Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “redesign”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15
All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Design for Reliability (DfR) in Space Life Support

The engineering process of Design for Reliability (DfR) is well established in the automotive and aerospace industries. DfR should be useful in the future development of space life support systems. DfR is a sequence of tasks that develop system requirements and plan reliability analysis and testing. First and fundamentally, the reliability requirement is defined. Next the system reliability model is developed, often using a reliability block diagram. The overall system reliability requirement is allocated to the subsystems and an estimate of the attainable reliability is made. This expected reliability can be improved by simplifying the design by removing components or by replacing less reliable components. Improving reliability can require difficult compromises, such as reducing performance requirements, increasing budget, or extending testing. The actual system reliability can be determined only by testing, which should continue long enough to provide the required confidence in the measured value. New systems often have unexpected design errors that cause failures in early testing. The usual reliability improvement process of testing, finding the failure modes, and redesigning to remove them reduces the failure rate and is referred to as “reliability growth.” After redesign has been completed, the system should be further tested to determine the actual achieved reliability more accurately. If the final system failure rate is too high, redundant systems can be used to improve overall operational reliability. Adding redundancy simply to increase the one- or two-fault tolerance metric may sometimes reduce reliability. Reliability can be improved in three ways: redesigning the system to include more reliable subsystems and components, reliability growth testing and failure mode removal, and by using parallel redundant systems. DfR should combine these approaches to achieve the required reliability while managing performance, cost, and schedule.

Reliability↗
NASA NTRS2024

X-57 Cruise Motor GVT Using Fixed-Base Correction Technique

The National Aeronautics and Space Administration (NASA) Armstrong Flight Research Center (AFRC) completed a modal survey of the X-57 Maxwell aircraft cruise motor system to help inform cruise motor redesign efforts. X-57 Maxwell was an electric propulsion demonstrator aircraft developed by NASA to inform airworthiness standards for electrified-aircraft. The cruise motor system modal survey was completed in spring of 2023 utilizing the fixed-base correction (FBC) ground vibration test (GVT) technique developed by ATA Engineering, to decouple the motor modes from the aircraft modes. Previously during the full aircraft GVT, a detailed modal assessment of the cruise motors was not performed. Owing to the X-57 project’s phase in the aircraft development cycle when the motor redesign effort occurred, the cruise motor GVT could only be performed with the cruise motor system installed on the aircraft, with most of its installation hardware (wiring, baffling, sensors, etc.) attached. An impact hammer was used to provide excitation input at various locations within the tight confines of the cruise motor installation. To better support motor redesign efforts, the FBC methodology was utilized to fix, separate and de-couple the cruise motor modes from aircraft modal response. During the GVT, this required additional impact tap tests on candidate fixed-boundary points for each degree of freedom (DOF) to be fixed. Additional triaxial accelerometers installed at the candidate points were used to compute frequency response functions (FRFs) in X, Y, and Z directions to enable those DOFs to be numerically fixed. Test data was acquired using Hottinger Brüel & Kjær’s LAN-XI data acquisition hardware and BK Connect software. FBC post-test processing was performed using the Structural Modification Using Frequency Response Functions (SMURF) technique with ATA Engineering’s Interface between MATLAB, Analysis, Test (IMAT) software. Utilizing the FBC technique relieved test engineers from having to instrument the entire aircraft to identify and separate aircraft response from cruise motor modes of interest. The FBC technique also permitted structural analysis engineers to omit secondary components from their finite element model (FEM) of the cruise motor system. This FBC modal survey was successful, and the first time NASA AFRC utilized the FBC method on an aircraft rather than a test fixture, and also using an impact hammer rather than multiple shakers allowing significant project schedule and cost savings

Modal Survey↗
NASA NTRS2024

High Reliability at Minimum Cost

This paper investigates the minimum cost of improving the reliability of complex technical systems. The two major methods to improve reliability are redesigning the system for higher reliability or providing redundant components to replace failed elements. The costs of redesign for reliability or adding redundancy are estimated. The most cost-effective combination for high reliability can be identified. The cost of increasing the intrinsic reliability of a system can be modeled as cost proportional to 1/(system failure rate) a , where the exponent “a” measures the difficulty of increasing reliability. The “a” exponent can vary from 0.25 to about 2.5. Operational reliability can also be increased by using redundant systems. The failure rate for N parallel redundant units is (system failure rate) N . The cost of redundancy is N times the system cost. The total redundant system cost is proportional to N/(system failure rate) a . The cost of redundancy increases as N gets larger, but larger N allows a higher system failure rate, which reduces the system design cost. There is a certain N, a certain level of redundancy, that has the minimum cost to achieve the required overall redundant system failure rate. The minimum cost for the redundant system is achieved at the optimum level of redundancy. The N for minimum cost is equal to -a ln (redundant system failure rate). The minimum cost of the N redundant systems is proportional to N * (original system failure rate) a . The optimum redesigned individual system failure rate is proportional to exp (-1/a), so the greater the difficulty, the higher the optimum individual system failure rate. Increasing the intrinsic reliability of a system encounters diminishing returns and at some point it becomes more cost-effective to add redundancy. The difficulty of increasing intrinsic system reliability determines the optimum design for high reliability at minimum cost.

reliability↗
NASA NTRSDate not supplied

Design for Reliability (DfR) in Space Life Support

The engineering process of Design for Reliability (DfR) is well established in the automotive and aerospace industries. DfR should be useful in the future development of space life support systems. DfR is a sequence of tasks that develop system requirements and plan reliability analysis and testing. First and fundamentally, the reliability requirement is defined. Next the system reliability model is developed, often using a reliability block diagram. The overall system reliability requirement is allocated to the subsystems and an estimate of the attainable reliability is made. This expected reliability can be improved by simplifying the design by removing components or by replacing less reliable components. Improving reliability can require difficult compromises, such as reducing performance requirements, increasing budget, or extending testing. The actual system reliability can be determined only by testing, which should continue long enough to provide the required confidence in the measured value. New systems often have unexpected design errors that cause failures in early testing. The usual reliability improvement process of testing, finding the failure modes, and redesigning to remove them reduces the failure rate and is referred to as “reliability growth.” After redesign has been completed, the system should be further tested to determine the actual achieved reliability more accurately. If the final system failure rate is too high, redundant systems can be used to improve overall operational reliability. Adding redundancy simply to increase the one- or two-fault tolerance metric may sometimes reduce reliability. Reliability can be improved in three ways: redesigning the system to include more reliable subsystems and components, reliability growth testing and failure mode removal, and by using parallel redundant systems. DfR should combine these approaches to achieve the required reliability while managing performance, cost, and schedule.

Reliability↗
NASA NTRSDate not supplied

High Reliability at Minimum Cost

This paper investigates the minimum cost of improving the reliability of complex technical systems. The two major methods to improve reliability are redesigning the system for higher reliability or providing redundant components to replace failed elements. The costs of redesign for reliability or adding redundancy are estimated. The most cost-effective combination for high reliability can be identified. The cost of increasing the intrinsic reliability of a system can be modeled as cost proportional to 1/(system failure rate) a , where the exponent “a” measures the difficulty of increasing reliability. The “a” exponent can vary from 0.25 to about 2.5. Operational reliability can also be increased by using redundant systems. The failure rate for N parallel redundant units is (system failure rate) N . The cost of redundancy is N times the system cost. The total redundant system cost is proportional to N/(system failure rate) a . The cost of redundancy increases as N gets larger, but larger N allows a higher system failure rate, which reduces the system design cost. There is a certain N, a certain level of redundancy, that has the minimum cost to achieve the required overall redundant system failure rate. The minimum cost for the redundant system is achieved at the optimum level of redundancy. The N for minimum cost is equal to -a ln (redundant system failure rate). The minimum cost of the N redundant systems is proportional to N * (original system failure rate) a . The optimum redesigned individual system failure rate is proportional to exp (-1/a), so the greater the difficulty, the higher the optimum individual system failure rate. Increasing the intrinsic reliability of a system encounters diminishing returns and at some point it becomes more cost-effective to add redundancy. The difficulty of increasing intrinsic system reliability determines the optimum design for high reliability at minimum cost.

reliability↗
NASA NTRSDate not supplied

Status of the Advanced Oxygen Generation Assembly

Future Exploration missions will require an Oxygen Generation Assembly (OGA) to electrolyze water to supply oxygen for crew metabolic consumption. The system design will be based on the International Space Station (ISS) OGA but with added improvements based on lessons learned during ISS operations and technological advances since the original OGA was designed and built. The goal of these improvements will be to reduce spares mass and crew maintenance time while increasing reliability. Over the past year, the team has performed additional design reviews, testing and analysis in an effort to optimize upgrade efforts and achieve the best value that meets Exploration mission requirements. Upgrades that will be incorporated include: redesign of the electrolysis cell stack, redesign of the hydrogen dome, replacement of the hydrogen sensors, redesign of the recirculation loop deionizing bed, and incorporation of recirculation loop nitrogen purging and water flushing. The ISS OGA will be upgraded to an Advanced OGA (AOGA) configuration and its operation demonstrated in a relevant flight environment.

Kevin Takada↗
DOE OSTI2024

Improving the User Interface of the DeepLynx Data Warehouse

DeepLynx is an open-source ontology-based data warehouse created by INL to support the creation and life cycle of digital engineering projects, with a particular emphasis on digital twins [1]. Digital twins are systems that represent physical assets and process in a real-time digital environment [1]. Most well-known commercial data warehouses use Graphical User Interfaces (GUIs) for users to interact with their systems [3]. Limited publications have addressed the design of these interfaces and understanding of their target users. The current users and development team acknowledge the need to improve the current UI, not just for aesthetics but to improve functionality and workflow of DeepLynx. Traditional data warehouse users are developers, data scientists and business analysts [2]. DeepLynx users have a vast range of experience using data warehouses, and diverse roles, including engineers, scientists and management positions. Because there is a broader audience of target users for DeepLynx than a typical data warehouse, it is essential that DeepLynx has a useable and intuitive user interface. To achieve this the team performed human-computer interaction methods, including a Heuristic Evaluation of current UI using Neilsen’s Usability Heuristic, create personas based on current users by designing a user survey, data analysis and develop of personas. Followed by a redesign of the UI following using Neilsen’s Usability Heuristic and Norman’s Principles of Interactive Design in industry standard software Figma. Lastly a Heuristic Evaluation of new UI design, using Neilsen’s Usability Heuristic and User testing of redesign UI and have a group of users complete a Thinking Aloud Test of the new UI. Preliminary results of the Heuristic Evaluation of current UI arise issue with Consistency and Standards, Visibility of System Status, Match System and Real World and Recognition Rather than Recall. These issues were addressed in the proposed redesign by applying Neilsen’s Usability Heuristic and Norman’s Principles of Interactive Design. Next steps include formalized list of lessons learned and design implications for future publications.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2026

RCSB protein data Bank: Next‐generation advanced search for exploration of experimental structures and computed structure models

Abstract The Protein Data Bank (PDB), established in 1971, is the primary global, open‐access archive for experimentally determined 3D macromolecular structures (proteins, RNA, DNA). The research‐focused RCSB.org web‐portal provides access to these data alongside more than one million machine‐learning‐predicted structure models, greatly expanding the available structural landscape. Rapid growth of both experimental and computational structures has increased the need for powerful yet accessible search tools that serve a broad and diverse scientific community. Herein, we describe a redesigned RCSB Protein Data Bank RCSB.org Advanced Search capability that supports intuitive discovery of 3D structures through a unified interface. This interface integrates annotation‐, sequence‐, and 3D structure‐based searches, embeds an interactive 3D viewer, and incorporates curated biological knowledge, such as catalytic site definitions from Mechanism and Catalytic Site Atlas and ligand‐guided structural motifs, for constructing geometry‐driven queries. A new Chemical Search tool allows definition of chemical queries via an integrated drawing tool or standard identifiers, seamlessly combining them with annotation filters. By allowing query definition directly within spatial and chemical contexts, these search interfaces reduce the need for detailed knowledge of residue numbering, chain identifiers, or external cheminformatics software. This capability enables efficient exploration of structures, chemical diversity, and structure–function relationships across all life domains. The redesigned interfaces can be accessed directly at rcsb.org/search/advanced for Advanced Search and rcsb.org/search/chemical for Chemical Search.

Rose, Yana [Research Collaboratory for Structural ↗
DOE OSTI2022

Cross-kingdom expression of synthetic genetic elements promotes discovery of metabolites in the human microbiome

Small molecules encoded by biosynthetic pathways mediate cross-species interactions and harbor untapped potential, which has provided valuable compounds for medicine and biotechnology. Since studying biosynthetic gene clusters in their native context is often difficult, alternative efforts rely on heterologous expression, which is limited by host-specific metabolic capacity and regulation. Here, in this work, we describe a computational-experimental technology to redesign genes and their regulatory regions with hybrid elements for cross-species expression in Gram-negative and -positive bacteria and eukaryotes, decoupling biosynthetic capacity from host-range constraints to activate silenced pathways. These synthetic genetic elements enabled the discovery of a class of microbiome-derived nucleotide metabolites—tyrocitabines—from Lactobacillus iners. Tyrocitabines feature a remarkable orthoester-phosphate, inhibit translational activity, and invoke unexpected biosynthetic machinery, including a class of “Amadori synthases” and “abortive” tRNA synthetases. Our approach establishes a general strategy for the redesign, expression, mobilization, and characterization of genetic elements in diverse organisms and communities.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

From TPL assessment to design optimization: Wave energy converter control co-design applied to the RM3

The Reference Model (RM) project developed six marine energy converter concepts using a sequential design methodology, which, while widely adopted in the industry, often overlooks interactions between system components, resulting in suboptimal designs. One such example is the Reference Model 3 (RM3), a two-body point absorber wave energy converter (WEC). An assessment using the Technology Performance Level (TPL) revealed that RM3’s low power-to-cost ratio, partly due to expensive steel construction, limits its techno-economic performance. Here, this study aims to redesign RM3 by reducing its scale and employing control co-design to integrate WEC and Power Take-Off (PTO) dynamics, constraints, and cost considerations within an optimization framework. We demonstrate the limitations of RM3’s current PTO design and explore the benefits of scaling down to enhance techno-economic viability by lowering material costs. Using WecOptTool, we conduct a parameter sweep over gear ratios and spring stiffnesses for various Commercial Off-The-Shelf generators in irregular wave conditions. Our findings emphasize the importance of aligning PTO components with WEC dynamics, showing that control co-design and strategic scaling can improve RM3’s power-to-cost ratio. This study presents a transferable example of applied control co-design for other WECs, supporting early-stage developers in their design decisions.

Off the shelf components↗
DOE OSTI2021

Engineered pH-Sensitive Protein G/IgG Interaction

While natural protein–protein interactions have evolved to be induced by complex stimuli, rational design of interactions that can be switched-on-demand still remain challenging in the protein design world. Here, we demonstrate that a computationally redesigned natural interface for improved binding affinity could further be mutated to adopt a pH switchable interaction. The redesigned interface of Protein G/human IgG Fc domain (referred to as PrG/hIgG), when incorporated with histidine and glutamic acid on PrG (PrG-EHHE), showed a switch in binding affinity by 50-fold when the pH was altered from mild acidic to mild basic. The wild-type (WT) interface showed a negligible switch. The overall binding affinity under mild acidic pH for PrG-EHHE outperformed the wild-type PrG (PrG-WT) interaction. Overall, we find that the new reagent PrG-EHHE can be revolutionary in IgG purification, since the standard method of using an extreme acidic pH for elution can be circumvented.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Computationally restoring the potency of a clinical antibody against Omicron

The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs and revealed how quickly viral escape can curtail effective options. When the SARS-CoV-2 Omicron variant emerged in 2021, many antibody drug products lost potency, including Evusheld and its constituent, cilgavimab. Cilgavimab, like its progenitor COV2-2130, is a class 3 antibody that is compatible with other antibodies in combination4 and is challenging to replace with existing approaches. Rapidly modifying such high-value antibodies to restore efficacy against emerging variants is a compelling mitigation strategy. We sought to redesign and renew the efficacy of COV2-2130 against Omicron BA.1 and BA.1.1 strains while maintaining efficacy against the dominant Delta variant. Here we show that our computationally redesigned antibody, 2130-1-0114-112, achieves this objective, simultaneously increases neutralization potency against Delta and subsequent variants of concern, and provides protection in vivo against the strains tested: WA1/2020, BA.1.1 and BA.5. Deep mutational scanning of tens of thousands of pseudovirus variants reveals that 2130-1-0114-112 improves broad potency without increasing escape liabilities. Our results suggest that computational approaches can optimize an antibody to target multiple escape variants, while simultaneously enriching potency. Our computational approach does not require experimental iterations or pre-existing binding data, thus enabling rapid response strategies to address escape variants or lessen escape vulnerabilities.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Current profile and normalized beta control via feedback linearization and Lyapunov techniques

Abstract Simultaneous control of the current profile and normalized plasma beta is an essential control problem in the development of advanced tokamak scenarios. However, this control problem is especially challenging due to the nonlinear nature of the current, heat, and particle transport dynamics, as well as the difficulty to understand and accurately model such processes. In this work, a nonlinear, robust, model-based controller for the simultaneous regulation of the current profile and normalized beta has been designed using feedback linearization and Lyapunov redesign techniques. Feedback linearization avoids approximate linearization of the plasma dynamics, retaining the original physics content of the model. Moreover, the use of Lyapunov redesign techniques makes the controller robust against the uncertainties arising during the modeling process. The controller’s performance in the presence of unknown dynamics is tested in nonlinear, one-dimensional simulations using the Control Oriented Transport SIMulator (COTSIM) code, which employs plasma models that are significantly more complex than those employed for control synthesis.

Physics↗
DOE OSTI2022

Active rotor coning for a 25 MW downwind offshore wind turbine

A two-bladed downwind turbine system was upscaled from 13.2 MW to 25 MW by redesigning aerodynamics, structures, and controls. In particular, three 25-MW rotors were developed, and the final version is a fully redesigned model of the original rotor. Despite their radically large sizes, it was found that these 25-MW turbine rotors satisfy this limited set of structural design drivers at the rated condition and that larger blade lengths are possible with conewise load-alignment. In addition, flapwise morphing (varying the cone angle with a wind-speed schedule) was investigated to minimize mean and fluctuating blade root bending loads using steady inflow proxies for the maximum and lifetime damage equivalent load moments. Compared to the fixed coned rotor case, morphing can provide an Annual Energy Production (AEP) increase of 6%, and the maximum blade root flapwise bending moment increases 21% (still under the constraint, i.e., 10% of the ultimate moments) as a trade-off. The resulting series of 25-MW rotors can be a valuable baseline for further development and assessment of ultra-large-scale wind turbines.

17 WIND ENERGY↗
DOE OSTI2021

Finding diverse ways to improve algebraic connectivity through multi-start optimization

The algebraic connectivity, also known as the Fiedler value, is a spectral measure of network connectivity that can be increased through edge addition. We present an algorithm for producing many diverse ways to add a fixed number of edges to a network to achieve a near optimal Fiedler value. Previous Fielder value optimization algorithms (i.e. the greedy algorithm) output only one solution. Obtaining a single solution is rarely good enough for real-world network redesign problems, as practical constraints (political, physical or financial) may prevent implementation. Our algorithm takes a multi-start optimization approach, adding a random initial edge and then applies a greedy heuristic to improve the Fiedler value. The random choice moves us to a new region of the search space, enabling discovery of diverse solutions. Additionally, we present a Determinantal Point Process framework for quantifying diversity. We then apply a Markov chain Monte Carlo technique to sift through the large number of output solutions and locate a smaller, more manageable collection of highly diverse solutions that can be presented to network redesign engineers. We demonstrate the effectiveness of our algorithm on real-world graphs with varied structures.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2026

Synthetic overlapping genes stabilize genetic systems

Overlapping genes—wherein two different proteins are translated from alternative reading frames of the same DNA sequence—provide a means to stabilize an engineered gene by directly linking its evolutionary fate with that of an overlapping gene. However, creating overlapping gene pairs is challenging, as it requires redesigning both protein products to accommodate overlap constraints. Here, we present a new “overlapping, alternate-frame insertion” (OAFI) method for creating synthetic overlapping genes by inserting an “inner” gene, encoded in an alternate frame, into a flexible region of an “outer” gene. Using OAFI, we create new overlapping gene pairs of genetic reporters and bacterial toxins within an antibiotic resistance gene. We show that both the inner and outer genes retain function despite redesign, with translation of the inner gene influenced by its overlap position in the outer gene. Importantly, we show that, despite these inner gene sequences not contributing to outer gene function, selection for the outer gene alters the permitted inactivating mutations in the inner gene, and that overlapping toxins can restrict horizontal gene transfer of the antibiotic resistance gene. Overall, OAFI offers a versatile tool for synthetic biology, expanding the applications of overlapping genes in gene stabilization and biocontainment.

Biological and medical sciences↗
DOE OSTI2021

Accurate and Accelerated Neuromorphic Network Design Leveraging A Bayesian Hyperparameter Pareto Optimization Approach

Neuromorphic systems allow for extremely efficient hardware implementations for neural networks (NNs). In recent years, several algorithms have been presented to train spiking NNs (SNNs) for neuromorphic hardware. However, SNNs often provide lower accuracy than their artificial NNs (ANNs) counterparts or require computationally expensive and slow training/inference methods. To close this gap, designers typically rely on reconfiguring SNNs through adjustments in the neuron/synapse model or training algorithm itself. Nevertheless, these steps incur significant design time, while still lacking the desired improvement in terms of training/inference times (latency). Designing SNNs that can mimic the accuracy of ANNs with reasonable training times is an exigent challenge in neuromorphic computing. In this work, we present an alternative approach that looks at such designs as an optimization problem rather than algorithm or architecture redesign. We develop a versatile multiobjective hyperparameter optimization (HPO) for automatically tuning HPs of two state-of-the-art SNN training algorithms, SLAYER and HYBRID. We emphasize that, to the best of our knowledge, this is the first work trying to improve SNNs’ computational efficiency, accuracy, and training time using an efficient HPO. We demonstrate significant performance improvements for SNNs on several datasets without the need to redesign or invent new training algorithms/architectures. Our approach results in more accurate networks with lower latency and, in turn, higher energy efficiency than previous implementations. In particular, we demonstrate improvement in accuracy and more than 5× reduction in the training/inference time for the SLAYER algorithm on the DVS Gesture dataset. In the case of HYBRID, we demonstrate 30% reduction in timesteps while surpassing the accuracy of the state-of-the-art networks on CIFAR10. Further, our analysis suggests that even a seemingly minor change in HPs could change the accuracy by 5 - 6×.

Parsa, Maryam↗
DOE OSTI2022

Enabling New Flexibility in the SUNDIALS Suite of Nonlinear and Differential/Algebraic Equation Solvers

In recent years, the SUite of Nonlinear and DIfferential/ALgebraic equation Solvers (SUNDIALS) has been redesigned to better enable the use of application-specific and third-party algebraic solvers and data structures. Throughout this work, we have adhered to specific guiding principles that minimized the impact to current users while providing maximum flexibility for later evolution of solvers and data structures. The redesign was done through the addition of new linear and nonlinear solvers classes, enhancements to the vector class, and the creation of modern Fortran interfaces. The vast majority of this work has been performed “behind-the-scenes,” with minimal changes to the user interface and no reduction in solver capabilities or performance. These changes allow SUNDIALS users to more easily utilize external solver libraries and create highly customized solvers, enabling greater flexibility on extreme-scale, heterogeneous computational architectures.

97 MATHEMATICS AND COMPUTING↗