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At least 217 records · Page 12

Potential Signature of Population III Pair-instability Supernova Ejecta in the BLR Gas of the Most Distant Quasar at z = 7.54*

The search for Population III stars has fascinated and eluded astrophysicists for decades. One promising place for capturing evidence of their presence must be high-redshift objects; signatures should be recorded in their characteristic chemical abundances. We deduce the Fe and Mg abundances of the broadline region (BLR) from the intensities of ultraviolet Mg ii and Fe ii emission lines in the near-infrared spectrum of UKIDSS Large Area Survey (ULAS) J1342+0928 at z = 7.54, by advancing our novel flux-to-abundance conversion method developed for quasars up to z ~ 3. We find that the BLR of this quasar is extremely enriched, by a factor of 20 relative to the solar Fe abundance, together with a very low Mg/Fe abundance ratio: [Fe/H] = +1.36 ± 0.19 and [Mg/Fe] =-1.11 ± 0.12, only 700 million years after the Big Bang. We conclude that such an unusual abundance feature cannot be explained by the standard view of chemical evolution that considers only the contributions from canonical supernovae. While there remains uncertainty in the high-mass end of the Population III initial mass function, here we propose that the larger amount of iron in ULAS J1342+0928 was supplied by a pair-instability supernova (PISN) caused by the explosion of a massive Population III star in the high-mass end of the possible range of 150–300 M ⊙ . Chemical evolution models based on initial PISN enrichment well explain the trend in [Mg/Fe]-z all the way from z < 3 to z = 7.54. We predict that stars with very low [Mg/Fe] at all metallicities are hidden in the galaxy, and they will be efficiently discovered by ongoing new-generation photometric surveys.

79 ASTRONOMY AND ASTROPHYSICS↗

Constraints on Populations of Neutrino Sources from Searches in the Directions of IceCube Neutrino Alerts

Beginning in 2016, the IceCube Neutrino Observatory has sent out alerts in real time containing the information of high-energy ($E$ ≳ 100 TeV) neutrino candidate events with moderate to high (≳30%) probability of astrophysical origin. In this work, we use a recent catalog of such alert events, which, in addition to events announced in real time, includes events that were identified retroactively and covers the time period of 2011–2020. We also search for additional, lower-energy neutrinos from the arrival directions of these IceCube alerts. We show how performing such an analysis can constrain the contribution of rare populations of cosmic neutrino sources to the diffuse astrophysical neutrino flux. After searching for neutrino emission coincident with these alert events on various timescales, we find no significant evidence of either minute-scale or day-scale transient neutrino emission or of steady neutrino emission in the direction of these alert events. This study also shows how numerous a population of neutrino sources has to be to account for the complete astrophysical neutrino flux. Assuming that sources have the same luminosity, an $E$ -2.5 neutrino spectrum, and number densities that follow star formation rates, the population of sources has to be more numerous than 7 × 10 -9 Mpc -3 . This number changes to 3 × 10 -7 Mpc -3 if number densities instead have no cosmic evolution.

79 ASTRONOMY AND ASTROPHYSICS↗

Find the Gap: Black Hole Population Analysis with an Astrophysically Motivated Mass Function

We introduce a novel black hole mass function that realistically models the physics of pair-instability supernovae with a minimal number of parameters. Applying this to all events in the LIGO-Virgo Gravitational-Wave Transient Catalog 2 (GWTC-2), we detect a peak at M BHMG = 46$^{+17}_{-6}$ M ⊙ . Repeating the analysis without the black holes from the event GW190521, we find this feature at M BHMG =54± 6 M ⊙ . These results establish the edge of the anticipated "black hole mass gap" at a value compatible with the expectation from standard stellar structure theory. The mass gap manifests itself as a discontinuity in the mass function and is populated by a distinct, less-abundant population of higher-mass black holes. We find that the primary black hole population scales with power-law index -1.95 ± 0.51 (-1.97 ± 0.44) with (without) GW190521, consistent with models of star formation. Using Bayesian techniques, we establish that our mass function fits a new catalog of black hole masses approximately as well as pre-existing phenomenological mass functions. We also remark on the implications of these results for constraining or discovering new phenomena in nuclear and particle physics.

79 ASTRONOMY AND ASTROPHYSICS↗

The Effects of Dark Matter and Baryonic Physics on the Milky Way Subhalo Population in the Presence of the Large Magellanic Cloud

Given recent developments in our understanding of the Large Magellanic Cloud's (LMC) impact on the Milky Way's (MW) dark matter subhalo population, we compare the signatures of dark matter and baryonic physics on subhalos in MW systems with realistic LMC analogs. In particular, we study the effects of self-interacting dark matter~(SIDM), warm dark matter (WDM), and the Galactic disk on the peak maximum circular velocity ($V_{\mathrm{peak}}$) function, radial distribution, and spatial distribution of MW and LMC-associated subhalos using cosmological dark matter-only zoom-in simulations of MW+LMC systems. For a fixed abundance of subhalos expected to host dwarf galaxies ($V_{\mathrm{peak}}\gtrsim 20\ \mathrm{km\ s}^{-1}$), SIDM and WDM can produce a similar mass-dependent suppression of the subhalo $V_{\mathrm{peak}}$ function, while disk disruption is mass independent. Subhalos in the inner regions of the MW are preferentially disrupted by both self-interactions and the disk, while suppression in WDM is radially independent. The relative abundance of LMC-associated subhalos is not strongly affected by disk disruption or WDM, but is significantly suppressed in SIDM due to self-interactions with the LMC at early times and with the MW during LMC infall at late times, erasing spatial anisotropy in the MW subhalo population. Furthermore, these results provide avenues to distinguish dark matter and baryonic physics by combining properties of the MW and LMC subhalo populations probed by upcoming observations of satellite galaxies and stellar streams.

79 ASTRONOMY AND ASTROPHYSICS↗

Lessons Learnt from Comparing WhatsApp Privacy Concerns Across Saudi and Indian Populations

The purpose of this study is to understand the privacy concerns and behavior of non-WEIRD populations in online messaging platforms. Analysis of surveys (n=674) of WhatsApp users in Saudi Arabia and India revealed that Saudis had significantly higher concerns about being contacted by strangers. In contrast, Indians showed significantly higher concerns with respect to social contact from professional colleagues. Demographics impinge privacy preferences in both populations, but in different ways. Results from regression analysis show that there are statistically significant differences between the privacy behaviors of Saudis and Indians. In both cases, privacy concerns were strongly correlated with their reported privacy behaviors. Despite the differences, we identified technical solutions that could address the concerns of both populations of participants. We close by discussing the applicability of our recommendations, specifically those on transparency and consent, to other applications and domains.

Dev, Jayati↗

Multiplexed binary assembly and quantitative tracking of bacterial populations

Compositions and methods for tracking combinations of mutations in populations by coupling DNA assembly and paired-end sequencing technology with high-throughput sequencing. This allows for an unlimited number of mutation sites in a population of microorganisms to be identified, and allows sites to be sequenced across several replicates. Unique identifiers (DNA barcodes) can be used to measure fitness data by sequencing of the barcodes multiplexed with the mutation sites with high-throughput short sequencing read technology, allowing selections to be rapidly performed on populations of known combinatorial genotypes.

59 BASIC BIOLOGICAL SCIENCES↗

Strong Lensing Cosmology with Population-level Calibrated Neural Ratio Estimation

Strong gravitational lensing contains key information about cosmic acceleration. Modern and next-generation galaxy imaging surveys are expected to provide high-quality data on $\mathcal{O}(10^5)$ galaxy-galaxy lensing systems. The plethora and complexity of the data are likely to present computational challenges for parameter inference methods for fitting high-dimensional likelihoods, which are often analytically intractable. Neural Ratio Estimation (NRE) efficiently computes individual likelihood ratios that can be combined into population-level posteriors. We use simulations to study the capacity of NRE to jointly predict the dark energy equation-of-state parameter $w$ and the total matter density $Ω_{m}$ from lensing images and companion spectroscopic information. We also introduce a post hoc posterior coverage calibration procedure that mitigates the model overconfidence that is typically found in neural density estimation applications. Our experiments show that the errors on both parameters decrease with increasing inference population sizes. In particular, for 100 lenses in a standard $Λ$CDM Universe, our calibrated NRE model achieves median fractional uncertainty of $22.8\%$ in $w$ and $2.9\%$ in $Ω_{m}$. This proof of concept demonstrates a potentially scalable approach for efficient cosmological parameter inference with large populations of galaxy-scale lenses observed in future surveys.

Jarugula, Sreevani [Fermilab] (ORCID:0000000253867↗

Advancing process-based flood frequency analysis for assessing flood hazard and population flood exposure

Recent studies have showcased the use of process-based hydrological models with Stochastic Storm Transposition (SST) techniques to conduct Flood Frequency Analysis (FFA). This framework, referred hereby FFA-SST, has proved to be a robust strategy to estimate peak flows of specific annual exceedance probability (e.g., 100-year peak flow) that can reflect natural and anthropogenic disturbances, including changes in land use and meteorological patterns. With the objective of advancing the FFA-SST framework, this study presents for the first time the use of an Integrated Surface-Subsurface Hydrological Model (ISSHM) to conduct FFA-SST by extending the analysis from peak flow responses to flood extent, enabling a unique view and analysis of flood hazard and population flood exposure at the basin scale. As a proof-of-concept, we used the ISSHM, Advanced Terrestrial Simulator (Amanzi-ATS) model, and the SST model, RainyDay, to conduct FFA-SST by simulating the flood response to 5,000 annual synthetic storm events in a 2,227 $km^2$ Southeast Texas watershed. We demonstrate that ATS, without site-specific calibration, provides a robust process-based representation of peak flows, flood extent, streamflow, evapotranspiration, soil moisture content, and water storage changes. Our results and analyses, covering frequency curves up to a 500-year return period for peak flows, basin inundation fractions, and the number of people exposed to flooding, offer a unique perspective to analyze flood impacts across spatial scales. Overall, this study provides critical insights for flood risk management by extending the FFA-SST framework to include both flood hazard and population flood exposure analyses at the basin scale. Such an approach will empower stakeholders and disaster emergency agencies with a more comprehensive understanding of flood impacts across the entire basin domain, facilitating informed decision-making for flood risk assessment and management.

58 GEOSCIENCES↗

Wireworm (Coleoptera: Elateridae) genomic analysis reveals putative cryptic species, population structure, and adaptation to pest control

The larvae of click beetles (Coleoptera: Elateridae), known as “wireworms,” are agricultural pests that pose a substantial economic threat worldwide. We produced one of the first wireworm genome assemblies (Limonius californicus), and investigated population structure and phylogenetic relationships of three species (L. californicus, L. infuscatus, L. canus) across the northwest US and southwest Canada using genome-wide markers (RADseq) and genome skimming. We found two species (L. californicus and L. infuscatus) are comprised of multiple genetically distinct groups that diverged in the Pleistocene but have no known distinguishing morphological characters, and therefore could be considered cryptic species complexes. We also found within-species population structure across relatively short geographic distances. Genome scans for selection provided preliminary evidence for signatures of adaptation associated with different pesticide treatments in an agricultural field trial for L. canus. We demonstrate that genomic tools can be a strong asset in developing effective wireworm control strategies.

59 BASIC BIOLOGICAL SCIENCES↗

Social network structure and the spread of complex contagions from a population genetics perspective

Ideas, behaviors, and opinions spread through social networks. If the probability of spreading to a new individual is a non-linear function of the fraction of the individuals’ affected neighbors, such a spreading process becomes a “complex contagion”. This non-linearity does not typically appear with physically spreading infections, but instead can emerge when the concept that is spreading is subject to game theoretical considerations (e.g. for choices of strategy or behavior) or psychological effects such as social reinforcement and other forms of peer influence (e.g. for ideas, preferences, or opinions). Here we study how the stochastic dynamics of such complex contagions are affected by the underlying network structure. Motivated by simulations of complex contagions on real social networks, we present a framework for analyzing the statistics of contagions with arbitrary non-linear adoption probabilities based on the mathematical tools of population genetics. The central idea is to use an effective lower-dimensional diffusion process to approximate the statistics of the contagion. This leads to a tradeoff between the effects of ”selection” (microscopic tendencies for an idea to spread or die out), random drift, and network structure. Our framework illustrates intuitively several key properties of complex contagions: stronger community structure and network sparsity can significantly enhance the spread, while broad degree distributions dampen the effect of selection compared to random drift. Finally, we show that some structural features can exhibit critical values that demarcate regimes where global contagions become possible for networks of arbitrary size. Our results draw parallels between the competition of genes in a population and memes in a world of minds and ideas. Our tools provide insight into the spread of information, behaviors, and ideas via social influence, and highlight the role of macroscopic network structure in determining their fate.

59 BASIC BIOLOGICAL SCIENCES↗

Uncultivated Viral Populations Dominate Estuarine Viromes on the Spatiotemporal Scale

Viruses are ubiquitous and abundant in the oceans, and viral metagenomes (viromes) have been investigated extensively via several large-scale ocean sequencing projects. However, there have not been any systematic viromic studies in estuaries. Here, we investigated the viromes of the Delaware Bay and Chesapeake Bay, two Mid-Atlantic estuaries. Deep sequencing generated a total of 48,190 assembled viral sequences (>5 kb) and 26,487 viral populations (9,204 virus clusters and 17,845 singletons), including 319 circular viral contigs between 7.5 kb and 161.8 kb. Unknown viruses represented the vast majority of the dominant populations, while the composition of known viruses, such as pelagiphage and cyanophage, appeared to be relatively consistent across a wide range of salinity gradients and in different seasons. A difference between estuarine and ocean viromes was reflected by the proportions of Myoviridae, Podoviridae, Siphoviridae, Phycodnaviridae, and a few well-studied virus representatives. The difference in viral community between the Delaware Bay and Chesapeake Bay is significantly more pronounced than the difference caused by temperature or salinity, indicating strong local profiles caused by the unique ecology of each estuary. Interestingly, a viral contig similar to phages infecting Acinetobacter baumannii (“Iraqibacter”) was found to be highly abundant in the Delaware Bay but not in the Chesapeake Bay, the source of which is yet to be identified. Highly abundant viruses in both estuaries have close hits to viral sequences derived from the marine single-cell genomes or long-read single-molecule sequencing, suggesting that important viruses are still waiting to be discovered in the estuarine environment.

59 BASIC BIOLOGICAL SCIENCES↗

Modeling COVID-19 Impacts on Prison Population

The goal of this project was to develop a unique, high-level, concept model that will (1) help examine the consequences COVID-19 has had on prison population and flow dynamics in Illinois and (2) explore (to the extent possible) how that will unfold in the short- and mid-term future. Argonne has unique expertise in dynamic systems modeling and highly specialized simulation capabilities, which will be helpful in developing such a model. The ultimate objective of this CRADA is to develop with the Illinois Public Sentencing Policy Advisory Council (SPAC) the capability to identify and understand factors and interactions associated with prison population and flow dynamics in Illinois. This understanding will then potentially lead to improvements in the allocation of various resources and services. This approach would also be useful to other states.

59 BASIC BIOLOGICAL SCIENCES↗

Chemical Cartography with APOGEE: Mapping Disk Populations with a 2-process Model and Residual Abundances

We apply a novel statistical analysis to measurements of 16 elemental abundances in 34,410 Milky Way disk stars from the final data release (DR17) of APOGEE-2. Building on recent work, we fit median abundance ratio trends [X/Mg] versus [Mg/H] with a 2-process model, which decomposes abundance patterns into a "prompt" component tracing core-collapse supernovae and a "delayed" component tracing Type Ia supernovae. For each sample star, we fit the amplitudes of these two components, then compute the residuals Δ[X/H] from this two-parameter fit. The rms residuals range from ~0.01–0.03 dex for the most precisely measured APOGEE abundances to ~0.1 dex for Na, V, and Ce. The correlations of residuals reveal a complex underlying structure, including a correlated element group comprised of Ca, Na, Al, K, Cr, and Ce and a separate group comprised of Ni, V, Mn, and Co. Selecting stars poorly fit by the 2-process model reveals a rich variety of physical outliers and sometimes subtle measurement errors. Residual abundances allow for the comparison of populations controlled for differences in metallicity and [α/Fe]. Relative to the main disk (R = 3–13 kpc), we find nearly identical abundance patterns in the outer disk (R = 15–17 kpc), 0.05–0.2 dex depressions of multiple elements in LMC and Gaia Sausage/Enceladus stars, and wild deviations (0.4–1 dex) of multiple elements in ω Cen. The residual abundance analysis opens new opportunities for discovering chemically distinctive stars and stellar populations, for empirically constraining nucleosynthetic yields, and for testing chemical evolution models that include stochasticity in the production and redistribution of elements.

79 ASTRONOMY AND ASTROPHYSICS↗

High-resolution (30-m) urban land cover projections for Los Angeles California Urban Area: 2010 to 2100 under SSP3 and SSP5 [Updated simulations based on population-driven urban intensity transitions]

These data (v3) are updated from previous versions (1 and 2) in that they include consider the effects of population on transitions in urban land intensity. This leads to more reasonable differences in urban land projections under variant SSPs. For the present dataset, both SSP3 and SSP5 are provided. These data represent simulations of future land use and land cover (LULCC) for Los Angeles urban area (U.S. Census Bureau defined area) as raster tiff images at a 30-m pixel resolution and at decadal time steps from 2010 to 2100. LULCC classes in this product follow the National Land Cover Dataset (NLCD) classification. NLCD 21-24 correspond to open developed, low developed, medium developed, and high developed urban land classes, respectively. Only urban land cover classes (NLCD class 21, 22, 23, and 24) are dynamic over time; however, all NLCD classes are included in the final product. Therefore, NLCD classes that do not convert to an urban class will be similar to year 2000. The products were developed using a hybridized statistical and cellular automata approach. Linear mixed models (LMMs) were used to estimate future urban land budgets based on 1-km urban land fraction projections from Gao and Pesaresi (2021), whereas separate generalized linear mixed models (GLMMs) were used to estimate shifts in urban land intensities based on retrospective shifts in NLCD urban class intensities over a 20- year period. Based on urban land allocations from the statistical models, a cellular-automata and downscaling routine was used to simulate dynamic urban land expansion at a 30-m resolution based on suitability criteria. Scenarios of future urban landcover change projections include variant solutions for the Shared Socioeconomic Pathway 5 (SSP5) and SSP 3 based on different population assumptions, different land use intensification assumptions, variable land zoning constraints, and iterative adjustments to correct for over allocation of urban expansion across decadal time periods from 2010 to 2100. This results in 320 raster products.

Land↗

Increasing Electric Vehicle Adoption Among Disadvantaged Populations: A Case Study in LA

In the shift towards 100% carbon-free energy, ensuring equitable access to clean energy benefits is crucial. The adoption of electric vehicles (EVs), particularly in the personal light-duty vehicle segment, has gained traction, driven by various incentives at the federal, state, and local levels. However, disadvantaged populations face unique challenges in embracing EVs. This paper, using Los Angeles as a case study, explores EV adoption patterns among disadvantaged population groups in both a business-as-usual scenario and an equity scenario. Modeling reveals that by 2035, over half of EV owners will be from low- to middle income backgrounds with limited access to home charging. Strategies such as increasing incentives for used EV purchase from $2500 to $4000, targeted for disadvantaged communities, can boost EV adoption among low-middle income groups by 2%, while providing a $300 annual voucher to households using public charging can further facilitate equitable EV adoption.

ADVANCED PROPULSION SYSTEMS↗

Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease

Abstract INTRODUCTION Cognitively unimpaired (CU) amyloid beta (Aβ)+ individuals with elevated plasma glial fibrillary acidic protein (GFAP) have an increased risk of Alzheimer's disease (AD)‐related progression. We tested the utility of plasma GFAP for population enrichment CU populations in clinical trials. METHODS We estimated longitudinal progression, effect size, and costs of hypothetical clinical trials designed to test an estimated 25% drug effect on reducing tau positron emission tomography (PET) accumulation in the medial temporal lobe (MTL) and temporal neocortical region (NEO‐T). RESULTS CU GFAP+/Aβ+ individuals present an increased annual rate of change and effect size in tau PET MTL and tau PET NEO‐T compared to the other groups. An enrichment strategy selecting CU GFAP+/Aβ+ individuals would require a smaller sample size (≈ 57% reduction) and fewer Aβ PET scans (≈ 74% reduction) than trials enriched with Aβ PET alone, reducing total clinical trial costs by up to 64%. DISCUSSION Our results suggest that clinical trials focusing on preclinical AD recruiting Aβ+ individuals with elevated GFAP levels would improve cost effectiveness. Highlights Cognitively unimpaired (CU) glial fibrillary acidic protein (GFAP)+/amyloid beta (Aβ)+ shows increased changes in tau positron emission tomography (PET) . CU GFAP+/Aβ+ enriched clinical trials require a reduced sample size compared to Aβ+ only. CU GFAP+/Aβ+ enrichment reduces Aβ PET scans required and costs. CU GFAP+/Aβ+ enrichment allows the selection of individuals at early stages of the Alzheimer's disease continuum.

Neurosciences & Neurology↗