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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 253 records · Page 14
All sourcesNASA NTRSDOE OSTI
NASA NTRS2017

Synchronization of Human Autonomic Nervous System Rhythms with Geomagnetic Activity in Human Subjects

A coupling between geomagnetic activity and the human nervous system's function was identified by virtue of continuous monitoring of heart rate variability (HRV) and the time-varying geomagnetic field over a 31-day period in a group of 10 individuals who went about their normal day-to-day lives. A time series correlation analysis identified a response of the group's autonomic nervous systems to various dynamic changes in the solar, cosmic ray, and ambient magnetic field. Correlation coefficients and p values were calculated between the HRV variables and environmental measures during three distinct time periods of environmental activity. There were significant correlations between the group's HRV and solar wind speed, Kp, Ap, solar radio flux, cosmic ray counts, Schumann resonance power, and the total variations in the magnetic field. In addition, the time series data were time synchronized and normalized, after which all circadian rhythms were removed. It was found that the participants' HRV rhythms synchronized across the 31-day period at a period of approximately 2.5 days, even though all participants were in separate locations. Overall, this suggests that daily autonomic nervous system activity not only responds to changes in solar and geomagnetic activity, but is synchronized with the time-varying magnetic fields associated with geomagnetic field-line resonances and Schumann resonances.

Magnetic Fields↗
NASA NTRSDate not supplied

Human Factors Impact of Different Ramp Controller Scheduling Advisories for ATD-2 Surface Metering in a Human-in-the-Loop Simulation

A human-in-the-loop (HITL) simulation took place in 2019 at NASA Ames Research Center’s Future Flight Central, an airport simulator with a full-scale 360-degree view that showed real-time airport operations at Dallas/Fort Worth International Airport (DFW). The HITL was part of the NASA/FAA Airspace Technology Demonstration 2 (ATD-2) project which involves an on-going field demonstration at Charlotte Douglas International Airport (CLT). In the field demonstration, metering on the airport surface takes place with one of the goals being to reduce runway queue length by holding aircraft at the gate during busy times, thereby reducing fuel burn and CO2 emissions. This goal has been successfully accomplished at CLT by showing Ramp Controllers when to release aircraft at the gate so as to reduce aircraft waiting in the queue. Among the questions that the current simulation at DFW was designed to address were, "Which types of advisories to the Ramp Controllers work best, those that show a ±2 minute window for a release time from the gate, or a ±5 minute window for an arrival time at the spot (where Air Traffic Control takes over) or both?" and "How do these different types of advisories affect Ramp Controller workload and situation awareness?" Another question was, “Does a ramp that is less restrictive than the one at CLT affect compliance with these advisories?”

Bonny K Parke↗
DOE OSTI2018

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Identifying tumor antigen-specific T cells from cancer patients has been a goal of tumor immunologists for several decades. Here we show that co-expression of CD103 and CD39 on CD8 TIL highly enriched for tumor-reactive T cells. This cell population, which is only present in TIL from primary and metastatic tumors, exhibited features of exhausted cells and displayed characteristics of tissue-resident memory T cells. CD39+CD103+ CD8 TIL had a distinct TCR repertoire compared to other CD8 TIL subsets and were clonally expanded within the tumor. They were highly enriched for tumor antigen recognition and efficiently killed autologous tumor cells. Finally, patients with head and neck cancer whose CD8 TIL contained a higher frequency of CD39+CD103+ cells experienced a greater overall survival. This work describes a simple method for detecting tumor-reactive CD8 TIL, which should help define mechanisms of current immunotherapies and may lead to the development of future immunotherapies.

cancer, immunotherapy, transcriptomics, t-cells, h↗
DOE OSTI2022

From Mouse to Human: Cellular Morphometric Subtype Learned From Mouse Mammary Tumors Provides Prognostic Value in Human Breast Cancer

Mouse models of cancer provide a powerful tool for investigating all aspects of cancer biology. In this study, we used our recently developed machine learning approach to identify the cellular morphometric biomarkers (CMB) from digital images of hematoxylin and eosin (H&E) micrographs of orthotopic Trp53-null mammary tumors (n = 154) and to discover the corresponding cellular morphometric subtypes (CMS). Of the two CMS identified, CMS-2 was significantly associated with shorter survival (p = 0.0084). We then evaluated the learned CMB and corresponding CMS model in MMTV-Erbb2 transgenic mouse mammary tumors (n = 53) in which CMS-2 was significantly correlated with the presence of metastasis (p = 0.004). We next evaluated the mouse CMB and CMS model on The Cancer Genome Atlas breast cancer (TCGA-BRCA) cohort (n = 1017). Kaplan–Meier analysis showed significantly shorter overall survival (OS) of CMS-2 patients compared to CMS-1 patients (p = 0.024) and added significant prognostic value in multi-variable analysis of clinical and molecular factors, namely, age, pathological stage, and PAM50 molecular subtype. Thus, application of CMS to digital images of routine workflow H&E preparations can provide unbiased biological stratification to inform patient care.

60 APPLIED LIFE SCIENCES↗