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NASA NTRS2019

Transitioning the NASA SLR Network to Event Timing Mode for Reduced Systematics, Improved Stability and Data Precision

NASA's legacy Satellite Laser Ranging (SLR) network produces about one-third of the global SLR data to support spacegeodesy. This network of globally distributed stations has been using Time Interval Units (TIU) for range measurements for thelast 25 + years. To improve the reliability of the SLR network and satisfy the need for stable millimeter precision data, a phasedreplacement of the TIUs in the network with picosecond-precise Event Timer Modules was initiated in 2015. This schemeallowed the time of flight and laser transmit epoch measurement to one picosecond resolution. For a network with globalscientific impact, transitioning to a new data generation metrological scheme requires significant data scrutiny and long-termscience data validation. Any long-term testing/measurement has the potential to interrupt the station's daily operational dataflow to the International Laser Ranging Service (ILRS) as the station under test will have to put its test data into quarantine.We have demonstrated a very effective way to test and implement the new device without removing the old hardware andwithout the need for the orbit analysis. This operationally noninvasive scheme performed concurrent test measurements enablinguninterrupted operational data flow to the users, while allowing simultaneous test data capture for short- and long-termsystematics and stability analysis. Extensive analysis of the test data was performed by the NASA SLR engineering team andthe ILRS Analysis Standing Committee, to uncover biases and any dependencies on the satellite ranges (for nonlinear scaleissues). Multi-ETM comparison was also performed at two of the SLR stations through the interchange of hardware to establishthe inter-device range biases and stability. Such benchmarked hardware was subsequently sent to the remaining stationsto allow traceability and normalize the network performance. The range bias intercomparison performed using the multiyearSLR data analysis agreed well with the engineering changes, thus validating the approach to flush out station-specific rangingsystematics affecting precise orbit determination. Such an improvement and rebalancing of the current network will allowan orderly transition of the current NASA SLR network operating at a maximum rate of 10 Hz to the NASA next generationSpace Geodesy Satellite Laser Ranging (SGSLR) network operating at 2 kHz (McGarry et al. in J Geod, 2018. https ://doi.org/10.1007/s0019 0-018-1191-6; Merkowitz et al. in J Geod, 2018. https ://doi.org/10.1007/s0019 0-018-1204-5).

Varghese, Thomas↗

NASA NTRS2019

Defining Navigation Requirements for Future Precision Lander Missions

Human mission concepts for both the Moon and Mars require landing precision capabilities beyond the current state of art. The Safe and Precise Landing Integrated Capabilities Evolution (SPLICE) project leverages previous work at NASA to develop multimission precision landing and hazard avoidance (PL&HA) technologies to meet the advanced landing requirements. SPLICE aims to develop guidance, navigation and control (GN&C) capabilities for both Moon and Mars lander missions. The approach the project is using to identify a standard suite begins with developing a PL&HA requirements matrix to inform technology investments. The approach to develop a multi-mission navigation requirements matrix includes identifying representative concepts of operations for both robotic and human missions. It also identifies navigation sensor options with estimated performance parameters. This paper summarizes the concepts of operations and sensors considered to develop the SPLICE PL&HA requirements matrix. A description of the analysis used to determine candidate optimal sensor suites and initial results are provided.

Dwyer Cianciolo, Alicia↗

NASA NTRS2008

Overview of terrain relative navigation approaches for Precise Lunar Landing

The driving precision landing requirement for the Autonomous Landing and Hazard Avoidance Technology project is to autonomously land within 100m of a predetermined location on the lunar surface. Traditional lunar landing approaches based on inertial sensing do not have the navigational precision to meet this requirement. The purpose of Terrain Relative Navigation (TRN) is to augment inertial navigation by providing position or bearing measurements relative to known surface landmarks. From these measurements, the navigational precision can be reduced to a level that meets the 100m requirement. There are three different TRN functions: global position estimation, local position estimation and velocity estimation. These functions can be achieved with active range sensing or passive imaging. This paper gives a survey of many TRN approaches and then presents some high fidelity simulation results for contour matching and area correlation approaches to TRN using active sensors. Since TRN requires an a-priori reference map, the paper concludes by describing past and future lunar imaging and digital elevation map data sets available for this purpose.

Montgomery, James F.↗

NASA NTRS2019

The SPLICE Project: Continuing NASA Development of GN&C Technologies for Safe and Precise Landing

Guidance, Navigation and Control (GN&C) technologies for precise and safe landing are essential for future robotic science and human exploration missions to solar system destinations with targeted surface locations that pose a signiﬁcant risk to successful landing and subsequent mission operations. These Entry, Descent and Landing (EDL) technologies are a part of the NASA domain called PL&HA (Precision Landing and Hazard Avoidance) and are considered high-priority capabilities within NASA space technology development roadmaps to promote and enable new mission concepts. The SPLICE (Safe & Precise Landing – Integrated Capabilities Evolution) project is a multi-center, multi-directorate NASA project focused on continuing the decade-plus of NASA investments and projects focused on PL&HA technology development and infusion. This paper highlights the GN&C technologies in development within SPLICE, along with the simulation and ﬁeld test plans for validation of the capabilities and Technology Readiness Level (TRL) maturation toward infusion into potential near-term robotic lunar landing missions.

Tse, Teming↗

NASA NTRS2021

ICESat-2 Precision Orbit Determination

The ICESat-2 Precision Orbit Determination (POD) system computes the precise position of the laser altimeter instrument in inertial space, a measurement necessary for accurate geolocation of individual photon surface returns. ICESat-2 POD solutions are generated by the reduction of Global Positioning System (GPS) double-difference carrier phase observable residuals with NASA Goddard Space Flight Center's GEODYN software. Independent satellite laser ranging (SLR) measurements are withheld from the POD solutions and used as an independent arbiter of POD performance. Measurement model updates in the form of estimated GPS antenna phase center and satellite laser ranging retro-reflector tracking point offset vectors as well as a GPS antenna phase center variation map have led to significant improvement in POD performance. GPS residual analysis and orbit precision analysis show no significant anomalous temporal or geographic POD performance issues. The independent SLR residual analysis indicates that POD solutions have achieved a radial orbit accuracy just below 1.5 cm, thus exceeding the mission radial orbit accuracy requirement of 3.0 cm by more than a factor of 2. Future POD processing updates have been identified and will lead to even further improvements in POD performance.

T. C. Thomas↗

NASA NTRSDate not supplied

Improving Efficacy and Safety of Pharmacological Treatment Through Precision Medicine and Pharmacogenomics for Human Deep Space Exploration

INTRODUCTION: Future spaceflight will require increased crew medical autonomy as exploration class missions expanding duration and distance from Earth, especially for Mars missions. As mission duration increases, it will be even more essential to have appropriate amounts of effective medication to ensure the maintenance of crew health and performance. Conversely, mass and volume constraints will become more severe as future spaceflight expands beyond low Earth orbit, where resupply is difficult or becomes impossible. These constraints thus convey an urgency to further tailor medications included in the spacecraft formulary and increased examination of appropriate dosing regimens. BACKGROUND: Precision Health is an exciting area of cutting-edge research and medicine focused on maintaining an individual’s health and performance through in-depth understanding of an individual’s unique factors and molecular profiles. This approach can be adapted to better predict, monitor, and address physiological responses to the spaceflight environment. One example is the field of pharmacogenomics (PGX),the study of how the expressed genome impacts drug responses with the goal of prescribing the right dose of the right drug at the right time. Specifically, PGX testing provides valuable information on an individual’s precise allelic variations to guide physicians in making informed decisions on pharmaceutical choice and dosing to avoid adverse drug events and maximize pharmacological efficacy. The goal of this study was to evaluate which drugs in the current space pharmacy could be evaluated using PGX testing and to understand the potential impact on the health and wellness of the astronaut population. Additionally, we sought to evaluate clinically available FDA-approved PGX testing solutions to better understand its applicability. METHODS: A complete list of drugs onboard the International Space Station (ISS) was analyzed for risk and likelihood of drug failure and PGX actionability. This analysis encompassed both personal astronaut medications, including supplements and over the counter drugs (n=151) and ISS MedKit formulary medications (n=95). Duplicate medications and different formulations were removed, which resulted in 157 total drugs used in the subsequent analysis. A 5x5 risk assessment table was produced by examining the likelihood of drug failure compared to the consequence of drug failure. Likelihood of individual drug failure was defined by whether existing processes are sufficient to prevent adverse events, as ranked from 1 (very low, can easily be prevented) to 5 (very high, cannot be prevented) during a Mars mission. In contrast, the consequence of drug failure was defined by impact to safety, schedule, cost or technical and ranked from 1 (very low) to 5 (very high).A comprehensive assessment of commercially available PGX solutions is currently underway to evaluate specimen requirements, cost/benefit analysis (cost vs. number of alleles assessed), utility of variant analysis, relevance to inflight medication usage, quality of reporting in enabling clinical application, and ease of integration into electronic medical records. RESULTS: Risk assessments(LxC 5x5 table) indicated29medicationswere in the yellow or red zone driven predominantly by drug failure or safety concerns, with the remainder(n=128)of the medications in the green zone where risk is acceptable. We found that current PGX testing results could impact 21% of the total medications in the ISS MedKit and IMAK; of these, 9 medications currently have direct clinically actionable guidance available. Results of the clinical PGX solution evaluations as related to these medications will be presented. CONCLUSION: PGX testing has demonstrated clear benefits in terrestrial medicine and clinical environments for the selection of proper medications, avoiding adverse drug reactions, and maximizing drug efficacy. We propose that similar benefits would be bestowed on the astronaut and commercial spaceflight passenger population by performing preemptive pre-flight PGX testing to reduce risk of mission failure due to ineffective or toxic medications, improve targeting drug efficacy and safety, and further open the door to countermeasure research exploring PGX-related allelic variants. For example, PGX results could allow tailoring of specific medications at optimal doses more precisely to each individual astronaut, particularly in areas of space motion sickness, sleep aids, and analgesics. An additional benefit is that PGX results could provide information for better planning of the components of a space pharmacy for deep space missions to be more cost effective and more efficient in the utilization of limited pharmaceutical resources. Finally, while PGX testing of the astronaut corps is not currently conducted, this approach could provide immediate impact in support of mission success by reducing risks, optimizing astronaut performance, and providing valuable insights into long-term astronaut health. Such advancements in clinical decision making are important next steps in building dynamic individual risk profiles for astronauts, increasing crew autonomy and providing tailored countermeasures

Alice R W Tang↗

NASA NTRSDate not supplied

Implementation of a Six Degree of Freedom Precision Lunar Landing Algorithm Using Dual Quaternion Representation

In this study, a powered descent guidance algorithm using a unit dual quaternion represen- tation of the vehicle dynamics is implemented in a high-fidelity simulation and on representative flight hardware. This Dual-Quaternion Guidance (DQG) algorithm is applied to the precision lunar landing problem which levies complex constraints upon the trajectory, including state triggered attitude constraints to enable terrain-relative navigation and hazard detection as well as real-time requirements for landing site re-designation. The investigation explores DQG’s usefulness as a mission design tool as well as a real-time guidance algorithm and defines real-time performance requirements for the hazard detection and avoidance (HDA) re-targeting phase of precision lunar landing. The experiment is presented in two parts. First, DQG is implemented within a high-fidelity Monte Carlo simulation to tune the algorithm’s parameters for the simulated vehicle, to refine the mission design, and to develop guidance update timing requirements to perform the HDA maneuver. DQG generates trajectories online for the divert which are tracked by the vehicle’s inner-loop controllers to the targeted landing site. Second, DQG is run on representative hardware to demonstrate real-time operation through a divert maneuver. These results allow for rapid, flexible, optimal mission design satisfying complex constraints, and for the definition of real-time performance requirements for the HDA operations inherent in precision lunar landing. The HDA divert maneuver is found to require guidance trajectory updates in less than three seconds. DQG is found to be too slow to meet this update timing on the descent and landing computer (DLC) in its current implementation. DQG running on alternative hardware can meet the update rate requirement. Algorithm implementation improvements are also recommended which are expected to speed up computation sufficiently to meet requirements on the DLC.

GN&C↗

DOE OSTI2025

A High-Precision, Fast, Robust, and Cost-Effective Muon Detector Concept for the FCC-ee

We propose a high-precision, fast, robust and cost-effective muon detector concept for an FCC-ee experiment. This design combines precision drift tubes with fast plastic scintillator strips to enable both spatial and timing measurements. The drift tubes deliver two-dimensional position measurements perpendicular to the tubes with a resolution around 100~$\mu$m. Meanwhile, the scintillator strips, read out with the wavelength-shifting fibers and silicon photomultipliers, provide fast timing information with a precision of 200~ps or better and measure the third coordinate along the tubes with a resolution of about 1~mm.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

DOE OSTI2024

Precision Measurements of the Neutron Magnetic Form Factor to High Momentum Transfer using Durand's Method

Protons and neutrons, collectively known as nucleons, along with electrons, constitute the funda- mental building blocks of the visible universe. Understanding their internal structure is crucial for addressing key scientific questions about our origin and existence. Elastic electron-nucleon scatter- ing provides insights into the spatial distributions of charge and current within nucleons through their electromagnetic form factors. Accurate knowledge of these form factors over a broad range of Q2, the squared four-momentum transfer in the scattering process, reveals details about the nucleon’s internal structure. However, high-Q2 data of the nucleon electromagnetic form factor is scarce due to the challenges associated with such measurements. This thesis reports preliminary results from high-precision measurements of the neutron magnetic form factor (Gn M ) to unprecedented Q2 using Durand’s method, also known as the “ratio” method. Systematic errors are greatly reduced by extracting Gn M from the ratio of neutron-coincident (D(e, e'n)) to proton-coincident (D(e, e'p)) quasi-elastic electron scattering from deuteron. The scattered electrons were detected in the BigBite spectrometer, which features multiple Gas Elec- tron Multiplier (GEM) layers with large active area for high-precision tracking at very high rates. Simultaneous nucleon detection was performed by the Super BigBite spectrometer, which utilizes a dipole magnet with large solid angle acceptance at forward angles and a novel hadron calorimeter with very high and comparable detection efficiencies for both protons and neutrons. This setup could handle very high luminosity, making high-Q2 measurements feasible. Data were collected at five Q2 points: 3, 4.5, 7.4, 9.9, and 13.6 (GeV/c)2. Preliminary results are reported for all, with the lowest two Q2 points in good agreement with existing world data, while the higher points significantly extend the Q2 range in which Gn M is known accurately. The precision of the highest Q2 point is expected to remain unmatched for years to come.

Datta, Provakar↗

NASA NTRSDate not supplied

Development of a Coherent Doppler Lidar for Precision Landing on Planetary Bodies

A coherent Doppler lidar has been developed by NASA for providing vector velocity and altitude data to landing vehicles. Future robotic and manned missions to planetary bodies demand precise ground-relative velocity and altitude data to execute complex descent maneuvers for safe, soft and pinpoint landing at a pre-designated site. Operating from over five kilometers altitude, this lidar provides velocity and range data within a few cm/sec and a few meters precision, respectively, depending on the vehicle dynamics. Two upcoming lunar landing missions will serve as the technology demonstration for robotic and manned landing missions to the Moon, Mars, and other solar system destinations. This paper describes the lidar design and its expected performance on landing vehicles.

Coherent Laser Radar↗

NASA NTRSDate not supplied

Demonstration of Lidar Sensors for Precision Safe Landing on Planetary Bodies

Missions to solar system bodies must meet increasingly ambitious objectives requiring highly reliable “precision landing”, and “hazard avoidance” capabilities. To meet these needs, we have developed two lidar sensor systems that can be used individually or in concert depending on the mission requirements. One is Navigation Doppler Lidar (NDL) capable of providing vehicle precision vector velocity and ground-relative altitude and the other is an Imaging Flash Lidar for Terrain Relative Navigation and Hazard Detection and Avoidance. Using both lidar sensors together will enable landing anywhere and under any lighting condition. The NDL performance has been extensively characterized through numerous ground and aircraft flight tests and will be soon demonstrated on two lunar landing missions (mid-2023). The Flash Lidar performance is currently being assessed onboard a drone and will soon be tested on helicopter and fixed-wing aircraft platforms. This paper describes both lidar sensors and their expected operation on landing vehicles.

Precision Landing↗

DOE OSTI2025

Atomically Precise Nanoclusters as Co‐Catalysts for Light‐Activated Microswimmer Motility

Microswimmers are self-propelled particles that navigate fluid environments, offering significant potential for applications in environmental pollutant decomposition, biosensing, and targeted drug delivery. Their performance relies on engineered catalytic surfaces. Gold nanoclusters (AuNCs), with atomically precise structures, tunable optical properties, and high surface area-to-volume ratio, provide a new optimal catalyst for enhancing microswimmer propulsion. Unlike bulk gold or nanoparticles, AuNCs may deliver tunable photocatalytic activity and increased catalytic specificity, making them ideal co-catalysts for hybrid microswimmers. For the first time, this study combines AuNCs with TiO 2 /Cr 2 O 3 Janus microswimmers, combining the unique properties of both materials. This hybrid system capitalizes on the tuned optical properties of AuNCs and their role as co-catalysts with TiO 2 , driving enhanced photocatalytic performance under ultraviolet (UV) excitation. Using motion analysis, it is shown that the AuNC-microswimmers exhibit significantly greater propulsion and mean squared displacement (MSD) as compared to controls. These findings suggest that the integration of nanoclusters with semiconductor materials enables state of the art, light-switchable microswimmers. These AuNC-microswimmer systems may thus offer new opportunities for environmental catalysis and other applications, providing precise control over catalytic and motile behaviors at the microscale.

36 MATERIALS SCIENCE↗

DOE OSTI2025

Multi-physics melt pool modeling and process optimization for laser direct energy deposition of Nb-based refractory C103: Defect formation, geometric precision, and process mapping

Recent developments in additive manufacturing (AM) technology have reignited interest in the fabrication of the Nb-based refractory C103 alloy offering solutions to the challenges posed by traditional manufacturing methods. However, the limited numerical and experimental studies on laser direct energy deposition (DED) of C103 have hindered the understanding of the relationships between process parameters and build quality. This has made it challenging to consistently produce parts with the desired quality and microstructure suitable for critical applications. In this study, we focus on optimizing the laser DED process for C103 by employing a hybrid approach that combines experimental techniques and computational fluid dynamics (CFD). This approach facilitates the development of process maps for defect detection and geometric precision. To achieve this, multi-layer C103 samples were fabricated using laser DED under various process parameters, enabling the creation of a process map for defect detection. Additionally, a multi-physics, multiphase simulation framework was developed within a high-performance computing (HPC) environment to establish process maps for geometric precision. Using these process maps, printability windows were identified for achieving both the desired geometric accuracy and defect-free prints. It was observed that prints with a power-to-velocity (P/V) ratio close to unity resulted in defect-free outcomes. This study provides a foundation for reducing design lead time and rejected parts, ultimately optimizing the laser DED process for C103.

Defect formation and geometric precision↗

DOE OSTI2025

Assessing the Impact of Measurement Precision on Metabolite Identification Probability in Multidimensional Mass Spectrometry-Based, Reference-Free Metabolomics

Identification of compounds with minimal ambiguity remains a central challenge in mass spectrometry-based metabolomics. Conventional compound identification relies on comparing analytical signatures (e.g., mass-to-charge ratio, collision cross section, tandem mass spectra) against reference data obtained from measurements of authentic chemical standards. The breadth of annotatable compounds using this approach is necessarily limited by availability of authentic standards, analytical throughput, and resolving power of the separations that underly the measurements. The maturation of computational methods, both theory-driven and artificial intelligence/machine learning-based, for prediction of various molecular properties relevant to multidimensional mass spectrometry measurements has opened the door to a new “reference-free” paradigm of compound annotation. Through augmenting existing reference data for molecular properties with computational predictions, the universe of identifiable chemical species can be expanded significantly beyond its current limits. An unexplored aspect of this novel approach is understanding how to gauge confidence in resulting annotations, especially as the compound search space is expanded. Intuitively, the confidence of a compound annotation is related to the inherent discriminatory power of the molecular properties used for identification, as well as the precision with which the properties are measured or predicted. In this work, we characterize this relationship between measurement precision and identification probability in a systematic and quantitative fashion for a defined region of chemical space that includes organic small molecule metabolites. Importantly, this work establishes a framework for conducting metabolite identification probability analysis that enables others to quantify this relationship for their own compounds and properties of interest.

Metabolite Identification↗

DOE OSTI2026

Improving statistical precision in Monte Carlo samples with negative weights via reweighting and uncertainty quantification

High statistical precision is critical for Monte Carlo (MC) samples in high energy physics and is degraded by negatively weighted events. This paper investigates a procedure to learn the relationship between the negative and positive weight distributions of any sample, allowing the reduction of statistical uncertainty by reweighting kinematically equivalent events with the same sign. A robust uncertainty quantification method is required for the practical application of such method. Two methods for the estimation of the reweighting uncertainty are developed: one at the event and another one at the final observable level. The latter method is strongly favored. The gains in statistical precision are then quantified. The method is demonstrated on Sherpa vector boson plus jets samples when using all generated events and when restricted to the signal region of a mock analysis. It is demonstrated to significantly reduce stochastic behavior in sparse MC samples while decreasing the overall uncertainty with a sufficiently well-known reweighting function.

Monte Carlo methods↗

NASA NTRS2004

Improved DORIS accuracy for precise orbit determination and geodesy

In 2001 and 2002, 3 more DORIS satellites were launched. Since then, all DORIS results have been significantly improved. For precise orbit determination, 20 cm are now available in real-time with DIODE and 1.5 to 2 cm in post-processing. For geodesy, 1 cm precision can now be achieved regularly every week, making now DORIS an active part of a Global Observing System for Geodesy through the IDS.

IDS↗

NASA NTRS2014

Alternative Solvents and Technologies for Precision Cleaning of Aerospace Components

Precision cleaning solvents for aerospace components and oxygen fuel systems, including currently used Vertrel-MCA, have a negative environmental legacy, high global warming potential, and have polluted cleaning sites. Thus, alternative solvents and technologies are being investigated with the aim of achieving precision contamination levels of less than 1 mg/sq ft. The technologies being evaluated are ultrasonic bath cleaning, plasma cleaning and supercritical carbon dioxide cleaning.

Green solvents↗

NASA NTRS2018

The Design & Development of the Ocean Color Instrument Precision Superduplex Hybrid Bearing Cartridge

A high precision, high-resolution Ocean Color Imaging (OCI) instrument is under development for the Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission which requires a pair of medium speed mechanisms to scan the ocean surface continuously. The design of the rotating telescope (RT) mechanism operating at 360 RPM and the half-angle mirror (HAM) mechanism synchronized at 180 RPM was concern for maintaining pointing precision over the required life and continuous operations. An effort was undertaken with the manufacturer to design and analyze a special bearing configuration to minimize axial and radial runout, minimize torque, and maintain nominal contact stresses and stiffness over the operating temperature range and to maximize life. The bearing design, development effort, analysis and testing will be discussed as will the technical challenges that this specific design imposed upon the mechanism engineers. Bearing performance, runout as achieved and verified during encoder installation and operating torque will be described.

mechanism↗