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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 217 records · Page 12
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure

Nucleoprotein (NP) is a key structural protein of influenza ribonucleoprotein complexes and is central to viral RNA packing and trafficking. NP also determines the sensitivity of influenza to myxovirus resistance protein 1 (MxA), an innate immunity factor that restricts influenza replication. A few critical MxA-resistant mutations have been identified in NP, including the highly conserved proline-283 substitution. This essential proline-283 substitution impairs influenza growth, a fitness defect that becomes particularly prominent at febrile temperature (39°C) when host chaperones are depleted. Here, we biophysically characterize proline-283 NP and serine-283 NP to test whether the fitness defect is caused by the proline-283 substitution introducing folding defects. We show that the proline-283 substitution changes the folding pathway of NP, making NP more aggregation prone during folding, but does not alter the native structure of the protein. These findings suggest that influenza has evolved to hijack host chaperones to promote the folding of otherwise biophysically incompetent viral proteins that enable innate immune system escape.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2026

New approaches to Bayesian uncertainty quantification for Nuclear Science (Final Technical Report)

Inverse problems play a central role in experimentation and theory/data comparisons for many areas of modern Nuclear Physics (NP) and High-Energy Physics (HEP). Bayes’s Theorem is a powerful tool for solving Inverse Problems, providing conceptually transparent and unbiased constraints on theoretical parameters and their uncertainties (“Bayesian Inference”) and enabling the quantification of agreement or tension between models and data. However, analyses based on Bayesian Inference are often challenging for NP and HEP applications, either because of the large number of parameters in the problem, the high computational cost, or both. We propose a multi-institutional collaboration to develop and deploy novel Bayesian analysis tools that advance the scientific scope of a broad range of current and future NP experiments. This project brings together NP domain scientists working on several high-profile NP projects for which new, high-performance Bayesian Uncertainty Quantification (“Bayesian UQ”) methods are essential to carry out the science, and data scientists who are developing state-of-the-art methods applicable to these problems. The NP projects in this proposal comprise measurements of the mass and fundamental nature of the neutrino; study of the Quark-Gluon Plasma that filled the early universe; and mapping of natural and anthropogenic radiation environments. While these NP projects have very different scientific goals, with datasets and analysis approaches that differ significantly, they share common requirements for improving computationally intensive Bayesian analyses using advanced Machine Learning algorithms and will benefit strongly from a coherent effort to develop general solutions. This proposal brings together these projects and forefront ML-based data science algorithms to develop such general solutions. The methods developed in this project will also be more widely applicable, thereby advancing science in the larger Nuclear Physics portfolio.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2020

Materials Data on NpFe2 by Materials Project

NpFe2 is Cubic Laves structured and crystallizes in the cubic Fd-3m space group. The structure is three-dimensional. Np is bonded in a 12-coordinate geometry to four equivalent Np and twelve equivalent Fe atoms. All Np–Np bond lengths are 2.96 Å. All Np–Fe bond lengths are 2.84 Å. Fe is bonded to six equivalent Np and six equivalent Fe atoms to form a mixture of corner, edge, and face-sharing FeNp6Fe6 cuboctahedra. All Fe–Fe bond lengths are 2.42 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on Zr2Np by Materials Project

NpZr2 crystallizes in the hexagonal P6/mmm space group. The structure is three-dimensional. Np is bonded in a 2-coordinate geometry to two equivalent Np and twelve equivalent Zr atoms. Both Np–Np bond lengths are 2.81 Å. All Np–Zr bond lengths are 3.33 Å. Zr is bonded in a 11-coordinate geometry to six equivalent Np and five equivalent Zr atoms. There are two shorter (2.81 Å) and three longer (3.02 Å) Zr–Zr bond lengths.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on NpMn2 by Materials Project

NpMn2 is Cubic Laves structured and crystallizes in the cubic Fd-3m space group. The structure is three-dimensional. Np is bonded in a 12-coordinate geometry to four equivalent Np and twelve equivalent Mn atoms. All Np–Np bond lengths are 3.01 Å. All Np–Mn bond lengths are 2.88 Å. Mn is bonded to six equivalent Np and six equivalent Mn atoms to form a mixture of face, edge, and corner-sharing MnNp6Mn6 cuboctahedra. All Mn–Mn bond lengths are 2.46 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on NpGa2 by Materials Project

NpGa2 crystallizes in the hexagonal P6/mmm space group. The structure is three-dimensional. Np is bonded in a 12-coordinate geometry to two equivalent Np and twelve equivalent Ga atoms. Both Np–Np bond lengths are 2.88 Å. All Np–Ga bond lengths are 3.11 Å. Ga is bonded in a distorted q6 geometry to six equivalent Np and five equivalent Ga atoms. There are three shorter (2.76 Å) and two longer (2.88 Å) Ga–Ga bond lengths.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on NpSnIr by Materials Project

NpIrSn crystallizes in the hexagonal P-62m space group. The structure is three-dimensional. Np is bonded in a 11-coordinate geometry to five Ir and six equivalent Sn atoms. There are four shorter (3.01 Å) and one longer (3.06 Å) Np–Ir bond lengths. There are two shorter (3.18 Å) and four longer (3.35 Å) Np–Sn bond lengths. There are two inequivalent Ir sites. In the first Ir site, Ir is bonded in a 9-coordinate geometry to six equivalent Np and three equivalent Sn atoms. All Ir–Sn bond lengths are 2.81 Å. In the second Ir site, Ir is bonded in a 9-coordinate geometry to three equivalent Np and six equivalent Sn atoms. All Ir–Sn bond lengths are 2.76 Å. Sn is bonded in a 10-coordinate geometry to six equivalent Np and four Ir atoms.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on NpAl2 by Materials Project

NpAl2 is Cubic Laves structured and crystallizes in the cubic Fd-3m space group. The structure is three-dimensional. Np is bonded in a 12-coordinate geometry to four equivalent Np and twelve equivalent Al atoms. All Np–Np bond lengths are 3.36 Å. All Np–Al bond lengths are 3.21 Å. Al is bonded to six equivalent Np and six equivalent Al atoms to form a mixture of corner, edge, and face-sharing AlNp6Al6 cuboctahedra. All Al–Al bond lengths are 2.74 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on Np3Al by Materials Project

Np3Al is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Al atoms to form NpNp8Al4 cuboctahedra that share corners with twelve equivalent NpNp8Al4 cuboctahedra, edges with eight equivalent AlNp12 cuboctahedra, edges with sixteen equivalent NpNp8Al4 cuboctahedra, faces with four equivalent AlNp12 cuboctahedra, and faces with fourteen equivalent NpNp8Al4 cuboctahedra. All Np–Np bond lengths are 3.05 Å. All Np–Al bond lengths are 3.05 Å. Al is bonded to twelve equivalent Np atoms to form AlNp12 cuboctahedra that share corners with twelve equivalent AlNp12 cuboctahedra, edges with twenty-four equivalent NpNp8Al4 cuboctahedra, faces with six equivalent AlNp12 cuboctahedra, and faces with twelve equivalent NpNp8Al4 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on Np3Tl by Materials Project

Np3Tl is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Tl atoms to form NpNp8Tl4 cuboctahedra that share corners with twelve equivalent NpNp8Tl4 cuboctahedra, edges with eight equivalent TlNp12 cuboctahedra, edges with sixteen equivalent NpNp8Tl4 cuboctahedra, faces with four equivalent TlNp12 cuboctahedra, and faces with fourteen equivalent NpNp8Tl4 cuboctahedra. All Np–Np bond lengths are 3.29 Å. All Np–Tl bond lengths are 3.29 Å. Tl is bonded to twelve equivalent Np atoms to form TlNp12 cuboctahedra that share corners with twelve equivalent TlNp12 cuboctahedra, edges with twenty-four equivalent NpNp8Tl4 cuboctahedra, faces with six equivalent TlNp12 cuboctahedra, and faces with twelve equivalent NpNp8Tl4 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on Np3Sn by Materials Project

Np3Sn is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Sn atoms to form distorted NpNp8Sn4 cuboctahedra that share corners with twelve equivalent NpNp8Sn4 cuboctahedra, edges with eight equivalent SnNp12 cuboctahedra, edges with sixteen equivalent NpNp8Sn4 cuboctahedra, faces with four equivalent SnNp12 cuboctahedra, and faces with fourteen equivalent NpNp8Sn4 cuboctahedra. All Np–Np bond lengths are 3.25 Å. All Np–Sn bond lengths are 3.25 Å. Sn is bonded to twelve equivalent Np atoms to form SnNp12 cuboctahedra that share corners with twelve equivalent SnNp12 cuboctahedra, edges with twenty-four equivalent NpNp8Sn4 cuboctahedra, faces with six equivalent SnNp12 cuboctahedra, and faces with twelve equivalent NpNp8Sn4 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on Np3In by Materials Project

Np3In is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent In atoms to form distorted NpNp8In4 cuboctahedra that share corners with twelve equivalent NpNp8In4 cuboctahedra, edges with eight equivalent InNp12 cuboctahedra, edges with sixteen equivalent NpNp8In4 cuboctahedra, faces with four equivalent InNp12 cuboctahedra, and faces with fourteen equivalent NpNp8In4 cuboctahedra. All Np–Np bond lengths are 3.24 Å. All Np–In bond lengths are 3.24 Å. In is bonded to twelve equivalent Np atoms to form InNp12 cuboctahedra that share corners with twelve equivalent InNp12 cuboctahedra, edges with twenty-four equivalent NpNp8In4 cuboctahedra, faces with six equivalent InNp12 cuboctahedra, and faces with twelve equivalent NpNp8In4 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on TmNp3 by Materials Project

Np3Tm is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Tm atoms to form NpTm4Np8 cuboctahedra that share corners with twelve equivalent NpTm4Np8 cuboctahedra, edges with eight equivalent TmNp12 cuboctahedra, edges with sixteen equivalent NpTm4Np8 cuboctahedra, faces with four equivalent TmNp12 cuboctahedra, and faces with fourteen equivalent NpTm4Np8 cuboctahedra. All Np–Np bond lengths are 3.26 Å. All Np–Tm bond lengths are 3.26 Å. Tm is bonded to twelve equivalent Np atoms to form TmNp12 cuboctahedra that share corners with twelve equivalent TmNp12 cuboctahedra, edges with twenty-four equivalent NpTm4Np8 cuboctahedra, faces with six equivalent TmNp12 cuboctahedra, and faces with twelve equivalent NpTm4Np8 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on ErNp3 by Materials Project

Np3Er is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Er atoms to form NpEr4Np8 cuboctahedra that share corners with twelve equivalent NpEr4Np8 cuboctahedra, edges with eight equivalent ErNp12 cuboctahedra, edges with sixteen equivalent NpEr4Np8 cuboctahedra, faces with four equivalent ErNp12 cuboctahedra, and faces with fourteen equivalent NpEr4Np8 cuboctahedra. All Np–Np bond lengths are 3.32 Å. All Np–Er bond lengths are 3.32 Å. Er is bonded to twelve equivalent Np atoms to form ErNp12 cuboctahedra that share corners with twelve equivalent ErNp12 cuboctahedra, edges with twenty-four equivalent NpEr4Np8 cuboctahedra, faces with six equivalent ErNp12 cuboctahedra, and faces with twelve equivalent NpEr4Np8 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on HoNp3 by Materials Project

Np3Ho is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Ho atoms to form NpHo4Np8 cuboctahedra that share corners with twelve equivalent NpHo4Np8 cuboctahedra, edges with eight equivalent HoNp12 cuboctahedra, edges with sixteen equivalent NpHo4Np8 cuboctahedra, faces with four equivalent HoNp12 cuboctahedra, and faces with fourteen equivalent NpHo4Np8 cuboctahedra. All Np–Np bond lengths are 3.28 Å. All Np–Ho bond lengths are 3.28 Å. Ho is bonded to twelve equivalent Np atoms to form HoNp12 cuboctahedra that share corners with twelve equivalent HoNp12 cuboctahedra, edges with twenty-four equivalent NpHo4Np8 cuboctahedra, faces with six equivalent HoNp12 cuboctahedra, and faces with twelve equivalent NpHo4Np8 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on YNp3 by Materials Project

Np3Y is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Y atoms to form NpY4Np8 cuboctahedra that share corners with twelve equivalent NpY4Np8 cuboctahedra, edges with eight equivalent YNp12 cuboctahedra, edges with sixteen equivalent NpY4Np8 cuboctahedra, faces with four equivalent YNp12 cuboctahedra, and faces with fourteen equivalent NpY4Np8 cuboctahedra. All Np–Np bond lengths are 3.30 Å. All Np–Y bond lengths are 3.30 Å. Y is bonded to twelve equivalent Np atoms to form YNp12 cuboctahedra that share corners with twelve equivalent YNp12 cuboctahedra, edges with twenty-four equivalent NpY4Np8 cuboctahedra, faces with six equivalent YNp12 cuboctahedra, and faces with twelve equivalent NpY4Np8 cuboctahedra.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on PmNp by Materials Project

NpPm is Magnesium-derived structured and crystallizes in the hexagonal P-6m2 space group. The structure is three-dimensional. Np is bonded to six equivalent Np and six equivalent Pm atoms to form NpPm6Np6 cuboctahedra that share corners with eighteen equivalent NpPm6Np6 cuboctahedra, edges with six equivalent NpPm6Np6 cuboctahedra, edges with twelve equivalent PmPm6Np6 cuboctahedra, faces with eight equivalent NpPm6Np6 cuboctahedra, and faces with twelve equivalent PmPm6Np6 cuboctahedra. All Np–Np bond lengths are 3.37 Å. All Np–Pm bond lengths are 3.55 Å. Pm is bonded to six equivalent Np and six equivalent Pm atoms to form PmPm6Np6 cuboctahedra that share corners with eighteen equivalent PmPm6Np6 cuboctahedra, edges with six equivalent PmPm6Np6 cuboctahedra, edges with twelve equivalent NpPm6Np6 cuboctahedra, faces with eight equivalent PmPm6Np6 cuboctahedra, and faces with twelve equivalent NpPm6Np6 cuboctahedra. All Pm–Pm bond lengths are 3.37 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on GdNp3 by Materials Project

Np3Gd is Uranium Silicide structured and crystallizes in the cubic Pm-3m space group. The structure is three-dimensional. Np is bonded to eight equivalent Np and four equivalent Gd atoms to form NpGd4Np8 cuboctahedra that share corners with twelve equivalent NpGd4Np8 cuboctahedra, edges with eight equivalent GdNp12 cuboctahedra, edges with sixteen equivalent NpGd4Np8 cuboctahedra, faces with four equivalent GdNp12 cuboctahedra, and faces with fourteen equivalent NpGd4Np8 cuboctahedra. All Np–Np bond lengths are 3.26 Å. All Np–Gd bond lengths are 3.26 Å. Gd is bonded to twelve equivalent Np atoms to form GdNp12 cuboctahedra that share corners with twelve equivalent GdNp12 cuboctahedra, edges with twenty-four equivalent NpGd4Np8 cuboctahedra, faces with six equivalent GdNp12 cuboctahedra, and faces with twelve equivalent NpGd4Np8 cuboctahedra.

36 MATERIALS SCIENCE↗