiation and cosmic neutrinos

We propose a supersymmetric scenario in which the small Yukawa couplings for the Dirac neutrino mass term are generated by the spontaneous-breaking of Pecci-Quinn symmetry. In this scenario, a right amount of dark matter relic density can be obtained by either right-handed sneutrino or axino LSP, and a sizable amount of axion dark radiation can be obtained. Interestingly, the decay of right-handed sneutrino NLSP to axino LSP is delayed to around the present epoch, and can leave an observable cosmological background of neutrinos at the energy scale of O(10−100) GeV.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS1992

Microgravitational effects on chromosome behavior (7-IML-1)

The effects of the two major space-related conditions, microgravity and radiation, on the maintenance and transmission of genetic information have been partially documented in many organisms. Specifically, microgravity acts at the chromosomal level, primarily on the structure and segregation of chromosomes, in producing major abberations such as deletions, breaks, nondisjunction, and chromosome loss, and to a lesser degree, cosmic radiation appears to affect the genic level, producing point mutations and DNA damage. To distinguish between the effects from microgravity and from radiation, it is necessary to monitor both mitotic and meiotic genetic damage in the same organism. The yeast Saccharomyces cerevisiae is used to monitor at high resolution the frequency of chromosome loss, nondisjunction, intergenic recombination, and gene mutation in mitotic and meiotic cells, to a degree impossible in other organisms. Because the yeast chromosomes are small, sensitive measurements can be made that can be extrapolated to higher organisms and man. The objectives of the research are: (1) to quantitate the effects of microgravity and its synergism with cosmic radiation on chromosomal integrity and transmission during mitosis and meiosis; (2) to discriminate between chromosomal processes sensitive to microgravity and/or radiation during mitosis and meiosis; and (3) to relate these findings to anomalous mitotic mating type switching and ascosporogenesis following meiosis.

Bruschi, Carlo↗
NASA NTRS1979

Cosmic ray isotope abundances from chromium to nickel

IRIS, a telescope consisting of a large-area precision Cerenkov detector, scintillators, spark chambers, and a passive stack of Lexan polycarbonate track detectors, was exposed to the primary cosmic radiation for 6.6 sq m sr hr in a balloon flight in 1976. This measurement has yielded the isotopic composition of the iron-group elements Cr, Mn, Fe, and Ni with an average mass resolution of 0.65 amu for the energies 320-500 MeV per amu at the detector. This experiment places the most severe constraints to date on deviation from solar-system composition of the source of the cosmic radiation. Upper limits of 10 percent are placed on the ratios Fe-54/Fe-56 and Fe-58/Fe-56, which are inconsistent with large departures from solar system source composition reported by other workers. The isotopic measurements of Fe and Ni preclude the possibility that these cosmic rays were produced in a single e-process zone. The mean mass of Mn is less than 55, indicating the presence of electron-capture species produced by spallation.

Tarle, G.↗
DOE OSTI2011

Cosmogenic gamma rays and the composition of cosmic rays

We discuss the prospects of detecting the sources of ultrahigh energy (UHE) cosmic ray (CR) nuclei via their emission of cosmogenic {gamma} rays in the GeV to TeV energy range. These {gamma} rays result from electromagnetic cascades initiated by high energy photons, electrons, and positrons that are emitted by CRs during their propagation in the cosmic radiation background and are independent of the simultaneous emission of {gamma} rays in the vicinity of the source. The corresponding production power by UHE CR nuclei (with mass number A and charge Z) is dominated by pion photo production ({proportional_to}A) and Bethe-Heitler pair production ({proportional_to}Z{sup 2}). We show that the cosmogenic {gamma}-ray signal from a single steady UHE CR source is typically more robust with respect to variations of the source composition and injection spectrum than the accompanying signal of cosmogenic neutrinos. We study the diffuse emission from the sum of extragalactic CR sources as well as the point-source emission of the closest sources.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
NASA NTRS1965

D region formation

Ionospheric absorption of charged particles and photons, and ionization by solar radiation, cosmic rays, and Lyman alpha radiation

D LAYER↗
DOE OSTI2015

The Majorana Parts Tracking Database

The MAJORANA DEMONSTRATOR is an ultra-low background physics experiment searching for the neutrinoless double beta decay of 76Ge. The MAJORANA Parts Tracking Database is used to record the history of components used in the construction of the DEMONSTRATOR. Transportation, storage, and processes undergone by parts such as machining or cleaning are linked to part records. Tracking parts provides a great logistics benefit and an important quality assurance reference during construction. In addition, the location history of parts provides an estimate of their exposure to cosmic radiation. A web application for data entry and a radiation exposure calculator have been developed as tools for achieving the extreme radiopurity required for this rare decay search.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗
DOE OSTI2011

Study of gravitational radiation from cosmic domain walls

In this paper, following the previous study, we evaluate the spectrum of gravitational wave background generated by domain walls which are produced if some discrete symmetry is spontaneously broken in the early universe. We apply two methods to calculate the gravitational wave spectrum: One is to calculate the gravitational wave spectrum directly from numerical simulations, and another is to calculate it indirectly by estimating the unequal time anisotropic stress power spectrum of the scalar field. Both analysises indicate that the slope of the spectrum changes at two characteristic frequencies corresponding to the Hubble radius at the decay of domain walls and the width of domain walls, and that the spectrum between these two characteristic frequencies becomes flat or slightly red tilted. The second method enables us to evaluate the GW spectrum for the frequencies which cannot be resolved in the finite box lattice simulations, but relies on the assumptions for the unequal time correlations of the source.

79 ASTRONOMY AND ASTROPHYSICS↗