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At least 253 records · Page 14
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

Evaluating Age Effects on HEPA Filter Performance

Nuclear grade high efficiency particulate air (HEPA) filters are routinely employed as the final control element in confinement ventilation systems. The traditional HEPA filter utilizes a pleated filter medium of fibrous glass that has been produced in a manner analogous to manufacturing paper. These filters are the physically weakest element in a containment ventilation system. Containment ventilation systems are designed to condition the air-stream (temperature, relative humidity, moisture, particle size distribution of aerosols, and aerosol concentration) to levels/conditions that fibrous glass HEPA filters can handle. Approximately 6000 nuclear grade HEPA filters are purchased each year for use in the DOE/NNSA complex. Additional filters are purchased for use in commercial nuclear power generation and ventilation systems of other nuclear applications. These filters are designed and tested in accordance with the American Society of Mechanical Engineers (ASME) AG-1 Code Nuclear Air and Gas Treatment. This code establishes design requirements and qualification procedures. Qualification testing of axial flow filters is described in paragraphs 5000 and following of AG-1. The series of qualification tests are intended to describe the operating envelope of HEPA filters and verify the reliability of a filter design. AG-1 qualification also confirms the pedigree of components used in manufacture for that filter design. The collective set of qualification tests establishes the assumed operating envelope for AG-1 filters. The effects of age on HEPA filter performance have been a concern for at least two decades. A combination of physical evaluation of aged filter media and a review of filter failure records resulted in Appendix C of the Nuclear Air Cleaning Handbook (NACH), Determination of HEPA Filter Life. This states that HEPA filters are not to be used beyond 10 years from the date of manufacture. Additionally, filters put into service in locations where they may become wet are to be taken out of service five years from date of manufacture. Filters that have become wet are to be taken out of service immediately. Finally, it should also be pointed out that filters held in Level B storage are subject to the same 10-year service life. Very limited bench-scale testing in the 1990's raised concern that aging HEPA filters do not have the strength to withstand an accident scenario. In May of 1999, the DNFSB released a Technical Report 23 entitled HEPA Filters Used in the Department of Energy's Hazardous Facilities. This report expressed concerns for the potential vulnerability of HEPA filters in vital safety systems. Concerns and uncertainty associated with degradation of HEPA filter performance over time led the DOE sites to limit HEPA filter service life to 10 years from the date of manufacture or five years in cases where filters may become wet. Establishment of a conservative service life needs to be based on data from a structured series of tests comparing the performance envelope of new and aged full-scale filters. A service life that is insufficiently conservative endangers workers and the public. One that is excessively conservative costs can cause hundreds of otherwise unnecessary filter changes. This increases exposure of employees, disrupts facility operations, and increase disposal costs by millions of dollars annually. Conclusive data are needed to resolve uncertainty associated with the damaging effects of aging on durability of HEPA filters. Therefore, this study needs to provide a sufficient body of evidence to allow DOE and site professionals to make prudent decisions. An updated version of ASME AG-1 Section FC included a non-mandatory appendix that would include the DOE guidance for service life of HEPA filters. Balloting of this revision generated significant resistance to inclusion of any kind of service life language citing the lack of supporting experimental data. Efforts to resolve negative votes failed and resistance to acceptance of the language increased. The result has been to not include service language in Section FC and requests to remove it from sections that already include such language. The recent activity of the ASME AG-1 Committee on Nuclear Air and Gas Treatment effectively de-emphasizes following DoE's service life guidelines. The DOE Office of Nuclear Safety under its NSR and D program provided the Mississippi State University Institute for Clean Energy Technology (ICET) finding to initiate a study to determine the effects of aging on AG-1 axial flow filters just prior to actions taken within the AG-1 committee regarding service life. The NSR and D funding facilitated timely development of a national technical working group comprised of members from the regulatory community, DOE complex, and commercial power to resolve uncertainty associated with effects of aging. The Department of Energy Office of Environmental Management (DOE-EM) has been funding the ICET to evaluate the performance envelope for AG-1 HEPA filters. ICET is one of DOE-EM's qualified suppliers. Synergy has been achieved by associating the NSR and D aged filter activities to testing activities evaluating the performance envelopes of separator and separator-less AG-1 HEPA filters funded by DOE-EM. The DOE-EM funded activities establish baseline data for the aged filter study and future EM funding will provide long term support for testing additional aged filters. EM funding of new filters includes analytical evaluation of media tensile strength by thermal analysis to establish baseline values and determine mass loss of moisture resistance and acrylic binders due to use. All of these values can be used for comparison of test results for aged filters. (authors)

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2016

Aging kinetics of levoglucosan orientational glass as a rate dispersion process and consequences for the heterogeneous dynamics view

Aging kinetics of a glass is currently modeled in terms of slowing of its α-relaxation dynamics, whose features are interpreted in terms of dynamic heterogeneity, i.e., formation and decay of spatially and temporally distinct nm-size regions. To test the merits of this view, we studied the calorimetric effects of aging an orientational glass of levoglucosan crystal in which such regions would not form in the same way as they form in liquids, and persist in structural glasses, because there is no liquid-like molecular diffusion in the crystal. By measuring the heat capacity, C{sub p}, we determined the change in the enthalpy, H, and the entropy, S, during two aging-protocols: (a) keeping the samples isothermally at temperature, T{sub a}, and measuring the changes after different aging times, t{sub a}, and (b) keeping the samples at different T{sub a}s and measuring the changes after the same t{sub a}. A model-free analysis of the data shows that as t{sub a} is increased (procedure (a)), H and S decrease according to a dispersive rate kinetics, and as T{sub a} is increased (procedure (b)), H and S first increase, reach a local maximum at a certain T{sub a}, and then decrease. Even though there is no translational diffusion to produce (liquid-like) free volume, and no translational-rotational decoupling, the aging features are indistinguishable from those of structural glasses. We also find that the Kohlrausch parameter, originally fitted to the glass-aging data, decreases with decrease in T{sub a}, which is incompatible with the current use of the aging data for estimating the α-relaxation time. We argue that the vibrational state of a glass is naturally incompatible with its configurational state, and both change on aging until they are compatible, in the equilibrium liquid. So, dipolar fluctuations seen as the α-relaxation would not be the same motions that cause aging. We suggest that aging kinetics is intrinsically dispersive with its own characteristic rate constant and it does not yield the α-relaxation rate. In this view, thermodynamic and other properties define the fictive temperature; the real or imaginary components of a dynamic property do not define it. While particles’ overall motions may still play a crucial role in (structural) glass physics, we conclude that translational diffusion alone is not a requirement for structure stabilization on aging of a kinetically frozen state.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2014

How good a clock is rotation? The stellar rotation-mass-age relationship for old field stars

The rotation-mass-age relationship offers a promising avenue for measuring the ages of field stars, assuming the attendant uncertainties to this technique can be well characterized. We model stellar angular momentum evolution starting with a rotation distribution from open cluster M37. Our predicted rotation-mass-age relationship shows significant zero-point offsets compared to an alternative angular momentum loss law and published gyrochronology relations. Systematic errors at the 30% level are permitted by current data, highlighting the need for empirical guidance. We identify two fundamental sources of uncertainty that limit the precision of rotation-based ages and quantify their impact. Stars are born with a range of rotation rates, which leads to an age range at fixed rotation period. We find that the inherent ambiguity from the initial conditions is important for all young stars, and remains large for old stars below 0.6 M {sub ☉}. Latitudinal surface differential rotation also introduces a minimum uncertainty into rotation period measurements and, by extension, rotation-based ages. Both models and the data from binary star systems 61 Cyg and α Cen demonstrate that latitudinal differential rotation is the limiting factor for rotation-based age precision among old field stars, inducing uncertainties at the ∼2 Gyr level. We also examine the relationship between variability amplitude, rotation period, and age. Existing ground-based surveys can detect field populations with ages as old as 1-2 Gyr, while space missions can detect stars as old as the Galactic disk. In comparison with other techniques for measuring the ages of lower main sequence stars, including geometric parallax and asteroseismology, rotation-based ages have the potential to be the most precise chronometer for 0.6-1.0 M {sub ☉} stars.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

Core-halo age gradients and star formation in the Orion Nebula and NGS 2024 young stellar clusters

We analyze age distributions of two nearby rich stellar clusters, the NGC 2024 (Flame Nebula) and Orion Nebula cluster (ONC) in the Orion molecular cloud complex. Our analysis is based on samples from the MYStIX survey and a new estimator of pre-main sequence (PMS) stellar ages, Age{sub JX} , derived from X-ray and near-infrared photometric data. To overcome the problem of uncertain individual ages and large spreads of age distributions for entire clusters, we compute median ages and their confidence intervals of stellar samples within annular subregions of the clusters. We find core-halo age gradients in both the NGC 2024 cluster and ONC: PMS stars in cluster cores appear younger and thus were formed later than PMS stars in cluster peripheries. These findings are further supported by the spatial gradients in the disk fraction and K-band excess frequency. Our age analysis is based on Age{sub JX} estimates for PMS stars and is independent of any consideration of OB stars. The result has important implications for the formation of young stellar clusters. One basic implication is that clusters form slowly and the apparent age spreads in young stellar clusters, which are often controversial, are (at least in part) real. The result further implies that simple models where clusters form inside-out are incorrect and more complex models are needed. We provide several star formation scenarios that alone or in combination may lead to the observed core-halo age gradients.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2025

Pathogenic SIV infection is associated with acceleration of epigenetic age in rhesus macaques

HIV infection accelerates biological aging, but the contribution of the host’s age to this process is unknown. We investigated the influence of SIV infection in macaques (SIVmac) on the risk of comorbidities and aging in young and old rhesus macaques (RMs) by assessing pathogenesis markers, DNA methylation–based epigenetic age (EA), and EA acceleration (EAA) in blood and tissues. Initially, upon SIV infection, the young RMs showed greater resilience to CD4 + T cell depletion, better control of T cell activation, hypercoagulation, and excessive inflammation, yet this resilience was progressively lost in the advanced stages of infection. During the late stages of infection, the young RMs, but not the aged ones, showed an increase in EA in PBMCs; also, EAA in the cerebellum and heart of young RMs was higher compared with old RMs. SIV infection was more pathogenic in aged animals in early stages, leading to a more rapid disease progression; however, accelerated aging mostly affected young animals, so that the levels of multiple key pathogenesis markers in the young RMs converged toward those specific to aged ones in the late stages of infection. We conclude that SIV infection–driven age acceleration is tissue specific, and that host age influences the susceptibility of different tissues to enhanced aging.

Research & Experimental Medicine↗
DOE OSTI2021

Constitutive Model Development for Aging Polymer Encapsulants (ASC P&EM FY2021 L2 Milestone 7836)

This SAND report fulfills the completion requirements for the ASC Physics and Engineering Modeling Level 2 Milestone 7836 during Fiscal Year 2021. The Sandia Simplified potential energy clock (SPEC) non-linear viscoelastic constitutive model was developed to predict a whole host of polymer glass physical behaviors in order to provide a tool to assess the effects of stress on these materials over their lifecycle. Polymer glasses are used extensively in applications such as electronics packaging, where encapsulants and adhesives can be critical to device performance. In this work, the focus is on assessing the performance of the model in predicting material evolution associated with long-term physical aging, an area that the model has not been fully vetted in. These predictions are key to utilizing models to help demonstrate electronics packaging component reliability over decades long service lives, a task that is very costly and time consuming to execute experimentally. The initiating hypothesis for the work was that a model calibration process can be defined that enables confidence in physical aging predictions under ND relevant environments and timescales without sacrificing other predictive capabilities. To test the hypothesis, an extensive suite of calibration and aging data was assembled from a combination of prior work and collaborating projects (Aging and Lifetimes as well as the DoD Joint Munitions Program) for two mission relevant epoxy encapsulants, 828DGEBA/DEA and 828DGEBA/T403. Multiple model calibration processes were developed and evaluated against the entire set of data for each material. A qualitative assessment of each calibration's ability to predict the wide range of aging responses was key to ranking the calibrations against each other. During this evaluation, predictions that were identified as non-physical, i.e., demonstrated something that was qualitatively different than known material behavior, were heavily weighted against the calibration performance. Thus, unphysical predictions for one aspect of aging response could generate a lower overall rating for a calibration process even if that process generated better quantitative predictions for another aspect of aging response. This insurance that all predictions are qualitatively correct is important to the overall aim of utilizing the model to predict residual stress evolution, which will depend on the interplay amongst the different material aging responses. The DSC-focused calibration procedure generated the best all-around aging predictions for both materials, demonstrating material models that can qualitatively predict the whole host of different physical aging responses that have been measured. This step forward in predictive capability comes from an unanticipated source, utilization of calorimetry measurements to specify model parameters. The DSC-focused calibration technique performed better than compression-focused techniques that more heavily weigh measurements more closely related to the structural responses to be predicted. Indeed, the DSC-focused calibration procedure was only possible due to recent incorporation of the enthalpy and heat capacity features into SPEC that was newly verified during this L2 milestone. Fundamentally similar aspects of the two material model calibrations as well as parametric studies to assess sensitives of the aging predictions are discussed within the report. A perspective on the next steps to the overall goal of residual stress evolution predictions under stockpile conditions closes the report.

36 MATERIALS SCIENCE↗
DOE OSTI2024

Initial Testing of an In Situ Load Retention Aging Vessel

A thermal aging vessel instrumented with load cells was fabricated. The primary function of the vessel is to continuously monitor the in situ load retention of up to three compressed polymer coupons undergoing thermally accelerated aging under nitrogen. A secondary function is to enable gas sampling of the vessel headspace during thermal aging. Heating of the vessel is achieved using a custom heater jacket. To improve upon our conventional aging study methods which require periodic interruption of aging to perform load testing in an Instron machine at room temperature, this technology aims to automate/facilitate data acquisition/analysis, improve data quality, and enable uninterrupted compression of the polymer which represents the service condition. As an example case to assess functionality of the in situ vessel, the load retention of a siloxane elastomer material additively manufactured by direct-ink-writing (DIW) was measured at three different isothermal aging temperatures for ~1 month. Initial compression of the coupons while near the aging temperature was achieved by temporarily opening the heated vessel to access the interior chamber and manually tightening four nuts to drive the heated compression plate down onto the heated coupons. Initial testing demonstrated achievement of the primary load retention monitoring function. Unfortunately, the vessel leaked which prevented gas sampling; an active purge was used to maintain a nitrogen atmosphere. Welded or otherwise sealed joints, which could be implemented in a future design, would likely eliminate leak paths. To apply time-temperature superposition (TTS), a technique used to provide long-term prediction of the load retention from short-term isothermal data, the load retention needed to be calculated relative to the load at an estimated “equilibrium” time, after most of the transient viscoelastic physical relaxation occurred. The peak load immediately after compression could not be used as the load retention basis for two reasons: (1) age-related changes must be isolated from non-age-related physical relaxation before applying TTS and (2) the manual mechanism used to compress the specimens at the aging temperature was neither smooth nor repeatable which affected the peak load value. To better understand the effect of the mode of initial compression on the measured load, and possibly better estimate “equilibrium” physical relaxation times, systematic stress relaxation experiments were performed using an Instron machine with a thermal chamber. At a given temperature, the DIW polymer was compressed to a fixed strain in either a stepped or continuous manner at two different rates, then held at that strain for 24 hrs. The results indicated that, at a given temperature, the different stress relaxation curves appeared to converge to the same curve at some “equilibrium” time when the non-age-related physical relaxation was mostly complete. Though this observation suggests that the discontinuous manual compression employed by the vessel is feasible, a compression mechanism that is rapid, smooth, and repeatable would enhance its use.

36 MATERIALS SCIENCE↗
DOE OSTI2021

Calibration of the Hα Age–Activity Relation for M Dwarfs

In this work, we calibrate the relationship between Hα emission and M dwarf ages. We compile a sample of 892 M dwarfs with Hα equivalent width (Hα EW) measurements from the literature that are either comoving with a white dwarf of known age (21 stars) or in a known young association (871 stars). In this sample we identify 7 M dwarfs that are new candidate members of known associations. By dividing the stars into active and inactive categories according to their Hα EW and spectral type (SpT), we find that the fraction of active dwarfs decreases with increasing age, and the form of the decline depends on SpT. Using the compiled sample of age calibrators, we find that Hα EW and fractional Hα luminosity (L {sub Hα}/L {sub bol}) decrease with increasing age. Hα EW for SpT ≤ M7 decreases gradually up until ∼1 Gyr. For older ages, we found only two early M dwarfs that are both inactive and seem to continue the gradual decrease. We also found 14 mid-type M dwarfs, out of which 11 are inactive and present a significant decrease in Hα EW, suggesting that the magnetic activity decreases rapidly after ∼1 Gyr. We fit L {sub Hα}/L {sub bol} versus age with a broken power law and find an index of −0.11{sub −0.01}{sup +0.02} for ages ≲776 Myr. The index becomes much steeper at older ages, but a lack of field age-calibrators (≫1 Gyr) leaves this part of the relation far less constrained. Finally, from repeated independent measurements for the same stars, we find that 94% of them have a level of Hα EW variability ≤5 Å at young ages (<1 Gyr).

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS2018

Age of Martian Air: Time Scales for Martian Atmospheric Transport

The mean time since air in the Martian atmosphere was in the low-latitude boundary layer is examined using simulations of an idealized “mean age” tracer with the MarsWRF general circulation model. The spatial distribution and seasonality of the mean age in low- and mid-latitudes broadly follow contours of the mean meridional circulation, with the mean age increasing from 0 at the surface to a maximum of 60–100 sols in the upper atmosphere. Substantially older mean ages (exceeding 300 sols) are found in polar regions, with oldest ages in the lower atmosphere (10–100 Pa), above a near-surface layer with very young ages (around 20 sols). The annual maximum ages occur around the equinoxes, and the age in the polar lower atmosphere decreases during the autumn to winter transition. This autumn-winter decrease in age occurs because of mixing of polar and mid-latitude air when the polar vortex exhibits an annulus of high potential vorticity (PV) with a local minimum near the pole. There is no autumn-winter decrease and old ages persist throughout autumn and winter in simulations with CO2 phase changes disabled, and thus no latent heating, where there is a monopolar vortex (i.e., a monotonic increase in PV from equator to pole) forms. The altitudinal and seasonal variations in the mean age indicates similar variations in the transport of dust into polar regions and the mixing of polar air (with, e.g., low water vapor and high ozone concentrations during winter) into mid-latitudes.

Waugh, D. W.↗
NASA NTRS2021

Mapping Global Forest Age from Forest Inventories, Biomass and Climate Data

Forest age can determine the capacity of a forest to uptake carbon from the atmosphere. However, a lack of global diagnostics that reflect the forest stage and associated disturbance regimes hampers the quantification of age-related differences in forest carbon dynamics. This study provides a new global distribution of forest age circa 2010, estimated using a machine learning approach trained with more than 40 000 plots using forest inventory, biomass and climate data. First, an evaluation against the plot-level measurements of forest age reveals that the data-driven method has a relatively good predictive capacity of classifying old-growth vs. non-old-growth (precision = 0.81 and 0.99 for old-growth and non-old-growth, respectively) forests and estimating corresponding forest age estimates (NSE = 0.6 – Nash–Sutcliffe efficiency – and RMSE = 50 years – root-mean-square error). However, there are systematic biases of overestimation in young- and underestimation in old-forest stands, respectively. Globally, we find a large variability in forest age with the old-growth forests in the tropical regions of Amazon and Congo, young forests in China, and intermediate stands in Europe. Furthermore, we find that the regions with high rates of deforestation or forest degradation (e.g. the arc of deforestation in the Amazon) are composed mainly of younger stands. Assessment of forest age in the climate space shows that the old forests are either in cold and dry regions or warm and wet regions, while young–intermediate forests span a large climatic gradient. Finally, comparing the presented forest age estimates with a series of regional products reveals differences rooted in different approaches and different in situ observations and global-scale products. Despite showing robustness in cross-validation results, additional methodological insights on further developments should as much as possible harmonize data across the different approaches. The forest age dataset presented here provides additional insights into the global distribution of forest age to better understand the global dynamics in the forest water and carbon cycles. The forest age datasets are openly available at https://doi.org/10.17871/ForestAgeBGI.2021 (Besnard et al., 2021).

Simon Besnard↗
NASA NTRS2022

Is [Y/Mg] a Reliable Age Diagnostic for FGK Stars?

Current spectroscopic surveys are producing large catalogs of chemical abundances for stars of all types. The yttrium-to-magnesium ratio, [Y/Mg], has emerged as a candidate age indicator for solar twins in the local stellar neighborhood. However, it is unclear whether it is a viable age diagnostic for more diverse stellar types, so we investigate [Y/Mg] as an age indicator for the FGK-type planet host stars observed by Kepler. We find that the [Y/Mg] "Clock" is most precise for solar twins, with a [Y/Mg]/age slope of m = −0.0370 ±0.0071 dex Gyr −1 and σ Age = 2.6 Gyr. We attribute the lower precision compared to literature results to nonsolar twins contaminating our solar twin sample and recommend a 1.5 Gyr systematic uncertainty for stellar ages derived with any [Y/Mg]–Age relation. We also analyzed the [Y/Mg] Clock as a function of T eff , log⁡ g, and metallicity individually and find no strong trends, but we compute statistically significant [Y/Mg]–Age relations for subsamples defined by ranges in T eff , log g, and metallicity. Finally, we compare [Y/Mg] and rotation ages and find statistically similar trends as for isochrone ages, although we find that rotation ages perform better for GK dwarfs while isochrones perform better for FG subgiants. We conclude that the [Y/Mg] Clock is most precise for solar twins and analogs but is also a useful age diagnostic for FGK stars.

Travis A. Berger↗
DOE OSTI2019

Guide for Employing High-Resolution Gamma Spectroscopy for 252Cf Source Age and Isotopic Composition

Californium-252 is commonly used as a calibration source for neutron coincidence and neutron multiplicity counting in nuclear safeguards. Accurate knowledge of the neutron emission rate, age, and isotopics of the source (i.e., “source term”) are important for ensuring the best possible accuracies in item assay results. Californium-252 sources are not usually measured using gamma spectrometry, because of the assumption that their gamma-ray spectra appear to provide little information. However, gamma-ray signatures produced from 252Cf spontaneous fission products and odd-numbered Cf isotopes can be useful in determining source age and Cf isotopic composition. We demonstrate the utility of high-resolution gamma spectrometry in determining the age and isotopics of Cf neutron sources. In this work, five 252Cf sources were measured using a high-purity germanium detector. The neutron flux was small enough that radiation damage from prolonged neutron exposure was not substantial. Spectra were collected in 2-hour increments for 42–48 hours for quality control. The 2-hour spectra were added together to create a single spectrum for each source, and peak analyses were performed. Source ages were determined using a method that involved experimentally measuring the ratio of the gamma-ray emission rate of the 661.657 keV from 137Cs relative to a short-lived fission product and exploiting the dependence of this ratio on the source age. Source age was solved for using emission rates from four different gamma lines from four short-lived spontaneous fission products. Analysis results from all four fission products returned statistically similar source ages, but two had uncertainties greater than 25% because of high spontaneous fission product yield uncertainties as nominally high as 63%. Choosing short-lived fission products with small yield uncertainties is most important for accurately calculating source age. Additionally, the calculated ages did not always match the time since 248Cm separation well, which is often assumed to be the source age on the technical data sheet provided by the manufacturer. Activity ratios of 249Cf to 251Cf, the only Cf gamma emitters present in a 252Cf source, also did not match between experimental data and data on the technical data sheet provided by the vendor. It is thus recommended that newly purchased Cf sources be examined using gamma spectrometry to determine the source age and confirm isotopic composition of a 252Cf calibration source.

Watson, Mara M.↗
DOE OSTI2019

The Effect of Multistage Aging on Mechanical Properties and Microstructure of Forged 7050 Aluminum Alloys

A new four-stage aging treatment, which is composed of pre-aging, retrogression, natural aging (NA) and re-aging, is designed to increase the tensile properties and the fatigue life of forged 7050 aluminum alloy in this work. As compared to traditional T74 and RRA treatments, the four-stage aging-treated sample exhibits the highest tensile properties and ductility. The tensile strength and yield strength are 627 and 608 MPa, respectively, and the elongation is 11.3%. The results of TEM and DSC show that an increased G.P zones and fine η′ phase distributed in the matrix of the alloy are subjected by this new aging processing as compared with T74 and RRA treatments. The natural aging in four-stage aging treatment accelerates the diffusion of Mg vacancies, and promotes the precipitation of G.P zones in grain interior during re-aging stage. On the basis of dislocation shearing mechanism, more dense and fine G.P zones of four-stage aging temper result in the superior tensile strength as compared to T74 and RRA temper. In addition, a combination of shearable precipitates, fine GBPs and narrow PFZs is beneficial to the slip reversibility in the plastic zone at the crack tip, thereby reducing fatigue damage accumulation and increasing the fatigue life.

36 MATERIALS SCIENCE↗
DOE OSTI2014

Increased centrosome amplification in aged stem cells of the Drosophila midgut

Highlights: • Increased centrosome amplification in ISCs of aged Drosophila midguts. • Increased centrosome amplification in ISCs of oxidative stressed Drosophila midguts. • Increased centrosome amplification in ISCs by overexpression of PVR, EGFR, and AKT. • Supernumerary centrosomes can be responsible for abnormal ISC polyploid cells. • Supernumerary centrosomes can be a useful marker for aging stem cells. - Abstract: Age-related changes in long-lived tissue-resident stem cells may be tightly linked to aging and age-related diseases such as cancer. Centrosomes play key roles in cell proliferation, differentiation and migration. Supernumerary centrosomes are known to be an early event in tumorigenesis and senescence. However, the age-related changes of centrosome duplication in tissue-resident stem cells in vivo remain unknown. Here, using anti-γ-tubulin and anti-PH3, we analyzed mitotic intestinal stem cells with supernumerary centrosomes in the adult Drosophila midgut, which may be a versatile model system for stem cell biology. The results showed increased centrosome amplification in intestinal stem cells of aged and oxidatively stressed Drosophila midguts. Increased centrosome amplification was detected by overexpression of PVR, EGFR, and AKT in intestinal stem cells/enteroblasts, known to mimic age-related changes including hyperproliferation of intestinal stem cells and hyperplasia in the midgut. Our data show the first direct evidence for the age-related increase of centrosome amplification in intestinal stem cells and suggest that the Drosophila midgut is an excellent model for studying molecular mechanisms underlying centrosome amplification in aging adult stem cells in vivo.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Characterizing precipitate evolution of an Al–Zn–Mg–Cu-based commercial alloy during artificial aging and non-isothermal heat treatments by in situ electrical resistivity monitoring

In situ electrical resistivity monitoring technique was employed to continuously evaluate the precipitate evolution of an Al–Zn–Mg–Cu-based commercial alloy during typical artificial aging treatments. The effects of artificial aging on the precipitates stability during non-isothermal heat treatments were also explored. Conventional hardness test, transmission electron microscopy and differential scanning calorimetry were also adopted to verify the electrical resistivity results. The results indicated that both the precipitation process and its timely rate could be followed by the monitored electrical resistivity during artificial aging treatments. The electrical resistivity results gave overall information on continuous precipitation and dissolution processes, especially under high heating rates. Samples artificial aging heat treated at 120 °C for 24 h followed by aging at 150 °C for 24 h presented more stable state and coarser precipitates than the samples only artificial aging heat treated at 120 °C for 24 h or triple artificial aging heat treated at 120 °C/24 h + 195 °C/15 min + 120 °/24 h. While the incoherent η precipitates in the samples artificial aging heat treated at 120 °C for 24 h followed by aging at 150 °C for 24 h were more easiness to coarsening and dissolve during non-isothermal heat treatments as well. - Highlights: • In situ electrical resistivity monitoring technique was employed on an Al-Zn-Mg-Cu alloy. • The precipitate evolution during typical artificial aging treatments was studied. • The precipitate stability during non-isothermal heat treatments was explored. • The electrical resistivity wonderfully monitored continuous precipitation and dissolution. • The alloy submitted to a T7 treatment presents a more stable state during heating due to incoherent η precipitates.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Microstructure-based prediction of thermal aging strength reduction factors for grade 91 ferritic-martensitic steel

This study aimed to develop a microstructure-based mechanistic approach to address the long-term thermal aging effect on yield stress and ultimate tensile strength and to provide a physical basis for developing thermal aging factors for G91 for a design life of 60 years. Several heats of G91 steel were examined. Controlled aging experiments were conducted on two heats at temperatures of 550, 600, and 650 °C for times up to ~64,000 h. Specimens were also taken from archived creep-tested specimens of G91 and from a tube removed from the Kingston coal-fired power plant to obtain data that cover a wide range of temperatures and for aging times up to 155,000 h. Thermal aging caused significant subgrain recovery, coarsening of M 23 C 6 carbides at subgrain boundaries and MX carbonitrides within subgrains. The intermetallic Laves phase forms during aging and grows rapidly. The growth rate of the subgrain width and MX mean size during thermal aging were described by kinetic models. Thermal aging results in the reductions in the yield stress and the ultimate tensile strength of G91. The effects of thermal aging on the reductions in yield stress and ultimate tensile strength were well described by the microstructure-strength model that considers three superimposed strengthening mechanisms, namely, sub-boundary strengthening, MX precipitation hardening, and Mo solid solution strengthening. Furthermore, the model was independently validated by the ASME Code values and is being used by the ASME to develop the aging-induced strength reduction factors for G91 steel for a design life of 60 years.

36 MATERIALS SCIENCE↗
DOE OSTI2015

Age and sex differences in kidney microRNA expression during the life span of F344 rats

Background: Growing evidence suggests that epigenetic mechanisms of gene regulation may play a role in susceptibilities to specific toxicities and adverse drug reactions. MiRNAs in particular have been shown to be important regulators in cancer and other diseases and show promise as predictive biomarkers for diagnosis and prognosis. In this study, we characterized the global kidney miRNA expression profile in untreated male and female F344 rats throughout the life span. These findings were correlated with sex-specific susceptibilities to adverse renal events, such as male-biased renal fibrosis and inflammation in old age. Methods: Kidney miRNA expression was examined in F344 rats at 2, 5, 6, 8, 15, 21, 78, and 104 weeks of age in both sexes using Agilent miRNA microarrays. Differential expression was determined using filtering criteria of ≥1.5 fold change and ANOVA or pairwise t-test (FDR <5%) to determine significant age and sex effects, respectively. Pathway analysis software was used to investigate the possible roles of these target genes in age- and sex-specific differences. Results: Three hundred eleven miRNAs were found to be expressed in at least one age and sex. Filtering criteria revealed 174 differentially expressed miRNAs in the kidney; 173 and 34 miRNAs exhibiting age and sex effects, respectively. Principal component analysis revealed age effects predominated over sex effects, with 2-week miRNA expression being much different from other ages. No significant sexually dimorphic miRNA expression was observed from 5 to 8 weeks, while the most differential expression (13 miRNAs) was observed at 21 weeks. Potential target genes of these differentially expressed miRNAs were identified. Conclusions: The expression of 56% of detected renal miRNAs was found to vary significantly with age and/or sex during the life span of F344 rats. Pathway analysis suggested that 2-week-expressed miRNAs may be related to organ and cellular development and proliferation pathways. Male-biased miRNA expression at older ages correlated with male-biased renal fibrosis and mononuclear cell infiltration. These miRNAs showed high representation in renal inflammation and nephritis pathways, and included miR-214, miR-130b, miR-150, miR-223, miR-142-5p, miR-185, and miR-296*. Analysis of kidney miRNA expression throughout the rat life span will improve the use of current and future renal biomarkers and inform our assessments of kidney injury and disease.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2017

The Ages and Masses of a Million Galactic-disk Main-sequence Turnoff and Subgiant Stars from the LAMOST Galactic Spectroscopic Surveys

We present estimates of stellar age and mass for 0.93 million Galactic-disk main-sequence turnoff and subgiant stars from the LAMOST Galactic Spectroscopic Surveys. The ages and masses are determined by matching with stellar isochrones using a Bayesian algorithm, utilizing effective temperature T{sub eff}, absolute magnitude M{sub V}, metallicity [Fe/H], and α-element to iron abundance ratio [α/Fe] deduced from the LAMOST spectra. Extensive examinations suggest the age and mass estimates are robust. Overall, the sample stars have a median error of 34% for the age estimates, and half of the stars older than 2 Gyr have age uncertainties of only 20%–30%. The median error for the mass estimates of the whole sample of stars is ∼8%. The huge data set demonstrates good correlations among stellar age, [Fe/H] ([α/H]), and [α/Fe]. Particularly, double-sequence features are revealed in both the age–[α/Fe] and age–[Fe/H]([α/H]) spaces. In the [Fe/H]–[α/Fe] space, stars of 8–10 Gyr exhibit both the thin and thick disk sequences, while younger (older) stars show only the thin (thick) disk sequence, indicating that the thin disk became prominent 8–10 Gyr ago, while the thick disk formed earlier and was almost quenched 8 Gyr ago. Stellar ages exhibit positive vertical and negative radial gradients across the disk, and the outer disk of R ≳ 9 kpc exhibits a strong flare in stellar age distribution.

79 ASTRONOMY AND ASTROPHYSICS↗