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At least 253 records · Page 14

Pharmacokinetics, Metabolite Measurement, and Biomarker Identification of Dermal Exposure to Permethrin Using Accelerator Mass Spectrometry

Impregnating military uniforms and outdoor clothing with the insecticide permethrin is an approach to reduce exposure to insect borne diseases and to repel pests and disease vectors such as mosquitos and sandflies, but the practice exposes wearers to prolonged dermal exposure to the pesticide. Key metabolite(s) from a low dose dermal exposure of permethrin were identified using accelerator mass spectrometry. Metabolite standards were synthesized and a high performance liquide chromatography (HPLC) elution protocol to separate individual metabolites in urine was developed. Six human subjects were exposed dermally on the forearm to 25 mg of permethrin containing 1.0 µCi of 14 C for 8 h. Blood, saliva and urine samples were taken for 7d. Absorption/elimination rates and metabolite concentrations varied by individual. Average absorption was 0.2% of the dose. Serum concentrations rose until 12–24 h postdermal application then rapidly declined reaching predose levels by 72 h. Maximum saliva excretion occurred 6 h postdosing. The maximum urinary excretion rate occurred during 12–24 h; average elimination half-life was 56 h. 3-Phenoxybenzyl alcohol glucuronide was the most abundant metabolite identified when analyzing elution fractions, but most of the radioactivity was in still more polar fractions suggesting extensive degradative metabolism and for which there were no standards. Finally, analyses of archived urine samples with the ultra performance liquid chromatography-accelerator mass spectrometry-mass spectrometry (UPLC-AMS-MS) system isolated a distinct polar metabolite but it was much diminished from the previous analyses a decade earlier.

59 BASIC BIOLOGICAL SCIENCES↗

Classification of fragile topology enabled by matrix homotopy

Flat bands in twisted materials have attracted considerable attention due to the emergence of correlated phases that can be associated with the non-Wannier-representable nature of its single-particle states. Specifically, these bands can exhibit a class of topology that can be nullified by the addition of trivial bands, termed fragile topology, which has required an expansion of prior classification schemes. However, existing approaches for predicting fragile topology rely on momentum-space methods, e.g., Wilson loops, presenting a fundamental challenge for using fragile topology as a predictor of correlated phases in aperiodic systems, such as incommensurate twist angles in moiré materials. Here, we develop a ℤ 2 energy-resolved topological marker for classifying fragile phases using a system’s position-space description, enabling the direct classification of finite, disordered, and aperiodic materials. By translating the physical symmetries protecting the system’s fragile topological phase into matrix symmetries of the system’s Hamiltonian and position operators, we use matrix homotopy to construct our topological marker while simultaneously yielding a quantitative measure of topological robustness. We demonstrate our framework’s effectiveness in both a low-energy tight-binding model and a continuum photonic crystal model of 𝐶 2 ⁢𝒯-symmetric systems, and find that fragile topology can both persist under strong disorder and even exhibit disorder-induced reentrant phase transitions. Our photonic crystal results also demonstrate the robustness of fragile topology, and the applicability of our approach, to heterostructures lacking a bulk spectral gap. Overall, our framework serves as an efficient tool for elucidating fragile topology, offering guidance for the prediction and discovery of correlated phases in both crystalline and aperiodic materials.

Lee, Ki Young [Sandia National Laboratories (SNL-N↗

High energy particle production from proton synchrotron radiation in strong magnetic fields in relativistic quantum field theory

We investigate photon, pion, and 𝜌-meson production from proton synchrotron radiation in the presence of strong magnetic fields. The proton decay widths and the luminosities of the emitted particles are calculated within a relativistic quantum framework that incorporates Landau quantization. A scaling rule is derived for the transition probability between different Landau levels. This allows an evaluation of transitions for extremely high Landau numbers exceeding 10 15 . Furthermore, we calculate the momentum distribution of the emitted particles by properly including the proton recoil effect associated with particle emission. The results differ significantly from conventional semiclassical approaches.

Cosmic ray sources↗

Magnetic skyrmion diode: Unidirectional skyrmion motion via symmetry breaking of potential energy barriers

In this work, we realize a magnetic skyrmion diode operated by a unidirectional skyrmion transport that flows in only one direction, which is highly significant for information processing in spintronic and nanoelectronic devices. We easily control the skyrmion transport by engineering asymmetric shapes of geometric structures. Here, we present a simple method to describe the underlying mechanism behind the unidirectional skyrmion transport by characterizing the topography of potential energy surfaces from a purely geometric perspective. Our approach enables a deeper physical insight into skyrmion transport manipulation and efficient design of skyrmion-based devices in geometric structures.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Enhancement of magnetic domain wall velocity via resonant dissipation of standing wave modes of domain wall structure with perpendicular magnetic anisotropy

The dynamic behaviors of magnetic domain walls have significant implications for developing advanced spintronic devices. In this study, we investigate the intriguing resonance phenomenon within the magnetic domain wall structure, focusing on the dissipation mechanism and its impact on domain wall dynamic motion. By applying a static external magnetic field, we observe a remarkable amplification of domain wall velocity through the resonant excitations of the flexure modes. The resonance of the flexure mode exerts an indirect influence on the domain wall velocity through energy dissipation, leading to a significant enhancement from the predictions of the one-dimensional Walker model. We establish a robust model platform rooted in energy dissipation allows comprehensive understanding the dramatic enhancement of domain wall velocity observed during width-directional flexure mode resonance. By directly quantifying energy dissipation, our approach provides highly effective and accurate estimates of domain wall velocity, surpassing previous methods that focus solely on the instantaneous dynamics of the domain wall structure. These findings offer crucial insights into the fundamental mechanisms governing the dynamics of domain walls and other magnetic systems, such as magnetic skyrmions, bubbles, and magnetic vortices, paving the way for development and optimization of next-generation spintronic devices.

Collective dynamics↗

Infinitely many 4D N = 1 SCFTs with a = c

Here, we study a rich set of four-dimensional N = 1 superconformal field theories (SCFTs) with both central charges identical: a = c. We construct them via the diagonal N = 1 gauging of the flavor symmetry G of a collection of N = 2 Argyres–Douglas theories of type D p (G), with or without additional adjoint chiral multiplets. In this way, we construct infinitely many theories that flow to interacting SCFTs with a = c in the infrared. Lastly, we briefly highlight the features of the SCFTs without a = c that arise from generalizing this construction.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Landscape of 4d N = 1 SCFTs with a = c

We study a landscape of four-dimensional N = 1 superconformal field theories (SCFTs) with identical central charges. These theories are obtained by renormalization group flows triggered by supersymmetry-preserving superpotential deformations of the N = 1 gauging of the flavor symmetry of a collection of N = 2 D p ( G ) Argyres-Douglas SCFTs. In this work, we focus on the fixed points in the landscape of the S U ( 3 ) gauging of three copies of the D 2 ( S U ( 3 ) ) = H 2 theory together with an adjoint-valued chiral multiplet. We catalog the network of a = c fixed points, and, along the way, we find a variety of dualities and instances of supersymmetry enhancement. Published by the American Physical Society 2025

Kang, Monica Jinwoo (ORCID:0000000204542064)↗

Generalized symmetry constraints on deformed 4D SCFTs

We explore the consequence of generalized symmetries in four-dimensional N = 1 superconformal field theories. First, we classify all possible supersymmetric gauge theories with a simple gauge group that have a nontrivial one-form symmetry and flows to a superconformal field theory. Upon identifying unbroken discrete zero-form symmetries from the Adler-Bell-Jackiw (ABJ) anomaly, we find that many of these theories have mixed zero-form or one-form ’t Hooft anomalies. Then we classify the relevant deformations of these SCFTs that preserve the anomaly. From this mixed anomaly together with the anomalies of the discrete zero-form symmetries, we find obstructions for the relevant deformations of these SCFTs to flow to a trivially gapped phase. We also study non-Lagrangian SCFTs formed by gauging copies of Argyres-Douglas theories and constrain their deformations. In particular, we explore a new duality between the diagonal gauging of two D 3 ( S U ( N ) ) theories and S U ( N ) gauge theory with two adjoints. We also repeat our analysis for a host of nonsupersymmetric gauge theories having nontrivial one-form symmetry including examples that appear to flow to Bank-Zaks type CFTs. Published by the American Physical Society 2025

Kang, Monica Jinwoo (ORCID:0000000204542064)↗

X-ray free electron laser studies of electron and phonon dynamics of graphene adsorbed on copper

Here, we report optical pumping and x-ray absorption spectroscopy experiments at the Pohang Accelerator Laboratory free electron laser that probes the electron dynamics of a graphene monolayer adsorbed on copper in the femtosecond regime. By analyzing the results with ab initio theory we infer that the excitation of graphene is dominated by indirect excitation from hot electron-hole pairs created in the copper by the optical laser pulse. However, once the excitation is created in graphene, its decay follows a similar path as in many previous studies of graphene adsorbed on semiconductors, i.e., rapid excitation of strongly coupled optical phonons and eventual thermalization. It is likely that the lifetime of the hot electron-hole pairs in copper governs the lifetime of the electronic excitation of the graphene.

36 MATERIALS SCIENCE↗