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At least 253 records · Page 14

Oxygen Deficiency in Spaceflight & its Impact on Plants’ Adaptive Changes

The goal of this study was to investigate the effects of hypoxic conditions in spaceflight. The distribution of genes involved with hypoxia in Arabidopsis thaliana and Brassica rapa were analyzed with the results from past spaceflight experiments to evaluate genes for future studies. Transcriptomes data of two different spaceflight studies of Arabidopsis thaliana from the NASA GeneLab database, GLDS-7 and GLDS-17, were compared. DNA microarrays were utilized for transcription profiling to conduct these studies. For GLDS-7, the response in spaceflight was studied with approaches that collected gene expression data. Leaves, hypocotyls, and root tissues were compared to the whole plant. For GLDS-17, seedlings and undifferentiated cultured cells were placed in the Biological Research in Canisters (BRIC), specifically BRIC-16. The genes related to hypoxia in Arabidopsis thaliana from these two studies were compared to genes in Brassica rapa with the TOAST database to evaluate similarities. When transcriptomes were analyzed for GLDS-7 and 17, genes that were considered significant had p-values ≤ 0.05 and log fold change values ≤ -1 or ≥1. Sixteen genes fulfilled the criteria. The genes related to hypoxia were alcohol dehydrogenase, elongation factor, ethylene-responsive factor, GUS, heat-shock proteins, NAP, RAP2.12, and RD20. The genes most impacted by spaceflight were heat-shock proteins. These genes were compared with Brassica rapa through Arabidopsis Ensemble Orthology from the TOAST Database. Similarities were seen in alcohol dehydrogenase, elongation factor, ethylene-responsive factor, heat-shock proteins, NAP, and RAP2.12. Overall, transcription profiling indicates that plants’ survival in spaceflight is dependent on adaptive changes with gene expression. This study also indicates that there are similarities in gene expression between Arabidopsis thaliana and Brassica rapa with comparable gene expression. Future studies could include analyzing additional species to understand which genes could be modified to ensure better yield of space crops amid hypoxic conditions.

hypoxia↗

Evaluating Plant Suberin Mutants for Enhanced Water and Nutrient Uptake to Increase Biomass Production Under Elevated CO2 Concentrations

Spaceflight cabin environments such as the International Space Station (ISS) typically have elevated CO2(1500-7000 μmol mol-1), which can affect plant growth and development. On earth, findings from FACE (Free-Air CO2Enrichment) and climate change studies have shown that plants grown at elevated (~ 700 μmol mol-1) CO2contain reduced levels of essential elements such as nitrogen, zinc, and iron. We hypothesized that spacecraft environments with elevated CO2 might likewise result in less nutritious crops for human consumption. Literature showed that quantitative differences in root suberin content could determine the permeability of the internal plant tissues to both water and solutes. To evaluate if there was a correlation between growth under elevated CO2and root suberin content we grew Arabidopsis thaliana, wild type (WT)(col-0), esb1(Enhanced Suberin 1) and horst1(Hydroxylase of Root Suberized Tissue)under ambient (~ 420± 25μmol mol-1) and elevated (800 ± 25, 1600 ± 25, 4000 ± 25 μmol mol-1) CO2concentrations. Comparing the growth of esb1and horst1plants to WT under ambient and elevated CO2concentrations, esb1showed significantly (P-value < 0.05) lower total fresh biomass whereas the horst1exhibited no significant difference. RNA sequencing revealed genes related to water uptake or nutrient availability stress upregulated due to the exposure to 800 and 1600 μmol mol-1CO2.Comparing the elemental composition of leaf tissue between WT and horst1plants grown under elevated CO2,we found an overall decrease in elemental composition for WT, whereas horst1showed an average increase of 30-60 % in the elemental contentsat1600 μmol mol-1compared to plants grown at ambient CO2. In conclusion, our results showed that horst1like modification to edible crops could improve the nutritional (elemental) content to supplement astronaut’s diet.

Anirudha R Dixit↗

Functional Task Tests in Partial Gravity During Parabolic Flight

BACKGROUND Understanding how critical mission tasks are performed in partial gravity such as on the moon or Mars is necessary to define effective and comprehensive countermeasure strategies for preserving crew performance during exploration missions. We studied the performance of tasks such as standing, walking, and jumping during the partial gravity phases of parabolic flight. We hypothesized that the acute effects of partial gravity on vestibular, proprioceptive, and sensorimotor functions would negatively impact performance. METHODS Twelve subjects were tested over three flights of 30 parabolas each, including 10 parabolas at 0.25g, 10 parabolas at 0.5g, and 10 parabolas at 0.75g. Subjects also performed tests in 1g between parabolas. During the sit-to-stand with obstacle walk task, subjects rose from a seated position and walked as quickly as possible straight ahead towards a cone (4 m distance), walked around the cone making a 180° left turn, returned, and sat in the chair. On the way to and from the cone, subjects stepped over a 30 cm high obstacle. For the recovery from fall task, subjects lay prone for the pull-up phase and initial 10 sec of the parabola. Then they were asked to rise as quickly as possible and maintain a quiet stance for 10 sec. The tandem rail balance task involved standing with both feet on a 4.5 cm wide rail. The time ended when subjects either stepped off the rail or grabbed on to support straps. The jump down task started with the subjects standing on a 30 cm high platform, then the subjects were instructed to step off the platform, land with both feet simultaneously, and settle in a quiet stance. The cone of stability task involved subjects leaning about the ankles as far as they could in the anterior, posterior, and lateral directions without unfolding their arms or taking a step. The center of pressure distance between endpoints was calculated. Data were collected using inertial measurement units (Opal V2, APDM, Portland, OR) worn on the head and trunk, heart rate monitors (RS800CX, Polar, Kempele, Finland), and a force plate (Bertec, Columbus, OH). RESULTS Gravity level had a significant effect on performance, with the greatest changes from 1g tending to be at the 0.25g level (Table 1). Lower gravity levels were associated with increased times to complete the sit-to-stand obstacle walk task and the recovery from fall task, decreased change in heart rate during the recovery from fall task, decreased rail balance times, and increased cone of stability distance in the anterior-posterior direction. Table 1. Functional task performance at different gravity levels during parabolic flight. Measure0.25g0.5g0.75g1gp-valueSit-to-stand with obstacle walk time (sec)9.8 ±1.4*7.2 ±0.76.9 ±0.8*7.4 ±0.9<0.001Recovery from fall time to settle (sec)5.3 ± 0.9*4.6 ± 0.84.2 ± 0.64.3 ± 0.70.002Recovery from fall change in heart rate (bpm)6.0 ± 7.3*11.2 ± 6.5*14.9 ± 4.915.9 ± 6.5<0.001Rail balance with eyes open time (sec)2.7 ±0.8*4.8 ±2.16.6 ±4.78.4 ±6.70.031Rail balance with eyes closed time (sec)1.6 ±0.4*2.1 ±0.42.4 ±0.62.6 ±0.8<0.001Jump down time to settle (sec)2.1 ± 0.41.9 ± 0.42.0 ± 0.31.8 ± 0.30.328Cone of stability –anterior-posterior (cm)20.8 ±2.7*18.8 ±2.218.6 ±1.717.9 ±2.00.039Cone of stability –lateral (cm)26.8 ±6.624.4 ±2.123.0 ±2.123.8 ±2.30.215p-value: one-way repeated measures analysis of variance; *Significant pairwise difference from 1g (p<0.05). DISCUSSION These data suggest that there is a dose-response relationship between gravity level and functional task performance. The largest changes in performance were expected at the lowest gravity level (0.25g) because subjects would no longer be able to use the gravitational reference for the perception of upright. Understanding the extent of performance deficits informs the risks and design of countermeasures for exploration spaceflight missions. ACKNOWLEDGEMENT This work is supported by NASA’s Human Research Program Human Health Countermeasures Element.

T R Macaulay↗

Changes in Oculomotor Behavior and PVT Reaction Time During One Night of Sleep Deprivation

INTRODUCTION: The Psychomotor Vigilance Test (PVT) is a widely used objective measure of sustained attention, alertness, and fatigue. Previous studies consistently show that prolonged wakefulness and disrupted sleep patterns lead to increased lapses of attention and slower reaction times. These findings have critical implications for various professions, including healthcare, aviation, transportation safety, and spaceflight. In this study, we employed linear mixed models (LMM) to investigate hourly-measured 5-minute PVT reaction times during one night of total sleep deprivation. Our goal was to characterize the contribution of homeostatic sleep pressure (time awake) and circadian phase (salivary melatonin levels) on the dynamics of PVT reaction time. MATERIALS & METHODS: Data from twelve human participants were used in the analysis. Participants were healthy non-smokers, aged 18 and 40, with normal sleep habits defined as Pittsburg Sleep Quality Index scores < 5, and Morningness – Eveningness Questionnaire scores > 42 and < 58, respectively. Participants followed a constant-routine protocol and arrived at the NASA sleep laboratory approximately 1 to 2 hours after their habitual waking time. Tympanic temperature was measured every 30 min to provide a real-time estimate of circadian phase. Participants were required to stay awake throughout the laboratory experiment, which continued until their tympanic temperature had returned to baseline levels. This approach ensured that we could capture each participant's circadian trough and recovery, typically occurring between 24 and 26 hours after waking. The PVT and saliva melatonin were measured every hour, starting approximately from 3 hours after awakening. More information about the measurement protocol can be found in the publication by Stone et al. We used PVT reaction times between 100 and 10000 ms to calculate Reciprocal Reaction Times (RRTs). LMM models were employed to assess the contribution of time awake and saliva melatonin levels on changes in RRTs. Two models were created: the first model treated time awake as a fixed effect and the second model considered both the salivary melatonin level and time awake as fixed effects. Participants were included as a random effect in both models. We compared the models using an Analysis of Variance (ANOVA). The models were computed using the 'lmer' function from the 'lme4' package in R, and LMM p-values were determined using Satterthwaite's method. RESULTS: We found that time awake had a statistically significant effect on PVT RRTs during one night of sleep deprivation [χ2 = 2132.4, df = 1, p < 0.001]. In addition, the model including both saliva melatonin levels and time awake was statistically significantly better than one that uses just time awake [χ2 = 17.4, df = 1, p < 0.001]. DISCUSSION & CONCLUSION: As expected, these preliminary results suggest that the time awake and circadian phase each contribute to performance reductions as measured by the PVT. Future analyses will explore the contributions of other factors to the model.

sleep deprivation↗

Predictive Modeling of Human Perception Subjectivity: Feasibility Study of Mammographic Lesion Similarity

The majority of clinical content-based image retrieval (CBIR) studies disregard human perception subjectivity, aiming to duplicate the consensus expert assessment of the visual similarity on example cases. The purpose of our study is twofold: (i) discern better the extent of human perception subjectivity when assessing the visual similarity of two images with similar semantic content, and (ii) explore the feasibility of personalized predictive modeling of visual similarity. We conducted a human observer study in which five observers of various expertise were shown ninety-nine triplets of mammographic masses with similar BI-RADS descriptors and were asked to select the two masses with the highest visual relevance. Pairwise agreement ranged between poor and fair among the five observers, as assessed by the kappa statistic. The observers' self-consistency rate was remarkably low, based on repeated questions where either the orientation or the presentation order of a mass was changed. Various machine learning algorithms were explored to determine whether they can predict each observer's personalized selection using textural features. Many algorithms performed with accuracy that exceeded each observer's self-consistency rate, as determined using a cross-validation scheme. This accuracy was statistically significantly higher than would be expected by chance alone (two-tailed p-value ranged between 0.001 and 0.01 for all five personalized models). The study confirmed that human perception subjectivity should be taken into account when developing CBIR-based medical applications.

59 BASIC BIOLOGICAL SCIENCES↗

Measurement of the CP-violating phase phi sJ/psi phi using the flavor-tagged decay Bs(0) -> J/psi phi in 8 fb(-1) of p(p)over-bar collisions

We report an updated measurement of the CP-violating phase, {phi}{sub s}{sup J/{psi}{phi}} and the decay-width difference for the two mass eigenstates, {Delta}{Gamma}{sub s}, from the flavor-tagged decay B{sub s}{sup 0} {yields} J/{psi}{phi}. The data sample corresponds to an integrated luminosity of 8.0 fb{sup -1} accumulated with the D0 detector using p{bar p} collisions at {radical}s = 1.96 TeV produced at the Fermilab Tevatron collider. The 68% Bayesian credibility intervals, including systematic uncertainties, are {Delta}{Gamma}{sub s} = 0.163{sub -0.064}{sup +0.065} ps{sup -1} and {phi}{sub s}{sup J}/{psi}{phi} = -0.55{sub -0.36}{sup +0.38}. The p-value for the Standard Model point is 29.8%.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Updated Combination of CDF and D0 Searches for Standard Model Higgs Boson Production with up to 10.0 fb$^{-1}$ of Data

We combine results from the CDF and D0 Collaborations on direct searches for the standard model (SM) Higgs boson (H) in ppbar collisions at the Fermilab Tevatron at sqrt(s)=1.96 TeV. Compared to the previous Tevatron Higgs boson search combination, more data have been included, additional channels have been incorporated, and some previously used channels have been reanalyzed to gain sensitivity. Searches are carried out for hypothesized Higgs boson masses between 100 and 200 GeV/c^2. With up to 10 fb-1 of luminosity analyzed, the 95% C.L. median expected upper limits on Higgs boson production are factors of 0.89, 1.08, and 0.48 times the values of the SM cross section for Higgs bosons of mass m_H=115 GeV/c^2, 125 GeV/c^2, and 165 GeV/c^2, respectively. In the absence of signal, we expect to exclude the regions 100<m_{H}<120 GeV/c^2 and 139<m_H<184 GeV/c^2. We exclude, at the 95% CL, two regions: 100<m_H<103 GeV/c^2, and 147<m_H<180 GeV/c^2. There is a significant excess of data events with respect to the background estimation in the mass range 115<m_H<140 GeV/c^2, which causes our observed limits to not be as stringent as expected. At m_H=120 GeV/c^2, the p-value for a background fluctuation to produce this excess is \sim1.5x10^-3, corresponding to a local significance of 3.0 standard deviations. The global significance for such an excess anywhere in the full mass range investigated is approximately 2.5 standard deviations. We also combine separately searches for H to bb and H to WW. We find that the excess is concentrated in the H to bb channel, appearing in the searches over a broad range of m_H. The maximum local significance of 3.2 standard deviations corresponds to a global significance of approximately 2.9 standard deviations. Our results in the H to WW channels are also consistent with the possible presence of a low-mass Higgs boson.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

A Comparative Study of Automated Infrasound Detectors - PMCC and AFD with Analyst Review.

Automated detections calculated by the progressive multi-channel correlation (PMCC) method (Cansi, 1995) and the adaptive F detector (AFD) (Arrowsmith et al., 2009) are compared to the signals identified by five independent analysts. Each detector was applied to a four-hour time sequence recorded by the Korean infrasound array CHNAR. This array was used because it is composed of both small (<100 m) and large (~1000 m) aperture element spacing. The four hour time sequence contained a number of easily identified signals under noise conditions that have average RMS amplitudes varied from 1.2 to 4.5 mPa (1 to 5 Hz), estimated with running five-minute window. The effectiveness of the detectors was estimated for the small aperture, large aperture, small aperture combined with the large aperture, and full array. The full and combined arrays performed the best for AFD under all noise conditions while the large aperture array had the poorest performance for both detectors. PMCC produced similar results as AFD under the lower noise conditions, but did not produce as dramatic an increase in detections using the full and combined arrays. Both automated detectors and the analysts produced a decrease in detections under the higher noise conditions. Comparing the detection probabilities with Estimated Receiver Operating Characteristic (EROC) curves we found that the smaller value of consistency for PMCC and the larger p-value for AFD had the highest detection probability. These parameters produced greater changes in detection probability than estimates of the false alarm rate. The detection probability was impacted the most by noise level, with low noise (average RMS amplitude of 1.7 mPa) having an average detection probability of ~40% and high noise (average RMS amplitude of 2.9 mPa) average detection probability of ~23%.

58 GEOSCIENCES↗

Single-Pol Synthetic Aperture Radar Terrain Classification using Multiclass Confidence for One-Class Classifiers

Except in the most extreme conditions, Synthetic aperture radar (SAR) is a remote sensing technology that can operate day or night. A SAR can provide surveillance over a long time period by making multiple passes over a wide area. For object-based intelligence it is convenient to segment and classify the SAR images into objects that identify various terrains and man-made structures that we call “static features.” In this paper we introduce a novel SAR image product that captures how different regions decorrelate at different rates. Using superpixels and their first two moments we develop a series of one-class classification algorithms using a goodness-of-fit metric. P-value fusion is used to combine the results from different classes. We also show how to combine multiple one-class classifiers to get a confidence about a classification. This can be used by downstream algorithms such as a conditional random field to enforce spatial constraints.

Koch, Mark William↗

High Precision Track-Based Alignment of the Tracking Detector of the g-2 Experiment

In order for the analysis of data from the tracking detector to reduce the systematic uncertainty on the a_μ measurement and improve the sensitivity to a muon electric dipole moment, the internal position of the tracking modules must be known to a high level of precision. Track-based alignment was implemented with data from Run 1 using the Millepede II framework. An overview of the alignment methods, as well as the verification of alignment with simulation, will be given. A significant improvement in the mean p-value distribution and the fraction of reconstructed tracks after the alignment was achieved. A comparison of the accuracy in the determination of the beam's spatial distribution as a function of time will be presented before and after the alignment.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Heavy metals and trace elements in the groundwater in El Paso, Texas

The chemical elements studied here (Al, As, Ba, Cd, Cr, Cu, Fe, Pb, Mn, Hg, Ni, Se, Ag, Zn, Li, B) include toxic heavy metals and non-toxic elements which have occurred at high levels in El Paso, TX groundwater (Fe, Cu, Mn, As, Pb; up to 24,000, 17,000, 3200, 95, and 1000 ppb respectively). The objective of this study is to investigate the origins of these heavy metals in the groundwater. Previous works found some of these metals in the rocks of the mountains that recharge the watershed, and sufficient evidence for natural origins of arsenic in the groundwater. Statistical analyses in this report are consistent with natural origin also for the heavy metals studied but cannot dismiss human activity as a contributing factor. Interesting correlations with R-value>0.60, p-value<0.01 warrant further analysis.

Marquez B, Elia↗

Determining the bubble nucleation efficiency of low-energy nuclear recoils in superheated C$_3$F$_8$ dark matter detectors

The bubble nucleation efficiency of low-energy nuclear recoils in superheated liquids plays a crucial role in interpreting results from direct searches for weakly interacting massive particle (WIMP) dark matter. The PICO Collaboration presents the results of the efficiencies for bubble nucleation from carbon and fluorine recoils in superheated C$_3$F$_8$ from calibration data taken with 5 distinct neutron spectra at various thermodynamic thresholds ranging from 2.1 keV to 3.9 keV. Instead of assuming any particular functional forms for the nuclear recoil efficiency, a generalized piecewise linear model is proposed with systematic errors included as nuisance parameters to minimize model-introduced uncertainties. A Markov-Chain Monte-Carlo (MCMC) routine is applied to sample the nuclear recoil efficiency for fluorine and carbon at 2.45 keV and 3.29 keV thermodynamic thresholds simultaneously. The nucleation efficiency for fluorine was found to be $\geq 50\, \%$ for nuclear recoils of 3.3 keV (3.7 keV) at a thermodynamic Seitz threshold of 2.45 keV (3.29 keV), and for carbon the efficiency was found to be $\geq 50\, \%$ for recoils of 10.6 keV (11.1 keV) at a threshold of 2.45 keV (3.29 keV). Simulated data sets are used to calculate a p-value for the fit, confirming that the model used is compatible with the data. The fit paradigm is also assessed for potential systematic biases, which although small, are corrected for. Additional steps are performed to calculate the expected interaction rates of WIMPs in the PICO-60 detector, a requirement for calculating WIMP exclusion limits.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Relating Aerial Infrared Thermography Defects to Photovoltaic Performance: Preprint

In this research, we examine the relationship between aerial IR defect analysis and photovoltaic (PV) performance data for twelve utility- and commercial-scale solar sites in the United States. To do this, we fuse the site diagram geoJSON's, aerial infrared thermography (aIRT) defect analyses, and associated inverter time series, allowing for a direct comparison between site defects and time series data. Defect analyses were provided by Zeitview, under its Solar Insights platform. Following the data fusion process, we look at the relationship between system performance and aIRT defects. We investigate the relationship between degradation and hotspot defects, as well as the relationship between AC power data and offline strings and misaligned modules. In general, system degradation was not affected by long-term or balance-of-system (BoS) defects as they occurred infrequently in the data set. However, for one system, a near statistically significant relationship (p-value=0.057) was found when comparing the degradation of inverter blocks with several multi-hotspot defects to all other inverter blocks without this particular defect. There was strong alignment when comparing short-term recoverable module defects such as stuck trackers and offline strings to time series data. In general, we found that when an inverter block has more than 80% of modules flagged for one of these defects, its AC power time data is flat-lined and the inverter block is not producing.

aerial inspection↗

Image Characterization of Reactions Generated by an Aeroengine Micromixing Injector for Lean Direct Injection of Hydrogen and Hydrogen/Natural Gas Blend

An aeroengine micromixing injector, originally designed for lean direct injection of jet fuel, was adapted to work with hydrogen, natural gas, and any blend in between. The ultimate goal of the design was to achieve low NOx emissions when operated on pure hydrogen; to better characterize its performance, flame imaging diagnostics was implemented. Three types of cameras mounted parallel to the injector base and pointing towards the quartz combustor cylinder with the same angle were operated simultaneously: Nikon D90, Dynacolor FB-N9-U, and Phantom v7.1, to capture the visible spectrum, OH* chemiluminescence, and dynamic behavior of the flames, respectively. The current work also includes the overlapping of visible spectrum and OH* chemiluminescence, as an effort to qualitatively define the heat release over the flame area, i.e., UV over visible domain. Additionally, a z-type schlieren configuration was employed to reinforce the presence of some small-scale details occurring near the injector outlet ports. Using the airbox pressure drop, preheat temperature, fuel composition and flame temperature as the factors of study, a Box Behnken model was designed yielding into a 16-points matrix for the operability region, at atmospheric pressure. The main responses were extracted from the OH* images, because of its correlation with the flame heat release, these being the flame area and its average brightness, the heat release area and its center of gravity and leading edge. To assess the importance of the main factors and their interactions, an analysis of variance (ANOVA) was performed for each response, considering as significant each contributor with a p-value below 0.05. For these five responses it was found that all four main factors need to be included into the model (most of them because its own significance, others to ensure the model hierarchy), as well as some common interactions as the preheat and flame temperatures or pressure drop and fuel composition, and quadratic terms from fuel composition or flame temperature. Three of the five models presented R2 and coefficient of variance (C.V.) indicators around 0.97 and 5%, respectively; the leading edge ANOVA yielded into R2=0.78 and C.V.=18.88%; and the heat release area showed R2=0.91 and C.V.=24.13%. Lastly, the confinement ratio effect of the combustor over the flame structure was quantified, for three different conditions: the original 80 mm inner diameter and 200 mm length cylinder was compared against a shorter 150 mm tube (same inner diameter) and a narrower 47 mm inner diameter one (same 200 mm length). The length had a smaller effect than the inner diameter, even though both factors were not strong enough to make a significant deviation on most of the flame parameters: the difference was within the repeatability margin of error for the brightness, flame area, and center of gravity and leading edge of the heat release area.

Imaging diagnostics, flame characterization, OH* c↗

Measuring the Muon Neutrino Magnetic Moment in the NOvA Near Detector

Measuring an enhanced neutrino magnetic moment would be a clear indication of physics beyond the Standard Model, shedding light on the correct beyond Standard Model theory or the potential Majorana nature of neutrinos. It would manifest in the NOvA near detector as an excess of neutrino-on-electron elastic scattering interactions at low electron recoil energies. Leveraging an intense and highly pure muon neutrino beam, along with a finely segmented liquid scintillator detector technology specifically designed for electromagnetic shower separation, enables NOvA to achieve a potentially world-leading sensitivity in probing the effective muon neutrino magnetic moment. This analysis, based on neutrino data collected between 2014 and 2021, corresponding to an exposure of $13.8\times10^{20}$ protons-on-target, yields a result consistent with the Standard Model-only hypothesis with a p-value of 0.31. An upper limit on the effective muon neutrino magnetic moment is set at $\mu_{\nu_\mu}<19.1\times 10^{-10}\mu_B$ at $90\%$ confidence level. Despite facing statistical limitations stemming from low cross section of the signal process, systematic uncertainties have a significant impact on this result. To address these challenges, the NOvA Test Beam experiment focuses on mitigating some of the largest systematic uncertainties within NOvA by investigating particle interactions and energy deposition in a small-scale replica NOvA detector. This thesis describes the calibration of the NOvA Test Beam detector, which is a crucial step in analysing the Test Beam data before they can be utilised to reduce NOvA systematic uncertainties.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Searching for Strongly-Interacting Dark Matter with the Heavy Photon Search Experiment

The Heavy Photon Search Experiment (HPS) is a fixed-target experiment at Jefferson Lab’s Hall B, designed to explore a hidden sector (HS) of particles containing dark matter and a new force mediator known as the “heavy photon” (A'). The A' is a massive spin-1 gauge boson associated with a new U (1)D symmetry in the HS that kinetically mixes with the Standard Model () photon with a weak coupling strength parameterized by ¿, with ¿2 ~ 10-2 -10-10. HPS utilizes a high-intensity electron beam on a thin tungsten target to produce heavy photons in the MeV-GeV mass range via “dark bremsstrahlung,” a process analogous to SM bremsstrahlung but suppressed by ¿2. The A' can decay resonantly to SM leptons, allowing HPS to conduct both mass resonance searches for prompt decays (large ¿) and displaced vertex searches for long-lived particles (small ¿). In addition to the minimal A' model, HPS probes more complex extensions such as the QCD-like strongly-interacting massive particles (SIMPs) HS containing “dark” pions (pD) and vector mesons (VD), with pD as dark matter candidates. These particles introduce new thermal dark matter freeze- out scenarios and visible signals through long-lived VD decays to SM leptons, which are accessible to HPS. This analysis conducted a displaced vertex search for VD ¿ e-e+ in the mass range 30 MeV to 124 MeV and ¿ between 10-6 < ¿ < 10-2 using data from the 2016 Engineering Run (10.753 nb-1) at 2.3 GeV. Unlike the minimal A' search, SIMP signal kinematics required new approaches to signal normalization and SM background rejection. The strongest signal evidence was a local p-value of 0.01317 for mVD = 119 MeV, corresponding to a global significance of 0.9s. Although no signal was found, this search excluded a region of the SIMP parameter space at 90 % confidence. This work demonstrates HPS’s competitive capability to probe SIMP sectors within cosmologically significant parameters and introduces a new method for HPS displaced vertex searches using track vertical impact parameter cuts

Spellman, Alic [Univ. of California, Santa Cruz, C↗

Measurements of Angular Distributions of Drell-Yan Dimuons in $p+p$ and $p+d$ Interactions at 120 GeV/$c$

We present experimental results on the angular distributions of Drell-Yan muons produced by a 120 GeV/$c$ proton beam interacting with liquid hydrogen and deuterium targets. The dimuon angular distributions in both polar ($θ$) and azimuthal ($ϕ$) angles in the Collins-Soper frame are measured within the kinematic range of $4.5 < m_{μμ} < 10\ \mathrm{GeV}/c^2$, $0.19 < p_T < 2.24\ \mathrm{GeV}/c$, and $0 < x_F < 0.95$. Unlike the results of a previous proton-induced Drell-Yan experiment at a higher energy, the data reveal a pronounced $\cos 2ϕ$ modulation in the angular distributions. Comparison with perturbative QCD (pQCD) predictions shows statistically significant deviations, with p-values of 3.5% for the $p+p$ and 1.5% for the $p+d$ Drell-Yan processes. These results suggest the presence of nonperturbative QCD contributions.

Nagai, K. [Christian Brothers U.; Los Alamos; Taiw↗

Third-Party Supplier Risk Re-Classification Using Multi-Model Semantic Voting and External Web Augmentation

Risk decisions in many third-party risk management (TPRM) workflows rely on static inherent risk questionnaires (IRQ). These static forms provide a snapshot of the vendor from the business users’ perspective, as these requests are processed without cross-referencing for evidence. Consequently, responses can be misinformed or embellished with inaccuracies, thereby masking the vendor’s true risk to the enterprise. This paper presents a multi-stage verification framework to augment IRQs with web evidence and a deterministic ensemble of large language model assessors to reclassify risk. In a case study of 100 submissions previously misclassified as low risk, the proposed framework correctly identified 76% of the cases as high risk, while the existing workflow identified none. McNemar’s continuity corrected statistics of 74 were obtained with a two sided p-value of 2.65 × 10-23, indicating a significantly more effective workflow compared to the legacy model.

99 - GENERAL AND MISCELLANEOUS↗