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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 253 records · Page 14
All sourcesNASA NTRSDOE OSTI
NASA NTRS2002

Parathyroid hormone-dependent signaling pathways regulating genes in bone cells

Parathyroid hormone (PTH) is an 84-amino-acid polypeptide hormone functioning as a major mediator of bone remodeling and as an essential regulator of calcium homeostasis. PTH and PTH-related protein (PTHrP) indirectly activate osteoclasts resulting in increased bone resorption. During this process, PTH changes the phenotype of the osteoblast from a cell involved in bone formation to one directing bone resorption. In addition to these catabolic effects, PTH has been demonstrated to be an anabolic factor in skeletal tissue and in vitro. As a result, PTH has potential medical application to the treatment of osteoporosis, since intermittent administration of PTH stimulates bone formation. Activation of osteoblasts by PTH results in expression of genes important for the degradation of the extracellular matrix, production of growth factors, and stimulation and recruitment of osteoclasts. The ability of PTH to drive changes in gene expression is dependent upon activation of transcription factors such as the activator protein-1 family, RUNX2, and cAMP response element binding protein (CREB). Much of the regulation of these processes by PTH is protein kinase A (PKA)-dependent. However, while PKA is linked to many of the changes in gene expression directed by PTH, PKA activation has been shown to inhibit mitogen-activated protein kinase (MAPK) and proliferation of osteoblasts. It is now known that stimulation of MAPK and proliferation by PTH at low concentrations is protein kinase C (PKC)-dependent in both osteoblastic and kidney cells. Furthermore, PTH has been demonstrated to regulate components of the cell cycle. However, whether this regulation requires PKC and/or extracellular signal-regulated kinases or whether PTH is able to stimulate other components of the cell cycle is unknown. It is possible that stimulation of this signaling pathway by PTH mediates a unique pattern of gene expression resulting in proliferation in osteoblastic and kidney cells; however, specific examples of this are still unknown. This review will focus on what is known about PTH-mediated cell signaling, and discuss the established or putative PTH-regulated pattern of gene expression in osteoblastic cells following treatment with catabolic (high) or anabolic (low) concentrations of the hormone.

NASA Discipline Musculoskeletal↗
NASA NTRS1983

A NASTRAN DMAP procedure for calculation of base excitation modal participation factors

This paper presents a technique for calculating the modal participation factors for base excitation problems using a DMAP alter to the NASTRAN real eigenvalue analysis Rigid Format. The DMAP program automates the generation of the seismic mass to add to the degrees of freedom representing the shaker input directions and calculates the modal participation factors. These are shown in the paper to be a good measure of the maximum acceleration expected at any point on the structure when the subsequent frequency response analysis is run.

Case, W. R.↗
NASA NTRS1987

Microbial trace-fossil formation, biogenous, and abiotic weathering in the Antarctic cold desert

In the Antarctic cold desert (Ross Desert), the survival of the cryptoendolithic microorganisms that colonize the near-surface layer of porous sandstone rocks depends on a precarious equilibrium of biological and geological factors. An unfavorable shift of this equilibrium results in death, and this may be followed by formation of trace fossils that preserve the characteristic iron-leaching pattern caused by microbial activity. Similar microbial trace fossils may exist in the geological record. If life ever arose on early Mars, similar processes may have occurred there and left recognizable traces.

Friedmann, E. Imre↗
NASA NTRS2003

A New Fitting Procedure for the Blended He I 1083 nm Multiplet

The He I 1083 nm multiplet is a powerful tool for observing the outer solar atmosphere but is difficult to analyze because the lines are weak, highly variable, and spectrally blended, both internally and with other neighboring solar and telluric lines. After separation from nearby spectral features, two components of the He I multiplet are resolved. Fitting these lines with two unconstrained Gaussian profiles always gives a ratio of major to minor component of less than half the value which would be expected for optically thin lines. One possibility for explaining the discrepancy between the weakness of the lines and the ratio of the spectral components is to assume that the line formation regions are concentrated in laterally unresolved, optically thick structures with small filling factor. However, we present here a least-squares fitting technique using cubic splines with fixed breakpoints with the constraint that the blend is the sum of three identically shaped profiles shifted in wavelength according to the atomic structure of the blend and weighted by the corresponding statistics weights, in agreement with optically thin line formation. The basis functions for the fitting procedure have no built-in spectral symmetry or shape. The resulting underlying profiles tend to be asymmetric with excess absorption to the blue, consistent with formation by "hot" and "cool" spatial elements within the observed volume, with the hotter regions having differential motion toward the observer. The results agree well with NASA/XSO Spectromagnetograph observations in quiet sun and coronal holes. Partial funding of this research was provided through the NASA Sun-Earth Connection SR&T program.

Jones, H. P.↗
NASA NTRS1990

Observations and models of star formation in the tidal features of interacting galaxies

Multi-color surface photometry (BVri) is presented for the tidal features in a sample of interacting galaxies. Large color variations are found between the morphological components and within the individual components. The blue colors in the primary and the tidal features are most dramatic in B-V, and not in V-i, indicating that star formation instead of metallicity or age dominates the colors. Color variations between components is larger in systems shortly after interaction begins and diminishes to a very low level in systems which are merged. Photometric models for interacting systems are presented which suggest that a weak burst of star formation in the tidal features could cause the observed color distributions. Dynamical models indicate that compression occurs during the development of tidal features causing an increase in the local density by a factor of between 1.5 and 5. Assuming this density increase can be related to the star formation rate by a Schmidt law, the density increases observed in the dynamical models may be responsible for the variations in color seen in some of the interacting systems. Limitations of the dynamical models are also discussed.

Wallin, John F.↗
NASA NTRS2019

Structure Deformation Calculation Program Based on Displacement Theory for Shape Predictions

Separated programs were written in C/C++ to validate the Displacement Transfer Functions. The Structure Deformation Calculation Program was written to combine all of the programs to calculate deformed shapes of a structure using surface strain data and structural geometrical parameters. Users do not need to know the material properties, nor the complex internal structures geometry because the Displacement Theory is purely geometrical in nature. Users only need to know the structure types as defined in this report and information such as the structure length, depth factors, number of strain sensors, and the surface strains measured at the strain-sensing stations installed on the structures. Depending on the structure type, an applicable Displacement Transfer Function will be used. This program requires two input files created by users; the recorded strain data file in comma-separated values format and the structure geometry data file in text format. The program will output the out-of-plane deflections, slopes, cross-sectional twist angles, and depth factors if applicable. All output files are created in comma-separated values format. A section in this report describes step-by-step procedures on how to use the Structure Deformation Calculation Program for structure deformed shape calculations.

Displacement theory↗
NASA NTRS2003

Disuse exaggerates the detrimental effects of alcohol on cortical bone

BACKGROUND: Alcohol abuse is associated with an increased risk for osteoporosis. However, comorbidity factors may play an important role in the pathogenesis of alcohol-related bone fractures. Suboptimal mechanical loading of the skeleton, an established risk factor for bone loss, may occur in some alcohol abusers due to reduced physical activity, muscle atrophy, or both. The effect of alcohol consumption and reduced physical activity on bone metabolism has not been well studied. The purpose of this study was to determine whether mechanical disuse alters bone metabolism in a rat model for chronic alcohol abuse. METHODS: Alcohol was administered in the diet (35% caloric intake) of 6-month-old male rats for 4 weeks. Rats were hindlimb-unloaded the final 2 weeks of the experiment to prevent dynamic weight bearing. Afterward, cortical bone histomorphometry was evaluated at the tibia-fibula synostosis. RESULTS: At the periosteal surface of the tibial diaphysis, alcohol and hindlimb unloading independently decreased the mineralizing perimeter, mineral apposition rate, and bone formation rate. In addition, alcohol, but not hindlimb unloading, increased endocortical bone resorption. The respective detrimental effects of alcohol and hindlimb unloading to inhibit bone formation were additive; there was no interaction between the two variables. CONCLUSIONS: Reduced weight bearing accentuates the detrimental effects of alcohol on cortical bone in adult male rats by further inhibiting bone formation. This finding suggests that reduced physical activity may be a comorbidity factor for osteoporosis in alcohol abusers.

NASA Discipline Cell Biology↗
NASA NTRS1984

Homogeneity of gels and gel-derived glasses

The significance and implications of gel preparation procedures in controlling the homogeneity of multicomponent oxide gels are discussed. The role of physicochemical factors such as the structure and chemical reactivities of alkoxides, the formation of double-metal alkoxides, and the nature of solvent(s) are critically analyzed in the context of homogeneity of gels during gelation. Three procedures for preparing gels in the SiO2-B2O3-Na2O system are examined in the context of cation distribution. Light scattering results for glasses in the SiO2-B2O3-Na2O system prepared by both the gel technique and the conventional technique are examined.

Mukherjee, S. P.↗
NASA NTRS1990

Cirrus structure and radiative parameters from airborne lidar and spectral radiometer observations - The 28 October 1986 FIRE study

A description is presented of cirrus based on results from a FIRE observation flight in central Wisconsin on October 28, 1986. Cirrus structure and radiative parameters as determined by the ER-2 lidar and imaging spectral radiometers are presented. From the lidar observations a complex structure was shown with differing cloud layers extending over six kilometers of altitude range. Both thin and dense cirrus layers were present and mixed phase clouds were found at lower altitudes. As indicated by the cloud structure, precipitation of crystals from high, but vertically thin, layers produces a significant fraction of the lower cirrus. Multiple layers should be considered as normal for cirrus formations. It is noted that the cloud height is an important factor for satellite cloud retrievals and cloud climatology.

Spinhirne, James D.↗
NASA NTRS1994

Scaling of impact damage in fiber composites

Impact damage in fiber composite structures remains of much concern, and is often the limiting factor in establishing allowable strain levels. The complexity of impact damage formation usually dictates that experiments are required, but scaling of results from small laboratory scale specimens to large structures introduces additional uncertainty into the analysis. This presentation gives the results of an analytical and experimental investigation intended to develop procedures for prediction of damage formation and subsequent strength loss, with particular emphasis on scaling of results with respect to structure size. The experimental investigation involved both drop-weight and airgun impact on carbon/epoxy plates and cylinders. Five sizes of plates ranging from 50 by 50 by 1.072 mm to 250 by 250 by 5.36 mm, and two sizes of cylinders with diameters of 96.5 and 319 mm, were employed in the experimental program. Impact tests were carried out over a range of impact conditions, and specimens were inspected for damage by C-scan and deplying. Analysis procedures were developed for both quasistatic and dynamic impacts for both the plates and cylinders. As has been reported previously, comparison of predicted structural response and measured surface strains was quite good over the entire range of sizes employed in the program. The damage formation and strength loss after impact showed a number of interesting features that are significant with respect to scaling of size. The extent of delamination was observed to increase with specimen size more than would be expected if stresses controlled the delamination extent. This was explained on the basis that delamination is controlled by energy release rates, and thus incorporates the usual dependence on the absolute size characteristic of fracture mechanics. Additionally, the experiments indicated that delamination initiated at matrix cracks and is dependent on the absolute size of the ply group thicknesses. Both the initiation and propagation of delamination are seen to be controlled by fracture mechanics parameters, and thus show specific dependence on size that must be accounted for in extrapolating results from laboratory scale tests to full size structures.

Swanson, Stephen R.↗
NASA NTRS1994

Propagation velocities of laser-produced plasmas from copper wire targets and water droplets

Experiments were performed to determine the plasma propagation velocities resulting from KrF laser irradiation of copper wire target (75 microns diameter) and water droplets (75 microns diameter) at irradiance levels ranging from 25 to 150 GW/sq cm. Plasma propagation velocities were measured using a streak camera system oriented orthogonally to the high-energy laser propagation axis. Plasma velocities were studied as a function of position in the focused beam. Results show that both the shape of the plasma formation and material removal from the copper wire are different and depend on whether the targets are focused or slightly defocused (approximately = 0.5 mm movement in the beam axis). Plasma formation and its position relative to the target is an important factor in determining the practical focal point during high-energy laser interaction with materials. At irradiance of 100 GW/sq cm, the air plasma has two weak-velocity components which propagate toward and away from the incident laser while a strong-velocity component propagates away from the laser beam as a detonation wave. Comparison of the measured breakdown velocities (in the range of 2.22-2.27 x 10(exp 5) m/s) for air and the value calculated by the nonlinear breakdown wave theory at irradiance of 100 GW/sq cm showed a quantitative agreement within approximately 50% while the linear theory and Gaussian pulse theory failed. The detonation wave velocities of plasma generated from water droplets and copper wire targets for different focused cases were measured and analyzed theoretically. The propagation velocities of laser-induced plasma liquid droplets obtained by previous research are compared with current work.

Song, Kyo-Dong↗
NASA NTRS2002

Investigations of Martian Impact Crater Morphologies and Morphometries

We have made substantial progress towards completion of the original objectives and are continuing to include new data from the Mars Global Surveyor MOC and TES instruments as they become available (the MOLA instrument has ceased operation as of 2002). The project funding has been used to provide salary support to the PI and several undergraduate students, cover publication charges for two papers, reimburse travel expenses to conferences and workshops incurred by the PI and students, and cover a number of other expenses such as software upgrades and production costs of slides and color prints. This study is revising the PI's Catalog of Large Martian Impact Craters with information obtained from MGS and is utilizing data in the revised Catalog to investigate which planetary factors (such as location, elevation, terrain type, etc.) primarily affect the formation of specific ejecta morphologies and morphometries.

Barlow, Nadine G.↗
NASA NTRS1991

A contribution with review to the description of mineralization of bone and other calcified tissues in vivo

This manuscript considers certain aspects of mineral deposition in bone and other vertebrate calcifying tissues in order to examine physical, chemical, and biological factors important in the mineralization process. The paper in a discussion format principally presents a new data and the formulation of concepts based on such data as well as a summary of background material as necessary review. Mineralization is found to occur at spatially independent sites throughout the organic extracellular tissue matrices. Matrix vesicles and collagen fibrils each may serve as independent nucleation centers for mineral with vesicle mineralization being local and collagen mineralization dominating the tissues as a whole. Collagen fibril organization is suggested to be such that hole zones are aligned in three dimensions, creating extensive channels for mineral accommodation. Nucleation occurs initially in hole zones and crystal growth leads to the development of plate-like mineral particles whose orientation, disposition, and sizes within fibrils are detailed. Effects of diffusion, crystallinity, and critical nucleation and growth events are described with respect to their influence on mineral deposition in bulk and local regions of tissue matrices.

Review↗
NASA NTRS2015

A Photometric Machine-Learning Method to Infer Stellar Metallicity

Following its formation, a star's metal content is one of the few factors that can significantly alter its evolution. Measurements of stellar metallicity ([Fe/H]) typically require a spectrum, but spectroscopic surveys are limited to a few x 10(exp 6) targets; photometric surveys, on the other hand, have detected > 10(exp 9) stars. I present a new machine-learning method to predict [Fe/H] from photometric colors measured by the Sloan Digital Sky Survey (SDSS). The training set consists of approx. 120,000 stars with SDSS photometry and reliable [Fe/H] measurements from the SEGUE Stellar Parameters Pipeline (SSPP). For bright stars (g' < or = 18 mag), with 4500 K < or = Teff < or = 7000 K, corresponding to those with the most reliable SSPP estimates, I find that the model predicts [Fe/H] values with a root-mean-squared-error (RMSE) of approx.0.27 dex. The RMSE from this machine-learning method is similar to the scatter in [Fe/H] measurements from low-resolution spectra..

machine learning↗
NASA NTRS2021

On the Nature of AGN and Star Formation Enhancement in thez=3.1 SSA22Protocluster: The HST WFC3 IR View

We examine possible environmental sources of the enhanced star formation and active galactic nucleus (AGN) activity in the z=3.09 SSA22 protocluster using Hubble WFC3 F160W (∼1.6μm) observations of the SSA22 field, including new observations centered on eight X-ray selected protocluster AGN. To investigate the role of mergers in the observed AGN and star formation enhancement, we apply both quantitative (Sérsic-fit and Gini–M20)and visual morphological classifications to F160W images of protocluster Lyman-break galaxies (LBGs) in the fields of the X-ray AGN and z∼3field LBGs in SSA22 and GOODS-N. We find no statistically significant differences between the morphologies and merger fractions of protocluster and field LBGs, though we are limited by small number statistics in the protocluster. We also fit the UV-to-near-IR spectral energy distributions of F160W-detected protocluster and field LBGs to characterize their stellar masses and star formation histories. We find that the mean protocluster LBG is a factor of∼2 times more massive and more attenuated than the mean z∼3field LBG. We take our results to suggest that ongoing mergers are not more common among protocluster LBGs than field LBGs, though protocluster LBGs appear to be more massive. We speculate that the larger mass of the protocluster LBGs contributes to the enhancement of SMBH mass and accretion rate in the protocluster, which in turn drives the observed protocluster AGN enhancement

Erik B. Monson↗
NASA NTRS2005

Reactions of Air Transport Flight Crews to Displays of Weather During Simulated Flight

Display of information in the cockpit has long been a challenge for aircraft designers. Given the limited space in which to present information, designers have had to be extremely selective about the types and amount of flight related information to present to pilots. The general goal of cockpit display design and implementation is to ensure that displays present information that is timely, useful, and helpful. This suggests that displays should facilitate the management of perceived workload, and should allow maximal situation awareness. The formatting of current and projected weather displays represents a unique challenge. As technologies have been developed to increase the variety and capabilities of weather information available to flight crews, factors such as conflicting weather representations and increased decision importance have increased the likelihood for errors. However, if formatted optimally, it is possible that next generation weather displays could allow for clearer indications of weather trends such as developing or decaying weather patterns. Important issues to address include the integration of weather information sources, flight crew trust of displayed weather information, and the teamed reactivity of flight crews to displays of weather. Past studies of weather display reactivity and formatting have not adequately addressed these issues; in part because experimental stimuli have not approximated the complexity of modern weather displays, and in part because they have not used realistic experimental tasks or participants. The goal of the research reported here was to investigate the influence of onboard and NEXRAD agreement, range to the simulated potential weather event, and the pilot flying on flight crew deviation decisions, perceived workload, and perceived situation awareness. Fifteen pilot-copilot teams were required to fly a simulated route while reacting to weather events presented in two graphical formats on a separate visual display. Measures of flight crew reactions included performance-based measures such as deviation decision accuracy, and judgment-based measures such as perceived decision confidence, workload, situation awareness, and display trust. Results demonstrated that pilots adopted a conservative reaction strategy, often choosing to deviate from weather rather than ride through it. When onboard and NEXRAD displays did not agree, flight crews reacted in a complex manner, trusting the onboard system more but using the NEXRAD system to augment their situation awareness. Distance to weather reduced situation awareness and heightened workload levels. Overall, flight crews tended to adopt a participative leadership style marked by open communication. These results suggest that future weather displays should exploit the existing benefits of NEXRAD presentation for situation awareness while retaining the display structure and logic inherent in the onboard system.

Bliss, James P.↗
NASA NTRS1993

Cockpit checklists - Concepts, design, and use

Although the aircraft checklist has long been regarded as a foundation of pilot standardization and cockpit safety, it has escaped the scrutiny of the human factors profession. The improper use, or nonuse, of the normal checklist by flight crews is often cited as a major contributing factor to aircraft accidents. This paper reports the results of a field study of flight deck checklists and examines this seemingly mundane yet critical device from several perspectives: its functions, format, design, length, and usage, and the limitations of the humans who must interact with it. Certain sociotechnical factors, such as the airline 'culture', cockpit resource management, and production pressures that influence the design and use of this device, are also discussed. Finally, a list of design guidelines for normal checklists is provided. Although the focus of this paper is on the air transport industry, most of the principles discussed apply equally well to other high-risk industries, such as maritime transportation, power production, weapons systems, space flight, and medical care.

Degani, Asaf↗
NASA NTRS1985

Factors affecting dwell times on digital displaying

A series of exploratory tests were conducted to investigate the effects of advanced display formats and display media on pilot scanning behavior using Langley's oculometer, a desktop flight simulator, a conventional electro-mechanical meter, and various digital displays. The primary task was for the test subject to maintain level flight, on a specific course heading, during moderate turbulence. A secondary task of manually controlling the readout of a display was used to examine the effects of the display format on a subject's scan behavior. Secondary task scan parameters that were evaluated were average dwell time, dwell time histograms, and number of dwells per meter change. The round dial meter demonstrated shorter dwell times and fewer dwells per meter change than the digital displays. The following factors affected digital display scanning behavior: (1) the number of digits; (2) the update rate of the digits; (3) the display media; and (4) the character font. The size of the digits used in these tests (0.28 to 0.50 inches) did not affect scan behavior measures.

Williams, A. J.↗