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NASA NTRS1989

Tank Pressure Control Experiment on the Space Shuttle

The tank pressure control experiment is a demonstration of NASA intent to develop new technology for low-gravity management of the cryogenic fluids that will be required for future space systems. The experiment will use freon as the test fluid to measure the effects of jet-induced fluid mixing on storage tank pressure and will produce data on low-gravity mixing processes critical to the design of on-orbit cryogenic storage and resupply systems. Basic data on fluid motion and thermodynamics in low gravity is limited, but such data is critical to the development of space transfer vehicles and spacecraft resupply facilities. An in-space experiment is needed to obtain reliable data on fluid mixing and pressure control because none of the available microgravity test facilities provide a low enough gravity level for a sufficient duration to duplicate in-space flow patterns and thermal processes. Normal gravity tests do not represent the fluid behavior properly; drop-tower tests are limited in length of time available; aircraft low-gravity tests cannot provide the steady near-zero gravity level and long duration needed to study the subtle processes expected in space.

Source record↗

NASA NTRS2000

Thermal Field Imaging Using Ultrasound

It is often desirable to be able to determine the temperature field in the interiors of opaque fluids forced into convection by externally imposed temperature gradients. To measure the temperature at a point in an opaque fluid in the usual fashion requires insertion of a probe, and to determine the full field therefore requires either the ability to move this probe or the introduction of multiple probes. Neither of these solutions is particularly satisfactory, although they can lead to quite accurate measurements. As an alternative we have investigated the use of ultrasound as a relatively non-intrusive probe of the temperature field in convecting opaque fluids. The temperature dependence of the sound velocity can be sufficiently great to permit a determination of the temperature from timing the traversal of an ultrasound pulse across a chamber. In this paper we will present our results on convecting flows of transparent and opaque fluids. Our experimental cells consist of relatively narrow rectangular cavities made of thermally insulating materials on the sides, and metal top and bottom plates. The ultrasound transducer is powered by a pulser/receiver, the signal output of which goes to a very high speed signal averager. The average of several hundred to several thousand signals is then sent to a computer for storage and analysis. The experimental procedure is to establish a convective flow by imposing a vertical temperature gradient on the chamber, and then to measure, at several regularly spaced locations, the transit time for an ultrasound pulse to traverse the chamber horizontally (parallel to the convecting rolls) and return to the transducer. The transit time is related to the temperature of the fluid through which the sound pulse travels. Knowing the relationship between transit time and temperature (determined in a separate experiment), we can extract the average temperature across the chamber at that location. By changing the location of the transducer it is then possible to find the average temperature at different locations along the chamber, thereby determining the temperature profile along the system. (In the future we will construct an array of transducers. This will give us the capability to determine the temperature profile much more rapidly than at present, an important consideration if time-dependent phenomena are to be studied.) To validate our procedure we introduced encapsulated liquid crystal particles into glycerol. The liquid crystal particles' color varies depending on the temperature of the fluid. A photograph of the fluid through transparent sidewalls therefore gives a picture of the temperature field of the convecting fluid, independent of our ultrasound imaging. A representative result is shown in the Figure 1, which reveals a very satisfying correspondence between the two techniques. Therefore we have a great deal of confidence that the ultrasound imaging approach is indeed measuring the actual temperature profile of the fluid. The technique has also been applied to convecting liquid metal flows, and representative data will be presented from those experiments as well.

Andereck, D.↗

NASA NTRS2003

Three-Gorge Reservoir: A 'Controlled Experiment' for Calibration/Validation of Time-Variable Gravity Signals Detected from Space

With the advances of measurements, modern space geodesy has become a new type of remote sensing for the Earth dynamics, especially for mass transports in the geophysical fluids on large spatial scales. A case in point is the space gravity mission GRACE (Gravity Recovery And Climate Experiment) which has been in orbit collecting gravity data since early 2002. The data promise to be able to detect changes of water mass equivalent to sub-cm thickness on spatial scale of several hundred km every month or so. China s Three-Gorge Reservoir has already started the process of water impoundment in phases. By 2009,40 km3 of water will be stored behind one of the world s highest dams and spanning a section of middle Yangtze River about 600 km in length. For the GRACE observations, the Three-Gorge Reservoir would represent a geophysical controlled experiment , one that offers a unique opportunity to do detailed geophysical studies. -- Assuming a complete documentation of the water level and history of the water impoundment process and aided with a continual monitoring of the lithospheric loading response (such as in area gravity and deformation), one has at hand basically a classical forwardinverse modeling problem of surface loading, where the input and certain output are known. The invisible portion of the impounded water, i.e. underground storage, poses either added values as an observable or a complication as an unknown to be modeled. Wang (2000) has studied the possible loading effects on a local scale; we here aim for larger spatial scales upwards from several hundred km, with emphasis on the time-variable gravity signals that can be detected by GRACE and follow-on missions. Results using the Green s function approach on the PREM elastic Earth model indicate the geoid height variations reaching several millimeters on wavelengths of about a thousand kilometers. The corresponding vertical deformations have amplitude of a few centimeters. In terms of long-wavelength spherical harmonics, the induced geoid height variations are very close to the accuracy of GRACE- recoverable gravity field, while the low-degree (2 to 5) harmonics should be detectable. With a large regional time-variable gravity signal, the Three-Gorge experiment can serve as a useful calibration/verification for GRACE (including the elastic loading effects), and future gravity missions (especially for visco-elastic yielding as well as underground water variations).

Chao, Benjamin F.↗

NASA NTRS1966

Lunar Lander project: A study on future manned missions to the Moon

This project is based on designing a small lunar probe which will conduct research relating to future manned missions to the moon. The basic design calls for two experiments to be run. The first of these experiments is an enclosed environment section which will be exposed to solar radiation while on the moon. The purpose of this experiment is to determine the effect of radiation on an enclosed environment and how different shielding materials can be used to moderate this effect. The eight compartments will have the following covering materials: glass, polarized glass, plexiglass, polyurethane, and boron impregnated versions of the polyurethane and plexiglass. The enclosed atmosphere will be sampled by a mass spectrometer to determine elemental breakdown of its primary constituents. This is needed so that an accurate atmospheric processing system can be designed for a manned mission. The second experiment is a seismic study of the moon. A small penetrating probe will be shot into the lunar surface and data will be collected onboard the lander by an electronic seismograph which will store the data in the data storage unit for retrieval and transmission once every twenty-three hours. The project is designed to last ten years with possible extended life for an additional nine years at which point power requirements prevent proper functioning of the various systems.

Source record↗

NASA NTRS2010

NEPP non-volatile memory : FY09 summary report

This report documents the activities and results of the fiscal year 2009 (FY09) funding for the NASA Electronic Parts and Packaging (NEPP) program for non-volatile memory (NVM) devices. The FY09 task was divided into two main efforts: 1. Development of in-house measurement capability for flash devices 2. Reliability characterization of multi-level vs. single-level flash devices The FY09 NEPP Non Volatile Memory study was organized into these two sections in recognition of the continued and increasing importance of NVM to NASA. All NASA missions use NVM for boot code storage and some limited data archiving. Space-grade NVM has lagged commercial NVM development by many orders of magnitude, however. This gap in density only continues to increase as space-grade memories remain constant in the 1–16 Mbit levels, while commercial flash-based devices shrink in size and double in capacity every 18 months. Commercial flash devices are now at the 32 Gbit level, 10,000 times denser than current NASA NVM. This FY marks the beginning of a significant technological transition in NVM for NASA. The aggressive scaling of commercial NVMs has, as a by-product, made some of the flash devices radiation-tolerant enough to be at least considered for low-level radiation environment missions [Irom 2008]. This NEPP task is focused on understanding the reliability and potential future applications of such highly scaled flash memories.

Heidecker, Jason↗

NASA NTRS1982

Future orbital transfer vehicle technology study. Volume 2: Technical report

Missions for future orbit transfer vehicles (1995-2010) are identified and the technology, operations and vehicle concepts that satisfy the transportation requirements are defined. Comparison of reusable space and ground based LO2/LH2 OTV's was made. Both vehicles used advanced space engines and aero assist capability. The SB OTV provided advantages in life cycle cost, performance and potential for improvement. Comparison of an all LO2/LH2 OTV fleet with a fleet of LO2/LH2 OTVs and electric OTV's was also made. The normal growth technology electric OTV used silicon cells with heavy shielding and argon ion thrusters. This provided a 23% advantage in total transportation cost. The impact of accelerated technology was considered in terms of improvements in performance and cost effectiveness. The accelerated technology electric vehicle used GaAs cells and annealing but did not result in the mixed fleet being any cheaper than an all LO2/LH2 OTV fleet. It is concluded that reusable LO2/LH2 OTV's can serve all general purpose cargo roles between LEO and GEO for the forseeable future. The most significant technology for the second generation vehicle would be space debris protection, on-orbit propellant storage and transfer and on-orbit maintenance capability.

Davis, E. E.↗

NASA NTRS2018

A Comparative Study of Available Water in the Major River Basins of the World

Numerous large river basins of the world have few and irregular observations of the components of the terrestrial hydrological cycle with the exception of stream gauges at a few locations and at the outlet along with sparsely distributed rain gauges. Using observations from satellite sensors and output from global land surface models, it is possible to study these under-observed river basins. With populations greater than a billion people, some of these rivers (e.g., the Ganga-Brahmaputra, the Yangtze, the Nile and the Mekong) are the economic engines of the countries they transect, yet thorough assessment of their flow dynamics and variability in regard to water resource management is still lacking. In this paper, we use soil moisture (0-2m) and surface runoff from the NASA Global Land Data Assimilation System (GLDAS), evapotranspiration, and Normalized Difference Vegetation Index (NDVI) from the Moderate Resolution Imaging Spectroradiometer (MODIS) and rainfall from the Tropical Rainfall Measuring Mission (TRMM) and total water storage anomaly from the Gravity Recovery and Climate Experiment (GRACE) to examine variability of individual water balance components. To this end, understanding the inter-annual and intra-seasonal variability and the spatial variability of the water balance components in the major river basins of the world will help to plan for improved management of water resources for the future.

GLDAS↗

NASA NTRS2001

Evaluation of Design Concepts for Collapsible Cryogenic Storage Vessels

Future long-duration missions to Mars using in situ resource production to obtain oxygen from the Martian atmosphere for use as a propellant or for life support will require long term oxygen storage facilities. This report describes preliminary analysis of design concepts for lightweight, collapsible liquid oxygen storage tanks to be used on the surface of Mars. With storage at relatively low pressures, an inflatable tank concept in which the cryogen is stored within a fiber-reinforced Teflon FEP bladder is an efficient approach. The technology required for such a tank is well-developed through similar previous applications in positive expulsion bladders for zero-g liquid fuel rocket tanks and inflatable space habitat technology, though the liquid oxygen environment presents unique challenges. The weight of the proposed structure is largely dominated by the support structure needed to hold the tank off the ground and permit a vacuum insulation space to be maintained around the tank. In addition to the inflatable tank concept, telescoping tank concepts are studied. For a telescoping tank, the greatest difficulty is in making effective joints and seals. The use of shape memory alloy to produce a passive clamping ring is evaluated. Although the telescoping tank concepts are a viable option, it appears that inflatable tank concepts will be more efficient and are recommended.

Fleming, David C.↗

NASA NTRS2000

Magnetic Launch Assist: NASA's Vision for the Future

With the ever-increasing cost of getting to space and the need for safe, reliable, and inexpensive ways to access space. The National Aeronautics and Space Administration (NASA) is taking a look at technologies that will get us there. One of these technologies is Magnetic Launch Assist (MagLev). This is the concept of using both magnetic levitation and magnetic propulsion to provide an initial velocity by using electrical power from ground sources. The use of ground generated electricity can significantly reduce operational costs over the consumables necessary to attain the same velocity. The technologies to accomplish this are both old and new. The concept of MagLev has been around for a long time and several MagLev Trains have been developed. Where NASA's MagLev diverges from the traditional train is in the immense amount of power required to propel this vehicle to 183 meters per second in less than 10 seconds. New technologies or the upgrade of existing technologies will need to be investigated in the areas of energy storage and power switching. An added difficulty is the separation of a very large mass (the space vehicle) from the track and the aerodynamics of that vehicle while on the track. These are of great concern and require considerable study and testing. NASA's plan is to mature these technologies in the next 25 years to achieve our goal of launching a full sized space vehicle for under $300 a kilogram.

Jacobs, William A.↗

NASA NTRS2023

CFD Modeling of Bi-Directional PMD inside Cryogenic Propellant Tanks Onboard Parabolic Flights

Future cryogenic propulsion systems will require efficient methods with which to transfer cryogenic propellants from a depot storage tank to a customer receiver tank to minimize cost and maximize reusability. The Reduced Gravity Cryogenic Transfer project is currently developing advanced cryogenic fluid management technology and developing and validating new numerical models for three phases of transfer: line chilldown, tank chilldown, and tank fill. Additionally, multiple liquid nitrogen (LN 2 ) parabolic flight transfer rigs are being designed by universities and NASA to investigate the gravitational sensitivities that exist in these three technologies. In order to maximize the collection of low-g data during flights, it is required to extract as much (LN 2 as possible from the supply tank, despite variable gravity levels. The purpose of this paper is to present computational fluid dynamics (CFD) volume of fluid simulations of (LN 2 behavior in the supply tank onboard parabolic flights to validate the optimal design of a bi-directional propellant management device (PMD) using the commercial software FLOW-3D. A parametric study is conducted on the effects of gravity level, fill level, pore size, open area, thickness, and type of baffle on PMD performance. Based on results, the PMD as designed exceeds the targeted expulsion efficiency.

Jason Hartwig↗

NASA NTRSDate not supplied

Fabrication of Solid-State Li-S Battery Components for Electric Aviation

The development of high-energy, high-safety, and high-power batteries beyond electric automobile requirements is vital for future electric aviation applications. The transition to non-volatile solid-state electrolytes (SSE) promises many advantages over traditional flammable liquid electrolytes, and may also be an enabling technology for next generation chemistries. However, significant manufacturing challenges must be overcome before the adoption of such technology. Electrolytes developed in this study were produced as sulfide-polymer composites with densified thicknesses between 20-30 microns using several processing techniques [1]. Ionic conductivity and lithium metal compatibility for the composites were compared and shown to retain reasonable ionic conductivity with improved flexibility and scalability which identifies a critical path for the production of practical solid-state batteries. Films were produced 10-15 times thinner than comparable bulk cold pressed powder electrolytes and achieved thicknesses comparable to commercial polyolefin separators (25 micron) used in commercial liquid containing lithium-ion cells. Composite conductivities were maintained above 0.2mS/cm, which holds promise for future electric aviation applications. Processing techniques are investigated to further improve electrochemical performance.

battery↗

NASA NTRSDate not supplied

Validation of a Two-Phase CFD Model for Autogenous Pressurization and Expulsion

This paper presents a two-phase computational fluid dynamics (CFD) model for simulating autogenous pressurization and expulsion in a cryogenic liquid hydrogen storage tank, utilizing a volume-of-fluid (VOF) approach combined with the kinetics-based Schrage equation to accurately capture the phase boundary and interfacial heat, mass, and momentum transfer between liquid and vapor phases. The model is validated against experimental data from NASA's K-site tank facility, specifically experimental case 225, which involved pressurization and controlled expulsion of liquid hydrogen. Various turbulence models are evaluated to assess their influence on model accuracy. The CFD simulations successfully replicate key thermodynamic behaviors observed during the experiments, including pressure evolution, temperature profiles, and phase-change dynamics at the vapor-liquid interface. The predicted tank pressures, temperatures, and pressurant requirements agree with experimental data, with pressurant mass predictions within 16\% of observed values. This study highlights the importance of selecting appropriate turbulence models to accurately simulate complex flow and heat transfer phenomena during tank pressurization and expulsion. By enhancing the accuracy and reliability of CFD models for liquid hydrogen under cryogenic conditions, this research contributes to developing efficient cryogenic propellant management strategies for future space missions.

Computational Fluid Dynamics↗

NASA NTRSDate not supplied

Polymer Composite Material Screening for a Cryotank Application

Composites↗

NASA NTRS2026

Polymer Composite Material Testing for a Cryotank Application

Composite cryotanks will play a key role in enabling the next generation of efficient aircraft. Carbon fiber reinforced polymer (CFRP) composites have the benefits of reduced weight and potentially higher structural strength compared to traditional metallic fuel tanks. A material screening study was conducted to inform material selection for liquid hydrogen (LH2) fuel storage. Three composite materials were considered because of their aerospace grade toughness, strength, and existing data to compare against. These materials were a thermoplastic low-melt polyaryletherketone (LM-PAEK)/carbon fiber (CF), thermoset/CF, and hybrid thermoset/thermoplastic polyurethane (TPU) veil/CF composite. Mechanical screening tests included tension, compression, in-plane shear (IPS), and tensile-tensile fatigue (TTF). Each material was tested at both a baseline (no liquid nitrogen/LN2 cycling) and 100 LN2-cycled conditions to determine the knockdown factor, if any, of each material when exposed to environmental loading effects in a cryotank. Results show minimal effects of the LN2-cycling compared against baseline values. The three materials behaved similarly in tension; however, the thermoplastic/CF had the highest IPS toughness. The hybrid thermoset/TPU/CF composite had the lowest IPS strength, compressive strength, and toughness. LN2-cycling had minimal effects on tensile-tensile fatigue performance of the thermoplastic/CF material. Mechanical data was captured to guide material down selection for future commercially viable hydrogen aircraft design. In its current state, there does not exist a consolidated, publicly available database for CFRP composite material performance data at cryogenic temperatures. The next step in this work is to test the thermoplastic and thermoset CFRP composites, as well as the neat resins, at LH2 relevant temperature (20 K) to capture this crucial material property data. These results are essential to inform cryotank design and modeling efforts. The process to start this next round of testing has begun. Planned mechanical tests include toughness (single-edge notched beam), tension (unidirectional and quasi-isotropic), thermal expansion, and thermal conductivity. Some tests will also be conducted at an intermediate temperature of 111 K relevant to liquid natural gas (LNG), another attractive fuel choice. The ultimate goal is to manufacture a sub-scale cryotank part that can pass relevant burst, fatigue, permeation, and thermal cycling tests. This work is a part of NASA’s Commercially viable Hydrogen Aircraft for Robust Growth in Efficiency (CHARGE) Project under the larger NASA Subsonic Vehicle Technologies and Tools (SVTT) Project.

composites↗

NASA NTRS2015

Standardized Modular Power Interfaces for Future Space Explorations Missions

Earlier studies show that future human explorations missions are composed of multi-vehicle assemblies with interconnected electric power systems. Some vehicles are often intended to serve as flexible multi-purpose or multi-mission platforms. This drives the need for power architectures that can be reconfigured to support this level of flexibility. Power system developmental costs can be reduced, program wide, by utilizing a common set of modular building blocks. Further, there are mission operational and logistics cost benefits of using a common set of modular spares. These benefits are the goals of the Advanced Exploration Systems (AES) Modular Power System (AMPS) project. A common set of modular blocks requires a substantial level of standardization in terms of the Electrical, Data System, and Mechanical interfaces. The AMPS project is developing a set of proposed interface standards that will provide useful guidance for modular hardware developers but not needlessly constrain technology options, or limit future growth in capability. In 2015 the AMPS project focused on standardizing the interfaces between the elements of spacecraft power distribution and energy storage. The development of the modular power standard starts with establishing mission assumptions and ground rules to define design application space. The standards are defined in terms of AMPS objectives including Commonality, Reliability-Availability, Flexibility-Configurability and Supportability-Reusability. The proposed standards are aimed at assembly and sub-assembly level building blocks. AMPS plans to adopt existing standards for spacecraft command and data, software, network interfaces, and electrical power interfaces where applicable. Other standards including structural encapsulation, heat transfer, and fluid transfer, are governed by launch and spacecraft environments and bound by practical limitations of weight and volume. Developing these mechanical interface standards is more difficult but an essential part of defining physical building blocks of modular power. This presentation describes the AMPS projects progress towards standardized modular power interfaces.

Spacecraft Power↗

NASA NTRSDate not supplied

Validation of a Two-Phase CFD Model for Autogenous Pressurization and Expulsion

This paper presents a two-phase computational fluid dynamics (CFD) model for simulating autogenous pressurization and expulsion in a cryogenic liquid hydrogen storage tank, utilizing a volume-of-fluid (VOF) approach combined with the kinetics-based Schrage equation to accurately capture the phase boundary and interfacial heat, mass, and momentum transfer between vapor and liquid phases. The model is validated against experimental data from NASA's K-site tank facility, specifically experimental case 225, which involved autogenous pressurization and controlled expulsion of liquid hydrogen. Various turbulence models are evaluated to assess their influence on model accuracy. The CFD simulations successfully replicate key thermodynamic behaviors observed during the experiments, including pressure evolution, temperature profiles, and phase-change dynamics at the vapor-liquid interface. The predicted tank pressures and temperatures agree well with experimental data, whereas the pressurant mass predictions are within 16% of observed values. This study emphasizes the importance of selecting appropriate turbulence models to accurately simulate the complex flow and heat transfer phenomena during tank autogenous pressurization and expulsion. By improving the accuracy and reliability of CFD models for these processes, this research contributes to developing efficient cryogenic propellant management strategies for future space missions.

Computational Fluid Dynamics↗

NASA NTRS1998

Orbital Fluid Transfer System

An automated fluid and power interface system needs to be developed for future space missions which require on orbit consumable replenishment. Current method of fluid transfer require manned vehicles and extravehicular activity. Currently the US does not have an automated capability for consumable transfer on-orbit. This technology would benefit both Space Station and long duration satellites. In order to provide this technology the Automated Fluid Interface System (AFIS) was developed. The AFIS project was an advanced development program aimed at developing a prototype satellite servicer for future space operations. This mechanism could transfer propellants, cryogens, fluids, gasses, electrical power, and communications from a tanker unit to the orbiting satellite. The development of this unit was a cooperative effort between Marshall Space Flight Center in Huntsville, Alabama, and Moog, Inc. in East Aurora, New York. An engineering model was built and underwent substantial development testing at Marshall Space Flight Center (MSFC). While the AFIS is not suitable for spaceflight, testing and evaluation of the AFIS provided significant experience which would be beneficial in building a flight unit. The lessons learned from testing the AFIS provided the foundation for the next generation fluid transfer mechanism, the Orbital Fluid Transfer System (OFTS). The OFTS project was a study contract with MSFC and Moog, Inc. The OFTS was designed for the International Space Station (ISS), but its flexible design could used for long duration satellite missions and other applications. The OFTS was designed to be used after docking. The primary function was to transfer bipropellants and high pressure gases. The other items addressed by this task included propellant storage, hardware integration, safety and control system issues. A new concept for high pressure couplings was also developed. The results of the AFIS testing provided an excellent basis for the OFTS design. The OFTS meet the servicing requirements for ISS and could also provide the automated fluid and power interface system needed for on orbit consumable resupply of spacecraft into the new century.

Johnston, A. S., (Nick)↗

NASA NTRS2025

Innovative Drug Selection, Storage, and Shelf-Life Strategies for Exploration Spaceflight

Medications have been a part of space travel dating back to the Apollo missions. A safe and effective medication formulary is essential to maintaining crew health and performance during long-duration spaceflight outside of low Earth orbit (LEO). Distance from Earth creates four key operational changes that increase medical risks, including communication, resupply, crewmember health, and evacuation. The current spaceflight pharmaceutical formulary consists of medications indicated to treat a variety of anticipated medical events and healthcare needs during spaceflight, but depends on a robust consumables resupply chain, which may be strained for a Lunar, and possibly non-existent for a Mars mission. The specific medications selections for the formulary may change to optimally align with the mission, crew compliment, and spacecraft design. Medical support at long-duration exploration missions will differ from LEO missions due to mission duration, lack of consumables resupply, prolonged exposure to space radiation, and the absence of emergency medical return capability. Loss of medication resupply limits or removes the ability to replace medications that have been exhausted or degraded, potentially exacerbating the medical risk posture. To address these anticipated risks, long-duration missions must consider use of novel medical technologies, treatment modalities, and smart medical systems that offer greater crew autonomy, such as physiologically based pharmacokinetic modeling, drug repurposing, on demand drug synthesis, or wearable drug delivery / monitoring devices. Once an ideal formulary for exploration space is determined, it is essential to establish the chemical and physical stability of each medication compound, as well as its safety by identifying its degradation profiles and products. Although few studies have been conducted to provide evidence on the physicochemical stability of pharmaceuticals during space missions, the data suggests that the spaceflight environment may promote degradation in some pharmaceuticals. Formulary drug purity and efficacy should be verified by pharmaceutical stability assessments, and can be realized non-destructively, and accessed in remote environments. Non-destructive pharmaceutical analysis and statistical modelling techniques could optimize exploration spaceflight medical care by enabling early detection of suboptimal therapeutics. Likewise, novel packaging, storage strategies, and dosage form innovations are promising countermeasures to optimize pharmaceutical shelf life, purity, and quality of exploration spaceflight medications. As we prepare for more distant exploration missions, risk management planning for astronaut healthcare should include the assembly of a medication formulary that is comprehensive enough to prevent or treat anticipated medical events, remains safe and chemically stable, and retains sufficient potency to last for the duration of the mission. Following extensive review of the literature, we will present innovative formulary optimization strategies, pharmaceutical stability assessment techniques, and storage and packaging solutions that could enhance drug safety and efficacy for future exploration spaceflight missions.

Vernie R Daniels↗