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At least 217 records · Page 12
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

New approach to terahertz diagnostics of human psychoemotional state

A new approach to terahertz (THz) diagnostics of the human psychoemotional state is proposed, based on the analysis of the THz contribution to the total signal while simultaneously recording the IR and THz emissions from the human body (hereinafter referred to as the IR – THz image). The developed image-processing algorithm allows extraction of the informative contribution determined by the THz radiation from the total signal perceived by the recording system. Simultaneous registration of the IR – THz images of the human face and the psychophysiological indicators are carried out in situations of physical stress (short-term intense physical exercise – squats functional test), electrical stimulation, and information stress (cognitive load – simple arithmetic mental calculations). The obtained data are compared with those of similar measurements at rest. It is shown that using cluster analysis of IR – THz images it is possible to divide the test subjects into classes according to the type of reaction of the circulatory system under stressful conditions. (paper)

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2013

NEW TECHNIQUES FOR HIGH-CONTRAST IMAGING WITH ADI: THE ACORNS-ADI SEEDS DATA REDUCTION PIPELINE

We describe Algorithms for Calibration, Optimized Registration, and Nulling the Star in Angular Differential Imaging (ACORNS-ADI), a new, parallelized software package to reduce high-contrast imaging data, and its application to data from the SEEDS survey. We implement several new algorithms, including a method to register saturated images, a trimmed mean for combining an image sequence that reduces noise by up to {approx}20%, and a robust and computationally fast method to compute the sensitivity of a high-contrast observation everywhere on the field of view without introducing artificial sources. We also include a description of image processing steps to remove electronic artifacts specific to Hawaii2-RG detectors like the one used for SEEDS, and a detailed analysis of the Locally Optimized Combination of Images (LOCI) algorithm commonly used to reduce high-contrast imaging data. ACORNS-ADI is written in python. It is efficient and open-source, and includes several optional features which may improve performance on data from other instruments. ACORNS-ADI requires minimal modification to reduce data from instruments other than HiCIAO. It is freely available for download at www.github.com/t-brandt/acorns-adi under a Berkeley Software Distribution (BSD) license.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

The simulation of 3D mass models in 2D digital mammography and breast tomosynthesis

Purpose: This work proposes a new method of building 3D breast mass models with different morphological shapes and describes the validation of the realism of their appearance after simulation into 2D digital mammograms and breast tomosynthesis images. Methods: Twenty-five contrast enhanced MRI breast lesions were collected and each mass was manually segmented in the three orthogonal views: sagittal, coronal, and transversal. The segmented models were combined, resampled to have isotropic voxel sizes, triangularly meshed, and scaled to different sizes. These masses were referred to as nonspiculated masses and were then used as nuclei onto which spicules were grown with an iterative branching algorithm forming a total of 30 spiculated masses. These 55 mass models were projected into 2D projection images to obtain mammograms after image processing and into tomographic sequences of projection images, which were then reconstructed to form 3D tomosynthesis datasets. The realism of the appearance of these mass models was assessed by five radiologists via receiver operating characteristic (ROC) analysis when compared to 54 real masses. All lesions were also given a breast imaging reporting and data system (BIRADS) score. The data sets of 2D mammography and tomosynthesis were read separately. The Kendall's coefficient of concordance was used for the interrater observer agreement assessment for the BIRADS scores per modality. Further paired analysis, using the Wilcoxon signed rank test, of the BIRADS assessment between 2D and tomosynthesis was separately performed for the real masses and for the simulated masses. Results: The area under the ROC curves, averaged over all observers, was 0.54 (95% confidence interval [0.50, 0.66]) for the 2D study, and 0.67 (95% confidence interval [0.55, 0.79]) for the tomosynthesis study. According to the BIRADS scores, the nonspiculated and the spiculated masses varied in their degrees of malignancy from normal (BIRADS 1) to highly suggestive for malignancy (BIRADS 5) indicating the required variety of shapes and margins of these models. The assessment of the BIRADS scores for all observers indicated good agreement based on Kendall's coefficient for both the 2D and the tomosynthesis evaluations. The paired analysis of the BIRADS scores between 2D and tomosynthesis for each observer revealed consistent behavior for the real and simulated masses. Conclusions: A database of 3D mass models, with variety of shapes and margins, was validated for the realism of their appearance for 2D digital mammography and for breast tomosynthesis. This database is suitable for use in future observer performance studies whether in virtual clinical trials or in patient images with simulated lesions.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

SU-D-201-03: Imaging Cellular Pharmacokinetics of 18F-FDG in Inflammatory/Stem Cells

Purpose: Atherosclerosis is a progressive inflammatory condition that underlies coronary artery disease (CAD)—the leading cause of death in the USA. Thus, understating the metabolism of inflammatory cells can be a valuable tool for investigating CAD. To the best of our knowledge, we are the first to successfully investigate the pharmacokinetics of [18F]fluoro-deoxyglucose (18F-FDG) uptake in a single macrophages and compared with induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) with a novel imaging technique, radioluminescence microscopy, initially developed for cancer imaging. Methods: Live cells were cultured sparsely on Matrigel in a glass-bottom dish and starved for 1 hour before incubation with 250 microCi of 18F-FDG for 45 minutes. Excess radiotracer was removed using DMEM medium without glucose. Before imaging, DMEM (1 mL) was added to the cell culture and a 100 microm-thin CdWO4 scintillator plate was placed on top of the cells. Light produced following beta decay was imaged with a highly sensitive inverted microscope (LV200, Olympus) fitted with a 40x/1.3 high-NA oil objective, and an EM-CCD camera. The images were collected over 18,000 frames with 4×4 binning (1200 MHz EM Gain, 300ms exposure). Custom-written software was developed in MATLAB for image processing (Figure 1). For statistical analysis 10 different region-of-interests (ROIs) were selected for each cell type. Results: Figures 2A–2B show bright-field/fusion images for all three different cell types. The relationship between cell-to-cell comparisons was found to be linear for macrophages unlike iPSCs and MSCs, which were best fitted with moving or rolling average (Figure 2C). The average observed decay of 18F-FDG in a single cell of MSCs per second (0.067) was 20% and 36% higher compared to iPSCs (0.054) and macrophages (0.043), respectively (Figure 2D). Conclusion: MSCs was found to be 2–3x more sensitive to glucose molecule despite constant parameters for each cell type examined.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2026

Evaluation of sucrose crystallization kinetics using confocal microscopy: Determining differences in sucrose crystallization kinetics between single and polycrystal studies

Sucrose solution crystal growth kinetics are dependent on temperature, concentration, and impurities. A double polarized confocal microscopy system was used to obtain photographs with high contrast between growing crystals and the background for color background removal image processing. Seeded solutions of 72 wt% sucrose at 27, 35, 45, and 55°C were compared for single and polycrystals. Polycrystal analysis was determined to offer more rapid image processing and to be more applicable to systems in real operating conditions, while single-crystal analysis was determined to give more comprehensive descriptions of individual crystal behavior at the cost of slower processing.

36 MATERIALS SCIENCE↗
DOE OSTI2014

SU-E-J-47: Development of a High-Precision, Image-Guided Radiotherapy, Multi- Purpose Radiation Isocenter Quality-Assurance Calibration and Checking System

Purpose: To develop a system that can define the radiation isocenter and correlate this information with couch coordinates, laser alignment, optical distance indicator (ODI) settings, optical tracking system (OTS) calibrations, and mechanical isocenter walkout. Methods: Our team developed a multi-adapter, multi-purpose quality assurance (QA) and calibration device that uses an electronic portal imaging device (EPID) and in-house image-processing software to define the radiation isocenter, thereby allowing linear accelerator (Linac) components to be verified and calibrated. Motivated by the concept that each Linac component related to patient setup for image-guided radiotherapy based on cone-beam CT should be calibrated with respect to the radiation isocenter, we designed multiple concentric adapters of various materials and shapes to meet the needs of MV and KV radiation isocenter definition, laser alignment, and OTS calibration. The phantom's ability to accurately define the radiation isocenter was validated on 4 Elekta Linacs using a commercial ball bearing (BB) phantom as a reference. Radiation isocenter walkout and the accuracy of couch coordinates, ODI, and OTS were then quantified with the device. Results: The device was able to define the radiation isocenter within 0.3 mm. Radiation isocenter walkout was within ±1 mm at 4 cardinal angles. By switching adapters, we identified that the accuracy of the couch position digital readout, ODI, OTS, and mechanical isocenter walkout was within sub-mm. Conclusion: This multi-adapter, multi-purpose isocenter phantom can be used to accurately define the radiation isocenter and represents a potential paradigm shift in Linac QA. Moreover, multiple concentric adapters allowed for sub-mm accuracy for the other relevant components. This intuitive and user-friendly design is currently patent pending.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2020

The updated DESGW processing pipeline for the third LIGO/VIRGO observing run

The DESGW group seeks to identify electromagnetic counterpartsof gravitational wave events seen by the LIGO-VIRGO network, such as thoseexpected from binary neutron star mergers or neutron star- black hole mergers.DESGW was active throughout the first two LIGO observing seasons, followingup several binary black hole mergers and the first binary neutron star merger,GW170817. We describe the modifications to the observing strategy generationand image processing pipeline between the second (ending in August 2017)and third (beginning in April 2019) LIGO observing seasons. The modifica-tions include a more robust observing strategy generator, further parallelizationof the image reduction software and dierence imaging processing pipeline,data transfer streamlining, and a web page listing identified counterpart candi-dates that updates in real time. Taken together, the additional parallelizationsteps enable us to identify potential electromagnetic counterparts within fullycalibrated search images in less than one hour, compared to the 3-5 hours itwould typically take during the first two seasons. These performance improve-ments are critical to the entire EM followup community, as rapid identification(or rejection) of candidates enables detailed spectroscopic followup by multipleinstruments as soon as possible, leading to more information about the environ-ment immediately following such gravitational wave events.

Herner, Kenneth R.↗
DOE OSTI2019

The Updated DESGW Processing Pipeline for the Third LIGO/VIRGO Observing Run

The DESGW group seeks to identify electromagnetic counterparts of gravitational wave events seen by the LIGO-VIRGO network, such as those expected from binary neutron star mergers or neutron star- black hole mergers. DESGW was active throughout the first two LIGO observing seasons, following up several binary black hole mergers and the first binary neutron star merger, GW170817. We describe the modifications to the observing strategy generation and image processing pipeline between the second (ending in August 2017) and third (beginning in April 2019) LIGO observing seasons. The modifications include a more robust observing strategy generator, further parallelization of the image reduction software and difference imaging processing pipeline, data transfer streamlining, and a public webpage listing identified counterpart candidates that updates in real time. Taken together, the additional parallelization steps enable us to identify potential electromagnetic counterpa rts within fully calibrated search images in less than one hour, compared to the 3-5 hours it would typically take during the first two seasons. These performance improvements are critical to the entire EM followup community, as rapid identification (or rejection) of candidates enables detailed spectroscopic followup by multiple instruments as soon as possible, leading to more information about the environment immediately following such gravitational wave events.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2019

Nanoscale Resolution 3D Snapshot Particle Tracking by Multifocal Microscopy

Accurate, precise, and rapid particle tracking in three dimensions remains a challenge; yet, its achievement will significantly enhance our understanding of living systems. We developed a multifocal microscopy (MFM) that allows snapshot acquisition of the imaging data, and an associated image processing approach, that together allow simultaneous 3D tracking of many fluorescent particles with nanoscale resolution. The 3D tracking was validated by measuring a known trajectory of a fluorescent bead with an axial accuracy of 19 nm through an image depth (axial range) of 3 pm and 4 nm precision of axial localization through an image depth of 4 pm. A second test obtained a uniform axial probability distribution and Brownian dynamics of beads diffusing in solution. We also validated the MFM approach by imaging fluorescent beads immobilized in gels and comparing the 3D localizations to their "ground truth" positions obtained from a confocal microscopy z-stack of finely spaced images. Finally, we applied our MFM and image processing approach to obtain 3D trajectories of insulin granules in pseudoislets of MIN6 cells to demonstrate its compatibility with complex biological systems. Our study demonstrates that multifocal microscopy allows rapid (video rate) and simultaneous 3D tracking of many "particles" with nanoscale accuracy and precision in a wide range of systems, including over spatial scales relevant to whole live cells.

3D Tracking↗
DOE OSTI2022

Data Mining – Image Analysis of Radiography for Zr Redistribution

The research effort described in this report represents a first attempt to investigate the radial redistribution of Zr in ternary fuel alloys U-xPu-10Zr (x = 0, 8, 19) irradiated in the in-reactor fuel experiments during the operation of the U.S. Department of Energy’s (DOE’s) Experimental Breeder Reactor II (EBR-II) at Idaho National Laboratory (INL) using methods of image processing on post-irradiation neutron radiographs. Approximately 130,000 metal fuel pins were irradiated in EBR-II during its 30 years of operation to develop and characterize existing and prospective fuels. For many of the metal fuel irradiation experiments, neutron radiography imaging was performed historically now allowing application of modern image analysis techniques to characterize fuel behavior, such as fuel swelling, fluff formation, and now, fuel alloy constituent redistribution. The redistribution of fuel components depends on the temperature field, radially, within the fuel. Specifically, Zr is expected to redistribute radially towards the center of the pin, as well as towards the outer zones. Currently, direct imaging of a pin cross-section through optical methods or scanning electron microscopy (SEM) is used to study the constituents’ redistribution, which is very time-consuming and can only be applied to a limited number of pins. An automated image processing technique allowing for the investigation of fuel radial redistribution zones would significantly accelerate data analysis. In general, if the fuel temperature is hot enough, three redistribution zones are expected, corresponding to the main fuel components (e.g., U, Pu, Zr). While more assessment will be performed in fiscal year (FY)-2023, it seems possible to differentiate the pins according to their fuel composition using image analysis techniques on neutron radiographs of metallic fuel pins based on the analysis to date.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2015

SU-E-T-65: A Prospective Trial of Open Face Masks for Head and Neck Radiotherapy

Purpose: Open face head and neck masks allow for active patient monitoring during treatment and may reduced claustrophobia and anxiety compared to closed masks. The ability of open masks to limit intrafraction motion and to preserve the patient shape/position from simulation over protracted treatments should be considered. Methods: Thirty-two head and neck patients were prospectively randomized to treatment in a closed mask or a novel open face mask. All patients received daily volumetric imaging. The daily images were automatically rigidly registered to the planning CT’s offline using a commercial image processing tool. The shifts needed to optimize the registration, the mutual information coefficient (MI), and the Pearson correlation (PC) coefficients were recorded to evaluate shape preservation. The open group was set-up and monitored with surface imaging at treatment. The real time surface imaging information was recorded to evaluate intrafraction motion. Results: Sixteen patients were included in each group. Evaluations were made over a total of 984 fractions. The mean MI and PC showed significantly higher shape preservation for the open group than for the closed group (p = 0). The mean rotations for the open group were smaller or < 0.15° larger versus the closed group. The mean intrafraction motion for the open group was 0.93 +/−0.99 mm (2 SD). The maximum single fraction displacement was 3.2 mm. Fourteen of 16 patients showed no significant correlation of motion with fraction number (p > 0.05). Conclusion: The open masks preserved shape as well as the closed masks, and they limited motion to < 2 mm for 95% of the treated fractions. These results are consistent over treatment courses of up to 35 fractions. The open mask is suitable for treatment with or without active monitoring. This work was partially supported by Qfix.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

A method for normalizing pathology images to improve feature extraction for quantitative pathology

Purpose: With the advent of digital slide scanning technologies and the potential proliferation of large repositories of digital pathology images, many research studies can leverage these data for biomedical discovery and to develop clinical applications. However, quantitative analysis of digital pathology images is impeded by batch effects generated by varied staining protocols and staining conditions of pathological slides. Methods: To overcome this problem, this paper proposes a novel, fully automated stain normalization method to reduce batch effects and thus aid research in digital pathology applications. Their method, intensity centering and histogram equalization (ICHE), normalizes a diverse set of pathology images by first scaling the centroids of the intensity histograms to a common point and then applying a modified version of contrast-limited adaptive histogram equalization. Normalization was performed on two datasets of digitized hematoxylin and eosin (H&E) slides of different tissue slices from the same lung tumor, and one immunohistochemistry dataset of digitized slides created by restaining one of the H&E datasets. Results: The ICHE method was evaluated based on image intensity values, quantitative features, and the effect on downstream applications, such as a computer aided diagnosis. For comparison, three methods from the literature were reimplemented and evaluated using the same criteria. The authors found that ICHE not only improved performance compared with un-normalized images, but in most cases showed improvement compared with previous methods for correcting batch effects in the literature. Conclusions: ICHE may be a useful preprocessing step a digital pathology image processing pipeline.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2024

The Tiny Median Filter: A Small Size, Flexible Arbitrary Percentile Finder Scheme Suitable for FPGA Implementation

This document reports the design, implementation and testing of a small silicon resource usage, very flexible arbitrary percentile finding scheme called the Tiny Median Filter. It can be used not only as a median filter in image processing with square filtering windows, but also for applications of any percentile filter or maximum or minimum finder with any size of data set as long as the number of bits of the data is finite. It opens possibilities for image processing tasks with non-square or irregular filter windows. In this scheme, data swapping or data bit manipulating are avoided and high functional efficiency of the logic components is applied to save silicon resources. Some logic functions are absorbed into other functions to further reduce the complexity. The combinational logic paths are designed to be sufficiently short so that the firmware can be compiled to the maximum operating frequency allowed by the block memories of the FPGA devices. The Tiny Median Filter receives, processes and output data in non-stop manner with no irregular timing which helps to simplify design of surrounding stages.

Wu, Jinyuan [Fermilab] (ORCID:0000000344329521)↗
DOE OSTI2015

STRUCTURE AND DYNAMICS OF THE 2012 NOVEMBER 13/14 ECLIPSE WHITE-LIGHT CORONA

Continuing our series of observations of coronal motion and dynamics over the solar-activity cycle, we observed from sites in Queensland, Australia, during the 2012 November 13 (UT)/14 (local time) total solar eclipse. The corona took the low-ellipticity shape typical of solar maximum (flattening index ε = 0.01), a change from the composite coronal images we observed and analyzed in this journal and elsewhere for the 2006 and 2008-2010 eclipses. After crossing the northeast Australian coast, the path of totality was over the ocean, so further totality was seen only by shipborne observers. Our results include velocities of a coronal mass ejection (CME; during the 36 minutes of passage from the Queensland coast to a ship north of New Zealand, we measured 413 km s{sup –1}) and we analyze its dynamics. We discuss the shapes and positions of several types of coronal features seen on our higher-resolution composite Queensland coronal images, including many helmet streamers, very faint bright and dark loops at the bases of helmet streamers, voids, and radially oriented thin streamers. We compare our eclipse observations with models of the magnetic field, confirming the validity of the predictions, and relate the eclipse phenomenology seen with the near-simultaneous images from NASA's Solar Dynamics Observatory (SDO/AIA), NASA's Extreme Ultraviolet Imager on Solar Terrestrial Relations Observatory, ESA/Royal Observatory of Belgium's Sun Watcher with Active Pixels and Image Processing (SWAP) on PROBA2, and Naval Research Laboratory's Large Angle and Spectrometric Coronagraph Experiment on ESA's Solar and Heliospheric Observatory. For example, the southeastern CME is related to the solar flare whose origin we trace with a SWAP series of images.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2013

Radial differential interior tomography and its image reconstruction with differentiated backprojection and projection onto convex sets

Purpose: Interior tomography has been recognized as one of the most effective approaches in computed tomography (CT) to reduce radiation dose rendered to patients. In this work, the authors propose and evaluate an imaging method of radial differential interior tomography.Methods: In interior tomography, an x-ray beam is collimated to only irradiate the region of interest (ROI) with suspected lesions while the surrounding area/volume of normal tissues/organs is spared. In the proposed imaging method of radial differential interior tomography, the outcome is a ROI image that has gone through a radial differential filtering. The image reconstruction algorithm for the radial differential interior tomography is kept in the fashion of differentiated backprojection and projection onto convex sets, but the required a priori knowledge in a small round area becomes zero and may be more readily available in practice.Results: Using the projection data simulated by computer and acquired by CT scanner, the authors evaluate and verify the performance of the proposed radial differential interior tomography method and its associated image reconstruction algorithm. The preliminary results show that the proposed imaging method can generate an image that is the radial differentiation of a conventional tomographic image and is robust over noise that inevitably exist in practice.Conclusions: It is believed that the proposed imaging method may find its utility in advanced clinical applications wherein a ROI-based image processing and analysis is required for lesion visualization, characterization, and diagnosis.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2015

CHARACTERIZING THE ATMOSPHERES OF THE HR8799 PLANETS WITH HST/WFC3

We present results from a Hubble Space Telescope (HST) program characterizing the atmospheres of the outer two planets in the HR8799 system. The images were taken over 15 orbits in three near-infrared (near-IR) medium-band filters—F098M, F127M, and F139M—using the Wide Field Camera 3. One of the three filters is sensitive to a water absorption band inaccessible from ground-based observations, providing a unique probe of the thermal emission from the atmospheres of these young giant planets. The observations were taken at 30 different spacecraft rolls to enable angular differential imaging (ADI), and the full data set was analyzed with the Karhunen–Loéve Image Projection routine, an advanced image processing algorithm adapted to work with HST data. To achieve the required high contrast at subarcsecond resolution, we utilized the pointing accuracy of HST in combination with an improved pipeline designed to combine the dithered ADI data with an algorithm designed to both improve the image resolution and accurately measure the photometry. The results include F127M (J) detections of the outer planets, HR8799b and c, and the first detection of HR8799b in the water-band (F139M) filter. The F127M photometry for HR8799c agrees well with fitted atmospheric models, resolving the longstanding difficulty in consistently modeling the near-IR flux of the planet.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2020

The application of synchrotron micro-computed tomography to characterize the three-dimensional microstructure in irradiated nuclear fuel

This research demonstrated the first time that synchrotron X-ray micro-computed tomography (μ-CT) was utilized to analyze the three-dimensional (3-D) morphology of the microstructure of irradiated nuclear fuel. Both absorption contrast and propagation-based phase contrast enhanced μ-CT techniques were evaluated. Porosity and phase region volumes were determined in neutron irradiated uranium 10 wt.% zirconium (U-10Zr) using propagation-based phase contrast enhanced μ-CT. Volumes were determined by image processing software and algorithms, with the porosity volume subsequently compared to the ASTM E562 method. The 3-D porosity of a small region (~ 8 x 10 5 µm 3 ) located in the intermediate fuel redistribution zone that was removed via a focused ion beam was determined to be 7.2% via image processing. A detailed 3-D analysis of the porosity with respect to volume and morphology was provided. Five growth stages of pore evolution were observed including: nucleation, growth, coalescence, interconnected porosity, and extended/interconnected porosity. Four distinct phase regions were identified, including the pores, via both absorption contrast and propagation-based phase contrast enhanced μ-CT. A quantitative comparison of fuel swelling between this localized microscopic U-10Zr fuel region, previously irradiated in the Fast Flux Test Facility, and historic U-10Zr fuels irradiated in the Experimental Breeder Reactor-II (EBR-II) was conducted. It was determined that for similar burnups, the localized swelling in this microscopic fuel region was 7.7%, which was approximately one-half of the value of the macroscopic swelling reported in EBR-II irradiated fuel. With the advent of new specimen preparation tools for irradiated materials, as well as advances in characterization techniques, researchers can now obtain previously inaccessible microstructural insight into irradiated fuels. This possibility naturally lends itself to improved fuel performance models for the nuclear community.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2015

Benefits of utilizing CellProfiler as a characterization tool for U–10Mo nuclear fuel

Automated image processing techniques have the potential to aid in the performance evaluation of nuclear fuels by eliminating judgment calls that may vary from person-to-person or sample-to-sample. Analysis of in-core fuel performance is required for design and safety evaluations related to almost every aspect of the nuclear fuel cycle. This study presents a methodology for assessing the quality of uranium–molybdenum fuel images and describes image analysis routines designed for the characterization of several important microstructural properties. The analyses are performed in CellProfiler, an open-source program designed to enable biologists without training in computer vision or programming to automatically extract cellular measurements from large image sets. The quality metric scores an image based on three parameters: the illumination gradient across the image, the overall focus of the image, and the fraction of the image that contains scratches. The metric presents the user with the ability to ‘pass’ or ‘fail’ an image based on a reproducible quality score. Passable images may then be characterized through a separate CellProfiler pipeline, which enlists a variety of common image analysis techniques. The results demonstrate the ability to reliably pass or fail images based on the illumination, focus, and scratch fraction of the image, followed by automatic extraction of morphological data with respect to fission gas voids, interaction layers, and grain boundaries. - Graphical abstract: Display Omitted - Highlights: • A technique is developed to score U–10Mo FIB-SEM image quality using CellProfiler. • The pass/fail metric is based on image illumination, focus, and area scratched. • Automated image analysis is performed in pipeline fashion to characterize images. • Fission gas void, interaction layer, and grain boundary coverage data is extracted. • Preliminary characterization results demonstrate consistency of the algorithm.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗