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At least 235 records · Page 13

SU-E-T-429: Feasibility Study On Three-Dimensional GRID Therapy in Conventional Linacs

Purpose: Two-dimensional GRID therapy, traditionally planned and delivered using a dedicated GRID block or MLC modulation, has shown clinical efficacy in treating bulky tumors. However, the large dose to normal tissues outside target can be limiting. We hypothesize that modulation in the third dimension will improve dose sparing of normal tissues, maximize the bystander effect within the target, and ultimately improve the therapy effectiveness. This study aims to investigate the feasibility of a three-dimensional GRID technique using conventional LINACs to achieve a 3D lattice of high dose volumes within a target. Methods: Datasets of patient’s having large tumor sizes were used to investigate the planning and delivering of 3D GRID using a Varian TrueBeam linac. Original patient contours of PTV are exported from a TPS to DICOManTX where 3D GRID targets are generated in programmable configurations. A structure of avoidance (SOA), i.e., PTV minus GRID targets, is also generated to facilitate inverse planning to achieve the desired pattern. The artificial structures were sent back to the TPS where an IMRT or VMAT plan is designed to deliver a desired high dose to GRID targets while minimizing the dose to the SOA as much as possible. Results: The programmable GRID target generator enables us to modify the target geometry to maximize the peak-to-valley ratio. Preliminary results show that plans based on spherical GRID targets achieve a higher peak-to-valley dose ratio compared with cylindrical targets. High dose spillage outside the target was eliminated. IMRT planning requires the number of beams to be larger than 16, while for VMAT the number of arcs should be at least 4 in order to achieve dosimetric goals. Conclusion: Planning and delivering 3D GRID therapy using conventional LINACs was shown to be feasible. More research and development are required before this new modality can be implemented clinically.

60 APPLIED LIFE SCIENCES↗

SU-E-T-433: Field-In-Field Irradiation for Breast Cancer with VERO-4DRT System: A Feasibility Study

Purpose: The Vero-4DRT system is a dedicated system for high precision radiation therapy. However, the field size is limited at 15 cm x 15 cm and shapes by using multi-leaf collimator (MLC) without X-Jaw and Y-Jaw. Therefore VERO-4DRT system is not available to simple wedged irradiation for breast cancer. In this study, we suppose FIF with ring and/or tilt/pan angles whole breast irradiation (FIFWBI). The purpose of this study is to verify the feasibility of FIFWBI with VERO-4DRT system. Methods: As fundamental evaluation, we performed commissioning test with phantom. The absorbed dose evaluation at several reference points and dose distribution including split area were performed. We planned 10 demonstrative shapes in phantom for measuring these contents with i-plan workstation (BrainLAB). As clinical evaluation, the dose distribution and dose indexes were evaluated with actual patient data. Five patients with breast cancer were designed FIFWBI radiotherapy plan with split fields. Then, the dose distribution and dose indexes (including Dmax, Dmin, D95, D5 and Homogeneity index) were evaluated in these plans. Results: As the results of fundamental evaluation, all absorbed dose errors between calculated and measured doses were within 2%. The gamma passing rates with 2 mm/3% criteria in all cases were 96±2%. As the results of clinical evaluation, the values of Dmax, D95, D50, D5, and Homogeneity Index were 41.7±0.90 Gy, 49.4±0.34 Gy, 52.26±0.24 Gy, and 1.39±0.03, respectively. For Japanese breast cancer patients, this technique was feasible. However, the large split region was happened in FIFWBI in case of patient with large breast. Conclusion: We evaluated the FIFWBI technique with VERO-4DRT system. This technique is feasible for Japanese patients, but the patient with large breast should be disagreed with this technique.

60 APPLIED LIFE SCIENCES↗

SU-F-J-213: Feasibility Study of Using a Dual-Energy Cone Beam CT (DECBCT) in Proton Therapy Treatment Planning

Purpose: The aim of this study is to evaluate the feasibility of using a dual-energy CBCT (DECBCT) in proton therapy treatment planning to allow for accurate electron density estimation. Methods: For direct comparison, two scenarios were selected: a dual-energy fan-beam CT (high: 140 kVp, low: 80 kVp) and a DECBCT (high: 125 kVp, low: 80 kVp). A Gammex 467 tissue characterization phantom was used, including the rods of air, water, bone (B2–30% mineral), cortical bone (SB3), lung (LN-300), brain, liver and adipose. For the CBCT, Hounsfield Unit (HU) numbers were first obtained from the reconstructed images after a calibration was made based on water (=0) and air materials (=−1000). For each tissue surrogate, region-of-interest (ROI) analyses were made to derive high-energy and low-energy HU values (HUhigh and HUlow), which were subsequently used to estimate electron density based on the algorithm as previously described by Hunemohr N., et al. Parameters k1 and k2 are energy dependent and can be derived from calibration materials. Results: While for the dual-energy FBCT, the electron density is found be within +/−3% error relative to the values provided by the phantom vendor: −1.8% (water), 0.03% (lung), 1.1% (brain), −2.82% (adipose), −0.49% (liver) and −1.89% (cortical bones). While for the DECBCT, the estimation of electron density exhibits a relatively larger variation: −1.76% (water), −36.7% (lung), −1.92% (brain), −3.43% (adipose), 8.1% (liver) and 9.5% (cortical bones). Conclusion: For DECBCT, the accuracy of electron density estimation is inferior to that of a FBCT, especially for materials of either low-density (lung) or high density (cortical bone) compared to water. Such limitation arises from inaccurate HU number derivation in a CBCT. Advanced scatter-correction and HU calibration routines, as well as the deployment of photon counting CT detectors need be investigated to minimize the difference between FBCT and CBCT.

60 APPLIED LIFE SCIENCES↗

SU-G-JeP1-11: Feasibility Study of Markerless Tracking Using Dual Energy Fluoroscopic Images for Real-Time Tumor-Tracking Radiotherapy System

Purpose: The new real-time tumor-tracking radiotherapy (RTRT) system was installed in our institution. This system consists of two x-ray tubes and color image intensifiers (I.I.s). The fiducial marker which was implanted near the tumor was tracked using color fluoroscopic images. However, the implantation of the fiducial marker is very invasive. Color fluoroscopic images enable to increase the recognition of the tumor. However, these images were not suitable to track the tumor without fiducial marker. The purpose of this study was to investigate the feasibility of markerless tracking using dual energy colored fluoroscopic images for real-time tumor-tracking radiotherapy system. Methods: The colored fluoroscopic images of static and moving phantom that had the simulated tumor (30 mm diameter sphere) were experimentally acquired using the RTRT system. The programmable respiratory motion phantom was driven using the sinusoidal pattern in cranio-caudal direction (Amplitude: 20 mm, Time: 4 s). The x-ray condition was set to 55 kV, 50 mA and 105 kV, 50 mA for low energy and high energy, respectively. Dual energy images were calculated based on the weighted logarithmic subtraction of high and low energy images of RGB images. The usefulness of dual energy imaging for real-time tracking with an automated template image matching algorithm was investigated. Results: Our proposed dual energy subtraction improve the contrast between tumor and background to suppress the bone structure. For static phantom, our results showed that high tracking accuracy using dual energy subtraction images. For moving phantom, our results showed that good tracking accuracy using dual energy subtraction images. However, tracking accuracy was dependent on tumor position, tumor size and x-ray conditions. Conclusion: We indicated that feasibility of markerless tracking using dual energy fluoroscopic images for real-time tumor-tracking radiotherapy system. Furthermore, it is needed to investigate the tracking accuracy using proposed dual energy subtraction images for clinical cases.

60 APPLIED LIFE SCIENCES↗

Future Circular Collider Feasibility Study Report

Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model. The report reviews the experimental opportunities offered by the staged implementation of FCC, beginning with an electron-positron collider (FCC-ee), operating at several centre-of-mass energies, followed by a hadron collider (FCC-hh). Benchmark examples are given of the expected physics performance, in terms of precision and sensitivity to new phenomena, of each collider stage. Detector requirements and conceptual designs for FCC-ee experiments are discussed, as are the specific demands that the physics programme imposes on the accelerator in the domains of the calibration of the collision energy, and the interface region between the accelerator and the detector. The report also highlights advances in detector, software and computing technologies, as well as the theoretical tools/reconstruction techniques that will enable the precision measurements and discovery potential of the FCC experimental programme. The content and structure of this report are guided by the scope and priorities defined in the mandate of the FCC Feasibility Study. It is therefore not intended to serve as an exhaustive review of the full physics potential of FCC. Several topics, already covered in earlier reports such as the FCC CDR, are not reiterated here or are addressed only briefly, in alignment with the study’s focus. This volume reflects the outcome of a global collaborative effort involving hundreds of scientists and institutions, aided by a dedicated community-building coordination, and provides a targeted assessment of the scientific opportunities and experimental foundations of the FCC programme.

Benedikt, M. [European Organization for Nuclear Re↗

Geocellular model of St. Peter Sandstone for University of Illinois at Urbana-Champaign DDU Feasibility Study

The geocellular model of the St. Peter Sandstone was constructed for the University of Illinois at Urbana-Champaign DDU feasibility study. Starting with the initial area of review (18.0 km by 18.1 km [11.2 miles by 11.3 miles]) the boundaries of the model were trimmed down to 9.7 km by 9.7 km (6 miles by 6 miles) to ensure that the model enclosed a large enough volume so that the cones of depression of both the production and injection wells would not interact with each other, while at the same time minimizing the number of cells to model to reduce computational time. The grid-cell size was set to 61.0 m by 61.0 m (200 feet by 200 feet) for 160 nodes in the X and Y directions. The top surface of the St. Peter Sandstone was provided by geologists working on the project, and the average thickness of the formation was taken from the geologic prospectus they provided. An average thickness of 68.6 m (225 feet) was used for the St. Peter Sandstone, resulting in 45 layers for the model. Petrophysical data was taken from available rotary sidewall core data (Morrow et al., 2017). As geothermal properties (thermal conductivity, specific heat capacity) are closely related to mineralogy, specifically the percentage of quartz, available mineralogical data was assembled and used with published data of geothermal values to determine these properties (Waples and Waples, 2004; Robertson, 1988). The St. Peter Sandstone was divided into facies according to similar geothermal and petrophysical properties, and distributed according to available geophysical log data and prevailing interpretations of the depositional/diagenetic history (Will et al. 2014). Petrophysical and geothermal properties were distributed through geostatistical means according to the associated distributions for each lithofacies. The formation temperature was calculated, based on data from continuous temperature geophysical log from a deep well drilled into the Precambrian basement at the nearby Illinois Basin Decatur Project (IBDP) where CO2 is currently being sequestered (Schlumberger, 2012). Salinity values used in the model were taken from regional studies of brine chemistry in the St. Peter Sandstone, including for the IBDP (e.g., Panno et al. 2018). After being reviewed by the project's geologists, the model was then passed onto the geological engineers to begin simulations of the geothermal reservoir and wellbores.

15 GEOTHERMAL ENERGY↗

Geocellular Model of Mt. Simon Sandstone for University of Illinois at Urbana-Champaign DDU feasibility study

The geocellular model of the Mt. Simon Sandstone was constructed for the University of Illinois at Urbana-Champaign DDU feasibility study. Starting with the initial area of review (18.0 km by 18.1 km [11.2 miles by 11.3 miles]) the boundaries of the model were trimmed down to 9.7 km by 9.7 km (6 miles by 6 miles) to ensure that the model enclosed a large enough volume so that the cones of depression of both the production and injection wells would not interact with each other, while at the same time minimizing the number of cells to model to reduce computational time. The grid-cell size was set to 61.0 m by 61.0 m (200 feet by 200 feet) for 160 nodes in the X and Y directions. Within the model, 67 layers are represented that are parameterized with their sediment/rock properties and petrophysical data. The top surface of the Mt. Simon Sandstone was provided by geologists working on the project, and the average thickness of the formation was taken from the geologic prospectus they provided. An average thickness of 762 m (2500 feet) was used for the Mt. Simon Sandstone, resulting in 60 layers for the model. Petrophysical data was taken from available rotary sidewall core data (Morrow et al., 2017). As geothermal properties (thermal conductivity, specific heat capacity) are closely related to mineralogy, specifically the percentage of quartz, available mineralogical data was assembled and used with published data of geothermal values to determine these properties (Waples and Waples, 2004; Robertson, 1988). The Mt. Simon Sandstone was divided into three separate units (lower, middle, upper) according to similar geothermal and petrophysical properties, and distributed according to available geophysical log data and prevailing interpretations of the depositional/diagenetic history (Freiburg et al. 2016). Petrophysical and geothermal properties were distributed through geostatistical means according to the associated distributions for each lithofacies. The formation temperature was calculated, based on data from continuous temperature geophysical log from a deep well drilled into the Precambrian basement at the nearby Illinois Basin Decatur Project (IBDP) where CO2 is currently being sequestered (Schlumberger, 2012). Salinity values used in the model were taken from regional studies of brine chemistry in the Mt. Simon Sandstone, including for the IBDP (e.g., Panno et al. 2018). After being reviewed by the project's geologists, the model was then passed onto the geological engineers to begin simulations of the geothermal reservoir and wellbores.

15 GEOTHERMAL ENERGY↗

Feasibility studies for the design of disposal vaults for multi-purpose containers (MPCs): construction, operation, ventilation and management of heat - 15175

The Nuclear Decommissioning Authority (NDA) subsidiary, Radioactive Waste Management Ltd (RWM) is responsible for the safe implementation of a Geological Disposal Facility (GDF) for radioactive waste in the UK. As part of their generic programme to underpin the planned designs for a GDF, work is ongoing to explore a range of possible geological disposal concepts. This work developed GDF concept designs for Multi-Purpose Containers (MPC) disposal in the generic host rock types considered: higher strength (crystalline), lower strength sedimentary (sedimentary / clay formations) and evaporite rocks. This paper is specific to concepts for the disposal of MPC for Pressurised Water Reactor (PWR) spent nuclear fuel (SF). The key outcomes of the feasibility studies to improve the understanding of the MPC disposal concept and the specific challenges to construct, operate, ventilate, manage heat and backfill associated with this concept are summarised in this paper. The management of the high loading of radiogenic heat (from 12 PWR SF assemblies in MPCs compared to 4 in 'standard' disposal containers) during an extended open phase (delayed backfilling of the disposal area) of up to 300 years was investigated. The concept designs developed demonstrate it is feasible to construct, operate and ventilate disposal vaults to accommodate open 'storage' periods required for transitional thermal decay of high heat generating waste in higher strength and lower strength sedimentary host rock types considered by RWM. This work focused on developing two contrasting disposal concepts which are applicable to both higher strength and lower strength rock environments; both of which illustrate how vault temperature, stability and groundwater inflows can be controlled to delay backfilling and allow MPC package thermal output to decrease. MPC disposal in evaporite rock does not require a cooling period due to its high thermal conductivity and favourable performance at higher temperatures; therefore the concept developed for this rock includes immediate backfilling of disposal tunnels. A clear understanding of the interactions and limitations associated with heat management during the open period was developed by investigation of a 'Heating Ventilation and Air-Conditioning System' (HVAC). It was concluded that removal of heat from the disposal tunnels / vaults is feasible, but introduces significant operational complexity. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Feasibility study of electron transfer quantum well infrared photodetectors for spectral tuning in the long-wave infrared band

An electron transfer quantum well infrared photodetector (QWIP) consisting of repeating units of two coupled quantum wells (QWs) is capable of exhibiting a two color voltage dependent spectral response. However, significant electron transfer between the coupled QWs is required for spectral tuning, which may require the application of relatively high electric fields. Also, the band structure of coupled quantum wells is more complicated in comparison to a regular quantum well and, therefore, it is not always obvious if an electron transfer QWIP can be designed such that it meets specific performance characteristics. This paper presents a feasibility study of the electron transfer QWIP and its suitability for spectral tuning. Self consistent calculations have been performed of the bandstructure and the electric field that results from electron population within the quantum wells, from which the optical characteristics have been obtained. The band structure, spectral response, and the resonant final state energy locations have been compared with standard QWIPs. It is shown that spectral tuning in the long-wave infrared band can be achieved over a wide wavelength range of several microns while maintaining a relatively narrow spectral response FWHM. However, the total absorption strength is more limited in comparison to a standard QWIP, since the higher QW doping densities require much higher electric fields for electron transfer.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

The feasibility study and characterization of a two-dimensional diode array in “magic phantom” for high dose rate brachytherapy quality assurance

Purpose: High dose rate (HDR) brachytherapy is a radiation treatment technique capable of delivering large dose rates to the tumor. Radiation is delivered using remote afterloaders to drive highly active sources (commonly {sup 192}Ir with an air KERMA strength range between 20 000 and 40 000 U, where 1 U = 1 μGy m{sup 2}/h in air) through applicators directly into the patient's prescribed region of treatment. Due to the obvious ramifications of incorrect treatment while using such an active source, it is essential that there are methods for quality assurance (QA) that can directly and accurately verify the treatment plan and the functionality of the remote afterloader. This paper describes the feasibility study of a QA system for HDR brachytherapy using a phantom based two-dimensional 11 × 11 epitaxial diode array, named “magic phantom.”Methods: The HDR brachytherapy treatment plan is translated to the phantom with two rows of 10 (20 in total) HDR source flexible catheters, arranged above and below the diode array “magic plate” (MP). Four-dimensional source tracking in each catheter is based upon a developed fast iterative algorithm, utilizing the response of the diodes in close proximity to the {sup 192}Ir source, sampled at 100 ms intervals by a fast data acquisition (DAQ) system. Using a {sup 192}Ir source in a solid water phantom, the angular response of the developed epitaxial diodes utilized in the MP and also the variation of the MP response as a function of the source-to-detector distance (SDD) were investigated. These response data are then used by an iterative algorithm for source dwelling position determination. A measurement of the average transit speed between dwell positions was performed using the diodes and a fast DAQ.Results: The angular response of the epitaxial diode showed a variation of 15% within 360°, with two flat regions above and below the detector face with less than 5% variation. For SDD distances of between 5 and 30 mm the relative response of the epitaxial diodes used in the MP is in good agreement (within 8%) with radial dose function measurements found within the TG-43 protocol, with SDD of up to 70 mm showing a 40% over response. A method for four-dimensional localization of the HDR source was developed, allowing the source dwell position to be derived within 0.50 mm of the expected position. An estimation of the average transit speed for varying step sizes was determined and was found to increase from (12.8 ± 0.3) up to (38.6 ± 0.4) cm/s for a step size of 2.5 and 50 mm, respectively.Conclusions: Our characterization of the designed QA “magic phantom” with MP in realistic HDR photon fields demonstrates the promising performance for real-time source position tracking in four dimensions and measurements of transit times. Further development of this system will allow a full suite for QA in HDR brachytherapy and analysis, and for future in vivo tracking.

61 RADIATION PROTECTION AND DOSIMETRY↗

TH-AB-201-01: A Feasibility Study of Independent Dose Verification for CyberKnife

Purpose: CyberKnife irradiation is composed of tiny-size, multiple and intensity-modulated beams compared to conventional linacs. Few of the publications for Independent dose calculation verification for CyberKnife have been reported. In this study, we evaluated the feasibility of independent dose verification for CyberKnife treatment as Secondary check. Methods: The followings were measured: test plans using some static and single beams, clinical plans in a phantom and using patient’s CT. 75 patient plans were collected from several treatment sites of brain, lung, liver and bone. In the test plans and the phantom plans, a pinpoint ion-chamber measurement was performed to assess dose deviation for a treatment planning system (TPS) and an independent verification program of Simple MU Analysis (SMU). In the clinical plans, dose deviation between the SMU and the TPS was performed. Results: In test plan, the dose deviations were 3.3±4.5%, and 4.1±4.4% for the TPS and the SMU, respectively. In the phantom measurements for the clinical plans, the dose deviations were −0.2±3.6% for the TPS and −2.3±4.8% for the SMU. In the clinical plans using the patient’s CT, the dose deviations were −3.0±2.1% (Mean±1SD). The systematic difference was partially derived from inverse square law and penumbra calculation. Conclusion: The independent dose calculation for CyberKnife shows −3.0±4.2% (Mean±2SD) and our study, the confidence limit was achieved within 5% of the tolerance level from AAPM task group 114 for non-IMRT treatment. Thus, it may be feasible to use independent dose calculation verification for CyberKnife treatment as the secondary check. This research is partially supported by Japan Agency for Medical Research and Development (AMED)

60 APPLIED LIFE SCIENCES↗

Integrated pre-feasibility study for CO 2 geological storage in the Cascadia Basin, offshore Washington State, British Columbia

The Cascadia CarbonSAFE project conducted a pre-feasibility study to evaluate technical and nontechnical aspects of storing 50 million metric tons (MMT) of carbon dioxide in a safe, ocean basalt reservoir offshore Washington State and British Columbia. Sub-seafloor basalts are very common on Earth and enable geological mineralization as a long-term storage mechanism, permanently sequestering the carbon in solid rock form. This project evaluated the offshore storage complex, developed potential industrial source/transport scenarios, built an inventory of existing geophysical/geological data and environmental monitoring capabilities, conducted laboratory studies and reservoir modeling to determine storage capacity, and analyzed economic factors, regulatory requirements, and project management risks. Our team included researchers at Columbia University in New York, Pacific Northwest National Laboratory (PNNL) in Washington, University of Victoria in British Columbia, University of California at Santa Cruz, and GHG Underground in Maine, as well as collaborators at University of Iceland in Reykjavik and University of Washington in Saint Louis. In the study region, large emitters (>100,000 MT/year) generate a total of approximately 40 MMT annually from stationary sources, such as power plants, refineries, ammonia production, and mineral processing plants. Five potential industry source/transport scenarios were identified (three in U.SA S. and two in Canada) to potentially provide 50 MMT of carbon dioxide to the offshore reservoir. One scenario included net carbon-negative sources that would reduce atmospheric levels. The inventory of existing data illustrated that basalt properties in the region are potentially beneficial for long-term storage. Permeability is on the order of 0.1 to 1 Darcies within the uppermost 600 m of ocean crust and density-derived porosity reaches 10–20% in thin layers that provide act as flow channels and provide access to porous and permeable basalt. Fine-grained sediments overlying basalt provide a low-permeability barrier separating the storage reservoir from the overlying ocean. Subsurface monitoring of the storage complex benefits from a unique opportunity close proximity of to the nearby NEPTUNE cabled seafloor observatory, which actively transmits data to shore and could be used to monitor reservoir properties. Injection pressure changes, reservoir chemistry, seismicity, well head corrosion, and potential leakage monitoring would be feasible in real time. Using existing data and published models, the STOMP-CO 2 modeling code developed at PNNL was used to simulate carbon dioxide injection, storage, and mineralization in the reservoir. Preliminary simulations indicate that a 50 MMT carbon dioxide plume injected over a 20-year period remains well within the reservoir area, both laterally and vertically, for at least a 50-year period of post-injection monitoring. Laboratory studies on core samples from Cascadia measured dissolution rates in CO 2 –basalt–seawater mixtures and indicated large variability in rates with the potential for complete mineralization. Compared to published data, the dissolution rate measured in these samples is faster, decreasing the time until full conversion to carbonate minerals would occur. Adding geochemical reactivity in the STOMP-CO 2 model indicates that carbon dioxide would be fully converted to carbonate minerals in 135 years or less after injection ceases. The project assessed the viability and costs for the five scenarios using either dedicated offshore pipelines or shipping vessels. Carbon dioxide capture costs were not considered. Shipping incurred lower upfront CAPEX costs, and because most viable sources were located near the shore and waterways, shipping is preferred; no dedicated carbon dioxide pipelines exist in the region. The project also considered potential risks from mixed-use impacts on surrounding lands and ocean areas, such as active use by commercial and recreational fisherman, and other community considerations in planning for public engagement in the future. Other project risks were identified, including project management, permitting and compliance, and financing, as well as technical issues such as long-term instrumentation, plume migration, and model development. Geological concerns like reservoir permeability, seal, and induced seismicity held relatively low risk. The regulatory framework for offshore storage in the U.S. and Canada may be covered by general legal/regulatory programs, but is not yet fully defined. Existing programs appear to restrict the transportation of carbon dioxide across national boundaries (e.g., Canada to U.S.) and its sub-seabed disposal in some circumstances. Our assessment suggests that developing specific and separate pilot projects will help to advance the technical feasibility and regulatory requirements in each country, and lessons learned from such activities may be transferable elsewhere around the globe.

42 ENGINEERING↗

SU-E-T-21: A D-D Based Neutron Generator System for Boron Neutron Capture Therapy: A Feasibility Study

Purpose: To investigate the feasibility of a deuterium-deuterium (DD) neutron generator for application in boron neutron capture therapy (BNCT) of brain cancer Methods: MCNP simulations were performed using a head phantom and a monoenergetic neutron source, which resembles the point source in a DD generator that emits 2.45-MeV neutrons. Source energies ranging from 5eV to 2.45MeV were simulated to determine the optimal treatment energy. The phantom consisted of soft tissue, brain tissue, skull, skin layer, and a brain tumor of 5 cm in diameter. Tumor depth was varied from 5–10 cm. Boron-10 concentrations of 10 ppm, 15 ppm, and 30 ppm were used in the soft/brain tissues, skin, and tumor, respectively. The neutron flux required to deliver 60 Gy to the tumor as well as the normal tissue doses were determined. Results: Beam energies between 5eV and 10keV obtained doses with the highest dose ratios (3.3–25.9) between the tumor and the brain at various depths. The dose ratio with 2.45-MeV neutrons ranged from 0.8–6.6. To achieve the desired tumor dose in 40 minutes, the required neutron flux for a DD generator was between 8.8E10 and 5.2E11 n/s and the resulting brain dose was between 2.3 and 18 Gy, depending on the tumor depth. The skin and soft tissue doses were within acceptable tolerances. The boron-neutron interaction accounted for 54–58% of the total dose. Conclusion: This study shows that the DD neutron generator can be a feasible neutron source for BNCT. The required neutron flux for treatment is achievable with the current DD neutron technology. With a well-designed beam shaping assembly and treatment geometry, the neutron flux can be further improved and a 60-Gy prescription can be accurately delivered to the target while maintaining tolerable normal tissue doses. Further experimental studies will be developed and conducted to validate the simulation results.

60 APPLIED LIFE SCIENCES↗

COLD-SAT feasibility study safety analysis

The Cryogenic On-orbit Liquid Depot-Storage, Acquisition, and Transfer (COLD-SAT) satellite presents some unique safety issues. The feasibility study conducted at NASA-Lewis desired a systems safety program that would be involved from the initial design in order to eliminate and/or control the inherent hazards. Because of this, a hazards analysis method was needed that: (1) identified issues that needed to be addressed for a feasibility assessment; and (2) identified all potential hazards that would need to be controlled and/or eliminated during the detailed design phases. The developed analysis method is presented as well as the results generated for the COLD-SAT system.

Mchenry, Steven T.↗

Feasibility study of a single, elliptical heliocentric Earth-Mars trajectory

The initial intent of this design project was to evaluate the existence and feasibility of a single elliptical heliocentric Earth/Mars trajectory. This trajectory was constrained to encounter Mars twice in its orbit, within a time interval of 15 to 180 Earth days between encounters. The single ellipse restriction was soon found to be prohibitive for reasons shown later. Therefore, the approach taken in the design of the round-trip mission to Mars was to construct single-leg trajectories which connected two planets on two prescribed dates. Three methods of trajectory design were developed. Method 1 is an eclectic approach and employs Gaussian Orbit Determination (Method 1A) and Lambert-Euler Preliminary Orbit Determination (Method 1B) in conjunction with each other. Method 2 is an additional version of Lambert's Solution to orbit determination, and both a coplanar and a noncoplanar solution were developed within Method 2. In each of these methods, the fundamental variables are two position vectors and the time between the position vectors. In all methods, the motion was considered Keplerian motion and the reference frame origin was located at the sun. Perturbative effects were not considered in Method 1. The feasibility study of round-trip Earth/Mars trajectories maintains generality by considering only heliocentric trajectory parameters and planetary approach conditions. The coordinates and velocity components of the planets, for the standard epoch J2000, were computed from an approximate set of osculating elements by the procedure outlined in an ephemeris of coordinates.

Blake, M.↗

Flow Liner Slot Edge Replication Feasibility Study

Surface replication has been proposed as a method for crack detection in space shuttle main engine flowliner slots. The results of a feasibility study show that examination of surface replicas with a scanning electron microscope can result in the detection of cracks as small as 0.005 inch, and surface flaws as small as 0.001 inch, for the flowliner material.

Newman, John A.↗

Preconceptual Feasibility Study to Evaluate Alternative Means to Produce Plutonium-238

There is currently no large-scale production of 238Pu in the United States. Feasibility studies were performed at the Idaho National Laboratory to assess the capability of developing alternative 238Pu production strategies. Initial investigations indicate potential capability to provision radioisotope-powered systems for future space exploration endeavors. For the short term production of 238Pu, sealed canisters of dilute 237Np solution in nitric acid could be irradiated in the Advanced Test Reactor (ATR). Targets in the large and medium “I” positions of the ATR were irradiated over a simulated period of 306 days and analyzed using MCNP5 and ORIGEN2.2. Approximately 0.5 kg of 238Pu could be produced annually in the ATR with purity greater than 92%. Optimization of the irradiation cycles could further increase the purity to greater than 98%. Whereas the typical purity of space batteries is between 80 to 85%, the higher purity 238Pu produced in the ATR could be blended with existing lower-purity inventory to produce useable material. Development of irradiation methods in the ATR provides the fastest alterative to restart United States 238Pu production. The analysis of 238Pu production in the ATR provides the technical basis for production using TRIGA® (Training, Research, Isotopes, General Atomics) nuclear reactors. Preliminary analyses envisage a production rate of approximately 0.7 kg annually using a single dedicated 5-MW TRIGA reactor with continuous flow loops to achieve high purity product. Two TRIGA reactors represent a robust means of providing at over 1 kg/yr of 238Pu annually using dilute solution targets of 237Np in nitric acid. Further collaboration and optimization of reactor design, radiochemical methods, and systems analyses would further increase annual 238Pu throughput, while reducing the currently evaluated reactor requirements.

07 ISOTOPE AND RADIATION SOURCES↗