Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy
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A DC cylindrical magnetron sputter coater was commissioned and used to coat Nb 2.6 GHz superconducting radiofrequency (SRF) cavity with Nb 3 Sn. The sputter coater has two identical cylindrical magnetrons that can move, with a controlled speed, along the axis of the SRF cavity to coat the inside surface of the cavity. The design of the sputter coater is discussed, along with its performance. Initially, a sample holder that allows coating on flat substrates at positions similar to the equator and beam tubes of a 2.6 GHz SRF cavity was used to test conditions for fabricating Nb 3 Sn layers. Multilayers of Nb and Sn were sequentially sputtered on flat Nb and sapphire substrates mounted on the equivalent positions of the cavity's beam tubes and the equator using the two identical cylindrical magnetrons. Then, the Nb/Sn multilayers were annealed at 950 °C for 3 h. Here, the ~1.2 μm thick Nb 3 Sn film did not show any other Nb–Sn compounds and had a superconducting transition temperature of 17.61–17.76 K. The 2.6 GHz SRF cavity was coated using similar conditions as flat samples. Cryogenic RF testing of the Nb 3 Sn-coated cavity demonstrated a quality factor of 3.2 × 10 8 at an accelerating gradient of 5 MV/m at 4.4 K.
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Metal–organic frameworks (MOFs) are periodic, hybrid, atomically well-defined porous materials that typically form by self-assembly and consist of inorganic nodes (metal ions or clusters) and multitopic organic linkers. MOFs as a whole offer many intriguing properties, including ultrahigh porosity, tunable chemical functionality, and low density. These properties point to numerous potential applications, including gas storage, chemical separations, catalysis, light harvesting, and chemical sensing, to name a few. Reticular chemistry, or the linking of molecular building blocks into predetermined network structures, has been employed to synthesize thousands of MOFs. Given the vast library of candidate nodes and linkers, the number of potentially synthetically accessible MOFs is enormous. Nevertheless, a powerful complementary approach to obtain specific structures with desired chemical functionality is to modify known MOFs after synthesis. This approach is particularly useful when incorporation of particular chemical functionalities via direct synthesis is challenging or impossible. Here, the challenges may stem from limited stability or solubility of precursors, unwanted secondary reactivity of precursors, or incompatibility of functional groups with the conditions needed for direct synthesis. MOFs can be postsynthetically modified by replacing the metal nodes and/or organic linkers or via functionalization of the metal nodes and/or organic linkers.
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Here, we report a method for serial X-ray crystallography at X-ray free-electron lasers (XFELs), which allows for full use of the current 120-Hz repetition rate of the Linear Coherent Light Source (LCLS). Using a micropatterned silicon chip in combination with the high-speed Roadrunner goniometer for sample delivery, we were able to determine the crystal structures of the picornavirus bovine enterovirus 2 (BEV2) and the cytoplasmic polyhedrosis virus type 18 polyhedrin, with total data collection times of less than 14 and 10 min, respectively. Our method requires only micrograms of sample and should therefore broaden the applicability of serial femtosecond crystallography to challenging projects for which only limited sample amounts are available. By synchronizing the sample exchange to the XFEL repetition rate, our method allows for most efficient use of the limited beam time available at XFELs and should enable a substantial increase in sample throughput at these facilities.
Herein is reported the electrocatalytic reduction of CO 2 with the complex [Ni(bis-NHC)(dmpe)] 2+ ( 1 ) (bis-NHC = 1,l′:3,3′-bis(1,3-propanediyl)dibenzimidazolin-2,2′-diylidene; dmpe = 1,2-bis(dimethylphosphino)ethane).
The flux synthesis of a uranium gallophosphate and a uranium gallate, Cs 4 [UO 2 Ga 2 (PO 4 ) 4 ] and Cs 2 UO 2 Ga 2 O 5 , and 4 uranium phosphates, [Rb 2 Rb 3.93 Cl 0.93 ][(UO 2 ) 5 (PO 4 ) 5 ], Rb 11 [(UO 2 ) 8 (PO 4 ) 9 ], Rb 7.6 [(UO 2 ) 8 O 8.6 F 0.4 (PO 4 ) 2 ], and Rb 6 [(UO 2 ) 5 O 2 (PO 4 ) 4 ], is reported.
We present a 24 MW Electron Cyclotron (EC) system operating at 170 GHz and 3600 s pulse length is to be installed on ITER. The EC plant shall deliver 20 MW of this power to the plasma for Heating and Current Drive (H&CD) applications. The EC system is designed for plasma initiation, central heating, current drive, current profile tailoring, and Magneto-hydrodynamic control (in particular, sawteeth and Neo-classical Tearing Mode) in the flat-top phase of the plasma. A preliminary design review was performed in 2012, which identified a need for extended application of the EC system to the plasma ramp-up, flattop, and ramp down phases of ITER plasma pulse. The various functionalities are prioritized based on those applications, which can be uniquely addressed with the EC system in contrast to other H&CD systems. An initial attempt has been developed at prioritizing the allocated H&CD applications for the three scenarios envisioned: ELMy H-mode (15 MA), Hybrid (~12 MA), and Advanced (~9 MA) scenarios. In conclusion, this leads to the finalization of the design requirements for the EC sub-systems.
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Capsule Fill Tube Assemblies (CFTAs) consist of an ablator capsule and fill tube via a laser drilled funnel hole. This hole then tapers from 17 μm diameter at the outer surface of the ablator capsule to less than 5 μm diameter on the inside of the capsule over approximately 200 μm of wall thickness. Demand for better understanding of the fill tube perturbation during the capsule implosion has driven advancements in the fill tube design. Engineering efforts have been made on Hydrodynamic Growth Radiography Assemblies (HGRs) using multiple tube design variations, including alternative angles, depths, sizes, and location with engineered defects to showcase fill tube effects during an implosion. Furthermore, testing has shown that these CFTAs and HGRs have survived all fabrication and transport to from General Atomics to Lawrence Livermore National Laboratory. These assemblies have also passed cryogenic testing at General Atomics. An overview of alternative CFTA designs, fabrication methods and developments will be presented.
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