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At least 253 records · Page 14

Exploring Afro-Asian water fluxes in CMIP5 and CMIP6 models: Present-day evaluation and future projections

Accurate representation and projection of water fluxes are vital, particularly in monsoon regions where seasonal variability and changes significantly impact water resources, agriculture, hydroelectric power generation, and the economy. This study uses both CMIP5 and CMIP6 models to investigate the present-day representation of key water flux components (including precipitation, evaporation, water vapor, and moisture advection) over the Afro-Asian region during the summer monsoon (JJAS). We also examine future changes under two emission scenarios and assess the underlying physical mechanisms driving these changes while identifying sources of projection uncertainty. Our results show that both models reasonably capture the present-day characteristics of water flux components, although with noticeable biases. Across most regions, we find that CMIP6 models demonstrate slight improvements over CMIP5 in the representation of these components. In a warmer future, a robust intensification of JJAS precipitation (exceeding 0.25 mm/day) is projected across the Afro-Asian region. This increase is largely driven by the vertical thermodynamic term associated with increasing temperature. We find that model uncertainty is the primary source of uncertainty in water flux projections, accounting for over 50 % of the total variance.

Climate change↗

Emerging contaminants: Presentations at the 2009 Toxicology and Risk Assessment Conference

A session entitled 'Emerging Contaminants' was held in April 2009 in Cincinnati, OH at the 2009 Toxicology and Risk Assessment Conference. The purpose of the session was to share information on both programmatic and technical aspects associated with emerging contaminants. Emerging contaminants are chemicals or materials that are characterized by a perceived or real threat to human health or environment, a lack of published health standards or an evolving standard. A contaminant may also be 'emerging' because of the discovery of a new source, a new pathway to humans, or a new detection method or technology. The session included five speakers representing the Department of Defense (DoD), the Environmental Protection Agency (EPA), and each of the military services. The DoD created the Emerging Contaminant Directorate to proactively address environmental, health, and safety concerns associated with emerging contaminants. This session described the scan-watch-action list process, impact assessment methodology, and integrated risk management concept that DoD has implemented to manage emerging contaminants. EPA presented emerging trends in health risk assessment. Researchers made technical presentations on the status of some emerging contaminates in the assessment process (i.e. manganese, RDX, and naphthalene).

60 APPLIED LIFE SCIENCES↗

The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation

KSHV LANA1, a latent protein expressed during chronic infection to maintain a viral genome, inhibits major histocompatibility complex class I (MHC I) peptide presentation in cis as a means of immune evasion. Through deletional cloning, we localized this function to the LANA1 central repeat 1 (CR1) subregion. Other CR subregions retard LANA1 translation and proteasomal processing but do not markedly inhibit LANA1 peptide processing by MHC I. Inhibition of proteasomal processing ablates LANA1 peptide presentation. Direct expression of LANA1 within the endoplasmic reticulum (ER) overcomes CR1 inhibition suggesting that CR1 acts prior to translocation of cytoplasmic peptides into the ER. By physically separating CR1 from other subdomains, we show that LANA1 evades MHC I peptide processing by a mechanism distinct from other herpesviruses including Epstein-Barr virus (EBV). Although LANA1 and EBV EBNA1 are functionally similar, they appear to use different mechanisms to evade host cytotoxic T lymphocyte surveillance.

60 APPLIED LIFE SCIENCES↗

CXCR5+ CD8+ T cells potently infiltrate pancreatic tumors and present high functionality

Despite continued improvement in conventional therapy, pancreatic cancer continues to be one of the deadliest tumors worldwide with abysmal 5-year survival rate. New immunotherapeutic strategies that aim at improving antitumor cytotoxic CD8{sup +} T cell responses are being developed in solid tumors. To assist the development of immunotherapies, we investigated the CD8{sup +} T cells in pancreatic cancer patients. Compared to healthy individuals, pancreatic cancer patients presented a significant enrichment in the frequency of CD8{sup +}CXCR5{sup +} T cells. In the tumor microenvironment, the frequencies of CD8{sup +}CXCR5{sup +} T cells were further increased. In most cases, over half of tumor-infiltrating CD8{sup +} T cells were CD8{sup +}CXCR5{sup +} T cells. Compared to the circulating population, the tumor-infiltrating CD8{sup +}CXCR5{sup +} T cells expressed higher levels of PD-1 and TIM-3. Functional analyses demonstrated that upon CD3/CD28 activation, the percentages of TNF-expressing and IFN-γ-expressing cells in CD8{sup +}CXCR5{sup +} T cells were significantly higher than that in CD8{sup +}CXCR5{sup -} T cells. CD8{sup +}CXCR5{sup +} T cells also presented enhanced cytotoxicity than CD8{sup +}CXCR5{sup -} T cells. Upon PD-1 and TIM-3 blockade, the functions of CD8{sup +}CXCR5{sup +} T cells were further improved. The disease-free survival of pancreatic cancer patients following tumor resection was positively correlated with the frequencies of circulating and tumor-infiltrating CD8{sup +}CXCR5{sup +} T cells. Together, our study identified that CD8{sup +}CXCR5{sup +} T cells were a potent subset of CD8{sup +} T cells that were highly enriched in pancreatic cancer patients and could respond to anti-PD-1/anti-TIM-3 blockade by further upregulation in function.

60 APPLIED LIFE SCIENCES↗

Discussion: Presentation of Atmospheric 14 C O2 data

ABSTRACT Observations of radiocarbon ( 14 C) in Earth’s atmosphere and other carbon reservoirs are important to quantify exchanges of CO 2 between reservoirs. The amount of 14 C is commonly reported in the so-called Delta notation, i.e., Δ 14 C, the decay- and fractionation-corrected departure of the ratio of 14 C to total C from that ratio in an absolute international standard; this Delta notation permits direct comparison of 14 C/C ratios in the several reservoirs. However, as Δ 14 C of atmospheric CO 2 , Δ 14 CO 2 is based on the ratio of 14 CO 2 to total atmospheric CO 2 , its value can and does change not just because of change in the amount of atmospheric 14 CO 2 but also because of change in the amount of total atmospheric CO 2 , complicating ascription of change in Δ 14 CO 2 to change in one or the other quantity. Here we suggest that presentation of atmospheric 14 CO 2 amount as mole fraction relative to dry air (moles of 14 CO 2 per moles of dry air in Earth’s atmosphere), or as moles or molecules of 14 CO 2 in Earth’s atmosphere, all readily calculated from Δ 14 CO 2 and the amount of atmospheric CO 2 (with slight dependence on δ 13 CO 2 ), complements presentation only as Δ 14 CO 2 , and can provide valuable insight into the evolving budget and distribution of atmospheric 14 CO 2 .

Geochemistry & Geophysics↗

Vulnerability of Louisiana’s coastal wetlands to present-day rates of relative sea-level rise

Coastal Louisiana has lost about 5,000 km 2 of wetlands over the past century and concern exists whether remaining wetlands will persist while facing some of the world’s highest rates of relative sea-level rise (RSLR). Here we analyse an unprecedented data set derived from 274 rod surface-elevation table-marker horizon stations, to determine present-day surface-elevation change, vertical accretion and shallow subsidence rates. Comparison of vertical accretion rates with RSLR rates at the land surface (present-day RSLR rates are 12±8 mm per year) shows that 65% of wetlands in the Mississippi Delta (SE Louisiana) may keep pace with RSLR, whereas 58% of the sites in the Chenier Plain (SW Louisiana) do not, rendering much of this area highly vulnerable to RLSR. At least 60% of the total subsidence rate occurs within the uppermost 5–10 m, which may account for the higher vulnerability of coastal Louisiana wetlands compared to their counterparts elsewhere.

54 ENVIRONMENTAL SCIENCES↗

Present and Future of Central Production With STAR Detector at RHIC

The present status and future of the physics program of Central Production using the STAR detector at RHIC are described. The program focuses on particle production in the Double Pomeron Exchange (DPE) process. Forward protons from the DPE interaction are detected in the Roman Pot system installed at 55.5 m and 58.5 m on both sides of the STAR interaction point. The recoil system of charged particles from the DPE process is measured in the STAR Time Projection Chamber (TPC). The first data were taken during the 2009 RHIC Run 9 using polarized proton-proton collisions at {radical}(s) 200 GeV. The preliminary spectra of two pion and four pion invariant mass reconstructed by STAR TPC in central region of pseudo-rapidity |{eta}|<1, are presented. Plans to take data with the current system at {radical}(s) = 500 GeV and plans to upgrade the forward proton tagging system, so that it can reach higher masses and obtain large data samples to allow searching for glueballs that could be produced in the DPE process, are also discussed.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A LIBS method for simultaneous monitoring of the impurities and the hydrogenic composition present in the wall of the TJ-II stellarator

The study of plasma-wall interactions and impurity transport in the plasma fusion devices is critical for the development of future fusion reactors. An experiment to perform laser induced breakdown spectroscopy, using minor modifications of our existing laser blow-off impurity injection system, has been set up thus making both experiments compatible. The radiation produced by the laser pulse focused at the TJ-II wall evaporates a surface layer of deposited impurities and the subsequent radiation produced by the laser-produced plasma is collected by two separate lens and fiber combinations into two spectrometers. The first spectrometer, with low spectral resolution, records a spectrum from 200 to 900 nm to give a survey of impurities present in the wall. The second one, with high resolution, is tuned to the wavelengths of the Hα and Dα lines in order to resolve them and quantify the hydrogen isotopic ratio present on the surface of the wall. The alignment, calibration, and spectral analysis method will be described in detail. First experimental results obtained with this setup will be shown and its relevance for the TJ-II experimental program discussed.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Regulation of T cell expansion by antigen presentation dynamics

An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology. Recent experiments in mice have demonstrated that the expansion of a specific clone of T cells in response to cognate antigen obeys a striking inverse power law with respect to the initial number of T cells. Here, we show that such a relationship arises naturally from a model in which T cell expansion is limited by decaying levels of presented antigen. The same model also accounts for the observed dependence of T cell expansion on affinity for antigen and on the kinetics of antigen administration. Extending the model to address expansion of multiple T cell clones competing for antigen, we find that higher-affinity clones can suppress the proliferation of lower-affinity clones, thereby promoting the specificity of the response. Using the model to derive optimal vaccination protocols, we find that exponentially increasing antigen doses can achieve a nearly optimized response. We thus conclude that the dynamics of presented antigen is a key regulator of both the size and specificity of the adaptive immune response.

59 BASIC BIOLOGICAL SCIENCES↗

Modeling of Transport Processes in Liquid-Metal Fusion Blankets: Past, Present, and Future

The successful development of robust breeding blanket systems will strongly rely on computational tools for predicting the complex behavior of the electrically conducting liquid-metal (LM) breeder flowing in the complex-shaped blanket ducts in the presence of a strong plasma-confining magnetic field, volumetric heating, and tritium generation. Associated transport processes involve magnetohydrodynamic (MHD) flows, heat transfer, corrosion, and tritium transport. This paper is an overview of past and present efforts in the development, application, and verification and validation (V&V) of such computational tools. As a result of the ongoing campaign on V&V of computer codes for LM blankets, the international fusion community has identified several candidates that promise to become real blanket design and analysis tools in the near future. Among them are HIMAG, MHD-UCAS, COMSOL Multiphysics, ANSYS FLUENT, ANSYS CFX, and OpenFOAM. The progress, over the last decade, in the application of such codes in blanket studies is tremendous. This is illustrated with two examples for a dual-coolant lead-lithium (DCLL) blanket: (1) integrated computer modeling for the recently designed DCLL blanket in the United States and (2) application of the code MHD-UCAS to the analysis of PbLi flows and heat transfer in a generic DCLL blanket prototype at high Hartmann (Ha ~ 10 4 ) and Grashof numbers (Gr ~ 10 12 ). Here, this paper also presents an approach to the development of a new integrated computational tool called the virtual dual-coolant lead-lithium (VDCLL) blanket, which elaborates the existing U.S. MHD code HIMAG.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

PRESENT-DAY MASS FUNCTION OF SIX SMALL MAGELLANIC CLOUD INTERMEDIATE-AGE AND OLD STAR CLUSTERS

We determined the present-day mass functions (PDMFs) of the five intermediate-age star clusters Lindsay 1, Kron 3, NGC 339, NGC 416, and Lindsay 38 and the old star cluster NGC 121 in the Small Magellanic Cloud (SMC) based on observations with the Hubble Space Telescope Advanced Camera for Surveys. The global PDMFs are well matched by Salpeter-like power laws from their main-sequence turnoffs to {approx}0.6 M{sub sun} with a power-law exponent {alpha} ranging from 1.51 {+-} 0.11 (Lindsay 1) to 2.29 {+-} 0.15 (NGC 339). We derive total stellar masses of {approx}10{sup 5} M{sub sun}, except for Lindsay 38, whose mass is of the order of {approx}10{sup 4} M{sub sun}. Differences between the PDMFs most likely reflect the varying stages of dynamical evolution of the clusters. These SMC clusters do not follow the {alpha} versus concentration parameter c correlation as found for Galactic globular clusters of similar mass. This might be an age effect or due to their location in a galaxy where bulge and disk crossings do not play a role. No correlation is found between {alpha} and the cluster core and tidal radii (r{sub c} and r{sub t} , respectively), the half-light radii r{sub h} , age, central surface brightness, metallicity, and galactocentric radius r{sub gc}. All six clusters mass-segregated to different degrees. The two clusters Lindsay 1 and Kron 3 barely show signs for mass segregation, but have low-mass star deficient global PDMFs and might be the remnants of star clusters whose outer parts were stripped. A trend exists between the degree of mass segregation and the ratio age/relaxation time t{sub r,h}, which indicates the stage of dynamical evolution for a cluster. Our data thus suggest that the SMC clusters in the present sample had a range of initial densities and presumably different amounts of mass loss that led to different rates of dynamical evolution. The clusters' positions in the r{sub h,m}/r{sub t} versus r{sub 0}/r{sub h,m} plane imply that all of the clusters are tidally filled. Our SMC clusters with projected distances larger than 3 kpc from the SMC center should have Jacobi radii significantly larger than their observed King tidal radii. The clusters also have higher mean densities than the estimated central density of the SMC. It is possible that these clusters formed in a denser overall environment of the younger SMC, or that the cluster structures were unusually strongly influenced by encounters with giant molecular clouds.

79 ASTRONOMY AND ASTROPHYSICS↗

GAS ACCRETION IN THE M32 NUCLEUS: PAST AND PRESENT

Using adaptive optics assisted Gemini/NIFS data, I study the present and past gas accretion in the central 3'' of the M32 nucleus. From changes in the spectral slope and CO line depths near the center, I find evidence for unresolved dust emission resulting from black hole (BH) accretion. With a luminosity of {approx}2 x 10{sup 38} erg s{sup -1}, this dust emission appears to be the most luminous tracer of current BH accretion, 2 orders of magnitude more luminous than previously detected X-ray emission. These observations suggest that using high-resolution infrared data to search for dust emission may be an effective way to detect other nearby, low-luminosity BHs, such as those in globular clusters. I also examine the fossil evidence of gas accretion contained in the kinematics of the stars in the nucleus. The higher order moments (h3 and h4) of the line-of-sight velocity distribution show patterns that are remarkably similar to those seen on larger scales in elliptical galaxies and in gas-rich merger simulations. The kinematics suggests the presence of two components in the M32 nucleus, a dominant disk overlying a pressure supported component. I discuss possible formation scenarios for the M32 nucleus in the context of the kinematic data as well as previous stellar population studies. The kinematic measurements presented here are the highest quality available for the nucleus of M32, and may be useful for any future dynamical models of this benchmark system.

79 ASTRONOMY AND ASTROPHYSICS↗

Kinetic physics in ICF: present understanding and future directions

Kinetic physics has the potential to impact the performance of indirect-drive inertial confinement fusion (ICF) experiments. Systematic anomalies in the National Ignition Facility implosion dataset have been identified in which kinetic physics may play a role, including inferred missing energy in the hohlraum, drive asymmetry in near-vacuum hohlraums, low areal density and high burn-averaged ion temperatures (T i ) compared with mainline simulations, and low ratios of the DD-neutron and DT-neutron yields and inferred T i . Several components of ICF implosions are likely to be influenced or dominated by kinetic physics: laser-plasma interactions in the LEH and hohlraum interior; the hohlraum wall blowoff, blowoff/gas and blowoff/ablator interfaces; the ablator and ablator/ice interface; and the DT fuel all present conditions in which kinetic physics can significantly affect the dynamics. This review presents the assembled experimental data and simulation results to date, which indicate that the effects of long mean-free-path plasma phenomena and self-generated electromagnetic fields may have a significant impact in ICF targets. Finally, simulation and experimental efforts are proposed to definitively quantify the importance of these effects at ignition-relevant conditions, including priorities for ongoing study.

42 ENGINEERING↗

EXPECTED NUMBER OF MASSIVE GALAXY RELICS IN THE PRESENT DAY UNIVERSE

The number of present day massive galaxies that have survived untouched since their formation at high-z is an important observational constraint to the hierarchical galaxy formation models. Using three different semianalytical models based on the Millenium simulation, we quantify the expected fraction and number densities of the massive galaxies that form at z > 2 and have evolved in stellar mass less than 10% and 30%. We find that only a small fraction of the massive galaxies that already formed at z {approx} 2 have remained almost unaltered since their formation (<2% with {Delta}M{sub *}/M{sub *} < 0.1 and <8% with {Delta}M{sub *}/M{sub *} < 0.3). These fractions correspond to the following number densities of massive relics in the present day universe: {approx}1.2 Multiplication-Sign 10{sup -6} Mpc{sup -3} for {Delta}M{sub *}/M{sub *} < 0.1 and {approx}5.7 Multiplication-Sign 10{sup -6} Mpc{sup -3} for {Delta}M{sub *}/M{sub *} < 0.3. The observed number of relic candidates found in the nearby universe is rather uncertain today (with uncertainties up to a factor of {approx}100), preventing us from establishing firm conclusions about the ability of current theoretical expectations to predict such an important number.

79 ASTRONOMY AND ASTROPHYSICS↗

Land-use legacies and present fire regimes interact to mediate herbivory by altering the neighboring plant community

Past and present human activities, such as historic agriculture and fire suppression, are widespread and can create depauperate plant communities. Although many studies show that herbivory on focal plants depends on the density of herbivores or the composition of the surrounding plant community, it is unclear whether anthropogenic changes to plant communities alter herbivory. We tested the hypothesis that human activities that alter the plant community lead to subsequent changes in herbivory. At 20 sites distributed across 80 300 hectares, we conducted a field experiment that manipulated insect herbivore access (full exclosures and pseudo-exclosures) to four focal plant species in longleaf pine woodlands with diff erent land-use histories (post-agricultural sites or non-agricultural sites) and degrees of fi re frequency (frequent and infrequent). Plant cover, particularly herbaceous cover, was lower in post-agricultural and fi re suppressed woodlands. Density of the dominant insect herbivore at our site (grasshoppers) was positively related to plant cover. Herbivore access reduced biomass of the palatable forb Solidago odora in frequently burned post-agricultural sites and in infrequently burned non-agricultural woodlands and increased mortality of another forb (Pityopsis graminifolia ), but did not aff ect two other less palatable species ( Schizachyrium scoparium and Tephrosia virginiana ). Herbivory on S. odora exhibited a hump-shaped response to plant cover, with low herbivory at low and high levels of plant cover. Herbivore density had a weak negative effect on herbivory. These findings suggest that changes in plant cover related to past and present human activities can modify damage rates on focal S. odora plants by altering grasshopper foraging behavior rather than by altering local grasshopper density. The resulting changes in herbivory may have the potential to limit natural recovery or restoration eff orts by reducing the establishment or performance of palatable plant species.

60 APPLIED LIFE SCIENCES↗

Year 2 instrument status from the SPT-3G cosmic microwave background receiver (Conference Presentation)

The South Pole Telescope (SPT) is a millimeter-wavelength telescope surveying the cosmic microwave background (CMB). The SPT measures both the temperature and polarization of the CMB with a large aperture, resulting in high-resolution maps sensitive to signals across a wide range of angular scales on the sky. With these capabilities, the SPT has the potential to constrain inflationary gravitational waves as well as the effect of massive neutrinos on large-scale structure formation. The SPT was upgraded in late 2016 with a new receiver (SPT-3G) containing 16,0000 polarization-sensitive transition-edge sensor bolometers. Several key technological developments have enabled this large-format focal, including advances in detectors, readout electronics, and large millimeter-wavelength optics. We will discuss the implementation of these technologies in the SPT-3G receiver as well as the challenges they presented. In late 2017 the implementations of all three of these technologies were iterated to optimize total performance. Here, we present the current instrument status of the SPT-3G receiver.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

SU-F-T-124: Radiation Biological Equivalent Presentations OfLEM-1 and MKM Approaches in the Carbon-Ion Radiotherapy

Purpose: To study the correlations of the radiation biological equivalent doses (BED) along depth and lateral distance between LEM-1 and MKM approaches. Methods: In NIRS-MKM (Microdosimetric Kinetic Model) approach, the prescribed BED, referred as C-Eq, doses aims to present the relative biological effectiveness (RBE) for different energies of carbon-ions on a fixed 10% survival value of HCG cell with respect to convention X-ray. Instead of a fixed 10% survival, the BED doses of LEM-1 (Local Effect Model) approach, referred as X-Eq, aims to present the RBE over the whole survival curve of chordoma-like cell with alpha/beta ratio of 2.0. The relationship of physical doses as a function of C-Eq and X-Eq doses were investigated along depth and lateral distance for various sizes of cubic targets in water irradiated by carbon-ions. Results: At the center of each cubic target, the trends between physical and C-Eq or X-Eq doses can be described by a linear and 2nd order polynomial functions, respectively. Using fit functions can then calculate a scaling factor between C-Eq and X-Eq doses to have similar physical doses. With equalized C-Eq and X-Eq doses at the depth of target center, over- and under-estimated X-Eq to C-Eq are seen for depths before and after the target center, respectively. Near the distal edge along depth, sharp rising of RBE value is observed for X-Eq, but sharp dropping of RBE value is observed for C-Eq. For lateral locations near and just outside 50% dose level, sharp raising of RBE value is also seen for X-Eq, while only minor increasing with fast dropping for C-Eq. Conclusion: An analytical function to model the differences between the CEq and X-Eq doses along depth and lateral distance need to further investigated to explain varied clinic outcome of specific cancers using two different approaches to calculated BED doses.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗

Crystal structure of a TAPBPR–MHC I complex reveals the mechanism of peptide editing in antigen presentation

Central to CD8+ T cell–mediated immunity is the recognition of peptide–major histocompatibility complex class I (p–MHC I) proteins displayed by antigen-presenting cells. Chaperone-mediated loading of high-affinity peptides onto MHC I is a key step in the MHC I antigen presentation pathway. However, the structure of MHC I with a chaperone that facilitates peptide loading has not been determined. We report the crystal structure of MHC I in complex with the peptide editor TAPBPR (TAP-binding protein–related), a tapasin homolog. TAPBPR remodels the peptide-binding groove of MHC I, resulting in the release of low-affinity peptide. Changes include groove relaxation, modifications of key binding pockets, and domain adjustments. This structure captures a peptide-receptive state of MHC I and provides insights into the mechanism of peptide editing by TAPBPR and, by analogy, tapasin.

59 BASIC BIOLOGICAL SCIENCES↗