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All sourcesNASA NTRSDOE OSTI
NASA NTRS2022

Surface Biology and Geology (SBG) Thermal Infrared (TIR) Free -Flyer Concept

Scientists and engineers from the United States and Italy are developing a thermal infrared (TIR) free-flyer concept that forms an essential element of the NASA Surface Biology & Geology (SBG) designated observable and the greater NASA Earth System Observatory (ESO), which also includes observations of aerosols, clouds, convection, and precipitation; mass change; and surface deformation & change.In response to the recommendations from the 2017 National Academies decadal survey for Earth science, NASA initiated the SBG designated observable with five key research and applications focus areas: ecosystems and natural resources, hydrology, weather, climate, and solid Earth. SBG includes spaceborne measurements of hyperspectral imagery in the visible to shortwave infrared (0.4-2.5 um) and multispectral imagery in the mid and thermal infrared (3-12 um) that provide the remote sensing data needed to inform each research and applications area. High-level TIR data products include Earth surface temperature & emissivity, evapotranspiration, substrate composition, volcanic plumes, and high-temperature features. While the science, applications, and technology build on prior mission studies conducted for more than a decade, it has only been recently that a joint team of scientists and engineers from the NASA Jet Propulsion Laboratory (JPL), Agenzia Spaziale Italiana (ASI), Istituto Nazionale Geofisica e Volcanologia (INGV), and the Istituto Nazionale Astrofisica (INAF) have developed a compelling concept for a TIR free-flyer. In this concept, the TIR instrument is an eight-band radiometer. Seven of the bands are between 3 and 12 um with an additional band at 1.65 um. The instrument’s 68.8 deg total viewing angle and the free-flyer’s 665 km operational altitude results in a ground sampling distance (GSD) of <60 m at nadir, produces a swath width of 935 km, and allows for a 2-3-day revisit time. A two-band visible and near infrared (VNIR) camera, with <30 m GSD at nadir and 935 km swath width, will complement the TIR instrument. VNIR high-level data products include top & bottom of atmosphere reflectance and normalized difference vegetation indices (NDVI). The TIR instrument and VNIR camera will be mounted on a PLATiNO+ spacecraft, a multi-application, reconfigurable, and scalable platform. The launcher selected for the TIR free-flyer is the VEGA-C. To maximize the science and applications benefits the SBG-TIR free-flyer team are collaborating with personnel from the ESA Land Surface Temperature Monitoring mission (LSTM) as well individuals from the Thermal Infrared Imaging Satellite for High-resolution Natural resource Assessment (TRISHNA), a joint mission by CNES and ISRO. Pre-Phase A concept studies for the SBG-TIR free-flyer commenced in the spring 2021. This allows for the concept to be refined; for technical risks to be identified and mitigated, as necessary; and strategies for reducing the development schedule to be defined and assessed before conducting a NASA-ASI Mission Concept Review (MCR) in the spring of 2022 and a NASA Key Decision Point-A (KDP-A) as early as the summer of 2022. These are key milestones in being able to launch and begin operating the SBG-TIR free-flyer in the second half of the decade, so that many of the questions posed by the National Academies in the 2017 decadal survey can be answered.

Fabrizia-Buongiorno, Maria↗
NASA NTRS2012

Microgravity Science Glovebox (MSG), Space Science's Past, Present and Future Aboard the International Space Station (ISS)

The Microgravity Science Glovebox (MSG) is a double rack facility aboard the International Space Station (ISS), which accommodates science and technology investigations in a "workbench' type environment. The MSG has been operating on the ISS since July 2002 and is currently located in the US Laboratory Module. In fact, the MSG has been used for over 10,000 hours of scientific payload operations and plans to continue for the life of ISS. The facility has an enclosed working volume that is held at a negative pressure with respect to the crew living area. This allows the facility to provide two levels of containment for small parts, particulates, fluids, and gases. This containment approach protects the crew from possible hazardous operations that take place inside the MSG work volume and allows researchers a controlled pristine environment for their needs. Research investigations operating inside the MSG are provided a large 255 liter enclosed work space, 1000 watts of dc power via a versatile supply interface (120, 28, + 12, and 5 Vdc), 1000 watts of cooling capability, video and data recording and real time downlink, ground commanding capabilities, access to ISS Vacuum Exhaust and Vacuum Resource Systems, and gaseous nitrogen supply. These capabilities make the MSG one of the most utilized facilities on ISS. MSG investigations have involved research in cryogenic fluid management, fluid physics, spacecraft fire safety, materials science, combustion, and plant growth technologies. Modifications to the MSG facility are currently under way to expand the capabilities and provide for investigations involving Life Science and Biological research. In addition, the MSG video system is being replaced with a state-of-the-art, digital video system with high definition/high speed capabilities, and with near real-time downlink capabilities. This paper will provide an overview of the MSG facility, a synopsis of the research that has already been accomplished in the MSG, and an overview of the facility enhancements that will shortly be available for use by future investigators.

Spivey, Reggie↗
NASA NTRS1991

GLOBEC (Global Ocean Ecosystems Dynamics: Northwest Atlantic program

The specific objective of the meeting was to plan an experiment in the Northwestern Atlantic to study the marine ecosystem and its role, together with that of climate and physical dynamics, in determining fisheries recruitment. The underlying focus of the GLOBEC initiative is to understand the marine ecosystem as it related to marine living resources and to understand how fluctuation in these resources are driven by climate change and exploitation. In this sense the goal is a solid scientific program to provide basic information concerning major fisheries stocks and the environment that sustains them. The plan is to attempt to reach this understanding through a multidisciplinary program that brings to bear new techniques as disparate as numerical fluid dynamic models of ocean circulation, molecular biology and modern acoustic imaging. The effort will also make use of the massive historical data sets on fisheries and the state of the climate in a coordinated manner.

Source record↗
NASA NTRS1981

Variation Principles and Applications in the Study of Cell Structure and Aging

In this report we have attempted to show that "some reality lies concealed in biological variation". This "reality" has its principles, laws, mechanisms, and rules, only a few of which we have sketched. A related idea we pursued was that important information may be lost in the process of ignoring frequency distributions of physiological variables (as is customary in experimental physiology and gerontology). We suggested that it may be advantageous to expand one's "statistical field of vision" beyond simple averages +/- standard deviations. Indeed, frequency distribution analysis may make visible some hidden information not evident from a simple qualitative analysis, particularly when the effect of some external factor or condition (e.g., aging, dietary chemicals) is being investigated. This was clearly illustrated by the application of distribution analysis in the study of variation in mouse liver cellular and fine structure, and may be true of fine structural studies in general. In living systems, structure and function interact in a dynamic way; they are "inseparable," unlike in technological systems or machines. Changes in fine structure therefore reflect changes in function. If such changes do not exceed a certain physiologic range, a quantitative analysis of structure will provide valuable information on quantitative changes in function that may not be possible or easy to measure directly. Because there is a large inherent variation in fine structure of cells in a given organ of an individual and among individuals, changes in fine structure can be analyzed only by studying frequency distribution curves of various structural characteristics (dimensions). Simple averages +/- S.D. do not in general reveal all information on the effect of a certain factor, because often this effect is not uniform; on the contrary, this will be apparent from distribution analysis because the form of the curves will be affected. We have also attempted to show in this chapter that similar general statistical principles and mechanisms may be operative in biological and technological systems. Despite the common belief that most biological and technological characteristics of interest have a symmetric bell-shaped (normal or Gaussian) distribution, we have shown that more often than not, distributions tend to be asymmetric and often resemble a so-called log-normal distribution. We saw that at least three general mechanisms may be operative, i.e., nonadditivity of influencing factors, competition among individuals for a common resource, and existence of an "optimum" value for a studied characteristic; more such mechanisms could exist.

Economos, Angelos C.↗
NASA NTRS2015

Ecological Forecasting in the Applied Sciences Program and Input to the Decadal Survey

Ecological forecasting uses knowledge of physics, ecology and physiology to predict how ecosystems will change in the future in response to environmental factors. Further, Ecological Forecasting employs observations and models to predict the effects of environmental change on ecosystems. In doing so, it applies information from the physical, biological, and social sciences and promotes a scientific synthesis across the domains of physics, geology, chemistry, biology, and psychology. The goal is reliable forecasts that allow decision makers access to science-based tools in order to project changes in living systems. The next decadal survey will direct the development Earth Observation sensors and satellites for the next ten years. It is important that these new sensors and satellites address the requirements for ecosystem models, imagery, and other data for resource management. This presentation will give examples of these model inputs and some resources needed for NASA to continue effective Ecological Forecasting.

Ecology↗
NASA NTRS2012

Planetary Lake Lander - A Robotic Sentinel to Monitor a Remote Lake

The Planetary Lake Lander Project is studying the impact of rapid deglaciation at a high altitude alpine lake in the Andes, where disrupted environmental, physical, chemical, and biological cycles result in newly emerging natural patterns. The solar powered Lake Lander robot is designed to monitor the lake system and characterize both baseline characteristics and impacts of disturbance events such as storms and landslides. Lake Lander must use an onboard adaptive science-on-the-fly approach to return relevant data about these events to mission control without exceeding limited energy and bandwidth resources. Lake Lander carries weather sensors, cameras and a sonde that is winched up and down the water column to monitor temperature, dissolved oxygen, turbidity and other water quality parameters. Data from Lake Lander is returned via satellite and distributed to an international team of scientists via web-based ground data systems. Here, we describe the Lake Lander Project scientific goals, hardware design, ground data systems, and preliminary data from 2011. The adaptive science-on-the-fly system will be described in future papers.

Pedersen, Liam↗
NASA NTRS1985

Nasa's Land Remote Sensing Plans for the 1980's

Research since the launch of LANDSAT-1 has been primarily directed to the development of analysis techniques and to the conduct of applications studies designed to address resource information needs in the United States and in many other countries. The current measurement capabilities represented by MSS, TM, and SIR-A and B, coupled with the present level of remote sensing understanding and the state of knowledge in the discipline earth sciences, form the foundation for NASA's Land Processes Program. Science issues to be systematically addressed include: energy balance, hydrologic cycle, biogeochemical cycles, biological productivity, rock cycle, landscape development, geological and botanical associations, and land surface inventory, monitoring, and modeling. A global perspective is required for using remote sensing technology for problem solving or applications context. A successful model for this kind of activity involves joint research with a user entity where the user provides a test site and ground truth and NASA provides the remote sensing techniques to be tested.

Higg, H. C.↗
NASA NTRS2019

Integrating Remote Sensing Observations with NASA's GEOS-5 Modeling Framework in Support of Retrospective Analyses and Seasonal Prediction of Biosphere-Atmosphere CO2 Flux

The absorption of nearly half of all anthropogenic carbon dioxide (CO2) emissions by terrestrial and marine ecosystems has played a critical role in mitigating climate change. However, a persistent lack of understanding of these uptake processes impedes attribution, and thereby introduces large uncertainties into projections of the trajectory of carbon and climate in coming decades. A better understanding and quantification of the seasonal and interannual variability of carbon flux between the atmosphere and ocean and terrestrial biospheres is critically needed to improve predictions from Earth system models. We propose to bring together a diverse suite of remote sensing observations, mechanistic models, and NASA's Goddard Earth Observing System, version 5 (GEOS-5) model to address two objective 1) quantify the processes controlling the temporal variability of biosphere-atmosphere CO2 flux on seasonal and interannual timescales from 1989 to 2018 and 2) evaluating the predictability of the components of carbon flux on seasonal timescales. Because GEOS-5 has been developed to incorporate a variety of Earth system observations and includes a complete and physically consistent depiction of the atmosphere, land, and ocean carbon cycles, it represents a unique and ideal synthesis framework for this effort. By expanding the realism of processes that could be included in GEOS-5 seasonal forecasts, this effort supports NASA's goals toward an integrated Earth system modeling and prediction framework.We propose to integrate a number of observations into the GEOS-5 modeling system to refine retrospective estimates of both terrestrial and marine carbon flux and to test hypotheses regarding the effects of climate drivers on terrestrial carbon flux. This will include assimilating several satellite ocean color products in the NASA Ocean Biogeochemistry Model (NOBM) to improve the representation of ocean biology. We will also utilize remote sensing datasets to increase the temporal resolution of global land-use change estimates and fire emissions to better constrain the temporal variability of the terrestrial carbon cycle. This information will be incorporated into two NASA terrestrial biosphere models Catchment-CN, a dynamic vegetation model that is integrated within GEOS-5 and the Ecosystem Demography (ED) model, a core modeling resource supporting the Global Ecosystem Dynamics Investigation (GEDI) mission to map biomass. Fluxes will be evaluated through 1) comparison to top-down flux estimates inferred from surface CO2 observations and 2) comparison against available aircraft and satellite observations.By combining predictions of net ecosystem exchange and air-sea CO2 flux from land and ocean models with statistical predictions of land use change, fire, and fossil fuel emissions, we propose to create the first dynamical CO2 forecast on seasonal timescales. Because of the experimental nature of this endeavor, an important project objective will be to evaluate the limits to the predictability of different carbon cycle processes over lead times of 1-12 months using different satellite and surface data streams.

Ott, Lesley↗
NASA NTRS1992

The Breadboard Project - A functioning CELSS plant growth system

The primary objective of the Breadboard Project for the next 3-4 years is to develop, integrate and operate a Controlled Ecological Life Support System (CELSS) at a one-person scale. The focus of this project over the past two years has been the development of the plant growth facility, the first module of the CELSS. The other major modules, food preparation, biomass processing, and resource recovery, have been researched at the laboratory scale during the past two years and facilities are currently under construction to scale-up these modules to an operational state. This paper will outline the design requirements for the Biomass Production Chamber (BPC), the plant growth facility for the project, and the control and monitoring subsystems which operate the chamber and will present results from both engineering and biological tests of the facility. Three production evaluations of wheat, conducted in the BPC during the past year, will be described and the data generated from these tests discussed.

Knott, W. M.↗
NASA NTRSDate not supplied

RadLab Platform: Investigating Space Radiation

The RadLab Project, initiated by the Open Science Data Repository (OSDR) for Space Biology at NASA Ames Research Center (osdr.nasa.gov), aims to be an ongoing compilation of radiation data relevant to human space flight. Sponsored by the NASA Human Research Program, RadLab serves as the latest database in this domain. RadLab is intended to serve the needs of both the space radiation detector and space radiation biology communities. The RadLab architecture is being designed to accommodate data both from low Earth orbit (LEO) and beyond low Earth orbit (BLEO). Our long-term vision entails the establishment of a sustainable database receiving continuous updates through APIs connecting to other databases, as well as individual investigator contributions via a RadLab submission portal, modeled on the OSDR (https://osdr.nasa.gov/bio/submission-sso-login.html). In addition to serving as a resource for space biologists and space radiation physicists, such a database would facilitate the deployment of AI algorithms to study the impact of location in space and within spacecraft on the ambient space radiation field. The ultimate goal is to develop predictive dosimetry algorithms for future BLEO missions.

Sylvain V Costes↗
NASA NTRS1999

Preparing for Mars: the physiologic and medical challenges

As the twentieth century closes, retrospectives cite the Apollo moon missions as one of the important events of the past 100 years. A trip to Mars, however, would be even more challenging and significant. A round-trip Mars journey would require nearly three years away from Earth, a significant leap in complexity compared to the two week long Moon trips or the record-breaking fourteen-month flight on Mir. What would be the physiologic and medical challenges of a Mars flight? Two key areas of physiology present the greatest potential problems--calcium metabolism and radiation exposure. Data from Mir missions show that bone loss continues in space despite an aggressive countermeasure program. Average losses were 0.35% per month, but some load bearing areas lost >1% per month. A 1% loss rate, if it continued unabated for 30 months, could produce osteoporosis. Smaller losses could still increase fracture risk. Some bone loss can be well tolerated, particularly if the bone can be regained after the mission. But the effectiveness of post-flight rehabilitation to restore the density and quality of bone after spaceflight is not well known. Bone loss estimates are based on continuous weightlessness exposure, but this is not a requirement for a Mars trip. Most of the time on a Mars trip will be spent in the 1/3 Earth's gravity environment on Mars, and either intermittent or continuous artificial gravity can be provided for the transit between planets (although at an engineering cost). The dosing of the gravity exposure (e.g. the level and duration), however, has not been established. Radiation protection also requires a balance between engineering cost and human health. Excessive shielding could add billions of dollars to the cost of a mission. Trips in interplanetary space, however, expose the crew to heavy high-energy particles from cosmic rays (HZE particles), which have a high linear energy transfer. This high energy leads to significant biological damage (e.g. chromosomal aberrations, cancer induction). A recent report from the Committee on Space Biology and Medicine notes that only one systematic study of cancer induction from high-energy particles has been conducted (using the mouse Harderian gland). Predictions of cancer risk and acceptable radiation exposure in space are extrapolated from minimal data. Other areas of physiology also present problems, such as muscle loss, cardiovascular deconditioning, and vestibular adaptation. Despite all the issues, however, a focussed, aggressive research program that uses the resources of the International Space Station should pave the way for mankind's greatest adventure--a trip to Mars.

STS-90 Shuttle Project↗
NASA NTRS1975

The utility of Skylab photo-interpreted earth resources data in studies of marine geology and coastal processes in Puerto Rico and the Virgin Islands

The author has identified the following significant results. Three Skylab earth resources passes over Puerto Rico and St. Croix on 6 June and 30 November 1973 and 18 January 1974 resulted in color photography and multispectral photography and scanner imagery. Bathymetric and turbid water features are differentiable by use of the multispectral data. Photography allows mapping of coral reefs, offshore sand deposits, areas of coastal erosion, and patterns of sediment transport. Bottom sediment types could not be differentiated. Patterns of bottom dwelling biologic communities are well portrayed but are difficult to differentiate from bathymetric detail. Effluent discharges and oil slicks are readily detected and are differentiated from other phenomena by the persistence of their images into the longer wavelength multispectral bands.

Trumbull, J. V. A.↗
NASA NTRS1996

Advanced Environmental Monitoring and Control Program: Technology Development Requirements

Human missions in space, from the International Space Station on towards potential human exploration of the moon, Mars and beyond into the solar system, will require advanced systems to maintain an environment that supports human life. These systems will have to recycle air and water for many months or years at a time, and avoid harmful chemical or microbial contamination. NASA's Advanced Environmental Monitoring and Control program has the mission of providing future spacecraft with advanced, integrated networks of microminiaturized sensors to accurately determine and control the physical, chemical and biological environment of the crew living areas. This document sets out the current state of knowledge for requirements for monitoring the crew environment, based on (1) crew health, and (2) life support monitoring systems. Both areas are updated continuously through research and space mission experience. The technologies developed must meet the needs of future life support systems and of crew health monitoring. These technologies must be inexpensive and lightweight, and use few resources. Using these requirements to continue to push the state of the art in miniaturized sensor and control systems will produce revolutionary technologies to enable detailed knowledge of the crew environment.

Jan, Darrell↗
NASA NTRS2001

The International Space Station human life sciences experiment implementation process

The selection, definition, and development phases of a Life Sciences flight research experiment has been consistent throughout the past decade. The implementation process, however, has changed significantly within the past two years. This change is driven primarily by the shift from highly integrated, dedicated research missions on platforms with well defined processes to self contained experiments with stand alone operations on platforms which are being concurrently designed. For experiments manifested on the International Space Station (ISS) and/or on short duration missions, the more modular, streamlined, and independent the individual experiment is, the more likely it is to be successfully implemented before the ISS assembly is completed. During the assembly phase of the ISS, science operations are lower in priority than the construction of the station. After the station has been completed, it is expected that more resources will be available to perform research. The complexity of implementing investigations increases with the logistics needed to perform the experiment. Examples of logistics issues include- hardware unique to the experiment; large up and down mass and volume needs; access to crew and hardware during the ascent or descent phases; maintenance of hardware and supplies with a limited shelf life,- baseline data collection schedules with lengthy sessions or sessions close to the launch or landing; onboard stowage availability, particularly cold stowage; and extensive training where highly proficient skills must be maintained. As the ISS processes become better defined, experiment implementation will meet new challenges due to distributed management, on-orbit resource sharing, and adjustments to crew availability pre- and post-increment. c 2001. Elsevier Science Ltd. All rights reserved.

Research↗
NASA NTRS2018

Developing a Community of Practice for Applied Uses of Future PACE Data to Address Food Security Challenges

Ocean color satellite measurements have yielded valuable information about the base of the marine food web for over 20 years. The Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission is building an advanced spectrometer to further refine ecosystem monitoring. Higher spectral resolution data from PACE will enable identification of additional marine biological indicators and their response to multiple stressors to guide sustainable management. Seafood is an important source of protein for a significant number of people. Wild catches cannot match increasing demand and their sustainability is in question. Aquaculture is an ever more important industry to feed the world's population. We share early efforts to engage a community of practice around food security to increase satellite data product use in support of resource management, business decisions, and policy analysis. Understanding the needs of applied scientists as well as non-traditional users of satellite data early in the PACE mission process will improve planning and preparation for a broader user base and hopefully help to mitigate food insecurity.

Schollaert Uz, Stephanie↗
NASA NTRSDate not supplied

Creating a Wastewater Technology ‘Toolbox’ for Space Exploration ECLSS

Life Support Systems (LSS) are essential for manned spaceflight; without them, humans would not survive. Upcoming long-duration missions demand robust environmental control LSS (ECLSS) due to their insolation and limited prospect for immediate resupply. As part of LSS, water purification systems will require high reliability, sustainability, and efficiency due to transport mass limitations, because routine water delivery will be very difficult and costly to resupply future habitats. This suggests a highly effective treatment method and reuse of every wastewater source. A variety of wastewater streams are generated by crew, and although not all are currently treated, habitat success will require each stream to be treated and utilized as a ‘resource’ rather than 'waste’. These wastewater streams include human wastewater (urine, feces), food waste (plate waste, inedible plant biomass), humidity condensate, hygiene water (shower, oral, handwash), and laundry. Proven technologies are often relied upon due to long-term operations. For future, longer-term missions, this paradigm must shift to include technologies based on meeting mission requirements rather than sacrificing productivity in lieu of proven existing technology capabilities. Many physical, chemical, and biological water-processing technologies are proven and established for terrestrial applications. Herein, these technologies were collected into a ‘toolbox’ to perform possible functions towards effective water purification steps in reduced gravity. Selection criteria are dependent on approach (physical, chemical, or biological), complexity/components, terrestrial performance, and potential applicability to space life support. Utilization of this ‘toolbox’ approach provides a streamline methodology for technology development and down-selection into future architecture in direct response to the dynamic space life support requirements. Establishing the ‘toolbox’ also provides organized and efficient identification of the most appropriate technologies. From there, the technologies with the largest potential to be configured for mission requirements can be further developed and appropriately assessed. This presentation seeks to provide a comprehensive review of space life support water purification requirements and challenges, as well as to present a ‘toolbox’ methodology of available technologies to aid in the difficult process of selecting appropriate LSS water purification for short and long-term NASA mission architectures.

Luke Roberson↗
NASA NTRS2006

Planned Environmental Microbiology Aspects of Future Lunar and Mars Missions

With the establishment of the Constellation Program, NASA has initiated efforts designed similar to the Apollo Program to return to the moon and subsequently travel to Mars. Early lunar sorties will take 4 crewmembers to the moon for 4 to 7 days. Later missions will increase in duration up to 6 months as a lunar habitat is constructed. These missions and vehicle designs are the forerunners of further missions destined for human exploration of Mars. Throughout the planning and design process, lessons learned from the International Space Station (ISS) and past programs will be implemented toward future exploration goals. The standards and requirements for these missions will vary depending on life support systems, mission duration, crew activities, and payloads. From a microbiological perspective, preventative measures will remain the primary techniques to mitigate microbial risk. Thus, most of the effort will focus on stringent preflight monitoring requirements and engineering controls designed into the vehicle, such as HEPA air filters. Due to volume constraints in the CEV, in-flight monitoring will be limited for short-duration missions to the measurement of biocide concentration for water potability. Once long-duration habitation begins on the lunar surface, a more extensive environmental monitoring plan will be initiated. However, limited in-flight volume constraints and the inability to return samples to Earth will increase the need for crew capabilities in determining the nature of contamination problems and method of remediation. In addition, limited shelf life of current monitoring hardware consumables and limited capabilities to dispose of biohazardous trash will drive flight hardware toward non-culture based methodologies, such as hardware that rapidly distinguishes biotic versus abiotic surface contamination. As missions progress to Mars, environmental systems will depend heavily on regeneration of air and water and biological waste remediation and regeneration systems, increasing the need for environmental monitoring. Almost complete crew autonomy will be needed for assessment and remediation of contamination problems. Cabin capacity will be limited; thus, current methods of microbial monitoring will be inadequate. Future methodology must limit consumables, and these consumables must have a shelf life of over three years. In summary, missions to the moon and Mars will require a practical design that prudently uses available resources to mitigate microbial risk to the crew.

Ott, C. Mark↗
NASA NTRS1974

The application of sensitivity analysis to models of large scale physiological systems

A survey of the literature of sensitivity analysis as it applies to biological systems is reported as well as a brief development of sensitivity theory. A simple population model and a more complex thermoregulatory model illustrate the investigatory techniques and interpretation of parameter sensitivity analysis. The role of sensitivity analysis in validating and verifying models, and in identifying relative parameter influence in estimating errors in model behavior due to uncertainty in input data is presented. This analysis is valuable to the simulationist and the experimentalist in allocating resources for data collection. A method for reducing highly complex, nonlinear models to simple linear algebraic models that could be useful for making rapid, first order calculations of system behavior is presented.

Leonard, J. I.↗