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At least 235 records · Page 13

Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals

Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource (http://fantom.gsc.riken.jp) to facilitate researchers to explore transcriptional regulation and cellular states. In the course of the collaboration, primary data and analysis results have been expanded, and functionalities of the database systems enhanced. We believe that our data and web systems are invaluable resources, and we think the scientific community will benefit for this recent update to deepen their understanding of mammalian cellular organization. We introduce the contents of FANTOM5 here, report recent updates in the web resource and provide future perspectives.

59 BASIC BIOLOGICAL SCIENCES↗

A demonstration of improved constraints on primordial gravitational waves with delensing

We present a constraint on the tensor-to-scalar ratio, $r$, derived from measurements of cosmic microwave background (CMB) polarization $B$-modes with "delensing,'' whereby the uncertainty on $r$ contributed by the sample variance of the gravitational lensing $B$-modes is reduced by cross-correlating against a lensing $B$-mode template. This template is constructed by combining an estimate of the polarized CMB with a tracer of the projected large-scale structure. The large-scale-structure tracer used is a map of the cosmic infrared background derived from Planck satellite data, while the polarized CMB map comes from a combination of South Pole Telescope, BICEP/Keck, and Planck data. We expand the BICEP/Keck likelihood analysis framework to accept a lensing template and apply it to the BICEP/Keck data set collected through 2014 using the same parametric foreground modelling as in the previous analysis. From simulations, we find that the uncertainty on $r$ is reduced by $\sim10\%$, from $\sigma(r)$= 0.024 to 0.022, which can be compared with a $\sim26\%$ reduction obtained when using a perfect lensing template. Applying the technique to the real data, the constraint on $r$ is improved from $r_{0.05} < 0.090$ to $r_{0.05} < 0.082$ (95% C.L.). Furthermore, this is the first demonstration of improvement in an $r$ constraint through delensing.

79 ASTRONOMY AND ASTROPHYSICS↗

Gallium arsenide (GaAs) (001) after sublimation of arsenic (As) thin-film cap, by XPS

Survey and high energy resolution spectra are reported for MBE grown GaAs (001) that had been capped with As. The As cap was removed by heating in situ prior to analysis. The current data expands upon the spectral regions previously reported in Surface Science Spectra. High energy resolution spectral features reported include: 2p, 3s, 3p, 3d, and L3M45M45 peaks for As; 2p, 3s, 3p, 3d, and L3M45M45 peaks for Ga; and the valance band region.

As-capped GaAs↗

Grizzly Usage and Theory Manual

Grizzly is a multiphysics simulation code for characterizing the behavior of nuclear power plant (NPP) structures, systems and components (SSCs) subjected to a variety of age-related aging mechanisms. Grizzly simulates both the progression of aging processes, as well as the capacity of aged components to safely perform. This initial beta release of Grizzly includes capabilities for engineering-scale thermo-mechanical analysis of reactor pressure vessels (RPVs). Grizzly will ultimately include capabilities for a wide range of components and materials. Grizzly is in a state of constant development, and future releases will broaden the capabilities of this code for RPV analysis, as well as expand it to address degradation in other critical NPP components.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Space Shuttle Orbiter entry guidance and control system sensitivity analysis

An approach has been developed to determine the guidance and control system sensitivity to off-nominal aerodynamics for the Space Shuttle Orbiter during entry. This approach, which uses a nonlinear six-degree-of-freedom interactive, digital simulation, has been applied to both the longitudinal and lateral-directional axes for a portion of the orbiter entry. Boundary values for each of the aerodynamic parameters have been identified, the key parameters have been determined, and system modifications that will increase system tolerance to off-nominal aerodynamics have been recommended. The simulations were judged by specified criteria and the performance was evaluated by use of key dependent variables. The analysis is now being expanded to include the latest shuttle guidance and control systems throughout the entry speed range.

Stone, H. W.↗

Space platforms for science and applications

It is pointed out that space platforms offer a flexible and cost-effective evolutionary approach to conducting science and applications missions of several months' duration and can pave the way for major manned orbital facilities. General-purpose Low-Earth-Orbit space platforms are made possible by the Space Transportation System. Such platforms could remain in orbit for many years serviced as needed by the Shuttle. Attention is given to a Power System Platform, aspects of communications and data handling, stability and control, system and subsystem capability, a dynamics-analysis model of an expanded platform, command and data flow for a space platform, comparative costs of flying a pallet-size payload, a continually mannable Science and Applications Manned Space Platform, and a scenario of how the space platform might evolve.

Snoddy, W. C.↗

Recent developments in thermal analysis of large space structures

A numerical procedure for analysis of shadowed space heating of sparse structures, SSQ, is discussed. The SSQ program avoids inordinate computational complexity by confining attention to a single elemental location on a structural member of interest throughout an entire orbital period, proceeding then to similar treatment of individual alternate locations. The procedure considers a spacecraft in circular orbit and assumes fixed-Earth orientation of the spacecraft. Shadow orientation and interval duration, merged shadows, and computation of solar heat flux and thermal response are addressed. The output options of the SSQ FORTRAN 5 program and its efficiency are discussed. Application of the system to the analysis of a parabolic expandable truss antenna is considered.

Oneill, R. F.↗

Analysis of buoyancy effect on fully developed laminar heat transfer in a rotating tube

Laminar heat transfer is analyzed in a tube rotating about an axis perpendicular to the tube axis. The solution applies for flow that is either radially outward from the axis of rotation, or radially inward toward the axis of rotation. The conditions are fully developed, and there is uniform heat addition at the tube wall. The analysis is performed by expanding velocities and temperature in power series using the Taylor number as a perturbation parameter. Coriolis and buoyancy forces caused by tube rotation are included, and the solution is calculated through second-order terms. The secondary flow induced by the Coriolis terms always tends to increase the heat transfer coefficient; this effect can dominate for small wall heating. For radial inflow, buoyancy also tends to improve heat transfer. For radial outflow, however, buoyancy tends to reduce heat transfer; for large wall heating this effect can dominate, and there is a net reduction in heat transfer coefficient.

Siegel, R.↗

Display management subsystem, version 1: A user's eye view

The structure and application functions of the Display Management Subsystem (DMS) are described. The DMS, a subsystem of the Transportable Applications Executive (TAE), was designed to provide a device-independent interface for an image processing and display environment. The system is callable by C and FORTRAN applications, portable to accommodate different image analysis terminals, and easily expandable to meet local needs. Generic applications are also available for performing many image processing tasks.

Parker, Dolores↗

The effect of suspended particles on Jean's criterion for gravitational instability

The effect that the proper inclusion of suspended particles has on Jeans' criterion for the self-gravitational instability of an unbounded nonrotating adiabatic gas cloud is examined by formulating the appropriate model system, introducing particular physically plausible equations of state and constitutive relations, performing a linear stability analysis of a uniformly expanding exact solution to these governing equations, and exploiting the fact that there exists a natural small material parameter for this problem given by N sub 1/n sub 1, the ratio of the initial number density for the particles to that for the gas. The main result of this investigation is the derivation of an altered criterion which can substantially reduce Jeans' original critical wavelength for instability. It is then shown that the existing discrepancy between Jeans' theoretical prediction using and actual observational data relevant to the Andromeda nebula M31 can be accounted for by this new criterion of assuming suspended particles of a reasonable grain size and distribution to be present.

Wollkind, David J.↗

SEAPAK user's guide, version 2.0. Volume 2: Descriptions of programs

The SEAPAK is a user-interactive satellite data analysis package that was developed for the processing and interpretation of Nimbus-7/Coastal Zone Color Scanner (CZCS) and the NOAA Advanced Very High Resolution Radiometer (AVHRR) data. Significant revisions were made since version 1.0, and the ancillary environmental data analysis module was greatly expanded. The package continues to be user friendly and user interactive. Also, because the scientific goals of the ocean color research being conducted have shifted to large space and time scales, batch processing capabilities for both satellite and ancillary environmental data analyses were enhanced, thus allowing for large quantities of data to be ingested and analyzed.

Mcclain, Charles R.↗

An Investigation of Rotor Flow using DFDR Data

The purpose of the present study was to identify the specific cause of the turbulence that affected flights JAL 042 and JAL 046. This has been accomplished by expanding on the NTSB analysis to include a detailed examination of digital Flight Data Recorder (DFDR) information available from both JAL 042 and JAL 046 and the ANC rawinsonde.

Kahn, Brian H.↗

Urban Dynamics: Analyzing Land Use Change in Urban Environments

In FY99, the Earth Resource Observation System (EROS) staff at Ames continued managing the U.S. Geological Survey's (USGS) Urban Dynamics Research program, which has mapping and analysis activities at five USGS mapping centers. Historic land use reconstruction work continued while activities in geographic analysis and modeling were expanded. Retrospective geographic information system (GIS) development - the spatial reconstruction of a region's urban land-use history - focused on the Detroit River Corridor, California's Central Valley, and the city of Sioux Falls, South Dakota.

Acevedo, William↗

Radiation-induced chromosomal instability in human mammary epithelial cells

Karyotypes of human cells surviving X- and alpha-irradiation have been studied. Human mammary epithelial cells of the immortal, non-tumorigenic cell line H184B5 F5-1 M/10 were irradiated and surviving clones isolated and expanded in culture. Cytogenetic analysis was performed using dedicated software with an image analyzer. We have found that both high- and low-LET radiation induced chromosomal instability in long-term cultures, but with different characteristics. Complex chromosomal rearrangements were observed after X-rays, while chromosome loss predominated after alpha-particles. Deletions were observed in both cases. In clones derived from cells exposed to alpha-particles, some cells showed extensive chromosome breaking and double minutes. Genomic instability was correlated to delayed reproductive death and neoplastic transformation. These results indicate that chromosomal instability is a radiation-quality-dependent effect which could determine late genetic effects, and should therefore be carefully considered in the evaluation of risk for space missions.

NASA Center JSC↗

STS-121: Discovery Mission Management Team Briefing

The briefing opened with Bruce Buckingham (NASA Public Affairs) introducing John Shannon (Chairman, Mission Management Team, JSC), John Chapman (External Tank Project Manager), Mike Leinbach (Shuttle Launch Director), and 1st Lt. Kaleb Nordgren (USAF 45th Weather Squadron). John Shannon reported that the team for hydrogen loading was proceeding well and the external tank detanking was completed. During detanking the inspection team cracked foam caused by condensation and ice formation as the tank expanded and contracted. Aerothermal analysis and analysis fro ice formation will be completed before launch. John Chapman explained the mechanics of the external tank design, the foam cracking, bracket design, etc. Mike Leinbach discussed the inspection teams and their inspection final inspection for ice formation before and after external tank filling. The inspection team of eight very experienced personnel also use telescopes with cameras to find any problems before launch. Kaleb Nordgren discussed weather and said there was a 40% chance of weather prohibiting launch. The floor was the opened for questions from the press.

Source record↗

Numerical Optimization of the Thermal Field in Bridgman Detached Growth

The global modeling of the thermal field in two vertical Bridgman-like crystal growth configurations, has been performed to get optimal thermal conditions for a successful detached growth of Ge and CdTe crystals. These computations are performed using the CrysMAS code and expand upon our previous analysis [1] that propose a new mechanism involving the thermal field and meniscus position to explain stable conditions for dewetted Bridgman growth. The analysis of the vertical Bridgman configuration with two heaters, used by Palosz et al. for the detached growth of Ge, shows, consistent with their results, that the large wetting angle of germanium on boron nitride surfaces was an important factor to promote a successful detached growth. Our computations predict that by initiating growth much higher into the hot zone of the furnace, the thermal conditions will be favorable for continued detachment even for systems that did not exhibit high contact angles. The computations performed for a vertical gradient freeze configuration with three heaters representative of that used for the detached growth of CdTe, show favorable thermal conditions for dewetting during the entirely growth run described. Improved thermal conditions are also predicted for coated silica crucibles when the solid-liquid interface advances higher into the hot zone during the solidification process. The second set of experiments on CdTe growth described elsewhere has shown the reattachment of the crystal to the crucible after few centimeters of dewetted growth. The thermal modeling of this configuration shows a second solidification front appearing at the top of the sample and approaching the middle line across the third heater. In these conditions, the crystal grows detached from the bottom, but will be attached to the crucible in the upper part because of the solidification without gap in this region. The solidification with two interfaces can be avoided when the top of the sample is positioned below the middle position of the third furnace.

Stelian, C.↗

Space Shuttle Main Engine (SSME) Operational Capability

Through the years of the Space Shuttle Main Engine (SSME) program the engine has evolved and operational capabilities have been demonstrated beyond the original Shuttle requirements. In an effort to enhance flight safety and demonstrate safety features and margins, engines have been analyzed and tested at many different operating points. Various studies through the years evaluating the SSME for different applications both as a boost stage and upper stage have also added insight into the overall operational characteristics of the engine and have further defined safety margins for the Shuttle application. This paper will summarize the operational characteristics of the SSME from the original design requirements to the expanded capabilities demonstrated through analysis, lab testing and especially "off-nominal" engine testing leading to an increased understanding of the engine operational characteristics and safety margins. Basic engine characteristics such as thrust, mixture ratio, propellant inlet conditions, system redundancy, etc. will be examined.

Benefield, Philip↗

Dynamic Optimization of Multi-Spacecraft Relative Navigation Configurations in the Earth-Moon System

In this paper, the notion of relative navigation introduced by Hill, Lo and Born is analyzed for a large class of periodic orbits in the Earth-Moon three-body problem, due to its potential in supporting Moon exploration efforts. In particular, a navigation metric is introduced and used as a cost function to optimize over a class of periodic orbits. While the problem could be solve locally as an optimal control problem, a dynamical based approach that allows for a global/systematic view of the problem is proposed. First, the simpler problem of multiple spacecraft placement on a given periodic orbit is solved before the notion of continuation and bifurcation analysis is used to expand the range of solutions thus obtained.

Three Body Problem↗