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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 271 records · Page 15
All sourcesNASA NTRSDOE OSTI
DOE OSTI2013

RTOG 0913: A Phase 1 Study of Daily Everolimus (RAD001) in Combination With Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma

Purpose: To determine the safety of the mammalian target of rapamycin inhibitor everolimus (RAD001) administered daily with concurrent radiation and temozolomide in newly diagnosed glioblastoma patients. Methods and Materials: Everolimus was administered daily with concurrent radiation (60 Gy in 30 fractions) and temozolomide (75 mg/m{sup 2} per day). Everolimus was escalated from 2.5 mg/d (dose level 1) to 5 mg/d (dose level 2) to 10 mg/d (dose level 3). Adjuvant temozolomide was delivered at 150 to 200 mg/m{sup 2} on days 1 to 5, every 28 days, for up to 12 cycles, with concurrent everolimus at the previously established daily dose of 10 mg/d. Dose escalation continued if a dose level produced dose-limiting toxicities (DLTs) in fewer than 3 of the first 6 evaluable patients. Results: Between October 28, 2010, and July 2, 2012, the Radiation Therapy Oncology Group 0913 protocol initially registered a total of 35 patients, with 25 patients successfully meeting enrollment criteria receiving the drug and evaluable for toxicity. Everolimus was successfully escalated to the predetermined maximum tolerated dose of 10 mg/d. Two of the first 6 eligible patients had a DLT at each dose level. DLTs included gait disturbance, febrile neutropenia, rash, fatigue, thrombocytopenia, hypoxia, ear pain, headache, and mucositis. Other common toxicities were grade 1 or 2 hypercholesterolemia and hypertriglyceridemia. At the time of analysis, there was 1 death reported, which was attributed to tumor progression. Conclusions: Daily oral everolimus (10 mg) combined with both concurrent radiation and temozolomide followed by adjuvant temozolomide is well tolerated, with an acceptable toxicity profile. A randomized phase 2 clinical trial with mandatory correlative biomarker analysis is currently under way, designed to both determine the efficacy of this regimen and identify molecular determinants of response.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2020

Beam characterization at NSRL for radiobiological experiments—phase 1

An experimental campaign was carried out at the NASA Space Radiation Laboratory to perform an additional, independent dosimetric characterization of the beams of protons, helium and carbon ions for radiobiological experiments. The campaign was undertaken by the request and with the support from the National Cancer Institute, U.S. In this initial phase, the goals were to obtain a first assessment of the dosimetric reproducibility of the beam control system, including analysis of spatial homogeneity and evaluation of ion beam contamination. They should facilitate the design of further experimental campaigns for beam characterization for radiobiological experiments. Measurements included reference dosimetry with comparison of in-house and external ionization chambers and electrometers, lateral-dose profile measurements in air, depth-dose profile in a water tank, evaluation of water equivalent thickness of a HDPE binary range shifter and estimation of impurities of the investigated helium-ion beam. The experiments and results are presented.

43 PARTICLE ACCELERATORS↗
NASA NTRS1974

TDRSS telecommunications study. Phase 1: Final report

A parametric analysis of the telecommunications support capability of the Tracking and Data Relay Satellite System (TDRSS) was performed. Emphasis was placed on maximizing support capability provided to the user while minimizing impact on the user spacecraft. This study evaluates the present TDRSS configuration as presented in the TDRSS Definition Phase Study Report, December 1973 to determine potential changes for improving the overall performance. In addition, it provides specifications of the user transponder equipment to be used in the TDRSS.

Cahn, C. R.↗
DOE OSTI2014

Project Entitled "Developing a Mobile Torrefaction Machine" (STTR Phase 1 Final Technical Report)

The goal of this project, sponsored by Agri-Tech Producers, LLC (ATP), the small business grantee, was to determine if the torrefaction technology, developed by North Carolina State University (NCSU), which ATP has licensed, could be feasibly deployed in a mobile unit. The study adds to the area investigated, by having ATP’s STTR Phase I team give thoughtful consideration to how to use NCSU’s technology in a mobile unit. The findings by ATP’s team were that NCSU’s technology would best perform in units 30’ by 80’ (See Spec Sheet for the Torre-Tech 5.0 Unit in the Appendix) and the technical effectiveness and economic feasibility investigation suggested that such units were not easily, efficiently or safely utilized in a forest or farm setting. (Note rendering of possible mobile system in the Appendix) Therefore, the findings by ATP’s team were that NCSU’s technology could not feasibly be deployed as a mobile unit.

09 BIOMASS FUELS↗
NASA NTRS1972

Monitoring of Air Pollution by Satellites (MAPS), phase 1

Results are reported upon which the design of a satellite remote gas filter correlation (RGFC) instrument can be based. Although a final decision about the feasibility of measuring some of the pollutants with the required accuracy is still outstanding and subject to further theoretical and experimental verifications, viable concepts are presented which permit the initiation of the design phase. The pollutants which are of concern in the troposphere and stratosphere were selected. The infrared bands of these pollutants were identified, together with the bands of interfering gases, and the line parameters of the pollutants as well as interfering gases were generated through a computer program. Radiative transfer calculations (line-by-line) were made to establish the radiation levels at the top of the atmosphere and the signal levels at the detector of the RGFC instrument. Based upon these results the channels for the RGFC were selected. Finally, the problem areas, which need further investigations, were delineated and the supporting data requirements were established.

Ludwig, C. B.↗
NASA NTRS1977

DSS 13 automated antenna pointing subsystem phase 1 hardware

An automated antenna pointing subsystem (APS) is being installed at DSS 13 as part of the unattended station project. The function of the APS is to track an instructed position with the 26 meter antenna and to monitor the antenna servo system and meteorological conditions to ensure a proper operational environment. This article discusses the now-completed first phase of the digital hardware portion of the APS development.

Sievers, M. W.↗
DOE OSTI2022

Williston Basin Core-CM Initiative (Phase 1 Interim Report)

The Energy & Environmental Research Center (EERC) is leading the Williston Basin Coal Ore, Rare Earth Elements, and Critical Minerals (CORE-CM) Initiative, an initiative to drive the expansion and transformation of coal and coal-based resource usage within the Williston Basin to produce rare-earth elements (REEs), critical minerals (CMs), and nonfuel carbon-based products (NFCBPs). This project is the first phase in a long-term program and will set the stage for future work by assessing resource, market, technology, and infrastructure knowledge; identifying knowledge gaps; developing a series of plans to be carried out in future work; and initiating stakeholder engagement. Composed of several tasks, the project seeks to identify, characterize, and assess several necessary aspects vital to make this future work a reality.

01 COAL, LIGNITE, AND PEAT↗
NASA NTRS1991

Air-breathing hypersonic vehicle guidance and control studies; An integrated trajectory/control analysis methodology: Phase 1

A tool which generates optimal trajectory/control histories in an integrated manner is generically adapted to the treatment of single-stage-to-orbit air-breathing hypersonic vehicles. The methodology is implemented as a two point boundary value problem solution technique. Its use permits an assessment of an entire near-minimum-fuel trajectory and desired control strategy from takeoff to orbit while satisfying physically derived inequality constraints and while achieving efficient propulsive mode phasing. A simpler analysis strategy that partitions the trajectory into several boundary condition matched segments is also included to construct preliminary trajectory and control history representations with less computational burden than is required for the overall flight profile assessment. A demonstration was accomplished using a tabulated example (winged-cone accelerator) vehicle model that is combined with a newly developed multidimensional cubic spline data smoothing routine. A constrained near-fuel-optimal trajectory, imposing a dynamic pressure limit of 1000 psf, was developed from horizontal takeoff to 20,000 ft/sec relative air speed while aiming for a polar orbit. Previously unspecified propulsive discontinuities were located. Flight regimes demanding rapid attitude changes were identified, dictating control effector and closed-loop controller authority was ascertained after evaluating effector use for vehicle trim. Also, inadequacies in vehicle model representations and specific subsystem models with insufficient fidelity were determined based on unusual control characteristics and/or excessive sensitivity to uncertainty.

Hattis, Philip D.↗
DOE OSTI2018

Tribal Renewable Energy Report - Final Report: Bishop Paiute Tribe Residential Solar Program. Phase 1 (DOE Award # DE-EE0006949)

The objective of the project was to provide affordable renewable energy to 22 low income reservation homeowners; provide job training to tribal members and reduce air pollution by equivalent carbon offsets. The project exceeded grant objectives installing 66kW of rooftop solar on 22 low income single family homes and providing hands-on PV rooftop solar installation training to 24 tribal individuals (four more than planned). The project was a phased installment of an on-going partnership between the Tribe and GRID that was initiated in 2013 whereby 62 rooftop solar units were installed prior to this funded effort. The reported work in this report describes the funded effort where US Department of Energy provided partial funding through grant award IE0006949 and marks the first phase of an effort matching California Solar SASH Initiative funding with DOE Office of Indian Energy Funding and brings the total for the program to 84 installed systems (running total of 271 Kw installed) and the end of the project. Tribal workforce development was a key aspect of the project and trained 24tribal members for a total 1168 cumulative on-job training hours. The solar installations and training efforts were fully completed by September of 2016 with 66.6 kW installed - 8 kW more than the original estimate stated in the grant application.

14 SOLAR ENERGY↗
NASA NTRS1974

MIDAS, prototype Multivariate Interactive Digital Analysis System, Phase 1. Volume 2: Diagnostic system

The MIDAS System is a third-generation, fast, multispectral recognition system able to keep pace with the large quantity and high rates of data acquisition from present and projected sensors. A principal objective of the MIDAS Program is to provide a system well interfaced with the human operator and thus to obtain large overall reductions in turn-around time and significant gains in throughout. The hardware and software generated in Phase I of the over-all program are described. The system contains a mini-computer to control the various high-speed processing elements in the data path and a classifier which implements an all-digital prototype multivariate-Gaussian maximum likelihood decision algorithm operating 2 x 105 pixels/sec. Sufficient hardware was developed to perform signature extraction from computer-compatible tapes, compute classifier coefficients, control the classifier operation, and diagnose operation. Diagnostic programs used to test MIDAS' operations are presented.

Kriegler, F. J.↗
NASA NTRS1974

MIDAS, prototype Multivariate Interactive Digital Analysis System, phase 1. Volume 3: Wiring diagrams

The Midas System is a third-generation, fast, multispectral recognition system able to keep pace with the large quantity and high rates of data acquisition from present and projected sensors. A principal objective of the MIDAS Program is to provide a system well interfaced with the human operator and thus to obtain large overall reductions in turn-around time and significant gains in throughput. The hardware and software generated in Phase I of the overall program are described. The system contains a mini-computer to control the various high-speed processing elements in the data path and a classifier which implements an all-digital prototype multivariate-Gaussian maximum likelihood decision algorithm operating at 2 x 100,000 pixels/sec. Sufficient hardware was developed to perform signature extraction from computer-compatible tapes, compute classifier coefficients, control the classifier operation, and diagnose operation. The MIDAS construction and wiring diagrams are given.

Kriegler, F. J.↗
NASA NTRS1987

Long-life 3-axis satellite attitude sensing, phase 1

The purpose was to investigate the feasibility of new, moderate-cost, high reliability navigation sensors for high-altitude satellites, using stellar sources to obviate the use of gyroscopic devices. The primary investigation focused on the need for developing a star tracker model to replace an old star tracker which is still needed for current probe and satellite programs. One innovative element of the proposed star tracker was the design, development, and testing of technology components related to a phase scrambler plate. The purpose of the phase scrambler plate is to convert the impulse response of the optical system from a point image to a uniformly bright, square, angularly large, in-focus image of the star source. A collimated star source was built and tested. A breadboard star tracker with an 8 x 8 degree field of view was designed and built. It was tested in normal quad-cell mode (without the phase scrambler plate) and with the phase scrambler plate. Although the phase scrambler plate was crudely made, the performance of the star tracker breadboard was greatly improved using the phase scrambler plate, instead of system defocus. If further developed, the phase scrambler plate may be added as a low-cost retroconversion to any objective lens to greatly improve quad-cell or CCD array tracking; applications include star trackers, laser metrology, laser machining optics, and surveying instrumentation.

Arild, Tor↗
NASA NTRS1975

Future space transportation systems analysis study. Phase 1: Technical report, appendices

The transportation mass requirements developed for each mission and transportation mode were based on vehicle systems sized to fit the exact needs of each mission (i.e. rubber vehicles). The parametric data used to derive the mass requirements for each mission and transportation mode are presented to enable accommodation of possible changes in mode options or payload definitions. The vehicle sizing and functional requirements used to derive the parametric data will form the basis for conceptual configurations of the transportation elements in a later phase of study. An investigation of the weight growth approach to future space transportation systems analysis is presented. Parameters which affect weight growth, past weight histories, and the current state of future space-mission design are discussed. Weight growth factors of from 10 percent to 41 percent were derived for various missions or vehicles.

Source record↗
NASA NTRS1978

Study of aerodynamic technology for VSTOL fighter/attack aircraft, phase 1

A conceptual design study was performed of a vertical attitude takeoff and landing (VATOL) fighter/attack aircraft. The configuration has a close-coupled canard-delta wing, side two-dimensional ramp inlets, and two augmented turbofan engines with thrust vectoring capability. Performance and sensitivities to objective requirements were calculated. Aerodynamic characteristics were estimated based on contractor and NASA wind tunnel data. Computer simulations of VATOL transitions were performed. Successful transitions can be made, even with series post-stall instabilities, if reaction controls are properly phased. Principal aerodynamic uncertainties identified were post-stall aerodynamics, transonic aerodynamics with thrust vectoring and inlet performance in VATOL transition. A wind tunnel research program was recommended to resolve the aerodynamic uncertainties.

Driggers, H. H.↗
DOE OSTI2018

Employment Effects of Hydrogen and Fuel Cells: Phase 1 Report, Fuel Cell Electric Vehicles

This report describes employment impacts associated with the manufacture, distribution and sale (MDS) of light-duty fuel cell electric vehicles (FCEVs) under a mid-range scenario of market development and uptake. Termed “gross” employment, these estimates include direct and indirect, full-time and part-time jobs associated with manufacturing, distributing and selling FCEVs, but not the consequent reduction in employment resulting from reduced demand for conventional vehicles (i.e., displaced employment). The latter estimates are included in a forthcoming technical memorandum documenting Phase 2 of this study.

08 HYDROGEN↗
DOE OSTI2024

Measurement report: The Fifth International Workshop on Ice Nucleation phase 1 (FIN-01): intercomparison of single-particle mass spectrometers

Knowledge of the chemical composition and mixing state of aerosols at a single-particle level is critical for gaining insights into atmospheric processes. One common tool to make these measurements is single-particle mass spectrometry. There remains a need to compare the performance of different single-particle mass spectrometers (SPMSs). An intercomparison of SPMSs was conducted at the Aerosol Interaction and Dynamics in the Atmosphere (AIDA) chamber at the Karlsruhe Institute of Technology (KIT) in November 2014, as part of the first phase of the Fifth International Workshop on Ice Nucleation (FIN-01). In this paper we compare size distributions and mass spectra of atmospherically relevant particle types measured by five SPMSs. These include different minerals, desert and soil dusts, soot, bioaerosol (Snomax; protein granule), secondary organic aerosol (SOA), and SOA-coated mineral particles. Most SPMSs reported similar vacuum aerodynamic diameter (d va ) within typical instrumental ranges from ~100–200 nm (lower limit) to ~2–3 µm (upper limit). In general, all SPMSs exhibited a wide dynamic range (up to ~10 3 ) and high signal-to-noise ratio (up to ~10 4 ) in mass spectra. Common spectral features with small diversities in mass spectra were found with high average Pearson's correlation coefficients, i.e., for average positive spectra r avg-pos =0.74 ± 0.12 and average negative spectra r avg-neg =0.67 ± 0.22. We found that instrument-specific detection efficiency (DE) was more dependent on particle size than particle type, and particle identification favored the use of bipolar, rather than monopolar, instruments. Particle classification from “blind experiments” showed that all instruments differentiated SOA, soot, and soil dust and detected subtle changes in the particle internal mixing but had difficulties differentiating among specific mineral types and dusts. This study helps to further understand the capabilities and limitations of the single-particle mass spectrometry technique in general and the specific performance of the instrument in characterizing atmospheric aerosol particles.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2014

Predictors of Rectal Tolerance Observed in a Dose-Escalated Phase 1-2 Trial of Stereotactic Body Radiation Therapy for Prostate Cancer

Purpose: To convey the occurrence of isolated cases of severe rectal toxicity at the highest dose level tested in 5-fraction stereotactic body radiation therapy (SBRT) for localized prostate cancer; and to rationally test potential causal mechanisms to guide future studies and experiments to aid in mitigating or altogether avoiding such severe bowel injury. Methods and Materials: Clinical and treatment planning data were analyzed from 91 patients enrolled from 2006 to 2011 on a dose-escalation (45, 47.5, and 50 Gy in 5 fractions) phase 1/2 clinical study of SBRT for localized prostate cancer. Results: At the highest dose level, 6.6% of patients treated (6 of 91) developed high-grade rectal toxicity, 5 of whom required colostomy. Grade 3+ delayed rectal toxicity was strongly correlated with volume of rectal wall receiving 50 Gy >3 cm{sup 3} (P<.0001), and treatment of >35% circumference of rectal wall to 39 Gy (P=.003). Grade 2+ acute rectal toxicity was significantly correlated with treatment of >50% circumference of rectal wall to 24 Gy (P=.010). Conclusion: Caution is advised when considering high-dose SBRT for treatment of tumors near bowel structures, including prostate cancer. Threshold dose constraints developed from physiologic principles are defined, and if respected can minimize risk of severe rectal toxicity.

62 RADIOLOGY AND NUCLEAR MEDICINE↗