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DOE OSTI2021

Shotgun Immunoproteomic Approach for the Discovery of Linear B-Cell Epitopes in Biothreat Agents Francisella tularensis and Burkholderia pseudomallei

Peptide-based subunit vaccines are coming to the forefront of current vaccine approaches, with safety and cost-effective production among their top advantages. Peptide vaccine formulations consist of multiple synthetic linear epitopes that together trigger desired immune responses that can result in robust immune memory. The advantages of linear compared to conformational epitopes are their simple structure, ease of synthesis, and ability to stimulate immune responses by means that do not require complex 3D conformation. Prediction of linear epitopes through use of computational tools is fast and cost-effective, but typically of low accuracy, necessitating extensive experimentation to verify results. On the other hand, identification of linear epitopes through experimental screening has been an inefficient process that requires thorough characterization of previously identified full-length protein antigens, or laborious techniques involving genetic manipulation of organisms. In this study, we apply a newly developed generalizable screening method that enables efficient identification of B-cell epitopes in the proteomes of pathogenic bacteria. As a test case, we used this method to identify epitopes in the proteome of Francisella tularensis (Ft), a Select Agent with a well-characterized immunoproteome. Our screen identified many peptides that map to known antigens, including verified and predicted outer membrane proteins and extracellular proteins, validating the utility of this approach. We then used the method to identify seroreactive peptides in the less characterized immunoproteome of Select Agent Burkholderia pseudomallei (Bp). This screen revealed known Bp antigens as well as proteins that have not been previously identified as antigens. Although B-cell epitope prediction tools Bepipred 2.0 and iBCE-EL classified many of our seroreactive peptides as epitopes, they did not score them significantly higher than the non-reactive tryptic peptides in our study, nor did they assign higher scores to seroreactive peptides from known Ft or Bp antigens, highlighting the need for experimental data instead of relying on computational epitope predictions alone. The present workflow is easily adaptable to detecting peptide targets relevant to the immune systems of other mammalian species, including humans (depending upon the availability of convalescent sera from patients), and could aid in accelerating the discovery of B-cell epitopes and development of vaccines to counter emerging biological threats.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1980

Space Borne Event Timer

The Space Borne Event Timer is a part of the NASA laser ranging system that is intended to operate aboard the Space Shuttle orbiting over California. The object is to measure, by laser ranging, the earth movement along the San Andreas fault and possibly forecast future earthquakes. A number of cube reflector targets will be placed along both sides of the fault. The ranging system aboard the Space Shuttle will fire a burst of laser pulses at each target and detect the reflected light. Time differences between pulses from the two sides of the fault will indicate earth displacements. The Space Borne Event Timer is a CAMAC compatible system that provides extremely accurate timing data and controls the operation of the ranging system. For each event the time is given in 19.53 increments from the instant of firing the laser to the instant the reflected light is received back, within a range of 130 days.

Turko, B.↗

NASA NTRS1984

Einstein observations of selected close binaries and shell stars

Several evolved close binaries and shell stars were observed with the IPC aboard the HEAO 2 Einstein Observatory. No eclipsing target was detected, and only two of the shell binaries were detected. It is argued that there is no substantial difference in L(X) for eclipsing and non-eclipsing binaries. The close binary and shell star CX Dra was detected as a moderately strong source, and the best interpretation is that the X-ray flux arises primarily from the corona of the cool member of the binary at about the level of Algol-like or RS CVn-type sources. The residual visible-band light curve of this binary has been modeled so as to conform as well as possible with this interpretation. HD 51480 was detected as a weak source. Substantial background information from IUE and ground scanner measurements are given for this binary. The positions and flux values of several accidentally detected sources are given.

Guinan, E. F.↗

NASA NTRS1986

Comparison of the 1984 and 1985 AIS data over the Singatse Range (Yerington), Nevada

The Singatse Range is composed of a series of 53 types of volcanic, plutonic, metamorphic, and sedimentary rocks. In addition the Jurassic plutonic rocks are also of economic interest for their copper mineralization which is contained in a porphyry dike swarm. The 1984 and 1985 flight results from the Airborne Imaging Spectrometer (AIS) instrument flown in the NASA/JPL C-130 aircraft are contrasted and compared. The 1984 data are less noisy than the 1985, in which many sets of vertical stripings from bad detectors can be seen. Significantly however, enough of the hydrothermal alteration patterns can be seen in each line at the mutual crossing points that one can say that the specific targets were detected in both year's flights. The spectra of both years are corrupted by the second-order effect from the grating, but 0-H bond absorption at essentially correct wavelengths for sericite and/or kaolinite can be seen.

Lyon, R. J. P.↗

NASA NTRS1990

Networks for image acquisition, processing and display

The human visual system comprises layers of networks which sample, process, and code images. Understanding these networks is a valuable means of understanding human vision and of designing autonomous vision systems based on network processing. Ames Research Center has an ongoing program to develop computational models of such networks. The models predict human performance in detection of targets and in discrimination of displayed information. In addition, the models are artificial vision systems sharing properties with biological vision that has been tuned by evolution for high performance. Properties include variable density sampling, noise immunity, multi-resolution coding, and fault-tolerance. The research stresses analysis of noise in visual networks, including sampling, photon, and processing unit noises. Specific accomplishments include: models of sampling array growth with variable density and irregularity comparable to that of the retinal cone mosaic; noise models of networks with signal-dependent and independent noise; models of network connection development for preserving spatial registration and interpolation; multi-resolution encoding models based on hexagonal arrays (HOP transform); and mathematical procedures for simplifying analysis of large networks.

Ahumada, Albert J., Jr.↗

NASA NTRS1993

Charged particle activation studies on the surface of LDEF spacecraft

High energy proton induced nuclear reaction products are examined using seven elements, namely, Aluminum, Silicon, Nickel, Copper, Zirconium, Tantalum, and Tungsten. The samples were in the form of plates, 2 x 2 x 1/8 inches. Activities due to Na-22 from Al, Co-56 and Co-57 from Ni, Co-58 from Cu, and Y-88 from Zr targets were detected. No induced activity was observed in Si, Ta, and W, most probably due to the long cooling times. Only the Zr sample contained a weak Be-7 peak, although Ta and W were also located at the leading edge of the spacecraft. Gamma-rays of individual isotopes were measured using high-resolution Ge(Li) solid state detector coupled to 4096-multichannel analyzer. Activities were calculated for Co-56 (846 keV) and Co-57 (122 and 136 keV's) at the time of the entry of the spacecraft and found to be 0.014 plus or minus 0.005 c/sec. g, 0.018 plus or minus 0.002 c/sec. g, and 0.0024 plus or minus 0.0007 c/sec. g, respectively.

Olmez, Ilhan↗

NASA NTRS1992

Radio and X-ray emission from main-sequence K stars

A small VLA radio continuum survey of 12 selected active, main-sequence K stars is presented. The targets are uniformly distributed between spectral types K0 and K8; five are single stars, five are spectroscopic binaries, and two are visual binaries. All targets are within 25 pc and were selected based on strong X-rays, rapid rotation, or strong Ca II emission lines. Seven targets were detected at the observing frequency of 8.5 GHz (3.6 cm), while sensitive upper limits are reported for the nondetections. The radio luminosities are comparable to active M dwarfs. Radio and X-ray luminosities LR and LX fulfil a relation that was previously found for M dwarfs, with LR varies as LX over 3 orders of magnitude. We further find that the more rapidly rotating K dwarfs are stronger radio emitters, irrespective of spectral type.

Gudel, M.↗

NASA NTRS1992

Real-time processor for staring receivers

The design, fabrication, and testing of a state-of-the-art, high-throughput on-focal plane IR-image signal processor is described. The processing functions performed are frame differencing and thresholding. The final focal plane array will consist of a 128 x 128-pixel platinum-silicide detector bump-mounted to an on-chip CCD multiplexer. The processor is in a 128-channel parallel-pipeline format. Each channel consists of a pixel regenerator (charge differencer), 128-pixel frame store CCD memory, pixel differencer, second pixel regenerator, thresholder (analog comparator), and digital latch. Four parallel analog outputs and four parallel digital outputs are included. The digital outputs provide a bit map of the image. All analog clock signals (128 KHz, 256 KHz, and 5 MHz) are generated by on-chip TTL-input clock drivers. TTL clock driver inputs are generated off-chip. The technology is low-temperature surface and buried channel CCD/CMOS/indium bump. The design goal was 8-bit resolution at 77 K and 1000 frames/s. Applications include point- or extended-target motion detection with thresholding. Design trade-offs and enhancements (such as on-chip detector gain compensation and a simple window processor) are discussed.

Hanzal, Brian↗

NASA NTRS1999

A Second-Generation Volatile Organic Analyzer for the International Space Station

Early in the development of the Crew Health Care System (CHECS) for the International Space Station (ISS), it was recognized that detection of target volatile organic compounds would be a key component of the air monitoring strategy. Experiences during the NASA/Mir program supported the decision to include a real-time volatile organic analyzer (VOA) aboard ISS to help assess the impact of air quality events on crew health and determine the effectiveness of decontamination efforts. Toward this end, a joint development by the Toxicology Laboratory at Johnson Space Center and Graseby Dynamics produced a VOA that has been delivered and is ready for the first 5 years of ISS operation. The first-generation VOA selection criteria included minimizing size, weight, and power consumption while maintaining analytical performance. Measuring available technologies against these criteria, a VOA system based upon gas chromatography/ion mobility spectrometry (GC/IMS) was selected in the mid-90's. However, as NASA looks forward to later-stage ISS operations and to new frontiers such as human exploration of Mars, the ISS VOA (weighing 43 kg and consuming 160 watts) must be replaced by a smaller, less resource-intensive device. This paper will present a possible second-gene ration VOA based upon the same technology as the first-generation unit. Utilizing GC/IMS technology again will permit the instrumental data and experience gained during the initial phase of ISS to be applied to later ISS phases and advanced spacecraft missions. During the past 3 years, efforts to reduce the size of ion mobility spectrometers have been pursued by Graseby Dynamics, the manufacturer of the first-generation VOA. The concept of operation, expected analytical performance, and estimated size of a fully functional second-generation VOA based upon GC/mini-IMS technology will be presented. Furthermore, results of initial laboratory evaluations will be shown.

Limero, Thomas↗

NASA NTRS2002

The Star Formation History of Orion and its Environs

During the Winter and Fall 2001 observing campaigns, we obtained multifilter photometry using the Quest camera on the 1mt Schmidt of the Venezuelan National Observatory, to continue the survey of the Orion clouds. In the Winter 2001 season, we obtained photometry for 9 scans at DEC=+5, 3 scans at DEC=-5, and 2 scans at DEC=-3, while 2 additional scans at DEC=-3 were obtained during the Fall 2001 observing campaign (the width of each scan is 2.3 arc minutes). The photometric survey has not been completed this season because the instrument was damaged by lightening on Sep 2001 and operations were suspended until Dec 2001. Observations are still under way. Nonetheless, we have enough scans at -3 and +5 to start selecting candidates for spectroscopic follow up on the next season. Spectra of more than 300 objects was obtained with the FAST spectrograph on the Mt Hopkins 48 inch telescope during observing campaigns Jan-March 2001, and Oct-Dec 2001. Bad weather prevented observations with Hydra on the WIYN telescope on KPNO in Jan 2001. The FAST spectra are been analyzed to select the young population of the regions. Observations in the JHKL bands were obtained for a sample of 20-30 objects in Ori Ia and Ib from scan centered at DEC=-l, with the StellIRCam on the Mt Hopkins 48 inch telescope on Nov 2001. L band observations will be effective for picking up objects surrounded by accretion disks, in which inner disk holes prevent having any excess at shorter wavelength bands. Observations at 10 micrometers and 18 micrometers were obtained in que mode for a sample of 20 objects in Ori Ia and Ib in the same regions as the near IR photometry with the Gemini-South telescope. These new data is presently been reduced and analyzed, together with data from the observing campaigns of 2000. Analysis of Hydra fields at strips centered at DEC=-1 and +1 have confirmed 105 more candidates as low mass pre-main sequence objects. In addition, every target was detected at 10 micrometers and a few at 18 micrometers. With these data, combined with our optical and JHKL photometry, we will construct spectral energy distributions. This will allow us to begin studying the structure of disks around low mass T Tauri stars in the distributed population of the Orion clouds, for direct comparison with that of Taurus. Ours is the first determination of the infrared emission of protoplanetary disks around low mass stars in the Orion region.

Calvet, Nuria↗

NASA NTRS1982

Multispectral Photography

Model II Multispectral Camera is an advanced aerial camera that provides optimum enhancement of a scene by recording spectral signatures of ground objects only in narrow, preselected bands of the electromagnetic spectrum. Its photos have applications in such areas as agriculture, forestry, water pollution investigations, soil analysis, geologic exploration, water depth studies and camouflage detection. The target scene is simultaneously photographed in four separate spectral bands. Using a multispectral viewer, such as their Model 75 Spectral Data creates a color image from the black and white positives taken by the camera. With this optical image analysis unit, all four bands are superimposed in accurate registration and illuminated with combinations of blue green, red, and white light. Best color combination for displaying the target object is selected and printed. Spectral Data Corporation produces several types of remote sensing equipment and also provides aerial survey, image processing and analysis and number of other remote sensing services.

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NASA NTRS2005

Detection of small, slow ground targets using Synthetic Aperture Radar

Synthetic aperture radar (SAR) along-track interferometry (ATI) is a technique for sensing Earth-surface motion. The technique involves interferometrically combining data from two radar images acquired from phase centers separated along the platform flight track.

Synthetic Aperture Radar↗

NASA NTRS2007

Phototransistors Development and their Applications to Lidar

Custom-designed two-micron phototransistors have been developed using Liquid Phase Epitaxy (LPE), Molecular Beam Epitaxy (MBE) and Metal-Organic Chemical Vapor Deposition (MOCVD) techniques under Laser Risk Reduction Program (LRRP). The devices were characterized in the Detector Characterization Laboratory at NASA Langley Research Center. It appears that the performance of LPE- and MBE-grown phototransistors such as responsivity, noise-equivalent-power, and gain, are better than MOCVD-grown devices. Lidar tests have been conducted using LPE and MBE devices under the 2-micrometer CO2 Differential Absorption Lidar (DIAL) Instrument Incubator Program (IIP) at the National Center for Atmospheric Research (NCAR), Boulder, Colorado. The main focus of these tests was to examine the phototransistors performances as compared to commercial InGaAs avalanche photodiode by integrating them into the Raman-shifted Eye-safe Aerosol Lidar (REAL) operating at 1.543 micrometers. A simultaneous measurement of the atmospheric backscatter signals using the LPE phototransistors and the commercial APD demonstrated good agreement between these two devices. On the other hand, simultaneous detection of lidar backscatter signals using MBE-grown phototransistor and InGaAs APD, showed a general agreement between these two devices with a lower performance than LPE devices. These custom-built phototransistors were optimized for detection around 2-micrometer wavelength while the lidar tests were performed at 1.543 micrometers. Phototransistor operation at 2-micron will improve the performance of a lidar system operating at that wavelength. Measurements include detecting hard targets (Rocky Mountains), atmospheric structure consisting of cirrus clouds and boundary layer. These phototransistors may have potential for high sensitivity differential absorption lidar measurements of carbon dioxide and water vapor at 2.05-micrometers and 1.9-micrometers, respectively.

Abedin, M. N.↗

NASA NTRS2010

Fluorogenic Cell-Based Biosensors for Monitoring Microbes

Fluorogenic cell-based sensor systems for detecting microbes (especially pathogenic ones) and some toxins and allergens are undergoing development. These systems harness the natural signaltransduction and amplification cascades that occur in mast cells upon activation with antigens. These systems include (1) fluidic biochips for automated containment of samples, reagents, and wastes and (2) sensitive, compact fluorometers for monitoring the fluorescent responses of mast cells engineered to contain fluorescent dyes. It should be possible to observe responses within minutes of adding immune complexes. The systems have been shown to work when utilizing either immunoglobulin E (IgE) antibodies or traditionally generated rat antibodies - a promising result in that it indicates that the systems could be developed to detect many target microbes. Chimeric IgE antibodies and rat immunoglobulin G (IgG) antibodies could be genetically engineered for recognizing biological and chemical warfare agents and airborne and food-borne allergens. Genetic engineering efforts thus far have yielded (1) CD14 chimeric antibodies that recognize both Grampositive and Gram-negative bacteria and bind to the surfaces of mast cells, eliciting a degranulation response and (2) rat IgG2a antibodies that act similarly in response to low levels of canine parvovirus.

Curtis, Theresa↗

NASA NTRS2003

NASA Tech Briefs, October 2003

Topics covered include: Cryogenic Temperature-Gradient Foam/Substrate Tensile Tester; Flight Test of an Intelligent Flight-Control System; Slat Heater Boxes for Thermal Vacuum Testing; System for Testing Thermal Insulation of Pipes; Electrical-Impedance-Based Ice-Thickness Gauges; Simulation System for Training in Laparoscopic Surgery; Flasher Powered by Photovoltaic Cells and Ultracapacitors; Improved Autoassociative Neural Networks; Toroidal-Core Microinductors Biased by Permanent Magnets; Using Correlated Photons to Suppress Background Noise; Atmospheric-Fade-Tolerant Tracking and Pointing in Wireless Optical Communication; Curved Focal-Plane Arrays Using Back-Illuminated High-Purity Photodetectors; Software for Displaying Data from Planetary Rovers; Software for Refining or Coarsening Computational Grids; Software for Diagnosis of Multiple Coordinated Spacecraft; Software Helps Retrieve Information Relevant to the User; Software for Simulating a Complex Robot; Software for Planning Scientific Activities on Mars; Software for Training in Pre-College Mathematics; Switching and Rectification in Carbon-Nanotube Junctions; Scandia-and-Yttria-Stabilized Zirconia for Thermal Barriers; Environmentally Safer, Less Toxic Fire-Extinguishing Agents; Multiaxial Temperature- and Time-Dependent Failure Model; Cloverleaf Vibratory Microgyroscope with Integrated Post; Single-Vector Calibration of Wind-Tunnel Force Balances; Microgyroscope with Vibrating Post as Rotation Transducer; Continuous Tuning and Calibration of Vibratory Gyroscopes; Compact, Pneumatically Actuated Filter Shuttle; Improved Bearingless Switched-Reluctance Motor; Fluorescent Quantum Dots for Biological Labeling; Growing Three-Dimensional Corneal Tissue in a Bioreactor; Scanning Tunneling Optical Resonance Microscopy; The Micro-Arcsecond Metrology Testbed; Detecting Moving Targets by Use of Soliton Resonances; and Finite-Element Methods for Real-Time Simulation of Surgery.

Source record↗

NASA NTRS2011

Study of Scattered Light from Known Debris Disks

Using the Spitzer Space Telescope, a group of edge on debris disks, surrounding main-sequence shell stars have been discovered in the infrared. These disks are of high interest because they not only have dust, but an observed amount of circumstellar gas. HD158352 was an ideal target to try and image the disk because it was one of the closest stars in this group. Using the Hubble Space Telescope's Space Telescope Imaging Spectrograph (STIS), we attempted to take a direct image of the light scattered from the known disk in a broad optical bandpass. Studying these particular type of disks in high detail will allow us to learn more about gas-dust interactions. In particular, this will allow us to learn how the circumstellar gas evolves during the planet-forming phase. Even though it was predicted that the disk should have a magnitude of 20.5 at 3", no disk was seen in any of the optical images. This suggests that the parameters used to predict the brightness of the disk are not what we first anticipated and adjustments to the model must be performed. We also present the blue visible light spectrum of the scattered light from the debris disk surrounding Beta Pictoris. We are analyzing archival observations taken by Heap, using Hubble Space Telescope's STIS instrument. A long slit with a bar was used to occult Beta Pictoris as well as the PSF star. This was done because it is necessary to subtract a PSF observed the same way at the target to detect the disk. It appears that we have detected light from the disk but the work was in progress at the time of the abstract deadline.

Rodriguez, Joseph E.↗

NASA NTRS2017

Experimentally Shocked and Altered Basalt: VNIR Spectra of Mars Analog Materials

Major occurrences of hydrous alteration minerals on Mars have been found in Noachian impact craters formed in basaltic targets and detected using visible/near infrared (VNIR) spectroscopy. Until recently phyllosilicates were detected only in craters in the southern hemisphere. However, it has been reported that at least nine craters in the northern plains apparently excavated thick layers of lava and sediment to expose phyllosilicates as well and two Hesperian-aged impact craters, Toro and Majuro, bear evidence of phyllosilicates in the southern highlands. Turner et al. 2015 reported that hydrated minerals were identified in three Amazonian aged complex impact craters, located at 52.42degN, 39.86degE in the Ismenius Lacus quadrangle, at 8.93degN, 141.28degE in Elysium, and within Stokes crater. These discoveries indicate that Mars was globally altered by water throughout its past but do not fully constrain formation conditions for phyllosilicate occurrences which have important implications for the evolution of the surface and biological potential of Mars.

Bell, M. S.↗

NASA NTRS2019

Star Tracker Accuracy Improvement and Optimization for Attitude Measurement in Three-Axis

High precision attitude measurement systems obviate the need for the beacon from the receiver making it possible for the spacecraft to beam a laser communications signal to a ground station without the ground station advertising its location. The research presented targets new detection and estimation methods to improve the accuracy in locating stars on a focal plane detector, and an understanding of the effects of changes in the optics design parameters and aberration, including defocus, on the navigation solution itself. This understanding can lead to an optimization of the attitude solution with respect to those optics realm parameter changes. The methodology discussed includes the development of a model of a current star tracker system. Using this model, multiple algorithms are implemented, including a multi-hypothesis method (MHT), to detect and estimate the position of the stars on the focal plane detector. It will be shown that using the MHT for detection and estimation, a greater accuracy can be found for each star estimation from more traditional detection and estimation algorithms. The approach then uses the model to develop statistics of the star tracker and the attitude estimation outputs to understand the accuracy, or variance, of the system's attitude solution. This solution is repeated for a range of defocus aberration, and a lower limit to the variance of the attitude solution is shown. A Cramer Rao lower bound solution is derived for the star tracker system and the results are compared to the Monte Carlo analysis from the model and shown to correlate very well. The approach uses a star image not as a Gaussian spot on the focal plane as done in previous work, and use of an image that includes the effects of aberrations of the optic system, and the effects of under-sampling and noise from the focal plane detector as well. Analysis includes exploring a star tracker's accuracy improvement through the combination of focus error and under-sampling effects alone, possibly contradicting conventional wisdom and approaches.

Lichter, Michael J.↗