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At least 253 records · Page 14

Assessment of the NASA Flight Assurance Review Program

The NASA flight assurance review program to develop minimum standard guidelines for flight assurance reviews was assessed. Documents from NASA centers and NASA headquarters to determine current design review practices and procedures were evaluated. Six reviews were identified for the recommended minimum. The practices and procedures used at the different centers to incorporate the most effective ones into the minimum standard review guidelines were analyzed and guidelines for procedures, personnel and responsibilies, review items/data checklist, and feedback and closeout were defined. The six recommended reviews and the minimum standards guidelines developed for flight assurance reviews are presented. Observations and conclusions for further improving the NASA review and quality assurance process are outlined.

Holmes, J.↗

Application of New CERCLA Five-Year Review Guidance at Hanford - 16403

Under CERCLA, the implementation of remedial actions established in records of decision (ROD) are required to be reviewed every five years to evaluate their effectiveness in protecting human health and the environment. Past reviews have included evaluation of actions that were not implemented under existing RODs and, therefore, not subject to the requirement. While commendable for its transparency, discussing these out-of-scope actions created confusion and elicited comments that required time and effort to resolve. The fourth CERCLA Five Year Review (FYR) at the Hanford Site embraces the EPA guidance designed to streamline the process and focuses on the specific objectives of the review. This guidance and the training materials developed jointly by multiple federal agencies including EPA, DOE, DOD, and Department of the Interior (DOI), demonstrate a focused approach to the FYR process and offer real-world examples for streamlining this important document. This paper discusses the focused approach and process changes implemented at the Hanford Site that reduced the size and complexity of the document and provided the DOE, Richland Operations Office, with an efficient, effective template for preparing subsequent reviews. One key change was a thorough evaluation of what operable units were discussed and what operable units were not discussed in the five-year review. This process resulted in a reduction of 14 operable unit discussions. Additionally, extensive referencing of previously published CERCLA documents including closure reports and periodic groundwater monitoring reports minimized the amount of analytical data tables necessary to support the discussion. The Hanford five year review made good use of technology and provided internet links to existing documents where detailed information and voluminous analytical data reside. This eliminated the use of extensive data tables and summaries. The resulting five protectiveness determinations include: 1) 'Protective' which is used when there is sufficient data to conclude that the remedy is functioning as intended; 2) 'Protective in the short term' which is used when the data and/or documentation review raises issues that could affect future protectiveness; 3) 'Will be protective' which is used when the remedy under construction is anticipated to be protective on completion; 4) 'Protectiveness deferred' which is typically used when additional information is needed; and 5) 'Not protective' which is used when risks are not under control. Reviewing only on the appropriate operable units, and supporting the analysis of remedy performance with focused data, the resulting protectiveness determinations and overall effectiveness of the document were significantly improved. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

SU-E-CAMPUS-J-04: Image Guided Radiation Therapy (IGRT): Review of Technical Standards and Credentialing in Radiotherapy Clinical Trials

Purpose: To review IGRT credentialing experience and unexpected technical issues encountered in connection with advanced radiotherapy technologies as implemented in RTOG clinical trials. To update IGRT credentialing procedures with the aim of improving the quality of the process, and to increase the proportion of IGRT credentialing compliance. To develop a living disease site-specific IGRT encyclopedia. Methods: Numerous technical issues were encountered during the IGRT credentialing process. The criteria used for credentialing review were based on: image quality; anatomy included in fused data sets and shift results. Credentialing requirements have been updated according to the AAPM task group reports for IGRT to ensure that all required technical items are included in the quality review process. Implementation instructions have been updated and expanded for recent protocols. Results: Technical issues observed during the credentialing review process include, but are not limited to: poor quality images; inadequate image acquisition region; poor data quality; shifts larger than acceptable; no soft tissue surrogate. The updated IGRT credentialing process will address these issues and will also include the technical items required from AAPM: TG 104; TG 142 and TG 179 reports. An instruction manual has been developed describing a remote credentialing method for reviewers. Submission requirements are updated, including images/documents as well as facility questionnaire. The review report now includes summary of the review process and the parameters that reviewers check. We have reached consensus on the minimum IGRT technical requirement for a number of disease sites. RTOG 1311(NRG-BR002A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases) is an example, here; the protocol specified the minimum requirement for each anatomical sites (with/without fiducials). Conclusion: Technical issues are identified and reported. IGRT guidelines are updated, with the corresponding credentialing requirements. An IGRT encyclopedia describing site-specific implementation issues is currently in development.

60 APPLIED LIFE SCIENCES↗

Reducing NPR 7120.5D to Practice: Preparing for a Life-Cycle Review

In March 2007, NASA issued revised rules for space flight project management, NPR 7120.5D, 'NASA Space Flight Program and Project Management Requirements.' Central to the new rules was the construct of Key Decision Points, maturity gates that the project team must pass in order to continue development. In order that the KDP decision be fully informed, the NPR required, as entrance criteria for the gate, the generation and delivery of specified planning, technical, and cost/schedule documents (gate products) and a life-cycle review, the Preliminary Design Review. Building on JPL experience on the Prometheus and Juno projects, the team successfully organized for and conducted these reviews on an aggressive schedule. Key actions were taken to proactively interact with the SRB, produce high-quality gate products with stakeholder review, generate review presentation materials, and handle a myriad of supporting logistical functions. A review preparation team was established, including a Review Captain and leads for documentation, information systems, and logistics, and their roles, responsibilities and task assignments were identified. Aids were produced, including a detailed review preparation schedule and a comprehensive gate products production table. Institutional support was leveraged early and often. Implementation strategy reflected the needs of a nationally-distributed team, as well as applicable export control and IT security requirements. This paper gives a brief overview of the GRAIL mission and its project management challenges, provides a detailed description of project PMSR and PDR preparation and execution activities, including positive and negative lessons learned, and identifies recommendations for future NASA (and non-NASA) project teams.

NPR 7120.5D↗

Smart manufacturing maturity models and their applicability: a review

The purpose of this paper is to review existing smart manufacturing (SM) maturity models' dimensions and maturity levels to assess their applicability and drawbacks. There are many maturity models available but many of them have not been validated or do not provide a useful guide or tool for applications. This gap creates the need for a review of the existing maturity model's applicability. Nineteen peer-reviewed maturity models related to “Digital Transformation,” “Industry 4.0” or “Smart Manufacturing” were selected based on a systematic literature review and five consulting firm models were selected based on the author's industry knowledge. The chosen models were analyzed to determine 10 categories of dimensions. Then they are assessed on a 1–5 scale for how applicable they are in the 10 categories of dimensions. The five “consulting firm” models have a first-mover advantage, are more widely used in industry and are more applicable, but some require payment, and they lack published details and validation. The 19 “peer reviewed” models are not as widely used, lack awareness in the industry and are not as easy to apply because of no web tool for self-assessment, but they are improving. The categories defined to characterize the models and facilitate comparisons for users include “Information Technology (IT) and Cyber-Physical System (CPS) and Data,” “Strategy and Organization,” “Supply Chain and Logistics,” “Products and Services,” “Culture and Employees,” “Technology and Capabilities,” “Customer and Market,” “Cybersecurity and Risk,” “Leadership and Management” and “Governance and Compliance.” The analyzed maturity models were particularly weak in the areas of cybersecurity, leadership and governance. Researchers and practitioners can use this review with consideration of their specific needs to determine if a maturity model is applicable or if a new model needs to be developed. The review can also aid in the development of maturity models through the discussion of each of the dimension categories. Finally, compared to existing reviews of SM maturity models, this research determines comprehensive dimension categories and focuses on applicability and drawbacks.

42 ENGINEERING↗

Literature Review for Sensor Impact Evaluation and Verification Use Cases - Building Controls and Fault Detection and Diagnosis (FDD)

This report summarizes a comprehensive literature review for the selected sensor suites used in building controls and fault detection and diagnostics (FDD), which is a Q2 deliverable of the Sensor Impact Evaluation and Verification project. The project’s overarching goal is to develop a framework for investigating the impact of sensor deployment and configuration for building energy optimization, fault detection and diagnosis (FDD), occupants’ thermal comfort, and potential grid efficiency. While the first phase of the literature review performed in Q1 reviewed the current methods of various sensor selection and placements and their impact, this report focuses on high impactful potential use cases for the selected sensor suites in building control and FDD. The use cases identified in this literature review will be further investigated and be included in the final sensor impact evaluation framework. For the review, the multi-laboratory team reviewed 241 research papers, technical reports, and books to identify existing technologies, the potential impact on energy savings and thermal comfort, and future research opportunities for the selected use cases in building controls and FDD. Along with the literature review, the team conducted a series of interviews with experts in sensors and controls area to identify the state-of-art sensor technologies, and the most impactful use cases in controls and FDD areas. The interview results will also be incorporated with the findings from the literature review in the next quarter, and the final use cases to be evaluated will be selected.

47 OTHER INSTRUMENTATION↗

I Hate Reviews!

In our business we have all kinds of reviews: financial reviews, strategy reviews, technical reviews, test reviews, design reviews, baseline reviews, etc., etc. Some ways to avoid the most common pitfalls that I find specifically in these kinds of reviews are given.

Little, Terry↗

The overview in safety review of human factors engineering and control room design in chinese AP1000 nuclear power plant - 174

The first AP1000 nuclear power plant is constructed in Sanmen county in Zhejiang Province in China, which has creative and distinctive design characteristics. Human factors engineering disciplines are applied to the design of the AP1000. In addition to the elements of the program review model(including human factors engineering program management, operating experience review, functional requirements analysis and allocation, task analysis, staffing, integration of human reliability analysis with human factors engineering, human system interface design, procedure development, training program development, human system interface verification and validation, design implementation, human performance monitoring),the minimum inventory of controls, displays, and alarms present in the main control room and at the remote shutdown workstation. These contents mentioned above are reviewed according to standards, rules and regulations. This article introduces review process, and several important issues during the reviewing are described in detail. These issues include many elements, such as operating experience review, task analysis, human system interface design, verification and validation,and so on. This paper emphasizes on the main control room design(including environment and layout). Background noise in the actual main control room may exceed too much to design value. Another important issue is about main control room habitability systems(VES) changes to satisfy post-actuation performance requirements in AP1000 design change proposal. All the wall panel displays will be closed in this design change proposal. Review process and proposal are described in the paper. Since the AP1000 unit in China is the first constructed all over the world, verification and validation are especially important and necessary. The plan of verification and validation, the results summary report of verification and validation, the report of human engineering discrepancies are focus attention. Verification and validation in human factors engineering include HSI task support verification, HFE design verification and integrated system validation. This paper introduces the review process of verification and validation, the issues found in verification and validation. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Systems Innovation: Modernization & Efficiencies for ESH&Q Reviews

Environmental compliance reviews at INL have traditionally been managed through fragmented systems, relying on multiple spreadsheets and manual processes. This inefficiency led to time-consuming status updates and redundant tasks, such as manually sending reminder emails and transferring data from Excel to the Environmental Review Process (ERP). Initial attempts to streamline these processes using Power Automate and Excel revealed significant limitations, necessitating a more comprehensive solution. To address these immediate inefficiencies, automated workflows were developed using Power Automate. These workflows were designed to send scheduled status update reminders and capture responses through standardized forms, with submitted data flowing directly into centralized Excel trackers. This automation reduced the administrative burden, improved data accuracy, and enabled faster, more consistent reporting. Specifically, email automation achieved a 65% efficiency gain, while data integration saw a 48% improvement, resulting in 91% of project statuses being updated within two months. Despite the improvements brought by Power Automate, the fragmented nature of the review processes persisted. To further enhance efficiency and accuracy, the Integrated Review Tool (IRT) was developed. The IRT aims to centralize review initiation and connect team systems, creating an interconnected data infrastructure that preserves team autonomy while enhancing overall efficiency. This tool automates email reminders, centralizes reviews, and streamlines data integration, significantly improving the accuracy and efficiency of environmental compliance reviews. The design and development of the IRT involved advanced systems methodology, process mapping, project management, and collaboration with subject matter experts. The minimum viable product design is 100% complete, and system development is currently underway, with expected outcomes including a centralized entry point for all ESH&Q reviews, automated routing, real-time tracking and analytics, AI integration, and a user-friendly interface. This project demonstrates the potential of leveraging automation and integrated systems to enhance efficiency, accuracy, and decision-making in environmental reporting and compliance processes at INL.

99 - GENERAL AND MISCELLANEOUS↗

2021 Annual Merit Review Report, Vehicle Technologies Office

The 2021 U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy’s (EERE) Vehicle Technologies Office (VTO) Annual Merit Review (AMR) was held June 21-25, 2021, virtually, due to extenuating circumstances resulting from the global coronavirus disease (COVID-19) pandemic. The review encompassed work done by VTO: 273 individual activities were reviewed by 281 reviewers. Exactly 1,152 individual review responses were received for the VTO technical reviews. The objective of the meeting was to review the accomplishments and plans for VTO over the previous 12 months, and provide an opportunity for industry, government, and academia to give inputs to DOE with a structured and formal methodology. The meeting also provided attendees with a virtual forum for interaction and technology information transfer.

33 ADVANCED PROPULSION SYSTEMS↗

2022 Annual Merit Review Report, Vehicle Technologies Office: Results Report

The 2022 U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy’s (EERE) Vehicle Technologies Office (VTO) Annual Merit Review (AMR) was held June 21-23, 2022, as a hybrid event with in-person and virtual attendance. The review encompassed work done by VTO: 213 individual activities were reviewed by 255 reviewers. Exactly 1,051 individual review responses were received for the VTO technical reviews. The objective of the meeting was to review the accomplishments and plans for VTO over the previous 12 months, and provide an opportunity for industry, government, and academia to give inputs to DOE with a structured and formal methodology. The meeting also provided attendees with a virtual forum for interaction and technology information transfer.

33 ADVANCED PROPULSION SYSTEMS↗

An exploration of the feasibility of radiation therapist participation in treatment reviews

As radiation oncologists' (ROs') workload has increased over time, treatment review clinics have become recognized as an area of RO practice into which radiation therapist (RT) practice could extend. There has been limited utilization of RTs in this role in Australia and a paucity of data on the acceptability and opinions regarding RTs practising in this role in an Australian context. The purpose of this audit was to investigate the feasibility of RT participation in review clinics at Calvary Mater Newcastle. Feasibility was determined by two methods: an audit of 200 treatment reviews to determine medical intervention (MI) levels required and a survey of 80 clinical staff to explore attitudes towards RT participation in clinics. Medical intervention was required in 59% (n = 118) of observed reviews, with the lowest being for breast (33%) and prostate (28%) cancers. MI peaked at 73% between fractions 16–20 and was lowest early and late in the treatment period at 48%. There were 60 responses to the staff survey. All but one respondent agreed that RTs would be willing to participate in treatment review clinics, but all five consultant ROs indicated they would not be willing to delegate reviews to RTs. Neither feasibility measure reached acceptable levels to recommend RT participation in treatment review clinics. Further investigation and RT education are required to help meet the future RO workforce shortfall. As MI rates are lowest for breast and prostate cancer RT participation could be targeted to these clinics.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

WE-H-BRC-09: Simulated Errors in Mock Radiotherapy Plans to Quantify the Effectiveness of the Physics Plan Review

Purpose: A standard tool for ensuring the quality of radiation therapy treatments is the initial physics plan review. However, little is known about its performance in practice. The goal of this study is to measure the effectiveness of physics plan review by introducing simulated errors into “mock” treatment plans and measuring the performance of plan review by physicists. Methods: We generated six mock treatment plans containing multiple errors. These errors were based on incident learning system data both within the department and internationally (SAFRON). These errors were scored for severity and frequency. Those with the highest scores were included in the simulations (13 errors total). Observer bias was minimized using a multiple co-correlated distractor approach. Eight physicists reviewed these plans for errors, with each physicist reviewing, on average, 3/6 plans. The confidence interval for the proportion of errors detected was computed using the Wilson score interval. Results: Simulated errors were detected in 65% of reviews [51–75%] (95% confidence interval [CI] in brackets). The following error scenarios had the highest detection rates: incorrect isocenter in DRRs/CBCT (91% [73–98%]) and a planned dose different from the prescribed dose (100% [61–100%]). Errors with low detection rates involved incorrect field parameters in record and verify system (38%, [18–61%]) and incorrect isocenter localization in planning system (29% [8–64%]). Though pre-treatment QA failure was reliably identified (100%), less than 20% of participants reported the error that caused the failure. Conclusion: This is one of the first quantitative studies of error detection. Although physics plan review is a key safety measure and can identify some errors with high fidelity, others errors are more challenging to detect. This data will guide future work on standardization and automation. Creating new checks or improving existing ones (i.e., via automation) will help in detecting those errors with low detection rates.

60 APPLIED LIFE SCIENCES↗

Redefining the Practice of Peer Review Through Intelligent Automation—Part 3: Automated Report Analysis and Data Reconciliation

One method for addressing existing peer review limitations is the assignment of peer review cases on a completely blinded basis, in which the peer reviewer would create an independent report which can then be cross-referenced with the primary reader report of record. By leveraging existing computerized data mining techniques, one could in theory automate and objectify the process of report data extraction, classification, and analysis, while reducing time and resource requirements intrinsic to manual peer review report analysis. Once inter-report analysis has been performed, resulting inter-report discrepancies can be presented to the radiologist of record for review, along with the option to directly communicate with the peer reviewer through an electronic data reconciliation tool aimed at collaboratively resolving inter-report discrepancies and improving report accuracy. All associated report and reconciled data could in turn be recorded in a referenceable peer review database, which provides opportunity for context and user-specific education and decision support.

42 ENGINEERING↗

Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence

Background: Polybrominated diphenyl ethers (PBDEs) are ubiquitous in the environment, with well-documented and widespread human exposure. A recent systematic review and meta-analysis of human studies found an association between prenatal serum PBDE concentrations and a decrease in the IQ of children. Objective: Our goal was to demonstrate the application of systematic review methods, including meta-analysis (if possible), to animal toxicology data to draw conclusions about hazard. We performed a systematic review of experimental animal studies on the neurotoxicity of PBDEs following developmental exposure. Outcomes assessed included measures related to learning, memory, and attention, which parallel the intelligence-related outcomes evaluated in the systematic review of human studies. Methods: We searched PubMed, Embase, and Toxline for experimental studies in non-human mammals published in English through August 15, 2016. Evaluation of risk of bias and the overall body of evidence followed guidance developed by the National Toxicology Program’s Office of Health Assessment and Translation (OHAT). Results: The animal data on PBDEs and learning, memory, and attention were available for BDEs 47, 99, 153, 203, 206, and 209 and the technical mixture DE-71. These data were diverse and complex, with studies using varying designs and outcomes. There were concerns about risk of bias for many studies, and study reporting of methods and results was often incomplete. A meta-analysis of six studies showed consistent evidence of an increase in latency (effect size of 25.8 [CI, 20.3 to 31.2]) in the last trial of the Morris water maze in PBDE-exposed animals, with low heterogeneity. However, for most endpoints, there were unexplained inconsistencies across studies. There was also no consistent evidence of a dose-response relationship. Conclusions: Our analyses illustrates the application of systematic review methods to a chemical hazard assessment. There is a moderate level of evidence that exposure to BDEs 47, 99, and 209 affects learning. For other PBDEs and other endpoints, the level of evidence was low or very low. The meta-analysis led to stronger conclusions than would have been drawn based on a qualitative review of the evidence. The systematic review also identified factors that increased concerns about risk of bias in individual studies that might be remedied by better study reporting.

Polybrominated Diphenyl Ether↗

Review of Particle Physics

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group (http://pdg.lbl.gov). The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. Contents Abstract, Contributors, Highlights and Table of ContentsAcrobat PDF (150 KB) IntroductionAcrobat PDF (456 KB) Particle Physics Summary Tables Gauge and Higgs bosonsAcrobat PDF (155 KB) LeptonsAcrobat PDF (134 KB) QuarksAcrobat PDF (84 KB) MesonsAcrobat PDF (871 KB) BaryonsAcrobat PDF (300 KB) Searches (Supersymmetry, Compositeness, etc.)Acrobat PDF (91 KB) Tests of conservation lawsAcrobat PDF (330 KB) Reviews, Tables, and Plots Detailed contents for this sectionAcrobat PDF (37 KB) Constants, Units, Atomic and Nuclear PropertiesAcrobat PDF (278 KB) Standard Model and Related TopicsAcrobat PDF (7.3 MB) Astrophysics and CosmologyAcrobat PDF (2.7 MB) Experimental Methods and CollidersAcrobat PDF (3.8 MB) Mathematical Tools or Statistics, Monte Carlo, Group Theory Acrobat PDF (1.3 MB) Kinematics, Cross-Section Formulae, and PlotsAcrobat PDF (3.9 MB) Particle Listings Illustrative key and abbreviationsAcrobat PDF (235 KB) Gauge and Higgs bosonsAcrobat PDF (2 MB) LeptonsAcrobat PDF (1.5 MB) QuarksAcrobat PDF (1.2 MB) Mesons: Light unflavored and strangeAcrobat PDF (4 MB) Mesons: Charmed and bottomAcrobat PDF (7.4 MB) Mesons: OtherAcrobat PDF (3.1 MB) BaryonsAcrobat PDF (3.97 MB) Miscellaneous searchesAcrobat PDF (2.4 MB) IndexAcrobat PDF (160 KB)

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

2013 DOE Vehicle Technologies Office Annual Merit Review

The 2013 U.S. Department of Energy (DOE) Fuel Cell Technologies Office (FCTO) and Vehicle Technologies Office (VTO) Annual Merit Review and Peer Evaluation Meeting (AMR) was held May 13-17, 2013, in Crystal City, Virginia. The review encompassed all of the work done by the FCTO and the VTO: a total of 287 individual activities were reviewed for VTO, by a total of 187 reviewers. A total of 1,382 individual review responses were received for the VTO technical reviews. The objective of the meeting was to review the accomplishments and plans for VTO over the previous 12 months, and provide an opportunity for industry, government, and academia to give inputs to DOE on the Office with a structured and formal methodology. The meeting also provided attendees with a forum for interaction and technology information transfer.

33 ADVANCED PROPULSION SYSTEMS↗

2014 Annual Merit Review, Vehicle Technologies Office: Results Report

The 2014 U.S. Department of Energy (DOE) Fuel Cell Technologies Office (FCTO) and Vehicle Technologies Office (VTO) Annual Merit Review and Peer Evaluation Meeting (AMR) was held June 16-20, 2014, in Washington, DC. The review encompassed all of the work done by the FCTO and the VTO: a total of 295 individual activities were reviewed for VTO, by a total of 179 reviewers. A total of 1,354 individual review responses were received for the VTO technical reviews. The objective of the meeting was to review the accomplishments and plans for VTO over the previous 12 months, and provide an opportunity for industry, government, and academia to give inputs to DOE on the Office with a structured and formal methodology. The meeting also provided attendees with a forum for interaction and technology information transfer.

33 ADVANCED PROPULSION SYSTEMS↗