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At least 217 records · Page 12

Lowest-order QED radiative corrections in unpolarized elastic electron–deuteron scattering beyond the ultra-relativistic limit for the proposed deuteron charge radius measurement at Jefferson laboratory

Analogous to the well-known proton charge radius puzzle, a similar puzzle exists for the deuteron charge radius, r d . There are discrepancies observed in the results of r d , measured from electron-deuteron (e - d) scattering experiments, as well as from atomic spectroscopy. In order to help resolve the charge radius puzzle of the deuteron, the PRad collaboration at Jefferson Lab has proposed an experiment for measuring r d , named DRad. This experiment is designed to measure the unpolarized elastic e - d scattering cross section in a low-Q 2 region. To extract the cross section with a high precision, having reliable knowledge of QED radiative corrections is important. Here, in this paper, we present complete numerical calculations of the lowest-order radiative corrections in e - d scattering for the DRad kinematics. The calculations have been performed within a covariant formalism and beyond the ultra-relativistic approximation ($m^2_e$ $\ll$ Q 2 ). Besides, we present a systematic uncertainty on r d arising from higher-order radiative corrections, estimated based on our cross-section results.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Cold atoms in space: community workshop summary and proposed road-map

We summarise the discussions at a virtual Community Workshop on Cold Atoms in Space concerning the status of cold atom technologies, the prospective scientific and societal opportunities offered by their deployment in space, and the developments needed before cold atoms could be operated in space. The cold atom technologies discussed include atomic clocks, quantum gravimeters and accelerometers, and atom interferometers. Prospective applications include metrology, geodesy and measurement of terrestrial mass change due to, e.g., climate change, and fundamental science experiments such as tests of the equivalence principle, searches for dark matter, measurements of gravitational waves and tests of quantum mechanics. We review the current status of cold atom technologies and outline the requirements for their space qualification, including the development paths and the corresponding technical milestones, and identifying possible pathfinder missions to pave the way for missions to exploit the full potential of cold atoms in space. Finally, we present a first draft of a possible road-map for achieving these goals, that we propose for discussion by the interested cold atom, Earth Observation, fundamental physics and other prospective scientific user communities, together with the European Space Agency (ESA) and national space and research funding agencies.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

High quality draft genome sequence of Meganema perideroedes str. Gr1 T and a proposal for its reclassification to the family Meganemaceae fam. nov.

Meganema perideroedes Gr1 T is a filamentous bacterium isolated from an activated sludge wastewater treatment plant where it is implicated in poor sludge settleability (bulking). M. perideroedes is the sole described species of the genus Meganema and of the proposed novel family “Meganemaceae” . Here we describe the features of the type strain Gr1 T along with its annotated genome sequence. The 3,409,949 bp long draft genome consists of 22 scaffolds with 3,033 protein-coding and 59 RNA genes and is a part of Genomic Encyclopedia of Type Strains , Phase I: the one thousand microbial genomes KMG project. Notably, genome annotation indicated the potential for facultative methylotrophy. However, the ability to utilize methanol as a carbon source could not be empirically demonstrated for the type strain or for in situ Meganema spp. strains.

59 BASIC BIOLOGICAL SCIENCES↗

Proposal of a Nomogram for Predicting Survival in Patients with Siewert Type II Adenocarcinoma of the Esophagogastric Junction After Preoperative Radiation

Background: Preoperative radiotherapy tends to be more frequently used for patients with adenocarcinoma of the esophagogastric junction (AEG); however, the prognostic values of postoperative pathologic characteristics in these patients remain unclear. This study aimed to examine the outcomes in Siewert type II AEG patients receiving preoperative radiotherapy to identify the predictive factors for overall survival (OS). Methods and Results: A total of 1818 AEG patients undergoing preoperative radiotherapy were reviewed. Univariate analyses showed that age, sex, histology, tumor grade, positive lymph node (PLN), lymph node ratio, and log odds of positive lymph nodes (LODDS) were significantly correlated with OS; however, only age, grade, PLN, and LODDS were identified as independent risk factors in a multivariate regression model. Subsequently, patients were randomly grouped into training and validation cohorts (1:1 ratio), and the beta coefficients of these variables in the training set were used to generate the nomogram. The composite nomogram showed improved prognostic accuracy in the training, validation, and entire cohorts compared with that of TNM stage alone. Conclusions: In conclusion, our proposed nomogram represents a promising tool for estimating OS in Siewert type II AEG patients after preoperative radiotherapy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

An important class of intron retention events in human erythroblasts is regulated by cryptic exons proposed to function as splicing decoys

During terminal erythropoiesis, the splicing machinery in differentiating erythroblasts executes a robust intron retention (IR) program that impacts expression of hundreds of genes. We studied IR mechanisms in the SF3B1 splicing factor gene, which expresses ~50% of its transcripts in late erythroblasts as a nuclear isoform that retains intron 4. RNA-seq analysis of nonsense-mediated decay (NMD)-inhibited cells revealed previously undescribed splice junctions, rare or not detected in normal cells, that connect constitutive exons 4 and 5 to highly conserved cryptic cassette exons within the intron. Minigene splicing reporter assays showed that these cassettes promote IR. Genome-wide analysis of splice junction reads demonstrated that cryptic noncoding cassettes are much more common in large (>1 kb) retained introns than they are in small retained introns or in nonretained introns. Functional assays showed that heterologous cassettes can promote retention of intron 4 in the SF3B1 splicing reporter. Although many of these cryptic exons were spliced inefficiently, they exhibited substantial binding of U2AF1 and U2AF2 adjacent to their splice acceptor sites. We propose that these exons function as decoys that engage the intron-terminal splice sites, thereby blocking cross-intron interactions required for excision. Developmental regulation of decoy function underlies a major component of the erythroblast IR program.

59 BASIC BIOLOGICAL SCIENCES↗

Proposal for secondary enclosure setup for experiments to expose plasma facing materials to tritiated plasma in VISIONI

VISIONI is an equipment at SCK-CEN that allows the exposure of candidate plasma facing materials to tritium - deuterium plasmas at ITER first wall conditions. VISIONI itself, being a vacuum setup, acts as primary confinement. To protect operators against exposure to a tritiated atmosphere VISIONI must be placed in a secondary confinement. The current Tritium lab at SCK-CEN has a walk-in process cell which can be used to enclose the plasma chamber and diagnostics of the VISIONI setup, which have a limited tritium inventory. This allows easy accessibility to the setup in a well-ventilated environment. Routine operations should be conducted from outside the process cell and maintenance operations can be conducted from within the process cell with proper protections. The tritium storage and supply can be enclosed in a glove box with a dedicated air detritiation system which is activated during an experiment or in case of an incident. The detritiation system will oxidize tritium and capture it on molecular sieves. By using this confinement approach it is possible to expose materials to a tritiated plasma while maintaining good accessibility of the VISIONI setup. This paper describes the proposed confinement system and compares it to the most common approach where the entire system is enclosed into one large glovebox.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Jupiter: A Proposed Benchmark for Lead Void Worth with Plutonium

In the summer of 2017, a series of measurements were performed at the National Criticality Experiments Research Center (NCERC) in collaboration with the Japanese Atomic Energy Agency (JAEA) to measure the reactivity worth of voids in an array of lead and plutonium. This experiment, called Jupiter, measured multiple configurations of an array of aluminum boxes containing plutonium, aluminum, and lead plates. For some configurations, a selection of the lead interstitial plates were swapped with aluminum spacer frames to create “voids” in the lead interstitial material. Comparing the excess reactivity of the systems provides an empirical value of the lead void reactivity worth. These measurements were part of a larger collaboration to measure lead void reactivity worth with multiple nuclear material types and enrichments. This included other measurement series with both highly-enriched uranium (HEU), and a mixture of HEU and natural uranium to simulate low-enriched uranium (LEU). These data sets will be useful to the JAEA for a potential lead-bismuth cooled accelerator driven system. Additionally, there are not very many benchmarks in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) handbook sensitive to lead cross sections. Given that lead is widely used as a radiation shield and is part of new reactor designs, having more benchmarks in the ICSBEP handbook to better support cross section validation is important. Additional integral experiments could also aid in determining whether improvements have been made in new lead cross section evaluations. A benchmark evaluation for this experiment is being proposed in order to help fulfill these needs. Such evaluations contain both measured data, results from detailed transport code models, and analyses of the uncertainties associated with each. Examples of these uncertainties include the uncertainty in the measured excess reactivity, the composition of components, or their positioning within the model. This means it is easier to make comparisons between the measured and simulated data and better understand where improvements can be made to nuclear data.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Proposal for a quantum random number generator using coherent light and a non-classical observable

The prototype quantum random number (random bit) generator (QRNG) consists of one photon at a time falling on a 50:50 beam splitter followed by random detection in one or the other output beams due to the irreducible probabilistic nature of quantum mechanics. Due to the difficulties in producing single photons on demand, in practice, pulses of weak coherent (laser) light are used. In this paper, we take a different approach, one that uses moderate coherent light. It is shown that a QRNG can be implemented by performing photon-number parity measurements. For moderate coherent light, the probabilities of obtaining even or odd parity in photon counts are 0.5 each. Photon counting with single-photon resolution can be performed through use of a cascade of beam splitters and single-photon detectors, as was done recently in a photon-number parity-based interferometry experiment involving coherent light. We highlight the point that unlike most quantum-based random number generators, our proposal does not require the use of classical de-biasing algorithms or post-processing of the generated bit sequence.

Gerry, Christopher C.↗

A proposed framework for the development and qualitative evaluation of West Nile virus models and their application to local public health decision-making

West Nile virus (WNV) is a globally distributed mosquito-borne virus of great public health concern. The number of WNV human cases and mosquito infection patterns vary in space and time. Many statistical models have been developed to understand and predict WNV geographic and temporal dynamics. However, these modeling efforts have been disjointed with little model comparison and inconsistent validation. In this paper, we describe a framework to unify and standardize WNV modeling efforts nationwide. WNV risk, detection, or warning models for this review were solicited from active research groups working in different regions of the United States. A total of 13 models were selected and described. The spatial and temporal scales of each model were compared to guide the timing and the locations for mosquito and virus surveillance, to support mosquito vector control decisions, and to assist in conducting public health outreach campaigns at multiple scales of decision-making. Our overarching goal is to bridge the existing gap between model development, which is usually conducted as an academic exercise, and practical model applications, which occur at state, tribal, local, or territorial public health and mosquito control agency levels. The proposed model assessment and comparison framework helps clarify the value of individual models for decision-making and identifies the appropriate temporal and spatial scope of each model. This qualitative evaluation clearly identifies gaps in linking models to applied decisions and sets the stage for a quantitative comparison of models. Specifically, whereas many coarse-grained models (county resolution or greater) have been developed, the greatest need is for fine-grained, short-term planning models (m–km, days–weeks) that remain scarce. We further recommend quantifying the value of information for each decision to identify decisions that would benefit most from model input.

60 APPLIED LIFE SCIENCES↗

pF3D Proposals

This report documents proposals for the Simulations of Laser-Plasma Interaction in National Ignition Facility.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Proposed Testing to Assess the Accuracy of Glass-To-Metal Seal Stress Analyses

The material characterization tests conducted on 304L VAR stainless steel and Schott 8061 glass have provided higher fidelity data for calibration of material models used in Glass - To - Metal (GTM) seal analyses. Specifically, a Thermo - Multi - Linear Elastic Plastic (thermo - MLEP) material model has be endefined for S S304L and the Simplified Potential Energy Clock nonlinear viscoelastic model has been calibrated for the S8061 glass. To assess the accuracy of finite element stress analyses of GTM seals, a suite of tests are proposed to provide data for comparison to model predictions.

Chambers, Robert S.↗

Differential Die-Away Instrument: Report on Neutron Detector Recovery Performance and Proposed Improvements

Four helium-3 ( 3 He) detector/preamplifier packages (¾”/KM200, DDSI/PDT-A111, DDA/PDT-A111, and DDA/PDT10A) were experimentally tested to determine the deadtime effects at different DT neutron generator output settings. At very high count rates, the ¾”/KM200 package performed best. At high count rates, the ¾”/KM200 and the DDSI/PDT-A111 packages performed very well, with the DDSI/PDT-A111 operating with slightly higher efficiency. All of the packages performed similarly at mid to low count rates. Proposed improvements include using a fast recovery LANL-made dual channel preamplifier, testing smaller diameter 3 He tubes, and further investigating quench gases.

07 ISOTOPE AND RADIATION SOURCES↗

Developing evidence-based prescriptive ventilation rate standards for commercial buildings in California: a proposed framework

Background - The goal of this project, with a focus on commercial buildings in California, was to develop a new framework for evidence-based minimum ventilation rate (MVR) standards that protect occupants in buildings while also considering energy use and cost. This was motivated by research findings suggesting that current prescriptive MVRs in commercial buildings do not provide occupants with fully safe and satisfactory indoor environments. Methods - The project began with a broad review in several areas ? the diverse strategies now used for standards or guidelines for MVRs or for environmental contaminant exposures, current knowledge about adverse human effects associated with VRs, and current knowledge about contaminants in commercial buildings, including their their presence, their adverse human effects, and their relationships with VRs. Based on a synthesis of the reviewed information, new principles and approaches are proposed for setting evidence-based VRs standards for commercial buildings, considering a range of human effects including health, performance, and acceptability of air. Results ? A review and evaluation is first presented of current approaches to setting prescriptive building ventilation standards and setting acceptable limits for human contaminant exposures in outdoor air and occupational settings. Recent research on approaches to setting acceptable levels of environmental exposures in evidence-based MVR standards is also described. From a synthesis and critique of these materials, a set of principles for setting MVRs is presented, along with an example approach based on these principles. The approach combines two sequential strategies. In a first step, an acceptable threshold is set for each adverse outcome that has a demonstrated relationship to VRs, as an increase from a (low) outcome level at a high reference ventilation rate (RVR, the VR needed to attain the best achievable levels of the adverse outcome); MVRs required to meet each specific outcome threshold are estimated; and the highest of these MVRs, which would then meet all outcome thresholds, is selected as the target MVR. In a second step, implemented only if the target MVR from step 1 is judged impractically high, costs and benefits are estimated and this information is used in a risk management process. Four human outcomes with substantial quantitative evidence of relationships to VRs are identified for initial consideration in setting MVR standards. These are: building-related symptoms (sometimes called sick building syndrome symptoms), poor perceived indoor air quality, and diminished work performance, all with data relating them directly to VRs; and cancer and non-cancer chronic outcomes, related indirectly to VRs through specific VR-influenced indoor contaminants. In an application of step 1 for offices using a set of example outcome thresholds, a target MVR of 9 L/s (19 cfm) per person was needed. Because this target MVR was close to MVRs in current standards, use of a cost/benefit process seemed unnecessary. Selection of more stringent thresholds for one or more human outcomes, however, could raise the target MVR to 14 L/s (30 cfm) per person or higher, triggering the step 2 risk management process. Consideration of outdoor air pollutant effects would add further complexity to the framework. For balancing the objective and subjective factors involved in setting MVRs in a cost-benefit process, it is suggested that a diverse group of stakeholders make the determination after assembling as much quantitative data as possible.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Proposed Use Cases for the IDC

In support of the International Data Center (IDC) Reengineering Phase 2 project, a list of proposed use cases with brief descriptions is provided for review.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗

INL Review of Fueling Machine Inspection Tool Development Proposal

A review of a technical proposal for James Fischer Nuclear. The document describes an inspection tool to examine the graphite moderator in an AGR reactor. The system is an optical system to look at the graphite blocks for cracks. INL reviews the document for technical value.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Collaborative Proposal. Development of an Isotope-Enabled CESM for Testing Abrupt Climate Changes

We have made significant landmarks in our proposed work in the last 4 years (3 years plus 1 year of no cost extension). We have developed the simulation capability of the major isotopes in CESM. In particular, we have completed the implementation of the stable water isotopes (δ 18 O, δD) into the components for the atmosphere, ocean, land surface, runoff transport, sea ice, and coupler. In addition, the carbon isotopes (abiotic and biotic radiocarbon, δ 13 C) have been implemented into the CESM ocean and land models, and long spinup simulations have been completed (Jahn et al., 2015). Furthermore, we have added abiotic Neodymium to the CESM ocean model as a tracer of ocean circulation, also measured by the proxy data community. Fullycoupled simulations with the stable water isotopes and ocean radiocarbon are currently being run for the preindustrial and also the Last Glacial Maximum. We have secured 19 million core-hours on the NWSC Yellowstone supercomputer for 12 months. Together with some CESM Paleoclimate Working Group CSL Yellowstone core hours, we are guaranteed sufficient computing for the spin-up experiments and deglaciation simulations for 21 to 15ka.

54 ENVIRONMENTAL SCIENCES↗

Preliminary Assessment of the Impact on Reactor Vessel dpa Rates Due to Installation of a Proposed Low Enriched Uranium (LEU) Core in the High Flux Isotope Reactor (HFIR)

An assessment of the impact on the High Flux Isotope Reactor (HFIR) reactor vessel (RV) displacements-per-atom (dpa) rates due to operations with the proposed low enriched uranium (LEU) core described by Ilas and Primm has been performed and is presented herein. The analyses documented herein support the conclusion that conversion of HFIR to low-enriched uranium (LEU) core operations using the LEU core design of Ilas and Primm will have no negative impact on HFIR RV dpa rates. Since its inception, HFIR has been operated with highly enriched uranium (HEU) cores. As part of an effort sponsored by the National Nuclear Security Administration (NNSA), conversion to LEU cores is being considered for future HFIR operations. The HFIR LEU configurations analyzed are consistent with the LEU core models used by Ilas and Primm and the HEU balance-of-plant models used by Risner and Blakeman in the latest analyses performed to support the HFIR materials surveillance program. The Risner and Blakeman analyses, as well as the studies documented herein, are the first to apply the hybrid transport methods available in the Automated Variance reduction Generator (ADVANTG) code to HFIR RV dpa rate calculations. These calculations have been performed on the Oak Ridge National Laboratory (ORNL) Institutional Cluster (OIC) with version 1.60 of the Monte Carlo N-Particle 5 (MCNP5) computer code.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Proposal of a Novel Approach to Developing Material Models for Micro-scale Composites Based on Testing and Modeling of Macro-scale Composites

The Los Alamos National Laboratory's Weapon Systems Engineering division's Advanced Engineering Analysis group employs material constitutive models of composites for use in simulations of components and assemblies of interest. Experimental characterization, modeling and prediction of the macro-scale (i.e. continuum) behaviors of these composite materials is generally difficult because they exhibit nonlinear behaviors on the meso- (e.g. micro-) and macro-scales. Furthermore, it can be difficult to measure and model the mechanical responses of the individual constituents and constituent interactions in the composites of interest. Current efforts to model such composite materials rely on semi-empirical models in which meso-scale properties are inferred from continuum level testing and modeling. The proposed approach involves removing the difficulties of interrogating and characterizing micro-scale behaviors by scaling-up the problem to work with macro-scale composites, with the intention of developing testing and modeling capabilities that will be applicable to the mesoscale. This approach assumes that the physical mechanisms governing the responses of the composites on the meso-scale are reproducible on the macro-scale. Working on the macro-scale simplifies the quantification of composite constituents and constituent interactions so that efforts can be focused on developing material models and the testing techniques needed for calibration and validation. Other benefits to working with macro-scale composites include the ability to engineer and manufacture—potentially using additive manufacturing techniques—composites that will support the application of advanced measurement techniques such as digital volume correlation and three-dimensional computed tomography imaging, which would aid in observing and quantifying complex behaviors that are exhibited in the macro-scale composites of interest. Ultimately, the goal of this new approach is to develop a meso-scale composite modeling framework, applicable to many composite materials, and the corresponding macroscale testing and test data interrogation techniques to support model calibration.

36 MATERIALS SCIENCE↗