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At least 271 records · Page 15

Oculometric Analysis of Saccadic Compensation for Visual Motion Processing Impairment due to Alcohol and Sleep Disruption

The Visuomotor Control Laboratory at Ames Research Center has developed a 5-minute ocular tracking test that computes 21 largely independent metrics of visuomotor performance, reflecting neural signal processing along a number of distinct pathways through cortex, brainstem, and cerebellum. Human sensorimotor performance is resilient to the challenges and stressors of many operational environments, in part, because overall performance is achieved through multiple parallel systems. Our multidimensional oculometrics allow us to examine impacts on these sub-components separately. To illustrate this, we contrasted the effects of two mild neural stressors, acute sleep-deprivation and low-dose alcohol. We have previously shown that, in both cases, oculometric analysis is a highly sensitive indicator of impairment. Here we quantified not only the observed impact on the performance of one sub-system, smooth pursuit, which uses high-level cortical processing of visual motion to track a moving object, but also the observed (partial) compensation by an evolutionarily older mid-brain and brainstem subsystem, saccades, which generates jumps in eye position to catch up with the target when smooth pursuit is inadequate. Specifically, we examined the dose-response (effect size vs. dose size) of the ground lost (pursuit deficit) and the ground recouped (saccadic compensation) across three separate studies – acute low-dose alcohol administration (16 subjects), acute sleep loss (12 subjects), and acute sleep loss with caffeine intervention (9 subjects). We computed the dose-response slopes using linear regression. The figure below shows that, in the case of acute sleep deprivation, the resulting slopes for ground lost and ground recouped (mean ± SE across subjects) were significantly different (paired t-test, t(11) = 5.17, p < 0.001), indicating poor saccadic compensation. However, when sleep loss was coupled with caffeine ingestion, ground lost was decreased and ground recouped increased such that the slopes were no longer different (t(8) = -0.05, p = 0.965). With alcohol, the two slopes were large albeit not significantly different (t(15) = 0.96, p = 0.351), indicating significant pursuit impairment but effective saccadic compensation. Our findings show that sleep deprivation and alcohol affect oculomotor performance differently. Low-dose alcohol effects appear predominantly cortical, with effective brainstem compensation. Sleep loss and circadian disruption however appears to affect both cortical and brainstem pathways with caffeine providing an effective countermeasure to both effects. Beyond the mere detection of impairment, our oculometric assessment allows us to characterize the nature of the deficit, to provide insight into the neural substrate, and to assess the effectiveness of countermeasures.

pursuit↗

Is the Last Inflight Rest Break Really the Best?

As pilots experienced in augmented long-haul flights know, current FAA regulations limit options for scheduling in-flight rest periods, such that on many long-haul operations the landing pilot needs to use the final bunk period, closest to top of descent (TOD). However, the logistics of a particular flight (e.g., timing of the flight, timing of passenger service) and the pilot’s own physiology may mean that the last rest break isn’t always the best. To study this, we conducted a large survey of pilots flying these operations. Pilots completed the survey after eligible flights and provided us with information on which rest break they used, how much sleep they received, factors that disrupted sleep and ratings on the quality of their sleep, and they also provided fatigue and alertness ratings at top-of-descent. Pilots from another US-based carrier were also surveyed, in collaboration with our research partners at Washington State University, to increase the sample size and gather insights between operations.

in-flight rest↗

A New Class of Flares from Accreting Supermassive Black Holes

Accreting supermassive black holes (SMBHs) can exhibit variable emission across the electromagnetic spectrum and over a broad range of timescales. The variability of active galactic nuclei (AGNs) in the ultraviolet and optical is usually at the few tens of per cent level over timescales of hours to weeks1. Recently, rare, more dramatic changes to the emission from accreting SMBHs have been observed, including tidal disruption events2,3,4,5, ‘changing look’ AGNs6,7,8,9 and other extreme variability objects10,11. The physics behind the ‘re-ignition’, enhancement and ‘shut-down’ of accretion onto SMBHs is not entirely understood. Here we present a rapid increase in ultraviolet–optical emission in the centre of a nearby galaxy, marking the onset of sudden increased accretion onto a SMBH. The optical spectrum of this flare, dubbed AT 2017bgt, exhibits a mix of emission features. Some are typical of luminous, unobscured AGNs, but others are likely driven by Bowen fluorescence—robustly linked here with high-velocity gas in the vicinity of the accreting SMBH. The spectral features and increased ultraviolet flux show little evolution over a period of at least 14 months. This disfavours the tidal disruption of a star as their origin, and instead suggests a longer-term event of intensified accretion. Together with two other recently reported events with similar properties, we define a new class of SMBH-related flares. This has important implications for the classification of different types of enhanced accretion onto SMBHs.

Benny Trakhtenbrot↗

A Rapid change in x-ray variability and a jet ejection in the black hole transient MAXI J1820+070

We present Neutron Star Interior Composition Explorer X-ray and Arcminute Microkelvin Imager Large Array radio observations of a rapid hard-to-soft state transition in the black hole X-ray transient MAXI J1820+070. During the transition from the hard state to the soft state a switch between two particular types of quasiperiodic oscillations (QPOs) was seen in the X-ray power density spectra, from type-C to type-B, along with a drop in the strength of the broadband X-ray variability and a brief flare in the 7–12 keV band. Soon after this switch (∼2–2.5 hr) a strong radio flare was observed that corresponded to the launch of superluminal ejecta. Although hints of a connection between QPO transitions and radio flares have been seen in other black hole X-ray transients, our observations constitute the strongest observational evidence to date for a link between the appearance of type-B QPOs and the launch of discrete jet ejections.

Jeroen Homan↗

Establishing and Maintaining Healthy Sleep

The purpose of this presentation is to provide information on healthy sleep to the entire NASA workforce. This presentation is part of the Office of the Chief Health and Medical Officer Journey to Wellness series. I will describe how sleep works, what constitutes normal sleep, sleep hygiene, tips for shiftworkers, and how to recognize sleep disorders.

health↗

Perspectives on flood forecast-based early action and opportunities for Earth observations

This paper seeks to identify opportunities to integrate Earth observations (EO) into flood forecast-based early action and propose future directions for research and collaboration between EO and humanitarian communities. Forecast-based early action (FbA) is an approach to shift disaster response toward anticipation to mitigate impacts to at-risk communities; however, timely and accurate information is needed in the development of data-based triggers and thresholds for action. Therefore, this paper considers the readiness of a wide range of EO for flood monitoring and forecasting in the design, operations, and evaluation phases of FbA. The most significant opportunities for EO to inform FbA efforts lie in the design and evaluation phases, as EO can aid in the development of impact-based triggers. The EO products most readily applicable include precipitation, streamflow estimates, and exposure mapping, and those requiring the greatest amount of further research include vulnerability and impact assessments. This paper identifies collaboration opportunities for the EO and humanitarian communities to create tailored products, such as overlays combining flood extents with exposure maps. Such collaboration opportunities can be fostered by open data sharing, data verification efforts, and incentives for supporting boundary organizations capable of enabling the use of EO for FbA.

disasters↗

Implications of the Warm Corona and Relativistic Reflection Models for the Soft Excess in Mrk 509

We present the analysis of the first Nuclear Spectroscopic Telescope Array observations (∼220 ks), simultaneous with the last Suzaku observations (∼50 ks), of the active galactic nucleus of the bright Seyfert 1 galaxy Mrk 509. The time-averaged spectrum in the 1–79 keV X-ray band is dominated by a power-law continuum (Γ ∼ 1.8–1.9), a strong soft excess around 1 keV, and signatures of X-ray reflection in the form of Fe K emission (∼6.4 keV), an Fe K absorption edge (∼7.1 keV), and a Compton hump due to electron scattering (∼20–30 keV). We show that these data can be described by two very different prescriptions for the soft excess: a warm (kT ∼ 0.5–1 keV) and optically thick (τ ∼ 10–20) Comptonizing corona or a relativistically blurred ionized reflection spectrum from the inner regions of the accretion disk. While these two scenarios cannot be distinguished based on their fit statistics, we argue that the parameters required by the warm corona model are physically incompatible with the conditions of standard coronae. Detailed photoionization calculations show that even in the most favorable conditions, the warm corona should produce strong absorption in the observed spectrum. On the other hand, while the relativistic reflection model provides a satisfactory description of the data, it also requires extreme parameters, such as maximum black hole spin, a very low and compact hot corona, and a very high density for the inner accretion disk. Deeper observations of this source are thus necessary to confirm the presence of relativistic reflection and further understand the nature of its soft excess.

Javier Garcia↗

Climate Predicts Geographic and Temporal Variation in Mosquito-Borne Disease Dynamics on Two Continents

Climate drives population dynamics through multiple mechanisms, which can lead to seemingly context-dependent effects of climate on natural populations. For climate-sensitive diseases such as dengue, chikungunya, and Zika, climate appears to have opposing effects in different contexts. Here we show that a model, parameterized with laboratory measured climate-driven mosquito physiology, captures three key epidemic characteristics across ecologically and culturally distinct settings in Ecuador and Kenya: the number, timing, and duration of outbreaks. The model generates a range of disease dynamics consistent with observed Aedes aegypti abundances and laboratory-confirmed arboviral incidence with variable accuracy (28–85% for vectors, 44–88%for incidence). The model predicted vector dynamics better in sites with a smaller proportion of young children in the population, lower mean temperature, and homes with piped water and made of cement. Models with limited calibration that robustly capture climate-virus relationships can help guide intervention efforts and climate change disease projections.

Climate-change ecology↗

The Multiplanet System TOI-421: A Warm Neptune and a Super Puffy Mini-Neptune Transiting a G9 V Star in a Visual Binary

We report the discovery of a warm Neptune and a hot sub-Neptune transiting TOI-421 (BD-14 1137, TIC 94986319), a bright (V = 9.9) G9 dwarf star in a visual binary system observed by the Transiting Exoplanet Survey Satellite (TESS) space mission in Sectors 5 and 6. We performed ground-based follow-up observations—comprised of Las Cumbres Observatory Global Telescope transit photometry, NIRC2 adaptive optics imaging, and FIbre-fed Echellé Spectrograph, CORALIE, High Accuracy Radial velocity Planet Searcher, High Resolution Échelle Spectrometer, and Planet Finder Spectrograph high-precision Doppler measurements—and confirmed the planetary nature of the 16 day transiting candidate announced by the TESS team. We discovered an additional radial velocity signal with a period of five days induced by the presence of a second planet in the system, which we also found to transit its host star. We found that the inner mini-Neptune, TOI-421 b, has an orbital period of P(b) = 5.19672 ± 0.00049 days, a mass of M(b) = 7.17 ± 0.66 Mꚛ, and a radius of R(b) = 2.68 (+0.19,-0.18) Rꚛ, whereas the outer warm Neptune, TOI-421 c, has a period of P(c) = 16.06819 ± 0.00035 days, a mass of M(c) = 16.42 (+1.06,-1.04) Mꚛ, a radius of R(c) = 5.09{+0.16,-0.15) Rꚛ, and a density of ρ(c) = 0.685 (+0.080,-0.072) g/cu. cm. With its characteristics, the outer planet (ρ(c) = .685 {+0.080,-0.072) g/cu cm) is placed in the intriguing class of the super-puffy mini-Neptunes. TOI-421 b and TOI-421 c are found to be well-suited for atmospheric characterization. Our atmospheric simulations predict significant Lyα transit absorption, due to strong hydrogen escape in both planets, as well as the presence of detectable CH4 in the atmosphere of TOI-421 c if equilibrium chemistry is assumed.

Ilaria Carleo↗