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At least 199 records · Page 11

Validation of Stage N3 of the Eighth Edition AJCC Staging System for Nasopharyngeal Carcinoma

Objectives To validate stage nodal (N)3 of the 8th edition American Joint Committee on Cancer (AJCC) staging system for nasopharyngeal carcinoma (NPC). Methods This retrospective cohort study extracted NPC patients from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. Pathologically confirmed patients with complete data of level IV, N3a, and N3b lymph node metastasis were investigated. The included patients were divided into level IV, N3a, and N3b groups. Five‐year overall survival (OS) and cancer‐specific survival (CSS) were compared among the three groups. Results A total of 693 patients were included: 285 (41.13%) patients in the level IV group, 124 (17.89%) patients in the N3a group, and 284 (40.98%) patients in the N3b group. The 5‐year OS (57.1%, 55.0%, and 55.2%) and CSS (64.4%, 63.5%, and 64.4%) were not different among the level IV, N3a, and N3b groups. Multivariate regression analysis revealed that N stage was not an independent prognostic factor for OS (hazard ratio [HR] = 1.03, 95% confidence interval [CI]: 0.91–1.17; P = .65) or CSS (HR = 1.03, 95% CI: 0.89–1.19; P = .70). Conclusion Stage N3 of the 8th edition AJCC staging system for NPC is reasonable. Level of Evidence III Laryngoscope , 131:535–540, 2021

Pan, Xin‐Bin↗

Hierarchical Speed Planner for Automated Vehicles: A Framework for Lagrangian Variable Speed Limit in Mixed-Autonomy Traffic

Here, this article presents a novel hierarchical speed planning framework for variable speed limits in mixed-autonomy traffic environments, leveraging server-side macroscopic control and vehicle-side microscopic execution. The framework integrates real-time traffic state estimation (TSE) and reinforcement learning (RL)-based control to mitigate congestion and improve traffic flow. A TSE enhancement module combines macroscopic data from sources like INRIX with high-resolution observations from connected autonomous vehicles (CAVs), enabling predictive modeling to address latency and noise. The target speed design module employs kernel smoothing and a buffer zone strategy to optimize traffic density and flow around bottlenecks. The proposed system was validated in the largest open-road test to date with 100 CAVs, demonstrating an overall 8% traffic density decrease, with a specific decrease of 7% upstream, 10% downstream, and a 52% decrease during the congestion formation phase at bottlenecks.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Characteristics of locational uncertainty marginal price for correlated uncertainties of variable renewable generation and demands

With the rapid increase of variable renewable energy sources in power systems, how to manage and price the uncertainty of renewable resources’ power outputs is becoming an urgent issue. Current market designs considering the uncertainties are mainly based on the probabilistic scenario set of demand and renewable energy resources power outputs. This consideration makes market designs vulnerable to three significant challenges when put into practice. First, the accurate probability distribution of renewable generation is hard to obtain in real-time. Second, it is challenging to clear the market timely with many scenarios to guarantee accuracy. Third, generation cost recovery cannot be guaranteed for some scenarios. To overcome these challenges, this paper proposes a locational uncertainty marginal price model to price the uncertainty explicitly based on a scenario-free stochastic market-clearing model. Instead of using the probabilistic scenario set, the uncertainty of renewable energy sources and loads is modeled with distributionally-robust chance constraints. The correlation of uncertainties can be endogenously modeled in both the market-clearing and the locational uncertainty marginal price formation. Furthermore, this paper proves that generation cost recovery, revenue adequacy, and partial market equilibrium can be achieved using the locational uncertainty marginal price model. Numerical results from both the small and large systems simulations validate that the generation cost recovery is maintained no matter the generation participates in uncertainty mitigation or not. The transmission congestion surplus is also allocated appropriately among loads, renewable energy sources, and financial transmission right owners.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Noninvasive interrogation of local flow phenomena in twisted tape swirled flow via positron emission particle tracking ($\mathrm{PEPT}$)

Twisted tape inserts are often used to enhance the performance of heat exchangers. Previous simulations suggest the existence of secondary vortices and modified axial velocity profiles in these swirled flows, with only limited experimental evidence for these predictions. Here in this work, positron emission particle tracking (PEPT) is used to interrogate turbulent twisted tape swirl flow in a pipe. PEPT is a noninvasive, radiotracer based flow measurement technique that does not require optical access, making it suitable for measurements in a number of engineering flow systems. The existence of the modified velocity profile and secondary flows is confirmed using PEPT, and flow is seen to still be developing 20 diameters downstream of the twisted channel entrance. Secondary vortices are further confirmed by the presence of increased vorticity in these regions, and turbulent fluctuations are seen to increase in magnitude near these flow structures. These results are in line with predictions and point to possible regions of reduced heat transfer and hot spots in twisted tape based heat exchangers. Suggestions are made for future experiments to investigate heated flows, utilizing the ability of PEPT to image flows in opaque systems for validating simulation of flows in engineering equipment, such as nuclear heat transport equipment.

42 ENGINEERING↗

Accurate determination of uranium isotope abundances by wavelength modulation spectroscopy in atomic beams

The design and demonstration of an optical analysis system based on wavelength modulation spectroscopy in an atomic beam for uranium isotope abundance determinations is presented. This system probes the uranium 5f 3 6d7s 2 ( 5 L 6 ) → 5f 2 6d 2 7s 2 ( 5 K 5 ) transition at 861.031 nm, which is considered to be the most suitable transition for uranium isotopic analysis. A new laser characterization strategy was developed for the conditions where optimum laser wavelength modulation depth was small compared to the free spectral range (FSR) of etalons. Two capabilities enabled the higher-precision determination of isotope abundances of atomic beams: (1) reduction of low-frequency additive noise, especially the noise caused by black-body radiation and (2) suppression of non-absorption transmission losses. The performance of this system was validated with uranium samples of various isotopic compositions. Further, by comparing the measurements using natural uranium samples between the direct absorption and the wavelength modulation approaches, a 21-fold decrease in uncertainty of the integrated absorbance and a 6.8-fold improvement in the 1-σ precision of the number density were achieved. In addition, by comparing the results using uranium oxide samples, a 6.1-fold decrease in the uncertainty of inferred isotope abundance was obtained. These results demonstrate that the 1f-normalized 2f wavelength modulation spectroscopy (WMS-2f/1f) technique enables higher-precision analysis of atomic beams.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗

Characterizing Structure-Dependent TiS 2 /Water Interfaces Using Deep-Neural-Network-Assisted Molecular Dynamics

As a promising layered electrode material, TiS 2 -based capacitive deionization (CDI) devices for water desalination have attracted significant attention. However, TiS 2 /H 2 O interfacial features, potentially important for device optimization, remain unidentified. Using Deep Potential Molecular Dynamics (DPMD), we characterized distinct aqueous interfaces introduced by four TiS 2 terminations expected to be present as water intercalates into TiS 2 , namely, Armchair, Zigzag, Zigzag-L, and Zigzag-R. First, we assessed important representative physical properties of the system to validate the deep potentials (DPs). DPMD simulations agree well with experiments and first-principles simulations, suggesting the DPs are accurate and reliable. Subsequent simulations of these TiS 2 /water interfaces revealed how TiS 2 surface termination influences the structure of interfacial water. This effect is most evident in the first and second water layers close to the TiS 2 surface, and more pronounced when spontaneous dissociative adsorption of water occurs. The extent of water dissociation on each surface was evaluated using enhanced sampling. Zigzag-L is the only interface where proton transfer from adsorbed water to TiS 2 surface S atoms is thermodynamically and kinetically favored. The coexistence of surface four-fold-coordinated Ti (Ti 4c ) and one-fold-coordinated S (S 1c ) is found to be essential to making proton transfer feasible on the Zigzag-L surface. Furthermore, remaining unprotonated S 1c atoms can act as good proton acceptors after water dissociation. Thus, TiS 2 with Zigzag-L termination may be a surface to avoid in CDI device construction, given that pH fluctuations adversely affect performance. Furthermore, this work provides new understanding of TiS 2 /H 2 O interfacial features that could aid future design and optimization of TiS 2 -based CDI devices for water desalination.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

A novel in-situ Raman spectroscopic cell for aqueous geochemistry at the solid–liquid interface

In-situ Raman spectroscopy has the potential to be a powerful technique for monitoring geochemical reactions at a solid–liquid interface in real time. In this article, we present the development and testing of an in-situ Raman spectroscopic cell, which can be used for reaction systems at moderate temperatures and pressure [<1000 psi (6.89 MPa), <100 °C, relevant to subsurface geologic systems] and can hold samples large enough for chemical mapping of heterogeneous rock surfaces. The system is validated by measuring the temperature-dependent conversion of gypsum to calcite over time. Near total conversion of gypsum to calcite on the mineral surface took 29 hours at room temperature and 150 minutes at 100 °C, corresponding to an 11.6-fold increase in the conversion rate. Further, we anticipate that this cell can be an important tool in quantifying the rates of carbon mineralization relevant to geologic carbon sequestration, particularly for the elevated rates recently observed in mafic/ultramafic rocks.

47 OTHER INSTRUMENTATION↗

Linearized frequency domain Landau-Lifshitz-Gilbert equation formulation

We present a general finite element linearized Landau-Lifshitz-Gilbert equation (LLGE) solver for magnetic systems under weak time-harmonic excitation field. The linearized LLGE is obtained by assuming a small deviation around the equilibrium state of the magnetic system. Inserting such expansion into LLGE and keeping only first order terms gives the linearized LLGE, which gives a frequency domain solution for the complex magnetization amplitudes under an external time-harmonic applied field of a given frequency. We solve the linear system with an iterative solver using generalized minimal residual method. We construct a preconditioner matrix to effectively solve the linear system. The validity, effectiveness, speed, and scalability of the linear solver are demonstrated via numerical examples.

36 MATERIALS SCIENCE↗

Neuromuscular Junction Model Optimized for Electrical Platforms

Neuromuscular junctions (NMJs), specialized synapses between motor neurons and muscle fibers, are essential for muscle activity. A simple and reproducible cell-based in vitro NMJ platform is needed to test the impact of chemicals on the neuron-muscle communication. Our platform utilizes genetically modified neurons and muscle cells, optimized culture conditions, and commercially available multielectrode array system for recording action potentials. Neuronal cells (NSC34) were optogenetically modified with channelrhodopsin chimera to allow for simultaneous, light-mediated, millisecond-precise activation of neuronal population. This signal is propagated through functional synapses to the muscle fibers. Muscle cells (C2C12) were modified by incorporating gap junction protein (Connexin-43) to improve intracellular communication without affecting muscle differentiation. This communication between muscle fibers resulted in better signal propagation and signal strength. Optimized culture medium facilitated the growth and differentiation of both cell types together. Our system was validated using vecuronium, a muscle relaxant, which abolished the muscle response. This in vitro model provides a unique tool for establishing a NMJ platform that is easy to record and analyze. Potential applications include nondestructive long-term screening of drugs affecting the NMJ.

59 BASIC BIOLOGICAL SCIENCES↗

Analysis of Double-Output CLL Resonant Converter for All-Electric UAV Applications

This paper presents a double-output resonant converter with high-frequency isolation for unmanned aerial vehicle (UAV) applications. The proposed topology is developed by using a full-bridge resonant inverter and double-output half-bridge active rectifiers. For the control system, a phase-shifted pulse width modulation (PS-PWM) method is utilized to adjusts the power flow among the output rectifiers in a wide voltage range regulation with a central control. The theoretical analysis of the converter is explored using the system model under different load conditions with constant frequency. The proposed system is validated with experimental results using 60 V input source and generating 0 - 100 V in each output at a full power of 500 W with 96% maximum efficiency in the laboratory experimental setup.

Asa, Erdem↗

Scalable Distributed Reachability Analysis for Cyber-Physical Networked Microgrids with Communication Latency

Due to the high penetration of power-electronic-interfaced distributed energy resources (DERs), a microgrid's inertia is significantly reduced, making it sensitive to cyberand physical operational changes. When multiple microgrids are interconnected to form networked microgrids for improving system's resilience, the changes of one microgrid can quickly escalate to the overall system. In cyber-physical networked microgrids, the communication latency varies a lot. To efficiently quantify the impact of the communication latency on the dynamics of networked microgrids, a scalable distributed reachability analysis approach is presented in this paper. Reachable sets are calculated for each microgrid and then composited for the overall system dynamics evaluation. Extensive tests in the full paper will demonstrate the influence of communication latency on system dynamics and validate reachable sets can bound a system's all dynamic trajectories subject to latency changes. The test results also offer an insight into designing and managing the communication network for enhancing the system's resilience.

Li, Yan↗

A MW scale charging architecture for supporting extreme fast charging of heavy-duty electric vehicles

Extreme fast charging of electric vehicles technologies is coming. Heavy duty electric vehicles (HD-EVs) are in development and are expected to have multipliers bigger in battery capacity compared to the light duty counterparts. To meet short charging times, MW charging will be necessary. This paper presents a MW scale extreme DC fast charger with a communication and control architecture for HD-EVs. The system is validated in a controller hardware in the loop platform.

Starke, Michael↗

Risk-Constrained Reinforcement Learning for Inverter-Dominated Power System Controls

Here, this paper develops a risk-aware controller for grid-forming inverters (GFMs) to minimize large frequency oscillations in GFM inverter-dominated power systems. To tackle the high variability from loads/renewables, we incorporate a mean-variance risk constraint into the classical linear quadratic regulator (LQR) formulation for this problem. The risk constraint aims to bound the time-averaged cost of state variability and thus can improve the worst-case performance for large disturbances. The resulting risk-constrained LQR problem is solved through the dual reformulation to a minimax problem, by using a reinforcement learning (RL) method termed as stochastic gradient-descent with max-oracle (SGDmax). In particular, the zero-order policy gradient (ZOPG) approach is used to simplify the gradient estimation using simulated system trajectories. Numerical tests conducted on the IEEE 68-bus system have validated the convergence of our proposed SGDmax for GFM model and corroborate the effectiveness of the risk constraint in improving the worst-case performance while reducing the variability of the overall control cost.

Frequency control↗

Distributed Optimization for Nonrigid Nano-Tomography

Resolution level and reconstruction quality in nano-computed tomography (nano-CT) are in part limited by the stability of microscopes, because the magnitude of mechanical vibrations during scanning becomes comparable to the imaging resolution, and the ability of the samples to resist radiation induced deformations during data acquisition. In such cases, there is no incentive in recovering the sample state at different time steps like in time-resolved reconstruction methods, but instead the goal is to retrieve a single reconstruction at the highest possible spatial resolution and without any imaging artifacts. Here we propose a distributed optimization solver for tomographic imaging of samples at the nanoscale. Our approach solves the tomography problem jointly with projection data alignment, nonrigid sample deformation correction, and regularization. Projection data consistency is regulated by dense optical flow estimated by Farneback's algorithm, leading to sharp sample reconstructions with less artifacts. Synthetic data tests show robustness of the method to Poisson and low-frequency background noise. We accelerated the solver on multi-GPU systems and validated the method on three nano-imaging experimental data sets.

97 MATHEMATICS AND COMPUTING↗

Real-Time Coupling of Geographically Distributed Research Infrastructures: Taxonomy, Overview, and Real-World Smart Grid Applications

Novel concepts enabling a resilient future power system and their subsequent experimental evaluation are experiencing a steadily growing challenge: large scale complexity and questionable scalability. The requirements on a research infrastructure (RI) to cope with the trends of such a dynamic system therefore grow in size, diversity and costs, making the feasibility of rigorous advancements questionable by a single RI. Analysis of large scale system complexity has been made possible by the real-time coupling of geographically separated RIs undertaking geographically distributed simulations (GDS), the concept of which brings the equipment, models and expertise of independent RIs, in combination, to optimally address the challenge. This article presents the outputs of IEEE PES Task Force on Interfacing Techniques for Simulation Tools towards standardization of GDS as a concept. First, the taxonomy for setups utilized for GDS is established followed by a comprehensive overview of the advancements in real-time couplings reported in literature. The overview encompasses fundamental technological design considerations for GDS. The article further presents four application oriented case studies (real-world implementations) where GDS setups have been utilized, demonstrating their practicality and potential in enabling the analysis of future complex power systems.

distributed laboratories↗

Validation of a lightning protection system for a fusion-welded thermoplastic composite wind turbine blade tip

Fusion welding for thermoplastic composite wind turbine blades is being investigated as a replacement for adhesives in bond lines to reduce manufacturing time and cost and to promote ease of recyclability. Resistance welding uses an electrically conductive material, such as carbon fiber, embedded in the bond line to heat the joining surfaces and fuse them together under pressure. One main challenge with fusion joining for large wind blades is the ability to use this conductive heating element in the bond line while still protecting the blade from the catastrophic effects of a lightning strike. This paper outlines the design and manufacturing of a lightning protection system for a 5-m-long thermally welded blade tip. The outcomes of high voltage and high current lightning testing applied to the 5 m blade tip show that the proposed design was able to protect the fusion welded bond lines from significant lightning damage.

17 WIND ENERGY↗