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At least 271 records · Page 15

Automation of reliability evaluation procedures through CARE - The computer-aided reliability estimation program.

Description of an on-line interactive computer program called CARE (Computer-Aided Reliability Estimation) which can model self-repair and fault-tolerant organizations and perform certain other functions. Essentially CARE consists of a repository of mathematical equations defining the various basic redundancy schemes. These equations, under program control, are then interrelated to generate the desired mathematical model to fit the architecture of the system under evaluation. The mathematical model is then supplied with ground instances of its variables and is then evaluated to generate values for the reliability-theoretic functions applied to the model.

Mathur, F. P.↗

Flow and pressure regulation in the cardiovascular system

Principles and descriptive fragments which may contribute to a model of the regulating chains in the cardiovascular system are presented. Attention is given to the strain sensitivity of blood vessels, the law of the autonomy of the heart beat oscillator, the law of the encapsulation of body fluids, the law of the conservation of protein, the law of minimum 'arterial' pressure, the design of the 'mammalian' kidney, questions of homeokinetic organization, and the development of self-regulatory chains. Details concerning the development program for the heart muscle are considered along with the speed of response of the breathing rate and the significance of the pulmonary vascular pressure-flow characteristics.

Iberall, A.↗

Chemical Ecosystem Selection on Mineral Surfaces Reveals Long-Term Dynamics Consistent with the Spontaneous Emergence of Mutual Catalysis

How did chemicals first become organized into systems capable of self-propagation and adaptive evolution? One possibility is that the first evolvers were chemical ecosystems localized on mineral surfaces and composed of sets of molecular species that could catalyze each other’s formation. We used a bottom-up experimental framework; chemical ecosystem selection (CES) to evaluate this perspective and search for surface-associated; and mutually catalytic chemical systems based on the changes in chemistry they are expected to induce. Here, we report the results of preliminary CES experiments conducted using a synthetic “prebiotic soup” and pyrite grains, which yield dynamical patterns that are suggestive of the emergence of mutual catalysis. While more research is needed to better understand the specific patterns observed here and determine whether they are reflective of self-propagation, these results illustrate the potential power of CES to test competing hypotheses for the emergence of protobiological chemical systems.

autocatalysis↗

Stable Carbon Isotopic Signatures of Abiotic Organics from Hydrothermal Synthesis Experiments

Stable carbon isotopes can be powerful biogeochemical markers in the study of life's origins. Biogenic carbon fixation produces organics that are depleted in C-13 by about -20 to -30%0. Less attention has been paid to the isotopic signatures of abiotic processes. The possibility of abiotic processes producing organics with morphologies and isotopic signatures in the biogenic range has been at the center of recent debate over the Earth's earliest microfossils. The abiotic synthesis of organic compounds in hydrothermal environments is one possible source of endogenous organic matter to the prebiotic earth. Simulated hydrothermal settings have been shown to synthesize, among other things, single chain amphiphiles and simple lipids from a mix of CO, CO2, and H2. A key characteristic of these amphiphilic molecules is the ability to self-assemble in aqueous phases into more organized structures called vesicles, which form a selectively permeable boundary and serve the function of containing and concentrating other organic molecules. The ability to form cell like structures also makes these compounds more likely to be mistaken for biogenic. Hydrothermal simulation experiments were conducted from oxalic or formic acid in water at 175 C for 72 hr. The molecular and isotopic composition of the products of these reactions were determined and compared to biogenic fractionations . Preliminary results indicate isotopic fractionation during abiotic hydrocarbon synthesis in hydrothermal environments is on par with biological carbon fixation.

Stern, Jennifer C.↗

Direct Simulation of a Self-Similar Turbulent Mixing Layer

Three direct numerical simulations of incompressible turbulent plane mixing layers have been performed. All the simulations were initialized with the same two velocity fields obtained from a direct numerical simulation of a turbulent boundary layer with a momentum thickness Reynolds number of 300 computed by Spalart (J. Fluid Mech. 187, 61, 1988). In addition to a baseline case with no additional disturbances, two simulations were begun with two-dimensional disturbances of varying strength in addition to the boundary layer turbulence. After a development stage, the baseline case and the case with weaker additional two-dimensional disturbances evolve self-similarly, reaching visual thickness Reynolds numbers of up to 20 000. This self-similar period is characterized by a lack of large-scale organized pairings, a lack of streamwise vortices in the 'braid' regions, and scalar mixing that is characterized by 'marching' Probability Density Functions (PDFs). The case begun with strong additional two-dimensional disturbances only becomes approximately self-similar, but exhibits sustained organized large-scale pairings, clearly defined braid regions with streamwise vortices that span them, and scalar PDFs that are 'nonmarching.' It is also characterized by much more intense vertical velocity fluctuations than the other two cases. The statistics and structures in several experiments involving turbulent mixing layers are in better agreement with those of the simulations that do not exhibit organized pairings.

Rogers, Michael M.↗

The evolution of the FIGARO data reduction system

The Figaro data reduction system originated at Caltech around 1983. It was based on concepts being developed in the U.K. by the Starlink organization, particularly the use of hierarchical self-defining data structures and the abstraction of most user-interaction into a set of 'parameter system' routines. Since 1984 it has continued to be developed at AAO, in collaboration with Starlink and Caltech. It was adopted as Starlink's main spectroscopic data reduction package, although it is by no means limited to spectra; it has operations for images and data cubes and even a few (very specialized) for four-dimensional data hypercubes. It continued to be used at Caltech and will be used at the Keck. It is also in use at a variety of other organizations around the world. Figaro was originally a system for VMS Vaxes. Recently it was ported (at Caltech) to run on SUN's, and work is underway at the University of New South Wales on a DecStation version. It is hoped to coordinate all this work into a unified release, but coordination of the development of a system by organizations covering three continents poses a number of interesting administrative problems. The hierarchical data structures used by Figaro allow it to handle a variety of types of data, and to add new items to data structures. Error and data quality information was added to the basic file format used, error information being particularly useful for infrared data. Cooperating sets of programs can add specific sub-structures to data files to carry information that they understand (polarimetry data containing multiple data arrays, for example), without this affecting the way other programs handle the files. Complex instrument-specific ancillary information can be added to data files written at a telescope and can be used by programs that understand the instrumental details in order to produce properly calibrated data files. Once this preliminary data processing was done the resulting files contain 'ordinary' spectra or images that can be processed by programs that are not instrument-specific. The structures holding the instrumental information can then be discarded from the files. Much effort has gone into trying to make it easy to write Figaro programs; data access subroutines are now available to handle access to all the conventional items found in Figaro files (main data arrays, error information, quality information etc), and programs that only need to access such items can be very simple indeed. A large number of Figaro users do indeed write their own Figaro applications using these routines. The fact that Figaro programs are written as callable subroutines getting information from the user through a small set of parameter routines means that they can be invoked in numerous ways; they are normally linked and run as individual programs (called by a small main routine that is generated automatically), but are also available linked to run under the ADAM data acquisition system and there is an interface that lets them be called as part of a user-written Fortran program. The long-term future of Figaro probably depends to a large extent on how successfully it manages the transition from being a VMS-only system to being a multi-platform system.

Shortridge, K.↗

The Opera Instrument: An Advanced Curation Development for Mars Sample Return Organic Contamination Monitoring

Mars Sample Return (MSR) requires strict organic contamination control (CC) and contamination knowledge (CK) as outlined by the Mars 2020 Organic Contamination Panel (OCP). This includes a need to monitor surficial organic contamination to a ng/sq. cm sensitivity level. Archiving and maintaining this degree of surface cleanliness may be difficult but has been achieved. MSR's CK effort will be very important because all returned samples will be studied thoroughly and in minute detail. Consequently, accurate CK must be collected and characterized to best interpret scientific results from the returned samples. The CK data are not only required to make accurate measurements and interpretations for carbon-depleted martian samples, but also to strengthen the validity of science investigations performed on the samples. The Opera instrument prototype is intended to fulfill a CC/CK role in the assembly, cleaning, and overall contamination history of hardware used in the MSR effort, from initial hardware assembly through post-flight sample curation. Opera is intended to monitor particulate and organic contamination using quartz crystal microbalances (QCMs), in a self-contained portable package that is cleanroom-compliant. The Opera prototype is in initial development capable of approximately 100 ng/sq. cm organic contamination sensitivity, with additional development planned to achieve 1 ng/sq. cm. The Opera prototype was funded by the 2017 NASA Johnson Space Center Innovation Charge Account (ICA), which provides funding for small, short-term projects.

Fries, M. D.↗

The desktop interface in intelligent tutoring systems

The interface between an Intelligent Tutoring System (ITS) and the person being tutored is critical to the success of the learning process. If the interface to the ITS is confusing or non-supportive of the tutored domain, the effectiveness of the instruction will be diminished or lost entirely. Consequently, the interface to an ITS should be highly integrated with the domain to provide a robust and semantically rich learning environment. In building an ITS for ZetaLISP on a LISP Machine, a Desktop Interface was designed to support a programming learning environment. Using the bitmapped display, windows, and mouse, three desktops were designed to support self-study and tutoring of ZetaLISP. Through organization, well-defined boundaries, and domain support facilities, the desktops provide substantial flexibility and power for the student and facilitate learning ZetaLISP programming while screening the student from the complex LISP Machine environment. The student can concentrate on learning ZetaLISP programming and not on how to operate the interface or a LISP Machine.

Baudendistel, Stephen↗

Crew member and instructor evaluations of line oriented flight training

Results obtained from the NASA/UT/LOFT survey of 8300 crew members from four airlines is presented. As simulator training is very expensive and excellence in training is the objective, some effort is justified in evaluating LOFT and in determining what it is about the best scenarios that creates positive effects. Attention is given to the effects of different scenarios, self reports of crew resource management behaviors, organization, fleet and crew position differences.

Wilhelm, John↗

Solid-Sorbent Air Sampler

Portable unit takes eight 24-hour samples. Volatile organic compounds in air collected for analysis by portable, self-contained sampling apparatus. Sampled air drawn through sorbent material, commercial porous polymer of 2, 3-diphenyl-p-phenylene oxide. High-boiling-point organic compounds adsorbed onto polymer, while low-boiling-point organics pass through and returned to atmosphere. Sampler includes eight sample tubes filled with polymeric sorbent. Organic compounds in atmosphere absorbed when air pumped through sorbent. Designed for checking air in spacecraft, sampler adaptable to other applications as leak detection, gas-mixture analysis, and ambient-air monitoring.

Galen, T. J.↗

Continuous-Wave Laser Beam Fanning in Organic Solutions: A Novel Phenomenon

If a low-power cw Ar(+) laser beam (approx. 50 mW) is sent horizontally and focused on the entrance side of a cuvette containing an absorptive solution, the beam fans into the lower half of the cuvette instead of propagating through and forming self-phase-modulation fringes. We call this phenomenon self-beam fanning, which has been observed in several organic solutions. We present here several experimental results and a descriptive model of the phenomenon.

Abdeldayem, Hossin↗

Self-assembly of mesoscopically ordered chromatic polydiacetylene/silica nanocomposites

Nature abounds with intricate composite architectures composed of hard and soft materials synergistically intertwined to provide both useful functionality and mechanical integrity. Recent synthetic efforts to mimic such natural designs have focused on nanocomposites, prepared mainly by slow procedures like monomer or polymer infiltration of inorganic nanostructures or sequential deposition. Here we report the self-assembly of conjugated polymer/silica nanocomposite films with hexagonal, cubic or lamellar mesoscopic order using polymerizable amphiphilic diacetylene molecules as both structure-directing agents and monomers. The self-assembly procedure is rapid and incorporates the organic monomers uniformly within a highly ordered, inorganic environment. Polymerization results in polydiacetylene/silica nanocomposites that are optically transparent and mechanically robust. Compared to ordered diacetylene-containing films prepared as Langmuir monolayers or by Langmuir-Blodgett deposition, the nanostructured inorganic host alters the diacetylene polymerization behaviour, and the resulting nanocomposite exhibits unusual chromatic changes in response to thermal, mechanical and chemical stimuli. The inorganic framework serves to protect, stabilize, and orient the polymer, and to mediate its function. The nanocomposite architecture also provides sufficient mechanical integrity to enable integration into devices and microsystems.

NASA Discipline Life Support Systems↗

Will Organic Synthesis Within Icy Grains or on Dust Surfaces in the Primitive Solar Nebula Completely Erase the Effects of Photochemical Self Shielding?

There are at least 3 separate photochemical self-shielding models with different degrees of commonality. All of these models rely on the selective absorption of (12))C(16)O dissociative photons as the radiation source penetrates through the gas allowing the production of reactive O-17 and O-18 atoms within a specific volume. Each model also assumes that the undissociated C(16)O is stable and does not participate in the chemistry of nebular dust grains. In what follows we will argue that this last, very important assumption is simply not true despite the very high energy of the CO molecular bond.

Nuth, Joseph A., III↗

CO Self-Shielding as a Mechanism to Make O-16 Enriched Solids in the Solar Nebula

Photochemical self-shielding of CO has been proposed as a mechanism to produce solids observed in the modern, O-16 depleted solar system. This is distinct from the relatively O-16 enriched composition of the solar nebula, as demonstrated by the oxygen isotopic composition of the contemporary sun. While supporting the idea that self-shielding can produce local enhancements in O-16 depleted solids, we argue that complementary enhancements of O-16 enriched solids can also be produced via CO-16 based, Fischer-Tropsch type (FTT) catalytic processes that could produce much of the carbonaceous feedstock incorporated into accreting planetesimals. Local enhancements could explain observed O-16 enrichment in calcium-aluminum-rich inclusions (CAIs), such as those from the meteorite, Isheyevo (CH/CHb), as well as in chondrules from the meteorite, Acfer 214 (CH3). CO selfshielding results in an overall increase in the O-17 and O-18 content of nebular solids only to the extent that there is a net loss of CO-16 from the solar nebula. In contrast, if CO-16 reacts in the nebula to produce organics and water then the net effect of the self-shielding process will be negligible for the average oxygen isotopic content of nebular solids and other mechanisms must be sought to produce the observed dichotomy between oxygen in the Sun and that in meteorites and the terrestrial planets. This illustrates that the formation and metamorphism of rocks and organics need to be considered in tandem rather than as isolated reaction networks.

Solar Nebula↗

The Production of Complex Organics from Interstellar Ices

Infrared spectroscopy of ices in interstellar dense molecular clouds has shown that they contain a variety of simple molecules, as well as aromatic hydrocarbons. While in these clouds, these ices are processed by ultraviolet light and cosmic rays. High vacuum, UV irradiation laboratory simulations conducted using various realistic approx. 10 K interstellar mixed-molecular ice analogs, both with and without polycyclic aromatic hydrocarbons (PAHs), have been carried out in NASA-Ames' Astrochemistry Laboratory. Upon warming, these irradiated ices are found to produce refractory organic residues. These residues have been analyzed using a variety of techniques, including HPLC and laser desorption mass spectrometry, and they have been shown to contain a variety of complex organic compounds. Several of these compounds may be of prebiotic significance. In particular, we will discuss the detection of quinones (substituted PAHs that are used by living systems for electron transport) and amphiphiles (molecules that self-assemble to form membranes). Laboratory simulations have also demonstrated that the organic products can show isotopic enrichments in D that provide clues for the mechanisms of their formation. Similar compounds and D enrichments are seen in the organics found in primitive meteorites, suggesting a direct link between interstellar chemistry and the delivery of organics to newly formed planets.

Sandford, Scott A.↗

Bio-Organic Nanotechnology: Using Proteins and Synthetic Polymers for Nanoscale Devices

While the ability of proteins to self-assemble makes them powerful tools in nanotechnology, in biological systems protein-based structures ultimately depend on the context in which they form. We combine the self-assembling properties of synthetic diblock copolymers and proteins to construct intricately ordered, three-dimensional polymer protein structures with the ultimate goal of forming nano-scale devices. This hybrid approach takes advantage of the capabilities of organic polymer chemistry to build ordered structures and the capabilities of genetic engineering to create proteins that are selective for inorganic or organic substrates. Here, microphase-separated block copolymers coupled with genetically engineered heat shock proteins are used to produce nano-scale patterning that maximizes the potential for both increased structural complexity and integrity.

Molnar, Linda K.↗

Astronaut Exposures to Ionizing Radiation in a Lightly-Shielded Spacesuit

The normal working and living areas of the astronauts are designed to provide an acceptable level of protection against the hazards of ionizing radiation of the space environment. Still there are occasions when they must don a spacesuit designed mainly for environmental control and mobility and leave the confines of their better-protected domain. This is especially true for deep space exploration. The impact of spacesuit construction on the exposure of critical astronaut organs will be examined in the ionizing radiation environments of free space, the lunar surface and the Martian surface. The computerized anatomical male model is used to evaluate astronaut self-shielding factors and to determine space radiation exposures to critical radiosensitive human organs.

Wilson, J. W.↗