Results for “PAINT” — Page 12

NASA NTRSDate not supplied

Joint Acceptance Attenuation Factor of Integrated Pressure with Unsteady Pressure-Sensitive Paint Measurements

The Unsteady Pressure-Sensitive Paint (uPSP) is widely used to measure the surface pressure of scaled models in wind tunnel tests. Compared to the conventional pressure transducers, uPSP has the advantage of high spatial resolution. With multiple high-speed Complementary Metal Oxide Superconductor (CMOS) cameras, the uPSP data collected with the camera pixels are mapped to the surface grid of the scaled model and converted to pressure. The shot noise is the dominant component of the noise in the uPSP measurement. The integrated pressure is usually computed on the grid nodes of a user-defined patch. The effect of shot noise is reduced in the integrated pressure on the patch; however, the measurement of the aerodynamic pressure may also be attenuated by the decorrelation of the flow pressure field being measured. This paper discusses the Joint Acceptance Attenuation Factor (JAAF) of the integrated pressure with uPSP measurements. The JAAF, a function of frequency, is defined as the ratio of the Power Spectral Density (PSD) of the integrated aerodynamic pressure on the patch to the average PSD of the aerodynamic pressure on the grid nodes of the patch. In this paper, the JAAF is investigated for the integrated pressure on rectangular patches, whose edges are defined in the direction along the streamline or across the streamline. Based on the assumption that the surface pressure field can be described by the Corcos model, the closed-form formulas to compute the JAAFs of the integrated pressure on the discrete grid nodes of a rectangular patch and over the continuous area of a rectangular patch are derived respectively. It is shown that the JAAF of the integrated pressure over the continuous area of a rectangular patch is the limit of that on discrete nodes of the rectangular patch when the number of nodes in each row or column goes to infinity. The closed-form formulas of the JAAF derived in this paper, with estimated parameters of the model, are verified with the measurements of the uPSP and the conventional pressure transducer collected in the Space Launch System Ascent Unsteady Aerodynamics Test at NASA Ames Research Center in November 2017. The closed-form formulas of the JAAF of the integrated pressure on the rectangular patches, based on the Corcos model, provide an efficient method to estimate the attenuation of integration by the decorrelation of the flow pressure field and set references for the comparison of the spectrum of the integrated uPSP measurements and the conventional pressure transducer measurements. The work described in this paper is a part of NASA’s development of a new state-of-the-art uPSP capability in production wind tunnels. Funding was provided by the NASA Aerosciences Evaluation and Test Capabilities Portfolio Office.

acoustics↗

NASA NTRSDate not supplied

Joint Acceptance Attenuation Factor of Integrated Pressure with Unsteady Pressure-Sensitive Paint Measurements

The Unsteady Pressure-Sensitive Paint (uPSP) is widely used to measure the surface pressure of scaled models in wind tunnel tests. Compared to the conventional pressure transducers, uPSP has the advantage of high spatial resolution. With multiple high-speed Complementary Metal Oxide Superconductor (CMOS) cameras, the uPSP data collected with the camera pixels are mapped to the surface grid of the scaled model and converted to pressure. The shot noise is the dominant component of the noise in the uPSP measurement. The integrated pressure is usually computed on the grid nodes of a user-defined patch. The effect of shot noise is reduced in the integrated pressure on the patch; however, the measurement of the aerodynamic pressure may also be attenuated by the decorrelation of the flow pressure field being measured. This paper discusses the Joint Acceptance Attenuation Factor (JAAF) of the integrated pressure with uPSP measurements. The JAAF, a function of frequency, is defined as the ratio of the Power Spectral Density (PSD) of the integrated aerodynamic pressure on the patch to the average PSD of the aerodynamic pressure on the grid nodes of the patch. In this paper, the JAAF is investigated for the integrated pressure on rectangular patches, whose edges are defined in the direction along the streamline or across the streamline. Based on the assumption that the surface pressure field can be described by the Corcos model, the closed-form formulas to compute the JAAFs of the integrated pressure on the discrete grid nodes of a rectangular patch and over the continuous area of a rectangular patch are derived respectively. It is shown that the JAAF of the integrated pressure over the continuous area of a rectangular patch is the limit of that on discrete nodes of the rectangular patch when the number of nodes in each row or column goes to infinity. The closed-form formulas of the JAAF derived in this paper, with estimated parameters of the model, are verified with the measurements of the uPSP and the conventional pressure transducer collected in the Space Launch System Ascent Unsteady Aerodynamics Test at NASA Ames Research Center in November 2017. The closed-form formulas of the JAAF of the integrated pressure on the rectangular patches, based on the Corcos model, provide an efficient method to estimate the attenuation of integration by the decorrelation of the flow pressure field and set references for the comparison of the spectrum of the integrated uPSP measurements and the conventional pressure transducer measurements. The work described in this paper is a part of NASA’s development of a new state-of-the-art uPSP capability in production wind tunnels. Funding was provided by the NASA Aerosciences Evaluation and Test Capabilities Portfolio Office.

acoustics↗

NASA NTRS2023

Improvement of Pressure Sensitive Paint in A Cryogenic Oxygen-Poor Environment

This report details specific improvements to the use of Pressure Sensitive Paint (PSP) in an oxygen-poor environment, with an emphasis on cryogenic PSP in the National Transonic Facility (NTF). For this work, several improvements to the application of PSP and data acquisition have been investigated in the 0.3-m Transonic Cryogenic Tunnel (generally considered a pilot facility for the NTF) and these results will be presented. In addition, several improvements to the existing PSP system at NTF are presented as well as a brief section on further improvements that can be investigated.

Cryogenic ground testing↗

NASA NTRSDate not supplied

Analysis of Dynamic Mode Decomposition Outputs of Unsteady Pressure-Sensitive Paint Measurements in the NASA Wind Tunnel Tests

This paper discusses the Dynamic Mode Decomposition (DMD) outputs of the Unsteady Pressure-Sensitive Paint (uPSP) measurements, which were collected with four Phantom high-speed cameras at a constant sample frequency in the Ascent Transient Aerodynamics Test (ATAT) of the Space Launch System (SLS) Block 1 cargo vehicle in the 11-by-11-foot transonic test section of the Unitary Plan Wind Tunnel (UPWT) at NASA Ames Research Center in September 2019. In this paper, the effectiveness to use the DMD outputs of uPSP measurements in the diagnosis and analysis of the aerodynamic and acoustic phenomena in the SLS ATAT is demonstrated. The work described in the paper is a part of NASA’s development of a new state-of-the-art uPSP capability in production wind tunnels. Funding was provided by the NASA Aerosciences Evaluation and Test Capabilities (AETC) Project.

acoustics↗

NASA NTRSDate not supplied

Aeroacoustic Analysis using Dynamic Mode Decomposition of Unsteady Pressure-Sensitive Paint Measurements

In this paper, we present a new method for the diagnosis and analysis of aeroacoustic phenomena. Taking advantage of the well-known property that the measurements of the Unsteady Pressure-Sensitive Paint (uPSP) have much higher spatial resolution compared to those of the conventional pressure transducers, the method is based on the visualization and analysis of the outputs of the Dynamic Mode Decomposition (DMD) of the uPSP measurements. The uPSP measurements were collected with four Phantom high-speed cameras in the Ascent Transient Aerodynamics Test (ATAT) of the Space Launch System (SLS) Block 1 cargo vehicle in the 11-by-11-foot transonic test section of the Unitary Plan Wind Tunnel (UPWT) at NASA Ames Research Center in September 2019. The method presented in this paper is demonstrated by investigating an interesting phenomenon observed in the SLS ATAT – the vortex shedding tone generated by the forward attachment of the Solid Rocket Booster (SRB). As examples, the DMD outputs of the uPSP measurements in a subsonic test in the SLS ATAT are presented. It is shown the information retrieved from the DMD outputs of the uPSP measurements can be effectively used in the identification and diagnosis of the aeroacoustic phenomena. The work described in this paper is a part of NASA’s development of a new state-of-the-art uPSP capability in production wind tunnels. Funding was provided by the NASA Aerosciences Evaluation and Test Capabilities Portfolio Office.

acoustics↗

NASA NTRSDate not supplied

NASA’s Unsteady Pressure-Sensitive Paint Phase I Development Overview

Since 2019, a group out of NASA Ames Research Center(ARC)has been focused on implementing systematic updates to make unsteady pressure-sensitive paint (uPSP) a more viable capability for production wind tunnel testing. Focusing on the general categories of data acquisition, data transfer, data processing, and data visualization, the uPSP Development Team has made several improvements to increase data quality and innovate a more workable system that would provide valuable surface pressure data to customers. As a result of the COVID-19 pandemic and several initial demonstration tests prior to the formal start of the development effort, the decision was made to focus on launch vehicles as the test article. To-date this development has focused on implementation in the ARC Unitary Plan Wind Tunnel 11-by11-footTransonic Wind Tunnel due to the large optical access of the test section and that the NASA Advanced Supercomputer is located at ARC. This paper summarizes the project origins and the results of four years of development effort, which will all culminate in a final demonstration test in the first half of2024.

unsteady pressure-sensitive paint↗

NASA NTRSDate not supplied

Aeroacoustic Analysis using Dynamic Mode Decomposition of Unsteady Pressure-Sensitive Paint Measurements

In this paper, we present a new method for the diagnosis and analysis of aeroacoustic phenomena. Taking advantage of the well-known property that the measurements of the Unsteady Pressure-Sensitive Paint (uPSP) have much higher spatial resolution compared to those of the conventional pressure transducers, the method is based on the visualization and analysis of the outputs of the Dynamic Mode Decomposition (DMD) of the uPSP measurements. The uPSP measurements were collected with four Phantom high-speed cameras in the Ascent Transient Aerodynamics Test (ATAT) of the Space Launch System (SLS) Block 1 cargo vehicle in the 11-by-11-foot transonic test section of the Unitary Plan Wind Tunnel (UPWT) at NASA Ames Research Center in September 2019. The method presented in this paper is demonstrated by investigating an interesting phenomenon observed in the SLS ATAT – the vortex shedding tone generated by the forward attachment of the Solid Rocket Booster (SRB). As examples, the DMD outputs of the uPSP measurements in a subsonic test in the SLS ATAT are presented. It is shown the information retrieved from the DMD outputs of the uPSP measurements can be effectively used in the identification and diagnosis of the aeroacoustic phenomena. The work described in this paper is a part of NASA’s development of a new state-of-the-art uPSP capability in production wind tunnels. Funding was provided by the NASA Aerosciences Evaluation and Test Capabilities Portfolio Office.

acoustics↗

NASA NTRSDate not supplied

Spatiotemporal Analysis of High-Resolution Pressure-Sensitive Paint Measurements on a Launch Vehicle Wind Tunnel Model

An accurate understanding of unsteady aerodynamic loads is critical for launch vehicle structural design and for development of the vibro-acoustic environment for payload components. Analysts commonly use point-wise surface pressure measurements from wind tunnel testing to build statistical models of the in-flight turbulent boundary layer flow structures, often extrapolating over large swaths of the surface due to measurement sparsity. We present novel results from a transonic wind tunnel test using fast-response pressure-sensitive paint (PSP) and show how it can be used to visualize and quantify localized turbulent boundary layer wall pressure statistics with unprecedented spatial resolution. The wind tunnel model is a scaled model of the Space Launch System (SLS) rocket Block 1B Crew configuration and analysis focused on the compression corner between the Service Module fairing and the Universal Stage Adapter.

Corcos Model↗

DOE OSTI2016

Painting Dose: The ART of Radiation

The discovery of X rays in 1895 captivated society like no other scientific advance. Radiation instantly became the subject not only of numerous scientific papers but also of circus bazaars, poetry, fiction, costume design, comics, and marketing for household items. Its spread was “viral.” What is not well known, however, is its incorporation into visual art, despite the long tradition of medicine and surgery as a subject in art. Using several contemporary search methods, we identified 5 examples of paintings or sculpture that thematically feature radiation therapy. All were by artists with exhibited careers in art: Georges Chicotot, Marcel Duchamp, David Alfaro Siqueiros, Robert Pope, and Cookie Kerxton. Each artist portrays radiation differently, ranging from traditional healer, to mysterious danger, to futuristic propaganda, to the emotional challenges of undergoing cancer therapy. This range captures the complex role of radiation as both a therapy and a hazard. Whereas some of these artists are now world famous, none of these artworks are as well known as their surgical counterparts. The penetration of radiation into popular culture was rapid and pervasive; yet, its role as a thematic subject in art never fully caught on, perhaps because of a lack of understanding of the technology, radiation's intangibility, or even a suppressive effect of society's ambivalent relationship with it. These 5 artists have established a rich foundation upon which pop culture and art can further develop with time to reflect the extraordinary progress of modern radiation therapy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2017

Predictors of Radiation Therapy–Related Gastrointestinal Toxicity From Anal Cancer Dose-Painted Intensity Modulated Radiation Therapy: Secondary Analysis of NRG Oncology RTOG 0529

Purpose: NRG Oncology RTOG 0529 assessed the feasibility of dose-painted intensity modulated radiation therapy (DP-IMRT) to reduce the acute morbidity of chemoradiation with 5-fluorouracil (5FU) and mitomycin-C (MMC) for T2-4N0-3M0 anal cancer. This secondary analysis was performed to identify patient and treatment factors associated with acute and late gastrointestinal (GI) adverse events (AEs). Methods and Materials: NRG Oncology RTOG 0529 treatment plans were reviewed to extract dose-volume data for tightly contoured small bowel, loosely contoured anterior pelvic contents (APC), and uninvolved colon outside the target volume (UC). Univariate logistic regression was performed to evaluate association between volumes of each structure receiving doses ≥5 to 60 Gy (V5-V60) in 5-Gy increments between patients with and without grade ≥2 acute and late GI AEs, and grade ≥3 acute GI AEs. Additional patient and treatment factors were evaluated in multivariate logistic regression (acute AEs) or Cox proportional hazards models (late AEs). Results: Among 52 evaluable patients, grade ≥2 acute, grade ≥2 late, and grade ≥3 acute GI AEs were observed in 35, 17, and 10 patients, respectively. Trends (P<.05) toward statistically significant associations were observed between grade ≥2 acute GI AEs and small bowel dose (V20-V40), grade ≥2 late GI AEs and APC dose (V60), grade ≥3 acute GI AEs and APC dose (V5-V25), increasing age, tumor size >4 cm, and worse Zubrod performance status. Small bowel volumes of 186.0 cc, 155.0 cc, 41.0 cc, and 30.4 cc receiving doses greater than 25, 30, 35, and 40 Gy, respectively, correlated with increased risk of acute grade ≥2 GI AEs. Conclusions: Acute and late GI AEs from 5FU/MMC chemoradiation using DP-IMRT correlate with radiation dose to the small bowel and APC. Such associations will be incorporated in the dose-volume normal tissue constraint design for future NRG oncology anal cancer studies.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2015

Dose painting to treat single-lobe prostate cancer with hypofractionated high-dose radiation using targeted external beam radiation: Is it feasible?

Targeted focal therapy strategies for treating single-lobe prostate cancer are under investigation. In this planning study, we investigate the feasibility of treating a portion of the prostate to full-dose external beam radiation with reduced dose to the opposite lobe, compared with full-dose radiation delivered to the entire gland using hypofractionated radiation. For 10 consecutive patients with low- to intermediate-risk prostate cancer, 2 hypofractionated, single-arc volumetric-modulated arc therapy (VMAT) plans were designed. The first plan (standard hypofractionation regimen [STD]) included the entire prostate gland, treated to 70 Gy delivered in 28 fractions. The second dose painting plan (DP) encompassed the involved lobe treated to 70 Gy delivered in 28 fractions, whereas the opposing, uninvolved lobe received 50.4 Gy in 28 fractions. Mean dose to the opposing neurovascular bundle (NVB) was considerably lower for DP vs STD, with a mean dose of 53.9 vs 72.3 Gy (p < 0.001). Mean penile bulb dose was 18.6 Gy for DP vs 19.2 Gy for STD (p = 0.880). Mean rectal dose was 21.0 Gy for DP vs 22.8 Gy for STD (p = 0.356). Rectum V{sub 70} (the volume receiving ≥70 Gy) was 2.01% for DP vs 2.74% for STD (p = 0.328). Bladder V{sub 70} was 1.69% for DP vs 2.78% for STD (p = 0.232). Planning target volume (PTV) maximum dose points were 76.5 and 76.3 Gy for DP and STD, respectively (p = 0.760). This study demonstrates the feasibility of using VMAT for partial-lobe prostate radiation in patients with prostate cancer involving 1 lobe. Partial-lobe prostate plans appeared to spare adjacent critical structures including the opposite NVB.

61 RADIATION PROTECTION AND DOSIMETRY↗

DOE OSTI2026

Fast baryonic field painting for Sunyaev-Zel’dovich analyses: Transfer function vs hybrid effective field theory

Here, we present two approaches for “painting” baryonic properties relevant to the Sunyaev-Zel’dovich (SZ) effect—optical depth and Compton-y—onto three-dimensional N-body simulations, using the MillenniumTNG suite as a benchmark. The goal of these methods is to produce fast and accurate reconstruction methods to aid future analyses of baryonic feedback using the SZ effect. The first approach employs a Gaussian process emulator to model the SZ quantities via a transfer function, while the second utilizes hybrid effective field theory (HEFT) to reproduce these quantities within the simulation. Our analysis involves comparing both methods to the true MillenniumTNG optical depth and Compton-y fields using several metrics, including the cross-correlation coefficient, power spectrum, and power spectrum error. Additionally, we assess how well the reconstructed fields correlate with dark matter haloes across various mass thresholds. The results indicate that the transfer function method yields more accurate reconstructions for fields with initially high correlations (r ≈ 1), such as between the optical depth and dark matter fields. Conversely, the HEFT-based approach proves more effective in enhancing correlations for fields with weaker initial correlations (r ∼ 0.5), such as between the Compton-y and dark matter fields. Lastly, we discuss extensions of our methods to improve the reconstruction performance at the field level.

Liu, R. Henry [University of California, Berkeley,↗

DOE OSTI2026

Demonstration of a Novel Phase-Space Painting Method in a Coupled Lattice to Mitigate Space Charge in High-Intensity Hadron Beams

Multiturn charge-exchange injection is the primary method of creating high-intensity hadron beams in circular accelerators, and phase space painting during injection enables tailoring of the accumulated phase space distribution. A technique we call eigenpainting allows injection of particles into a single mode of a coupled ring, providing full four-dimensional control of the phase space distribution. Under ideal conditions, uniform eigenpainting generates a linear-force equilibrium distribution in the transverse plane, with zero volume in four-dimensional transverse phase space, even including space charge. Here, we have implemented eigenpainting for the first time in the spallation neutron source accumulator ring. Injecting 8.8 μ⁢C of an 800 MeV beam, we obtain a final ratio of intrinsic transverse emittances of ≈2.4. We analyze the effect of space charge on the final distribution through comparison of the reconstructed phase space to particle-in-cell simulations.

Evans, Nicholas J. [Oak Ridge National Laboratory ↗

DOE OSTI2024

Conductive Spray Paint Fabricated Cylindrical Coplanar Waveguide for Noncontact Liquid-Level Sensing

A noncontact liquid-level sensor using a cylindrical coplanar waveguide (CCPW) is proposed. The concept is demonstrated using a prototype device made by directly spraying conductive paint on the outer surface of a glass cylinder. The position of the air–liquid interface is measured using the time-domain reflection (TDR) signal from the CCPW. The geometric parameters of the prototype sensor were optimized using a full-wave simulation tool. The experimental results show that the prototype CCPW-based liquid-level sensor has a resolution of 29.8μm over a range of 210 mm at the sweeping frequency bandwidth of 500 MHz–4 GHz. The tradeoff between the resolution and the measurement range was discussed. The proposed sensor provides a low-cost, easy-to-fabricate, and noncontact method for liquid-level measurement, which has potential applications in fuel storage, chemical production, and wastewater treatment.

42 ENGINEERING↗

DOE OSTI2013

Failure-probability driven dose painting

Purpose: To demonstrate a data-driven dose-painting strategy based on the spatial distribution of recurrences in previously treated patients. The result is a quantitative way to define a dose prescription function, optimizing the predicted local control at constant treatment intensity. A dose planning study using the optimized dose prescription in 20 patients is performed.Methods: Patients treated at our center have five tumor subvolumes from the center of the tumor (PET positive volume) and out delineated. The spatial distribution of 48 failures in patients with complete clinical response after (chemo)radiation is used to derive a model for tumor control probability (TCP). The total TCP is fixed to the clinically observed 70% actuarial TCP at five years. Additionally, the authors match the distribution of failures between the five subvolumes to the observed distribution. The steepness of the dose–response is extracted from the literature and the authors assume 30% and 20% risk of subclinical involvement in the elective volumes. The result is a five-compartment dose response model matching the observed distribution of failures. The model is used to optimize the distribution of dose in individual patients, while keeping the treatment intensity constant and the maximum prescribed dose below 85 Gy.Results: The vast majority of failures occur centrally despite the small volumes of the central regions. Thus, optimizing the dose prescription yields higher doses to the central target volumes and lower doses to the elective volumes. The dose planning study shows that the modified prescription is clinically feasible. The optimized TCP is 89% (range: 82%–91%) as compared to the observed TCP of 70%.Conclusions: The observed distribution of locoregional failures was used to derive an objective, data-driven dose prescription function. The optimized dose is predicted to result in a substantial increase in local control without increasing the predicted risk of toxicity.

61 RADIATION PROTECTION AND DOSIMETRY↗

DOE OSTI2014

SU-E-J-136: Multimodality-Image-Based Target Delineation for Dose Painting of Pancreatic Cancer

Purpose: Dose escalated RT may provide improved disease local-control for selected unresectable pancreatic cancer. Accurate delineation of the gross tumor volume (GTV) inside pancreatic head or body would allow safe dose escalation considering the tolerances of adjacent organs at risk (OAR). Here we explore the potential of multi-modality imaging (DCE-MRI, ADC-MRI, and FDG-PET) to define the GTV for dose painting of pancreatic cancer. Volumetric variations of DCE-MRI, ADC-MRI and FDG-PET defined GTVs were assessed in comparison to the findings on CT, and to pathology specimens for resectable and borderline reseactable cases of pancreatic cancer. Methods: A total of 19 representative patients with DCE-MRI, ADC-MRI and FDG-PET data were analyzed. Of these, 8 patients had pathological specimens. GTV, inside pancreatic head/neck, or body, were delineated on MRI (denoted GTVDCE, and GTVADC), on FDG-PET using SUV of 2.5, 40% SUVmax, and 50% SUVmax (denoted GTV2.5, GTV40%, and GTV50%). A Kruskal-Wallis test was used to determine whether significant differences existed between GTV volumes. Results: Significant statistical differences were found between the GTVs defined by DCE-MRI, ADC-MRI, and FDG-PET, with a mean and range of 4.73 (1.00–9.79), 14.52 (3.21–25.49), 22.04 (1.00–45.69), 19.10 (4.84–45.59), and 9.80 (0.32–35.21) cm3 (p<0.0001) for GTVDCE, GTVADC, GTV2.5, GTV40%, and GTV50%, respectively. The mean difference and range in the measurements of maximum dimension of GTVs based on DCE-MRI, ADC-MRI, SUV2.5, 40% SUVmax, and 50% SUVmax compared with pathologic specimens were −0.84 (−2.24 to 0.9), 0.41 (−0.15 to 2.3), 0.58 (−1.41 to 3.69), 0.66 (−0.67 to 1.32), and 0.15 (−1.53 to 2.38) cm, respectively. Conclusion: Differences exists between DCE, ADC, and PET defined target volumes for RT of pancreatic cancer. Further studies combined with pathological specimens are required to identify the optimal imaging modality and/or acquisition method to define the GTV.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2014

SU-E-T-182: Feasibility of Dose Painting by Numbers in Proton Therapy with Contour-Driven Plan Optimization

Purpose: The work aims to 1) prove the feasibility of dose painting by numbers (DPBN) in proton therapy with usual contour-driven plan optimization and 2) compare the achieved plan quality to that of rotational IMRT. Methods: For two patients with head and neck cancers, voxel-by-voxel prescription to the target volume (PTV-PET) was calculated from {sup 18} FDG-PET images and converted to contour-based prescription by defining several sub-contours. Treatments were planned with RayStation (RaySearch Laboratories, Sweden) and proton pencil beam scanning modality. In order to determine the optimal plan parameters to approach the DPBN prescription, the effect of the number of fields, number of sub-contours and use of range shifter were tested separately on each patient. The number of sub-contours were increased from 3 to 11 while the number of fields were set to 3, 5, 7 and 9. Treatment plans were also optimized on two rotational IMRT systems (TomoTherapy and Varian RapidArc) using previously published guidelines. Results: For both patients, more than 99% of the PTV-PET received at least 95% of the prescribed dose while less than 1% of the PTV-PET received more than 105%, which demonstrates the feasibility of the treatment. Neither the use of a range shifter nor the increase of the number of fields had a significant influence on PTV coverage. Plan quality increased when increasing number of fields up to 7 or 9 and slightly decreased for a bigger number of sub-contours. Good OAR sparing is achieved while keeping high plan quality. Finally, proton therapy achieved significantly better plan quality than rotational IMRT. Conclusion: Voxel-by-voxel prescriptions can be approximated accurately in proton therapy using a contour-driven optimization. Target coverage is nearly insensitive to the number of fields and the use of a range shifter. Finally, plan quality assessment confirmed the superiority of proton therapy compared to rotational IMRT.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2014

WE-E-BRE-04: Dual Focal Spot Dose Painting for Precision Preclinical Radiobiological Investigations

Purpose: Recent progress in small animal radiotherapy systems has provided the foundation for delivering the heterogeneous, millimeter scale dose distributions demanded by preclinical radiobiology investigations. Despite advances in preclinical dose planning, delivery of highly heterogeneous dose distributions is constrained by the fixed collimation systems and large x-ray focal spot common in small animal radiotherapy systems. This work proposes a dual focal spot dose optimization and delivery method with a large x-ray focal spot used to deliver homogeneous dose regions and a small focal spot to paint spatially heterogeneous dose regions. Methods: Two-dimensional dose kernels were measured for a 1 mm circular collimator with radiochromic film at 10 mm depth in a solid water phantom for the small and large x-ray focal spots on a recently developed small animal microirradiator. These kernels were used in an optimization framework which segmented a desired dose distribution into low- and high-spatial frequency regions for delivery by the large and small focal spot, respectively. For each region, the method determined an optimal set of stage positions and beam-on times. The method was demonstrated by optimizing a bullseye pattern consisting of 0.75 mm radius circular target and 0.5 and 1.0 mm wide rings alternating between 0 and 2 Gy. Results: Compared to a large focal spot technique, the dual focal spot technique improved the optimized dose distribution: 69.2% of the optimized dose was within 0.5 Gy of the intended dose for the large focal spot, compared to 80.6% for the dual focal spot method. The dual focal spot design required 14.0 minutes of optimization, and will require 178.3 minutes for automated delivery. Conclusion: The dual focal spot optimization and delivery framework is a novel option for delivering conformal and heterogeneous dose distributions at the preclinical level and provides a new experimental option for unique radiobiological investigations. Funding Support: this work is supported by funding the National Sciences and Engineering Research Council of Canada, and a Mitacs-accelerate fellowship. Conflict of Interest: Dr. Lindsay and Dr. Jaffray are listed as inventors of the small animal microirradiator described herein. This system has been licensed for commercial development.

60 APPLIED LIFE SCIENCES↗