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At least 235 records · Page 13

The development and use of decision support framework for informing selection of select agent toxins with modelling studies to inform permissible toxin amounts

Many countries have worked diligently to establish and implement policies and processes to regulate high consequence pathogens and toxins that could have a significant public health impact if misused. In the United States, the Antiterrorism and Effective Death Penalty Act of 1996 (Public Law 104-132, 1996), as amended by the Bioterrorism Preparedness and Response Act of 2002 (Public Law 107-188, 2002) requires that the Department of Health and Human Services (HHS) [through the Centers for Disease Control and Prevention (CDC)] establish a list of bacteria, viruses, and toxins that have the potential to pose a severe threat to public health and safety. Currently, this list is reviewed and updated on a biennial basis using input from subject matter experts (SMEs). We have developed decision support framework (DSF) approaches to facilitate selection of select toxins and, where toxicity data are known, conducted modelling studies to inform selection of toxin amounts that should be excluded from select agent regulations. Exclusion limits allow laboratories to possess toxins under an established limit to support their research or teaching activities without the requirement to register with the Federal Select Agent Program. Fact sheets capturing data from a previously vetted SME workshop convened by CDC, literature review and SME input were developed to assist in evaluating toxins using the DSF approach. The output of the DSF analysis agrees with the current select toxin designations, and no other toxins evaluated in this study were recommended for inclusion on the select agent and toxin list. To inform the selection of exclusion limits, attack scenarios were developed to estimate the amount of toxin needed to impact public health. Scenarios consisted of simulated aerosol releases of a toxin in high-population-density public facilities and the introduction of a toxin into a daily consumable product supply chain. Using published inhalation and ingestion median toxic dose (TD 50 ) and median lethal dose (LD 50 ) values, where available, a range of toxin amounts was examined to estimate the number of people exposed to these amounts in these scenarios. Based on data generated by these models, we proposed toxin exclusion values corresponding to levels below those that would trigger a significant public health response (i.e., amounts estimated to expose up to ten people by inhalation or one hundred people by ingestion to LD 50 or TD 50 levels of toxin in the modeled scenarios).

60 APPLIED LIFE SCIENCES↗

A Program in Air Transportation Technology (Joint University Program)

The Joint University Program on Air Transportation Technology was conducted at Princeton University from 1971 to 1995. Our vision was to further understanding of the design and operation of transport aircraft, of the effects of atmospheric environment on aircraft flight, and of the development and utilization of the National Airspace System. As an adjunct, the program emphasized the independent research of both graduate and undergraduate students. Recent principal goals were to develop and verify new methods for design and analysis of intelligent flight control systems, aircraft guidance logic for recovery from wake vortex encounter, and robust flight control systems. Our research scope subsumed problems associated with multidisciplinary aircraft design synthesis and analysis based on flight physics, providing a theoretical basis for developing innovative control concepts that enhance aircraft performance and safety. Our research focus was of direct interest not only to NASA but to manufacturers of aircraft and their associated systems. Our approach, metrics, and future directions described in the remainder of the report.

Stengel, Robert F.↗

A Cabin Air Separator for EVA Oxygen

Presently, the Extra-Vehicular Activities (EVAs) conducted from the Quest Joint Airlock on the International Space Station use high pressure, high purity oxygen that is delivered to the Space Station by the Space Shuttle. When the Space Shuttle retires, a new method of delivering high pressure, high purity oxygen to the High Pressure Gas Tanks (HPGTs) is needed. One method is to use a cabin air separator to sweep oxygen from the cabin air, generate a low pressure/high purity oxygen stream, and compress the oxygen with a multistage mechanical compressor. A main advantage to this type of system is that the existing low pressure oxygen supply infrastructure can be used as the source of cabin oxygen. ISS has two water electrolysis systems that deliver low pressure oxygen to the cabin, as well as chlorate candles and compressed gas tanks on cargo vehicles. Each of these systems can feed low pressure oxygen into the cabin, and any low pressure oxygen source can be used as an on-board source of oxygen. Three different oxygen separator systems were evaluated, and a two stage Pressure Swing Adsorption system was selected for reasons of technical maturity. Two different compressor designs were subjected to long term testing, and the compressor with better life performance and more favorable oxygen safety characteristics was selected. These technologies have been used as the basis of a design for a flight system located in Equipment Lock, and taken to Preliminary Design Review level of maturity. This paper describes the Cabin Air Separator for EVA Oxygen (CASEO) concept, describes the separator and compressor technology trades, highlights key technology risks, and describes the flight hardware concept as presented at Preliminary Design Review (PDR)

Graf, John C.↗

Spatial and Temporal Deconfliction of Trajectories in the Presence of Uncertainties

Demonstration of conflict-free movement for multi-agent teams in challenging scenarios is crucial in developing trust and trustworthiness in an autonomous transport system. Tolerance verification queries are explored as a mechanism to enforce spatial and temporal deconfliction for a cooperating team of Unmanned Aerial Systems (UAS) with prescribed heterogeneous path-following performance. Obstacles in the environment are modelled as set of polyhedra, whereas each vehicle’s trajectory is represented as a sequence of polynomial curves with C2 continuity, expressed in a Bernstein basis. Each vehicle is modelled as a point mass and a safety distance, informed by the geometry of the UAS and the worst-case path-following error. This defines a tube around the trajectories where each UAS is most likely to fly through. In addition, obstacles in the environment have an associated safety buffer around them to account for the uncertainty in their location and geometric description. The tolerance verification queries explored in this paper combine the safety distance information from each UAS and environmental hazard to compute trajectories that are contained within the safe configuration space. Tolerance verification is also compared with other proximity queries to determine the suitability of each method along the different steps of the trajectory generation algorithm. This paper analyzes the fitness and performance of three proximity queries – collision, tolerance verification, and distance computations – between polyhedral and polynomial curves to ensure deconfliction between obstacles and vehicles, but also between polynomial curves to guarantee safe separation among cooperating UAS.

trajectory generation↗

Panel Session 132: Risk-Informed Approach for Decision Making in WM, D and D and SNF Management: Reasonable Assurance for Safety

Mr. Larry Camper organized a panel of experts to discuss approaches to better make risk-informed decisions in waste management, decommissioning, and the management of Spent Nuclear Fuel (SNF). The audience heard the perspectives from four panelists that addressed issues ranging from the technical basis used to make risk-informed decisions to for developing cleanup criteria and promulgating regulations and safety standards both domestically and abroad. A summary of each of the presentations given by the panelists is provided herein. This WMS BOD featured panel focused on the Risk-Informed Approach for Decision Making in WM, D and D and SNF Management and the Reasonable Assurance for Safety. The panelists addressed and discussed with the audience different approaches used for decision-making, summarizing ongoing probabilistic vs. deterministic approaches, including IAEA graded approach, and discussed policies/approaches to achieve reasonable assurance for safety rather than using absolute assurance. Panelists with presentations: Risk-Informed Decision Making - More than a Motto? (Paul Black); NRC Staff Perspective on Risk-Informed Approach and Reasonable Safety Assurance in D and D and LLW (Rateb (Boby) Abu Eid); Risk-Informed Decision-Making and Illustrative National Academies Studies (Charles Ferguson); IAEA's Revised Safety Guidance on Remediation (Michelle Roberts); NDA Radioactive Waste Strategy - A Risk Informed Approach (James McKinney)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Nuclear Safety [Vol. 37, No. 3, July-September 1996]

Nuclear Safety is a journal that covers significant issues in the field of nuclear safety. Its primary scope is safety in the design, construction, operation, and decommissioning of nuclear power reactors worldwide and the research and analysis activities that promote this goal, but it also encompasses the safety aspects of the entire nuclear fuel cycle, including fuel fabrication, spent-fuel processing and handling, and nuclear waste disposal, the handling of fissionable materials and radioisotopes, and the environmental effects of all these activities. Table of Contents for this issue follows. GENERAL SAFETY CONSIDERATIONS 181 Attitudes and Practices Regarding Disposal of Liquid Nuclear Waste at Clinton Laboratories in the Very Early Years: A Historical Analysis, S. H. Stow; 202 Off-Site Nuclear Emergency Management in Germany Under the Auspices of the Federal Structure, A. Bayer, S. Bittner, and H. Korn; DESIGN FEATURES: 211 Twenty-Fourth DOE/NRC Nuclear Air-Cleaning and Treatment Conference, R. R. Bellamy, J. J. Hayes, R. D. Porco, and M. W. First; OPERATING EXPERIENCES: 222 Explosion in the Tomsk-7 Reprocessing Plant on April 6, 1993, M. L. Hyder, W. G. Lussie, and F. E. Witmer; 234 Reactor Shutdown Experience, Compiled by J. W. Cletcher; U.S. NUCLEAR REGULATORY COMMISSION INFORMATION AND ANALYSES: 237 Assessment of Spent Fuel Cooling, J. G. Ibarra, W. R. Jones, G. F. Lanik, H. L. Ornstein, and S. V. Pullani; RECENT DEVELOPMENTS: 256 Reports, Standards, and Safety Guides, D. S. Queener; 260 Proposed Rule Changes as of June 30, 1996; ANNOUNCEMENTS: 210 Tennessee Industries Week; 221 21st International Symposium on The Scientific Basis for Nuclear Waste Management; 259 IAEA Programme of Scientific Meetings for 1997; 270 PSAM 4 (International Conference on Probabilistic Safety Assessment and Management); 265 The Authors; 268 Errata.

05 NUCLEAR FUELS↗

Development of phenomena identification and ranking table for Westinghouse lead fast reactor’s safety

The Westinghouse Lead-cooled Fast Reactor (LFR) is a medium-size, passively safe, economic, Gen-IV nuclear reactor. An important effort within the Westinghouse LFR program is the development of the safety analysis methodology, which comprises computer code development, model development, and experimental testing. A key initial task associated with the development of the safety analysis methodology is the identification of processes and phenomena that affect the plant's capability to meet selected safety performance indicators. This is accomplished through the development of a Phenomena Identification and Ranking Table (PIRT) for selected accident scenarios which, for this specific PIRT effort, included selected postulated design basis accidents and hypothetical beyond design basis accidents in LFRs. This paper describes the role of PIRT in the development of the Westinghouse LFR safety analysis methodology and the process used in the PIRT development. Specifically, the Westinghouse LFR PIRT assessed importance of pertinent phenomena and identified gaps in their knowledge-base by evaluating current modeling capabilities and data available for validation. The ultimate goal was to provide guidance on computer code development and validation efforts and to prioritize testing to support LFR design and licensing. The key phenomena and processes that are deemed highly important for the safety performance indicators, but for which the state of knowledge is low, are presented. The testing program and analyses development are planned to address significant phenomena in the PIRT.

Lead fast reactor↗

Qualification of System-Level Advanced Reactor Safety Analysis Software for Lead Systems: Final CRADA Report

SAS4A/SASSYS-1 is a simulation tool used to perform deterministic analysis of anticipated events as well as design basis and beyond design basis accidents for advanced liquid-metal-cooled nuclear reactors. With its origin as SAS1A in the late 1960s, the SAS series of codes has been under continuous use and development for over forty-five years and represents a critical investment in safety analysis capabilities for the U.S. Department of Energy. Although SAS4A/SASSYS-1 was developed to support the analysis of any liquid-metal-cooled nuclear reactor, it has primarily been utilized to design and analyze Sodium Fast Reactors (SFRs). As a result, most of the qualification basis for SAS4A/SASSYS-1 has utilized sodium as a coolant and geometry descriptions that are prototypic of SFR configurations. In this project, which partnered with Westinghouse Electric Company, LLC, the initial foundation for a qualification basis centered on prototypic pool-type lead-cooled systems has been established, where the end goal is to extend support for utilization of SAS4A/SASSYS-1 in Lead Fast Reactor (LFR) licensing or authorization. This project included three fundamental technical tasks: LFR V&V test suite development (Task 1); qualification support for LFRs (Task 2); and LFR modeling capabilities evaluation and improvement (Task 3)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Comprehensive framework for data-driven model form discovery of the closure laws in thermal-hydraulics codes

The two-phase two-fluid model is a basis of many thermal-hydraulics codes used in design, licensing, and safety considerations of nuclear power plants. Thermal-hydraulics codes rely on the closure laws to close the system of conservation equations and describe the interactions between phases. These laws, derived from years of experimental investigations, are semi-empirical correlations that lack generality and have a limited range of applicability. Increase of computational power, availability of new experiments, and development of high-fidelity simulations has increased the number of validation data. The discrepancies between the code predictions and the validation data are a great source of knowledge. Missing physics that are not included in the model but are important for the considered phenomena can be discovered by propagating the information from the experimental results through the model. Furthermore, physics-discovered data-driven model form (P3DM) methodology integrates available integral effect tests and separate effects tests to determine the necessary corrections to the model form of the closure laws. In contrast to existing calibration techniques, the methodology modifies the functional form of the closure laws. Based on the functional form of the correction, the missing physics that were not included in the original model can be discovered. The methodology provides the alternative to the machine learning approach, in which the model is discovered in the form of the intractable black-box relation. In this work, the methodology was applied to the CTF subchannel code to improve the prediction of the two-phase flow phenomena.

42 ENGINEERING↗

Preliminary criteria for the fracture control of space shuttle structures

The complex and multidisciplinary factors are presented which relate to the prevention of structural failure due to the initiation or propagation of cracks or crack-like defects. The fracture control criteria are applicable to space shuttle components which are: (1) susceptible to cracking or fracture on the basis of anticipated loads and environment, and (2) critical to either crew safety or system performance. The criteria define the design, fabrication, environmental control, inspection, maintenance, repair, and verification procedures required for adequate fracture control.

Source record↗

Study of toxicological evaluation of fire suppressants and extinguishers

The application of fluorocarbons as possible candidates for fire extinguishers and/or suppressants in confined spaces (such as spacecraft, aircraft, or submarines) was investigated, with special emphasis on their safety to man since they would be inhaled on an almost continuous basis. Short-term exposure experiments, using various animal species, were devised to look at specific parameters in order to determine which of the candidate compounds were sufficiently non-toxic to warrant long-term investigations. The following physiologic criteria were examined; tissue distribution, fluoride concentration, effect on mitochondria, microsomes, liposomes, and liver cell nuclei, erythrocyte fragility, clinical chemistry values, hematology, pathology, cardiac sensitization, behavioral effects. Various rodent species were used for initial investigations, with non-human primate exposures for Freon 116 which was warranted for negative results on rodents. Various types of exposure chambers were used, including closed dynamic chambers allowing for a recirculating atmosphere.

Source record↗

Integrated modeling and analysis of a space-truss article

MSC/NASTRAN is being used in the Controls-Structures Interaction (CSI) program at NASA Langley Research Center as a key analytical tool for structural analysis as well as the basis for control law development, closed-loop performance evaluation, and system safety checks. Guest investigators from academia and industry are performing dynamics and control experiments on a flight-like deployable space truss called Mini-Mast to determine the effectiveness of various active-vibration control laws. MSC/NASTRAN was used to calculate natural frequencies and mode shapes below 100 Hz to describe the dynamics of the 20-meter-long lightweight Mini-Mast structure. Gravitational effects contribute significantly to structural stiffness and are accounted for through a two-phase solution in which the differential stiffness matrix is calculated and then used in the eigensolution. Reduced modal models are extracted for control law design and evaluation of closed-loop system performance. Predicted actuator forces from controls simulations are then applied to the extended model to predict member loads and stresses. These pre-test analyses reduce risks associated with the structural integrity of the test article, which is a major concern in closed-loop control experiments due to potential instabilities.

Alan E Stockwell↗

In-situ Resources In Space

This tutorial is a primer on the motivational and materials science basis for utilizing space resources to lower the cost and increase the safety and reliability of human systems beyond Earth's orbit. Past research in materials processing in orbit will be briefly reviewed to emphasize the challenges and advantages inherent in processing materials in space. Data on resource availability from human Lunar and robotic/sensor missions beyond the Moon will be overviewed for resource relevance to human exploration and development of space. Specific scenarios such as propellant production on the Moon and Mars, and lunar photovoltaic power production from in-situ materials will be discussed in relation to exploration and commercialization of space. A conclusion will cover some of the visionary proposals for the use of space resources to extend human society and prosperity beyond Earth.

Curreri, Peter A.↗

Maturation of Structural Health Management Systems for Solid Rocket Motors

Concepts of an autonomous and automated space-compliant diagnostic system were developed for conditioned-based maintenance (CBM) of rocket motors for space exploration vehicles. The diagnostic system will provide real-time information on the integrity of critical structures on launch vehicles, improve their performance, and greatly increase crew safety while decreasing inspection costs. Using the SMART Layer technology as a basis, detailed procedures and calibration techniques for implementation of the diagnostic system were developed. The diagnostic system is a distributed system, which consists of a sensor network, local data loggers, and a host central processor. The system detects external impact to the structure. The major functions of the system include an estimate of impact location, estimate of impact force at impacted location, and estimate of the structure damage at impacted location. This system consists of a large-area sensor network, dedicated multiple local data loggers with signal processing and data analysis software to allow for real-time, in situ monitoring, and longterm tracking of structural integrity of solid rocket motors. Specifically, the system could provide easy installation of large sensor networks, onboard operation under harsh environments and loading, inspection of inaccessible areas without disassembly, detection of impact events and impact damage in real-time, and monitoring of a large area with local data processing to reduce wiring.

Quing, Xinlin↗

Bootstrapping Multi-Agent Unmanned Aerial Vehicle (UAV) System Integration Using Ground-Based Assets: Lessons Learned

In support of the Autonomy Teaming and TRAjectories for Complex Trusted Operational Reliability (ATTRACTOR) project, a fleet of unmanned ground vehicles (UGVs) was developed as a test and evaluation (T\&E) platform to reduce system integration gaps between simulation and live flight hardware. While simulation and hardware-in-the-loop bench testing provide adequate environments for preliminary validation, differences in system deployment architecture, software interfaces, and hardware infrastructure increase the risks to safety, property, and the project. Given ATTRACTOR’s goal of establishing a basis of certification of trust and trustworthiness in multi-agent autonomous systems, bridging these gaps was critical to successful project execution and feasibility assessment. In this paper we present the UGV fleet and its role in speeding up system integration, smoothing the transition from simulation to flight, and providing researchers an easy-to-use hardware test bed. An overview of the hardware and software on-board the vehicles is provided along with supporting infrastructure. The system integration process is documented including results in supporting both the overarching design reference mission (DRM) of ATTRACTOR and individual research efforts conducted since the creation of the fleet. Finally, we discuss the practical lessons learned regarding the testing, deployment, and operation of multi-agent autonomous systems.

Matthew P. Vaughan↗

Serious Gaming for Building a Basis of Certification via Trust and Trustworthiness of Autonomous Systems

Autonomous systems governed by a variety of adaptive and nondeterministic algorithms are being planned for inclusion into safety-critical environments, such as unmanned aircraft and space systems in both civilian and military applications. However, until autonomous systems are proven and perceived to be capable and resilient in the face of unanticipated conditions, humans will be reluctant or unable to delegate authority, remaining in control aided by machine-based information and decision support. Proving capability, or trustworthiness, is a necessary component of certification. Perceived capability is a component of trust. Trustworthiness is an attribute of a cyber-physical system that requires context-driven metrics to prove and certify. Trust is an attribute of the agents participating in the system and is gained over time and multiple interactions through trustworthy behavior and transparency. Historically, artificial intelligence and machine learning systems provide answers without explanation - without a rationale or insight into the machine “thinking”. In order to function as trusted teammates, machines must be able to explain their decisions and actions. This transparency is a product of both content and communication. NASA’s Autonomy Teaming & TRAjectories for Complex Trusted Operational Reliability (ATTRACTOR) project seeks to build a basis for certification of autonomous systems via establishing metrics for trustworthiness and trust in multi-agent team interactions, using AI (Artificial Intelligence) explainability and persistent modeling and simulation, in the context of mission planning and execution, with analyzable trajectories. Inspired by Massively Multiplayer Online Role Playing Games (MMORPG) and Serious Gaming, the proposed ATTRACTOR modeling and simulation environment is similar to online gaming environments in which player (aka agent) participants interact with each other, affect their environment, and expect the simulation to persist and change regardless of any individual agent’s active participation. This persistent simulation environment will accommodate individual agents, groups of self-organizing agents, and large-scale infrastructure behavior. The effects of the emerging adaptation and coevolution can be observed and measured to building a basis of measurable trustworthiness and trust, toward certification of safety-critical autonomous systems.

Allen, B. Danette↗

Modular High Temperature Gas-Cooled Reactor: Safety Design Approach

Deployment Objectives Flexibly co-locate with new industry users of nuclear energy Steam and electric cogeneration applications Direct process heat with temperature ranges from 700°C to 950°C Enabling Requirements Meet regulatory dose limits at the Exclusion Area Boundary (EAB) 25 rem Total Effective Dose Equivalent (TEDE) for duration of the release from 10 CFR 50.34 (10 CFR 52.79) at Exclusion Area Boundary (EAB) for design basis accidents EAB is estimated approximately 400 meters from the modular HTGR plant (to support co-location with industrial facilities) Meet safety goals for cumulative individual risk for normal and off-normal operation Design goal: meet EPA Protective Action Guides (PAGs) at EAB 1 rem TEDE for sheltering Design basis and beyond design basis events are considered Realistically evaluated at the EAB Emergency planning and protection

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Conceptual Design Standards for eXternal Visibility System (XVS) Sensor and Display Resolution

NASA is investigating eXternal Visibility Systems (XVS) concepts which are a combination of sensor and display technologies designed to achieve an equivalent level of safety and performance to that provided by forward-facing windows in today s subsonic aircraft. This report provides the background for conceptual XVS design standards for display and sensor resolution. XVS resolution requirements were derived from the basis of equivalent performance. Three measures were investigated: a) human vision performance; b) see-and-avoid performance and safety; and c) see-to-follow performance. From these three factors, a minimum but perhaps not sufficient resolution requirement of 60 pixels per degree was shown for human vision equivalence. However, see-and-avoid and see-to-follow performance requirements are nearly double. This report also reviewed historical XVS testing.

Bailey, Randall E.↗