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At least 217 records · Page 12

TOPEX/Poseidon - The ocean topography experiment

The configuration of the TOPEX/Poseidon mission is discussed in an overview of the launch and experimental objectives related to the deployment planned for 1992. The spacecraft carries equipment for radar altimetry and precise orbit determination, and the instruments are expected to provide precise observations of global ocean dynamics. Six scientific instruments are described including the Laser Retroreflector Array, the Tracking System Receiver, and GPS Demonstration Receiver. Also described are the orbit configuration of the satellite, verification of system performance, and the techniques for data processing. The observations from the TOPEX/Poseidon experiment can provide data that is free of sea-level variabilities and describes the general circulation of the ocean and its variability.

Fu, Lee-Lueng↗

Electronic Neural Networks

Viewgraphs on electronic neural networks for space station are presented. Topics covered include: electronic neural networks; electronic implementations; VLSI/thin film hybrid hardware for neurocomputing; computations with analog parallel processing; features of neuroprocessors; applications of neuroprocessors; neural network hardware for terrain trafficability determination; a dedicated processor for path planning; neural network system interface; neural network for robotic control; error backpropagation algorithm for learning; resource allocation matrix; global optimization neuroprocessor; and electrically programmable read only thin-film synaptic array.

Thakoor, Anil↗

CLAES south-looking aerosol observations for 1992

The Cryogenic Limb Etalon Array Spectrometer (CLAES) aboard the Upper Atmosphere Research Satellite (UARS) has made global observations of stratospheric aerosol during 1992. The instrument and measurement technique are briefly discussed. Samples of CLAES aerosol observations for south-looking days through the course of the Antarctic winter showing evolution of polar stratospheric clouds (PSCs) and the Pinatubo volcanic veil are shown and discussed.

Mergenthaler, J. L.↗

Gimbal Control Algorithms for the Global Precipitation Measurement Core Observatory

There are two gimbaled systems on the Global Precipitation Measurement Core Observatory: two single-degree-of-freedom solar arrays (SAs) and one two-degree-of-freedom high gain antenna (HGA). The guidance, navigation, and control analysis team was presented with the following challenges regarding SA orientation control during periods of normal mission science: (1) maximize solar flux on the SAs during orbit day, subject to battery charging limits, (2) minimize atmospheric drag during orbit night to reduce frequency of orbit maintenance thruster usage, (3) minimize atmospheric drag during orbits for which solar flux is nearly independent of SA orientation, and (4) keep array-induced spacecraft attitude disturbances within allocated tolerances. The team was presented with the following challenges regarding HGA control during mission science periods: (1) while tracking a ground-selected Tracking Data and Relay Satellite (TDRS), keep HGA control error below about 4', (2) keep array-induced spacecraft attitude disturbances small, and (3) minimize transition time between TDRSs subject to constraints imposed by item 2. This paper describes the control algorithms developed to achieve these goals and certain analysis done as part of that work.

Welter, Gary L.↗

Quantification of the epitope diversity of HIV-1-specific binding antibodies by peptide microarrays for global HIV-1 vaccine development

An effective vaccine against human immunodeficiency virus type 1 (HIV-1) will have to provide protection against a vast array of different HIV-1 strains. Current methods to measure HIV-1-specific binding antibodies following immunization typically focus on determining the magnitude of antibody responses, but the epitope diversity of antibody responses has remained largely unexplored. Here we describe the development of a global HIV-1 peptide microarray that contains 6564 peptides from across the HIV-1 proteome and covers the majority of HIV-1 sequences in the Los Alamos National Laboratory global HIV-1 sequence database. Using this microarray, we quantified the magnitude, breadth, and depth of IgG binding to linear HIV-1 sequences in HIV-1-infected humans and HIV-1-vaccinated humans, rhesus monkeys and guinea pigs. The microarray measured potentially important differences in antibody epitope diversity, particularly regarding the depth of epitope variants recognized at each binding site. Our data suggest that the global HIV-1 peptide microarray may be a useful tool for both preclinical and clinical HIV-1 research.

60 APPLIED LIFE SCIENCES↗

Digitally Synthesized Phased Antenna for Multibeam Global Positioning

In a system according to the proposed technique, the signal received by each element of the array antenna would be subjected to downconversion, and spread-spectrum demodulation and correlation as necessary; this processing would be performed separately from, and simultaneously with, similar processing of signals received by the other antenna elements. For the GPS implementation, following downconversion to baseband, the signals would be digitized, and all subsequent processing would be digital. In In the digital process, residual carriers would be removed and each signal would be correlated with a locally generated model pseudo random-noise code, all following normal GPS procedure. As part of this procedure, accumulated values would be added in software and the resulting signals would be phase-shifted in software by the amounts necessary to synthesize the desired antenna directional gain pattern of peaks and nulls. The principal advantage of this technique over the conventional radio-frequency-combining technique is that the parallel digital baseband processing of the signals from the various antenna elements would be a relatively inexpensive and flexible means for exploiting the inherent multiple-peak/multiple-null aiming capability of a phased-array antenna. In the original intended GPS application, the peaks and nulls could be directed independently for each GPS signal being tracked by the GPS receiver. This will improve the SNR simultaneously for each GPS signal being tracked while steering multiple nulls toward sources of interference. The technique could also be applied to other code-division multiple-access communication systems.

Charles E Dunn↗

NASA Tech Briefs, October 2012

Topics discussed include: Detection of Chemical Precursors of Explosives; Detecting Methane From Leaking Pipelines and as Greenhouse Gas in the Atmosphere; Onboard Sensor Data Qualification in Human-Rated Launch Vehicles; Rugged, Portable, Real-Time Optical Gaseous Analyzer for Hydrogen Fluoride; A Probabilistic Mass Estimation Algorithm for a Novel 7-Channel Capacitive Sample Verification Sensor; Low-Power Architecture for an Optical Life Gas Analyzer; Online Cable Tester and Rerouter; A Three-Frequency Feed for Millimeter-Wave Radiometry; Capacitance Probe Resonator for Multichannel Electrometer; Inverted Three-Junction Tandem Thermophotovoltaic Modules; Fabrication of Single Crystal MgO Capsules; Inflatable Hangar for Assembly of Large Structures in Space; Mars Aqueous Processing System; Hybrid Filter Membrane; Design for the Structure and the Mechanics of Moballs; Pressure Dome for High-Pressure Electrolyzer; Cascading Tesla Oscillating Flow Diode for Stirling Engine Gas Bearings; Compact, Low-Force, Low-Noise Linear Actuator; Ultra-Compact Motor Controller; Extreme Ionizing-Radiation-Resistant Bacterium; Wideband Single-Crystal Transducer for Bone Characterization; Fluorescence-Activated Cell Sorting of Live Versus Dead Bacterial Cells and Spores; Nonhazardous Urine Pretreatment Method; Laser-Ranging Transponders for Science Investigations of the Moon and Mars; Ka-Band Waveguide Three-Way Serial Combiner for MMIC Amplifiers; Structural Health Monitoring with Fiber Bragg Grating and Piezo Arrays; Low-Gain Circularly Polarized Antenna with Torus-Shaped Pattern; Stereo and IMU- Assisted Visual Odometry for Small Robots; Global Swath and Gridded Data Tiling; GOES-R: Satellite Insight; Aquarius iPhone Application; Monitoring of International Space Station Telemetry Using Shewhart Control Charts; Theory of a Traveling Wave Feed for a Planar Slot Array Antenna; Time Manager Software for a Flight Processor; Simulation of Oxygen Disintegration and Mixing With Hydrogen or Helium at Supercritical Pressure; A Superfluid Pulse Tube Refrigerator Without Moving Parts for Sub-Kelvin Cooling; Sapphire Viewports for a Venus Probe; The Mobile Chamber; Electric Propulsion Induced Secondary Mass Spectroscopy; and Radiation-Tolerant DC-DC Converters.

Source record↗

Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

The high morbidity and mortality associated with SARS-CoV-2 infection, the etiological agent of COVID-19, has had a major impact on global public health. Significant progress has been made in the development of an array of vaccines and biologics, however, the emergence of SARS-CoV-2 variants and breakthrough infections are an ongoing major concern. Furthermore, there is an existing paucity of small-molecule host and virus-directed therapeutics and prophylactics that can be used to counter the spread of SARS-CoV-2, and any emerging and re-emerging coronaviruses. Here, we describe herein our efforts to address this urgent need by focusing on the structure-guided design of potent broad-spectrum inhibitors of SARS-CoV-2 3C-like protease (3CL pro or Main protease), an enzyme essential for viral replication. The inhibitors exploit the directional effects associated with the presence of a gem-dimethyl group that allow the inhibitors to optimally interact with the S4 subsite of the enzyme. Several compounds were found to potently inhibit SARS-CoV-2 and MERS-CoV 3CL proteases in biochemical and cell-based assays. Specifically, the EC50 values of aldehyde 1c and its corresponding bisulfite adduct 1d against SARS-CoV-2 were found to be 12 and 10 nM, respectively, and their CC50 values were >50 μM. Furthermore, deuteration of these compounds yielded compounds 2c/2d with EC50 values 11 and 12 nM, respectively. Replacement of the aldehyde warhead with a nitrile (CN) or an α-ketoamide warhead or its corresponding bisulfite adduct yielded compounds 1g, 1e and 1f with EC50 values 60, 50 and 70 nM, respectively. High-resolution cocrystal structures have identified the structural determinants associated with the binding of the inhibitors to the active site of the enzyme and, furthermore, have illuminated the mechanism of action of the inhibitors. Overall, the high Safety Index (SI) (SI=CC50/EC50) displayed by these compounds suggests that they are well-suited to conducting further preclinical studies.

3-Chymotrypsin-like protease (3CLpro)↗

Solar filament material oscillations and drainage before eruption

Both large-amplitude longitudinal (LAL) oscillations and material drainage in a solar filament are associated with the flow of material along the filament axis, often followed by an eruption. However, the relationship between these two motions and a subsequent eruption event is poorly understood. We analyze a filament eruption using EUV imaging data captured by the Atmospheric Imaging Array on board the Solar Dynamics Observatory and the Hα images from the Global Oscillation Network Group. Hours before the eruption, the filament was activated, with one of its legs undergoing a slow rising motion. The asymmetric activation inclined the filament relative to the solar surface. After the active phase, LAL oscillations were observed in the inclined filament. The oscillation period increased slightly over time, which may suggest that the magnetic fields supporting the filament evolve to be flatter during the slow rising phase. After the oscillations, a significant amount of filament material was drained toward one filament endpoint, followed immediately by the violent eruption of the filament. The material drainage may further support the change in magnetic topology prior to the eruption. Moreover, we suggest that the filament material drainage could play a role in the transition from a slow to a fast rise of the erupting filament.

79 ASTRONOMY AND ASTROPHYSICS↗

Electronic neural network for solving traveling salesman and similar global optimization problems

This invention is a novel high-speed neural network based processor for solving the 'traveling salesman' and other global optimization problems. It comprises a novel hybrid architecture employing a binary synaptic array whose embodiment incorporates the fixed rules of the problem, such as the number of cities to be visited. The array is prompted by analog voltages representing variables such as distances. The processor incorporates two interconnected feedback networks, each of which solves part of the problem independently and simultaneously, yet which exchange information dynamically.

Thakoor, Anilkumar P.↗

The GPS Laser Retroreflector Array Project

Systematic co-location in space through the precision orbit determination of GPS satellites via satellite laser ranging will contribute significantly towards improving the accuracy and stability of the international terrestrial reference frame. NASA recently formed the GPS Laser Retroreflector Array Project to develop and deliver retroreflectors for integration on the next generation of GPS satellites. These retroreflectors will be an important contributor to achieving a global accuracy of 1.0 mm and 0.1 mm/year stability in the international terrestrial reference frame. We report here the current status of the GPS Laser Retroreflector Array Project.

Merkowitz, Stephen M.↗

Global spectroscopy and imaging of atmospheric X-ray bremsstrahlung - Instrumentation and initial results from the PEM/AXIS instrument aboard the Upper Atmosphere Research Satellite

The Atmospheric X-ray Imaging Spectrometer (PEM/AXIS) aboard NASA's Upper Atmosphere Research Satellite provides continuous horizon to horizon images, both day and night, of the 3- to 100-keV X-ray flux emitted from the top of the atmosphere. AXIS achieves a spatial resolution to better than 100 km using a one-dimensional array of 16 passively cooled silicon detectors. The primary purpose of this instrument is to provide a global monitor of electron energy input to the upper atmosphere. We describe the design, development, and calibration of AXIS and provide an assessment of its excellent on-orbit performance. The unique capabilities of X-ray imaging spectrometers are demonstrated through an analysis of specific examples from October and November 1991. Important new developments for follow-on instruments also will be described.

Chenette, D. L.↗

Evaluating dosimetric accuracy of flattening filter free compensator-based IMRT: Measurements with diode arrays

Purpose: Compensator-based IMRT coupled with the high dose rate flattening filter free (FFF) beams offers an intriguing possibility of delivering an intensity modulated radiation field in just a few seconds. As a first step, the authors evaluate the dosimetric accuracy of the treatment planning system (TPS) FFF beam model with compensators. Methods: A 6 MV FFF beam from a TrueBeam accelerator (Varian Medical Systems, Palo Alto CA) was modeled in PINNACLE TPS (v. 9.0, Philips Radiation Oncology, Fitchburg WI). Flat brass slabs from 0.3 to 7 cm thick and an 18 deg. brass wedge were used to adjust the beam model. A 2D (MAPCHECK) and 3D (ARCCHECK) diode arrays (Sun Nuclear Corp, Melbourne FL), were investigated for use with the compensator FFF beams. Corrections for diode sensitivity caused by the spectral changes in the beam were introduced. Four compensator plans based on the AAPM TG-119 report were developed. A composite ion chamber measurement, beam by beam MAPCHECK measurements, and a composite ARCCHECK measurement were performed. The array results were analyzed with the same thresholds as in TG-119 report--3%/3 mm with global dose normalization--as well as with the more stringent combinations of the gamma analysis criteria. Results: The FFF beam shows a greater variation of the effective attenuation coefficient with brass thickness due to the prevalence of the low energy photons compared to the conventional 6X beam. As a result, a compromise had to be made while trying to achieve dose agreement for a combination of field sizes, brass thicknesses, and measurement depths ({>=}5 cm in water). An agreement of measured and calculated dose to within 1% was observed for brass thicknesses up to 2 cm. For the 3 cm slab, an error of up to 2.8% was noted for the field sizes above 10 x 10 cm{sup 2}, and up to 3.8% for the 5 x 5 cm{sup 2} field. Both diode arrays exhibit a substantial sensitivity drop as the compensator thickness increases, reaching 10% for a 7 cm brass slab. A simple correction based on the brass thickness along the ray was introduced to counteract this effect. Pooled for five profiles, the average ratio of uncorrected and corrected MAPCHECK to ion chamber readings are 0.966 and 1.008, respectively. With the proper correction, all MAPCHECK measurement to calculation comparisons exhibit 100%{gamma}(3%/3 mm) passing rates with global dose-error normalization. For the TG-119-type plans, the average {gamma}(2%/2 mm) passing rate with local normalization is 94% (range 87.8%-98.3%). The lower ARCCHECK{gamma}-analysis passing rates (corrected for diode sensitivity) are predictable based on the observed PDD discrepancies. However, with the 3%/3 mm thresholds and global normalization, the average {gamma}-analysis passing rate is 96.4% (range 89.9%-100%). Conclusions: MAPCHECK analysis demonstrates high passing rates with the stringent {gamma}(2%/2 mm) and local normalization criteria combination. The geometry of the ARCCHECK array creates a stress test for the FFF TPS model because of the shallow depth of the entrance diodes and large air cavity. Hence, the ARCCHECK{gamma}-analysis passing rates are lower than with the MAPCHECK, while still on par with TG-119.

61 RADIATION PROTECTION AND DOSIMETRY↗

Localization of Southern Resident Killer Whales Using Two Star Arrays to Support Marine Renewable Energy

Tidal power has been identified as one of the most potential commercial-scale renewable energy sources. Puget Sound, Washington, is a potential site to deploy tidal power generating devices. The risk of injury for killer whales needs to be managed before the deployment of these types of devices can be approved by regulating authorities. A passive acoustic system consisting of two star arrays, each with four hydrophones, was designed and implemented for the detection and localization of Southern Resident killer whales. Deployment of the passive acoustic system was conducted at Sequim Bay, Washington. A total of nine test locations were chosen, within a radius of 250 m around the star arrays, to test our localization approach. For the localization algorithm, a least square solver was applied to obtain a bearing location from each star array. The final source location was determined by the intersection of the bearings given by each of the two star arrays. Bearing and distance errors were obtained to conduct comparison between the calculated and true (from Global Positioning System) locations. The results indicated that bearing errors were within 1.04º for eight of the test locations; one location had bearing errors slightly larger than expected due to the strong background noise at that position. For the distance errors, six of the test locations were within the range of 1.91 to 32.36 m. The other two test locations were near the intersection line between the centers of the two star arrays, which were expected to have large errors from the theoretical sensitivity analysis performed.

Passive acoustic system, localization, star array,↗

Rational Design and Reticulation of Infinite qbe Rod Secondary Building Units into Metal–Organic Frameworks through a Global Desymmetrization Approach for Inverse C 3 H 8 /C 3 H 6 Separation

Abstract The development of reticular chemistry has enabled the construction of a large array of metal–organic frameworks (MOFs) with diverse net topologies and functions. However, dominating this class of materials are those built from discrete/finite secondary building units (SBUs), yet the designed synthesis of frameworks involving infinite rod‐shaped SBUs remain underdeveloped. Here, by virtue of a global linker desymmetrization approach, we successfully targeted a novel Cu‐MOF (Cu‐ASY) incorporating infinite Cu‐carboxylate rod SBUs with its structure determined by micro electron diffraction (MicroED) crystallography. Interestingly, the rod SBU can be simplified as a unique cylindric sphere packingqbetubule made of [4 3 .6 2 ] tiles, which further connect the tritopic linkers to give a newly discovered 3,5‐connectedgfcnet. Cu‐ASY is a permanent ultramicroporous material featuring 1D channels with highly inert surfaces and shows a preferential adsorption of propane (C 3 H 8 ) over propene (C 3 H 6 ). The efficiency of C 3 H 8 selective Cu‐ASY is validated by multicycle breakthrough experiments, giving C 3 H 6 productivity of 2.2 L/kg. Density functional theory (DFT) calculations reveal that C 3 H 8 molecules form multiple C−H⋅⋅⋅π and atypical C−H⋅⋅⋅ H−C van der Waals interactions with the inner nonpolar surfaces. This work therefore highlights the linker desymmetrization as an encouraging and intriguing strategy for achieving unique MOF structures and properties.

Chemistry↗

The Implications of Global Change for the Co-Evolution of Argentina's Integrated Energy-Water-Land Systems

This study seeks to understand how Argentina’s energy, water, and land (EWL) systems will co-evolve under a representative array of human and earth system influences, including socioeconomic change, climate change, and climate policy. To capture Argentina’s sub-national EWL dynamics in the context of global change, we couple the Global Change Analysis Model with a suite of consistent, gridded sectoral downscaling models to explore multiple stakeholder-engaged scenarios. Across scenarios, Argentina has the economic opportunity to use its vast land resources to satisfy growing domestic and international demand for crops, such as oil (e.g., soy) and biomass. The human (rather than earth) system produces the most dominant changes in mid-century EWL resource use. A Reference scenario characterized by modest socioeconomic growth projects a 40% increase in Argentina’s agricultural production by 2050 (relative to 2020) by using 50,000 km 2 of additional cropland and 40% more water. A Climate Policy scenario designed to achieve net-zero carbon emissions globally shortly after mid-century projects that Argentina could use 100,000 km 2 of additional land (and 65% more water) to grow biomass and other crops. The burden of navigating these national opportunities and challenges could fall disproportionately on a subset of Argentina’s river basins. The Colorado and Negro basins could experience moderate-to-severe water scarcity as they simultaneously navigate substantial irrigated crop demand growth and climate-induced declines in natural water availability. Argentina serves as a generalizable testbed to demonstrate that multi-scale EWL planning challenges can be identified and managed more effectively via integrated analysis of coupled human-earth systems.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Photovoltaic array for Martian surface power

Missions to Mars will require electric power. A leading candidate for providing power is solar power produced by photovoltaic arrays. To design such a power system, detailed information on solar-radiation availability on the Martian surface is necessary. The variation of the solar radiation on the Martian surface is governed by three factors: (1) variation in Mars-Sun distance; (2) variation in solar zenith angle due to Martian season and time of day; and (3) dust in the Martian atmosphere. A major concern is the dust storms, which occur on both local and global scales. However, there is still appreciable diffuse sunlight available even at high opacity, so that solar array operation is still possible. Typical results for tracking solar collectors are also shown and compared to the fixed collectors. During the Northern Hemisphere spring and summer the isolation is relatively high, 2-5 kW-hr/sq m-day, due to the low optical depth of the Martian atmosphere. These seasons, totalling a full terrestrial year, are the likely ones during which manned mission will be carried out.

Appelbaum, J.↗