Results for “FLUIDICS” — Page 12

DOE OSTI2016

Apparatus comprising magnetically actuated valves and uses thereof

The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

42 ENGINEERING↗

DOE OSTI2016

Systems and methods for separating particles and/or substances from a sample fluid

Systems and methods for separating particles and/or toxins from a sample fluid. A method according to one embodiment comprises simultaneously passing a sample fluid and a buffer fluid through a chamber such that a fluidic interface is formed between the sample fluid and the buffer fluid as the fluids pass through the chamber, the sample fluid having particles of interest therein; applying a force to the fluids for urging the particles of interest to pass through the interface into the buffer fluid; and substantially separating the buffer fluid from the sample fluid.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2016

System and method for measuring particles in a sample stream of a flow cytometer using low-power laser source

A system and method for analyzing a particle in a sample stream of a flow cytometer or the like. The system has a light source, such as a laser pointer module, for generating a low powered light beam and a fluidics apparatus which is configured to transport particles in the sample stream at substantially low velocity through the light beam for interrogation. Detectors, such as photomultiplier tubes, are configured to detect optical signals generated in response to the light beam impinging the particles. Signal conditioning circuitry is connected to each of the detectors to condition each detector output into electronic signals for processing and is designed to have a limited frequency response to filter high frequency noise from the detector output signals.

Graves, Steven W.↗

DOE OSTI2016

Apparatus for atmospheric pressure pin-to-hole spark discharge and uses thereof

Disclosed herein are atmospheric pressure pin-to-hole pulsed spark discharge devices and methods for creating plasma. The devices include a conduit for fluidically communicating a gas, a plasma, or both, therethrough, portion of the conduit capable of being connected to a gas supply, and a second portion of the conduit capable of emitting a plasma; a positive electrode comprising a sharp tip; and a ground plate electrode. Disclosed are methods for treating a skin ulcer using non-thermal plasma include flowing a gas through a cold spark discharge zone simultaneously with the creation of a pulsed spark discharge to give rise to a non-thermal plasma emitted from a conduit, the non-thermal plasma comprising NO; and contacting a skin ulcer with said non-thermal plasma for sufficient time and intensity to give rise to treatment of the skin ulcer.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DOE OSTI2017

Fluid delivery manifolds and microfluidic systems

Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.

42 ENGINEERING↗

DOE OSTI2018

Amplification of biological targets via on-chip culture for biosensing

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

47 OTHER INSTRUMENTATION↗

DOE OSTI2018

Amplification of biological targets via on-chip culture for biosensing

The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2018

Sealed micro gas chromatography columns and methods thereof

The present application relates to microfabricated columns having a sealed flow channel. In particular, the channel is sealed during dicing, thereby preventing debris from accumulating within channels. In use, the seal is ruptured mechanically to connect one or more fluidic connections, which deliver analytes to the flow channel. Additional details are provided for making and using sealed columns.

Moorman, Matthew W.↗

DOE OSTI2019

Self-powered and reversible light-directed electrophoretic deposition device for use in smart windows and photodetector displays

According to one embodiment, a system includes a first sheet being nonopaque, a second sheet being nonopaque spaced from the first sheet, a spacer positioned between the first sheet and the second sheet, a chamber defined between the first and second sheets and the spacer, and a fluidic solution in the chamber. In addition, the first sheet includes a photoconductive layer. Moreover, solution has a plurality of particles, where the particles in the solution are attracted to illuminated portions of the photoconductive layer upon illumination of said portions in the absence of an external voltage applied to the first and second sheets.

Mora, Jeronimo↗

DOE OSTI2019

Magnetically controlled valve and pump devices and methods of using the same

Disclosed herein are embodiments of magnetically controlled valve and pump systems that can be used to control and facilitate fluid flow in fluidic devices. Various types of magnetically controlled valves and pumps are described as well as methods of magnetically-controlling such valves and pumps.

42 ENGINEERING↗

DOE OSTI2019

Microfluidic active mixing nozzle for three-dimensional printing of viscoelastic inks

A microfluidic printing nozzle for 3D printing may include a mixing chamber, a first inlet for connecting with a first ink source, the first inlet located at a first end of the mixing chamber, and a second inlet for connecting with a second ink source, the second inlet located at the first end of the mixing chamber. An outlet may be located at a second end of the mixing chamber, and a generally cylindrical impeller may be rotatably disposed in the mixing chamber between the first end and the second end. The cylindrical impeller may include an outer surface, and the outer surface of the impeller includes a groove, a protrusion, or both, to facilitate mixing of fluidic inks flowing from the first end to the second end of the mixing chamber.

47 OTHER INSTRUMENTATION↗

DOE OSTI2019

Apparatus for atmospheric pressure pin-to-hole spark discharge and uses thereof

Disclosed herein are atmospheric pressure pin-to-hole pulsed spark discharge devices and methods for creating plasma. The devices include a conduit for fluidically communicating a gas, a plasma, or both, therethrough, portion of the conduit capable of being connected to a gas supply, and a second portion of the conduit capable of emitting a plasma; a positive electrode comprising a sharp tip; and a ground plate electrode. Disclosed are methods for treating a skin ulcer using non-thermal plasma include flowing a gas through a cold spark discharge zone simultaneously with the creation of a pulsed spark discharge to give rise to a non-thermal plasma emitted from a conduit, the non-thermal plasma comprising NO; and contacting a skin ulcer with said non-thermal plasma for sufficient time and intensity to give rise to treatment of the skin ulcer.

Dobrynin, Danil V.↗

DOE OSTI2020

Fluid delivery manifolds and microfluidic systems

Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.

42 ENGINEERING↗

DOE OSTI2020

Self-powered and reversible light-directed electrophoretic deposition device for use in smart windows and photodetector displays

According to one embodiment, a method includes receiving light on a photoconductive layer of an electrophoretic deposition (EPD) device, the EPD device having a chamber defined by a first sheet, a second sheet and a spacer between the first and second sheets, where the first sheet is nonopaque and includes the photoconductive layer, where the second sheet is nonopaque and spaced from the first sheet, where a fluidic solution having a plurality of particles is in the chamber. The particles in the solution are attracted from suspension to illuminated portions of the photoconductive layer in the absence of an external voltage applied to the first and second sheets. The particles become deposited on the illuminated portions of the photoconductive layer.

42 ENGINEERING↗

DOE OSTI2020

Ultra-breathable and protective membranes with sub-5 nm carbon nanotube pores

In one embodiment, a product includes a plurality of carbon nanotubes and a fill material in interstitial spaces between the carbon nanotubes for limiting or preventing fluidic transfer between opposite sides of the product except through interiors of the carbon nanotubes. Moreover, the longitudinal axes of the carbon nanotubes are substantially parallel, where an average inner diameter of the carbon nanotubes is about 20 nanometers or less. In addition, the ends of the carbon nanotubes are open and the fill material is impermeable or having an average porosity that is less than the average inner diameter of the carbon nanotubes.

36 MATERIALS SCIENCE↗

DOE OSTI2021

Flow-regulated growth of nanotubes

A method for growing nanotubes via flow-regulated microfluidic electrochemical anodization, includes providing a microfluidic device having a fluid inlet; a fluid outlet; and a fluidic microchannel connecting the fluid inlet and outlet, wherein the microchannel includes a Pt cathode and a Ti anode separated by an electrical insulator; providing an electrolyte fluid flow through the microchannel; and providing an electrical current across the anode and cathode sufficient to cause electrochemical anodization growth of TiO2 nanotubes in the microchannel on a surface of the anode.

Wan, Jiandi↗

DOE OSTI2021

Modular assemblies and systems for cell cultures and methods thereof

The present invention relates to modular assemblies and systems for conducting cell analyses. In particular embodiments, an assembly has micron-scale fluidic structures, thereby minimizing sample use, and possesses a modular architecture that facilitates disassembly of the apparatus. Thus, one such modular assembly facilitates on-chip cell growth and on-chip assays; and then, as needed, the assembly can be disassembled to provide direct access to the cells that were incubated and treated within the chip. Methods of making and using such assemblies, as well as systems thereof, are further described herein.

Hatch, Anson↗

DOE OSTI2021

Branching heat exchangers

A heat exchanger includes an external casing and a core. The external casing includes a first inlet, a first outlet, a second inlet, and a second outlet. The core includes an array of branched channels connecting the first inlet and first outlet, an inlet header, and an outlet header. The inlet header is integrally formed with and fluidly connected to the first inlet. The outlet header is integrally formed with and fluidly connected to the first outlet. The branched channels and the external casing define a fluidic passage. The array of branched channels includes a first split, a first juncture, a secondary split, a secondary juncture, and a subset of splits and junctures. The first split and first juncture are common to an entirety of the array of branched channels. The subset of splits and junctures route fluid through interconnections between fluidly parallel branched channels.

Ranjan, Ram↗