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DOE OSTI2023

Probing the Structure and Dynamics of Fluid Mixtures in Porous Materials Through Ultrafast Vibrational Spectro-Microscopy and Many-Body Molecular Dynamics

This research program focused on the characterization of both molecular structure and dynamics of aqueous solutions in various metal-organic frameworks (MOFs) and organic polymers that have recently been proposed for applications in water treatment technologies. This was accomplished by integrating ultrafast vibrational spectroscopy and microscopy, which are sensitive to local environments, molecular orientation, and dynamical couplings, with many-body molecular dynamics (MB-MD) simulations, which enable realistic modeling of aqueous systems and porous materials under different thermodynamic conditions. Our studies allowed for identifying the physical mechanisms and characterizing the underlying molecular interactions between water and host materials that determine the adsorption and transport processes of water in various MOFs and β-cyclodextrin polymers – prototypical examples of porous materials and polymers, that have recently been proposed for technological applications in water purification. By combining bulk- and surface-sensitive, spatially resolved ultrafast vibrational spectroscopy with MB-MD simulations, it was possible to gain broad insight into the structure and mobility of water under heterogeneous confinement at various length scales. In particular, measurements of surface- and bulk-sensitive vibrational spectra at single crystal level, integrated with MB-MD simulations were used to characterize domain-specific, structure–binding affinity relationships. Besides providing specific information about the behavior of aqueous solutions in prototypical MOFs and organic polymers for potential applications in water treatment technologies, our studies also provided fundamental insights into the properties of aqueous solutions in confined heterogeneous environments, which have broad implications in many areas, ranging from heterogeneous catalysis to oil recovery, ion transport processes, and reaction-diffusion processes in crowded systems.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2022

Technical Characterization and Benefit Evaluation of 5G-Enabled Grid Data Transport and Applications

This report summarizes the Year 1 work of Pacific Northwest National Laboratory’s (PNNL’s) 5G Fabricated Resource and Asset Management Encompassment for energy infrastructure (Energy FRAME) project funded by the Department of Energy Office of Science’s Advanced Scientific Computing Research Program. 5G is a breakthrough technology that enables a fully mobile and connected society, and a 5G-enabled digital continuum will be one of the critical foundations for a clean energy economy and grid modernization. In collaboration with PNNL’s Advanced Wireless Communication team and Center for Advanced Technology Evaluation team, the project team has been evaluating the system performance of 5G testbeds in the PNNL 5G Innovation Studio, and has formulated a co-simulation test case of power system transmission, distribution, and communication (T&D&C) networks considering 5G technology and high penetration of distributed energy resources. The methodology developed in the 5G Energy FRAME project can be customized to fit different future grid scenarios to evaluate multiple (dynamic) configurations (computing, sensing, communication, environment) for different stakeholders. In summary, our main technical highlights in project Year 1 are as follows: 1) Technical characterization of 5G standalone architectures, 2) Formulation of co-simulation test case of T&D&C networks embedded with 5G, 3) Initial benefit evaluation of 5G communication platform for grid use cases, and 4) Additional extended discussions on edge computing, artificial intelligence and machine learning, and high-performance computing and cloud computing adoptions. In addition, a collection of system performance data is shared through the publicly available weblink, https://www.pnnl.gov/projects/5g-energy-frame/publications

24 POWER TRANSMISSION AND DISTRIBUTION↗

DOE OSTI2023

Functional composites by programming entropy-driven nanosheet growth

Here, nanomaterials must be systematically designed to be technologically viable. Driven by optimizing intermolecular interactions, current designs are too rigid to plug in new chemical functionalities and cannot mitigate condition differences during integration. Despite extensive optimization of building blocks and treatments, accessing nanostructures with the required feature sizes and chemistries is difficult. Programming their growth across the nano-to-macro hierarchy also remains challenging, if not impossible. To address these limitations, we should shift to entropy-driven assemblies to gain design flexibility, as seen in high-entropy alloys, and program nanomaterial growth to kinetically match target feature sizes to the mobility of the system during processing. In tis report, following a micro-then-nano growth sequence in ternary composite blends composed of block-copolymer-based supramolecules, small molecules and nanoparticles, we successfully fabricate high-performance barrier materials composed of more than 200 stacked nanosheets (125 nm sheet thickness) with a defect density less than 0.056 µm -2 and about 98% efficiency in controlling the defect type. Contrary to common perception, polymer-chain entanglements are advantageous to realize long-range order, accelerate the fabrication process (<30 min) and satisfy specific requirements to advance multilayered film technology. This study showcases the feasibility, necessity and unlimited opportunities to transform laboratory nanoscience into nanotechnology through systems engineering of self-assembly.

42 ENGINEERING↗

DOE OSTI2021

Design Guidelines for Deployable Wind Turbines for Military Operational Energy Applications

This document aims to provide guidance on the design and operation of deployable wind systems that provide maximum value to missions in defense and disaster relief. Common characteristics of these missions are shorter planning and execution time horizons and a global scope of potential locations. Compared to conventional wind turbine applications, defense and disaster response applications place a premium on rapid shipping and installation, short-duration operation (days to months), and quick teardown upon mission completion. Furthermore, defense and disaster response applications are less concerned with cost of energy than conventional wind turbine applications. These factors impart design drivers that depart from the features found in conventional distributed wind turbines, thus necessitating unique design guidance. The supporting information for this guidance comes from available relevant references, technical analyses, and input from industry and military stakeholders. This document is not intended to be a comprehensive, prescriptive design specification. This document is intended to serve as a written record of an ongoing discussion of stakeholders about the best currently available design guidance for deployable wind turbines to help facilitate the effective development and acquisition of technology solutions to support mission success. The document is generally organized to provide high-level, focused guidance in the main body, with more extensive supporting details available in the referenced appendices. Section 2 begins with a brief qualitative description of the design guidelines being considered for the deployable wind turbines. Section 3 provides an overview of the characteristics of the mobile power systems commonly used in U.S. military missions. Section 4 covers current military and industry standards and specifications that are relevant to a deployable wind turbine design. Section 5 presents the deployable turbine design guidelines for the application cases.

17 WIND ENERGY↗

DOE OSTI2026

Overview of NLR Automated Mobility District Implementation Research - Phases I, II, and III. The Convergence of Automation, Electrification, and On-Demand Services: Enabling Resilient Automated Mobility Districts

A research program by the National Renewable Energy Laboratory has been investigating the implementation prospects for fully automated passenger transport systems that are deployed to operate within dense urban settings, referred to as Automated Mobility Districts (AMDs). An AMD emphasizes the deployment of automated vehicles (AV) passenger transport services within a dense urban setting and other major activity centers with intense passenger origin-destination demand patterns, such as those found in large business districts, airports, and university and medical campuses. Phase I and II surveyed 10 early deployment sites and subsequently collected and evaluated the lessons learned from these early deployment sites, with particular attention to fleet operations, impacts of service reliability, and vehicle technology evolution as the field of companies was being progressively winnowed by the challenges of full automation.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

DOE OSTI2025

ELECTRIFICATION OF A HEAVY-DUTY OFF-ROAD MATERIAL HANDLER: ENERGY SAVINGS AND EMISSION REDUCTIONS

Federal regulations are driving the adoption of electrification technologies to reduce carbon dioxide equivalent (CO2e) emissions, a metric that quantifies the global warming potential of various greenhouse gases in terms of carbon dioxide (CO2). Although no specific CO2 regulations exist for heavy-duty off-road machines, future reductions are likely, given stricter emissions standards for on-road vehicles. The heavy-duty off-road sector offers significant fuel-saving potential, as its focus has traditionally been on reliability and performance rather than fuel efficiency. This dissertation examines fuel and CO2e savings opportunities on a heavy-duty off-road material handler, the Pettibone Cary-Lift 204i, from stock configuration to simple modifications to a complete teardown and reconfiguration of the machine with a plug-in series hybrid architecture using electrified hydraulics. The study begins by modeling the baseline machine’s fuel and energy consumption, calibrating with experimental data from custom operating cycles. An energy analysis identifies key areas for fuel savings. Two simple powertrain modifications result in a combined 16.2% fuel savings. Next, a Pugh-style analysis narrows a list of electrified architectures, leading to high-fidelity models that evaluate total lifetime CO2e and costs. Higher electrification levels reduce CO2e emissions but increase costs, and electricity grid emissions significantly impact CO2e for plug-in architectures. A plug-in series hybrid is chosen for the project. In its base control form, 49% fuel and 29% CO2e savings are expected from the plug-in series hybrid compared to the baseline machine. Further savings are pursued through regenerative braking (6.3%) and load-following hydraulic control (17.8%), totaling 24.1% fuel savings, and leading to a total of 61% fuel and 41% CO2e savings compared to the baseline. Battery chemistries and charging strategies are also analyzed for cost and CO2e impacts, finding LFP batteries as superior due to longevity, and overnight level 2 charging usually at a lower cost but resulting in higher emissions than opportunity DC fast-charging (DCFC). DCFC emissions are highly dependent on grid emissions, and DCFC cost is highly dependent on grid demand charges. Finally, artificial intelligence is applied to operating cycle recognition. Neural network accuracy ranges from 81% to 99%, with applications to worksite efficiency and safety improvements.

24 POWER TRANSMISSION AND DISTRIBUTION↗

DOE OSTI2022

Clean Cities Coalitions: Advancing Affordable, Domestic Transportation Fuels and Technologies Across the Country

This fact sheet provides an overview of the U.S. Department of Energy's (DOE's) Vehicle Technologies Office Clean Cities Coalition Network, which advances affordable, domestic transportation fuels and technologies nationwide. More than 75 active coalitions serve as the foundation of Clean Cities, working in communities across the country to help local decision makers and fleets understand and implement alternative and renewable fuels, idle-reduction measures, fuel economy improvements, new mobility choices, and emerging transportation technologies. At the national level, VTO develops and promotes publications, tools, and other unique resources to support coordinators. At the local level, coalitions leverage these resources to create networks of stakeholders.

accomplishments↗

DOE OSTI2022

Clean Cities Coalitions: Advancing Affordable, Domestic Transportation Fuels and Technologies Across the Country

accomplishments↗

DOE OSTI2024

Multi-Scale Integrated Monitoring System for Enhancing Methane Emission Detection, Quantification & Prediction

This report details the progress and findings of a comprehensive study on reviewing existing solutions, identifying technology gaps, and formulating an “all-in-one” integrated strategy for developing the next-generation multiscale methane monitoring and modeling platform, conducted under grant number DE-FE0032292. Co-led by Dr. David Ebert, Dr. Binbin Weng, and Dr. Chenghao Wang at the University of Oklahoma, the project’s goal was to develop an integrated approach for building this engineering platform to detect, quantify, and mitigate methane emissions across various temporal scale, spatial scales, and sectors. The planning grant study began with an extensive review of various methane sensing and monitoring technologies and systems, surveying over 100 technology providers globally. This review revealed the prevalence of optical methods over chemical methods in commercially available sensors, with Non-Dispersive Infrared (NDIR), Tunable Diode Laser Absorption Spectroscopy (TDLAS), and Optical Gas Imaging (OGI) cameras being the most prevalent options. A trend towards more advanced optical techniques was observed, driven by increased regulatory focus and technological advancements. The technical evaluation of these sensing technologies provided crucial insights into their capabilities and limitations. The study examined emerging technologies such as Differential Absorption LiDAR (DIAL), which show promise for high-precision and long-range detection. The team then investigated the features and application bandwidth of various sensing platforms, including handheld, fixed/stationary, mobile, aerials, and spaceborne monitors. Pilot field studies were conducted to assess the capabilities of solutions for different emission scenarios. Field work with sensor deployments was conducted at three distinct site types: an oil & gas industry site, a cattle ranching operation, and a waste processing facility. The team also conducted a thorough review of methane flux inverse modeling approaches, focused on physically based methods. These approaches were categorized into simple, intermediate, and advanced methods. A realtime WRF-GHG (Weather Research and Forecasting-Greenhouse Gas) modeling system was developed and applied, incorporating multiple data sources to guide field experiments and inform methane plume detection. The project identified and analyzed numerous categories of methane data sources, including satellite measurements, ground-based sensors, and inventory databases. Key platforms examined include EDGAR, EPA GHGI, NASA TROPOMI, Carbon Mapper, and Climate TRACE, among others. The team proposed an architecture for a comprehensive methane monitoring platform. This system incorporates multi-source data acquisition, advanced data processing and assimilation, interactive visualization tools, and analytical capabilities for emissions forecasting and scenario analysis. The proposed platform aims to provide a user-friendly interface catering to various stakeholders, from researchers to policymakers. The architecture includes sophisticated data ingestion methods, a centralized data warehouse, and advanced analytical tools for data fusion and interpretation. To ensure the relevance and effectiveness of the proposed system, a comprehensive survey was conducted to gather stakeholder input on system requirements. Key findings include a strong need for integrating various data types and formats, a preference for real-time data updates and advanced visualization tools, and a demand for user-friendly interfaces catering to different expertise levels.

03 NATURAL GAS↗

DOE OSTI2020

Mobility, Energy, and Electric Vehicle Typology for New York State

Mobility patterns, technology adoption and associated energy outcomes vary tremendously across settlement types. This paper explores how a highly geographically resolved exploration of the social, economic, techno-infrastructural and environmental domains of New York State is key to understanding observed variations in transportation technology adoption and associated mobility and energy outcomes. Current socioeconomic and mobility data sets at the census block group level are integrated in a hierarchical clustering approach to show how variations in mobility and energy outcomes are shaped by these domains - which may enhance progress on investments, or effectively inform planning and other decisions for state-wide goals. The clustering produces four settlement types to predict dependent variables of electric vehicle (EV) adoption rates, commute mode, vehicle fuel economy, and vehicles per household. This typology shows EV adoption rates among the core urban population, which is wealthy and highly-educated, are high - 3 EVs/1000 vehicles versus 1 EV/1000 vehicles among the urban working class. Commuting mode is closely linked with population and employment density - more than 90% of core urbanites use transit or active modes, compared with only 22% of suburbanites and 17% of rural residents. Household vehicle ownership also varies, with 2 vehicles per household in rural areas and only 0.5 in core urban settings. Important findings on differences among the rural, suburban, urban, and urban core settlement types suggest a need to explore how best to manage and anticipate very different types of services that may be supportive in achieving energy-efficient and affordable mobility systems state-wide.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2022

Engineering A Low-Cost Kelp Aquaculture System for Community-Scale Seaweed Farming at Nearshore Exposed Sites via User-Focused Design Process

For over 50 years, government fishery agencies have recognized the need to transition excess fishing capacity in coastal waters to aquaculture. For the most part, investment strategies to move wild capture and harvest efforts into aquaculture have failed since the technology and capital expense for entry, such as large fish pens, was not conducive for acceptance. In contrast, low trophic level aquaculture of shellfish and seaweeds is suitable as an addition to the livelihoods of seasonal fishing communities and to those displaced by fishery closures, especially if vessels and gear can be designed around existing fishing infrastructures, thus allowing fishers to maintain engagement with their primary fishery, while augmenting income via aquaculture. In this study, an inexpensive, lightweight, and highly mobile gear for kelp seaweed farming was developed and tested over a 3-year period in southern Maine, USA. The system was different from existing kelp farming operations used in nearshore waters that use low-scope mooring lines, and heavy, deadweight anchors. Instead, a highly mobile, easy to deploy system using lightweight gear was designed for exposed conditions. The entire system fit into fish tote boxes and was loadable onto a standard pickup truck. The seaweed system had small but efficient horizontal drag embedment anchors connected to a chain catenary and pretensioned with simple subsurface flotation. The system was able to be deployed and removed in less than 4 h by a crew of three using a 10 m vessel and produced a harvest of 12.7 kg/m over an 8-month fall-winter growth period. The target group for this seaweed research and development effort were coastal fishing communities who move seasonally into non-fishing occupations in service industries, such as construction, retail, etc. An economic assessment suggests farmers would realize an 8% return on investment after3 years and $13.50/h greater income as compared to a non-farming off season job at minimum wage. This low-cost seaweed farming system for fall-winter operations fits well into a “livelihood” strategy for fishing families who must work multiple jobs in the offseason when their main fishery is unavailable.

St-Gelais, Adam T.↗

DOE OSTI2020

Mobility Data and Models Informing Smart Cities

This presentation explores the interactions of Emerging Technology, Changing Urban Environments, and Urban Travel Behavior on Mobility and Energy Impacts. Key findings include quantifying impacts of emerging mobility, access and infrastructure associated with new mobility choices and services in urban areas. The results demonstrate new data collection methods and capabilities to understand and identify key levers to improve energy productivity of future mobility systems and of quickly evolving MaaS and COVID-19 contexts to monitor rapidly shifting urban mobility patterns. Under development are mode choice models for new modes versus traditional modes. Initial estimates are developed on the potential of workforce mobility strategies in shaping future energy-efficient mobility system impacts. For mode replacement and workforce mobility, this presentation offers observability into the changes in number of transactions per mode, after ride-hailing/TNC/MaaS introduction and in origins of workforce to enable user need-driven reimagining of efficient mobility systems: Seattle (SEA-TAC) airport: for every 100 new TNC transactions for ground transportation, ~27% replaced transit, 35% replaced parking, 17% replaced car rentals, and 21% replaced taxis. Similarly, at Denver International (DEN), ride-hailing transactions replaced transit, parking, car rental and taxis at a rate of 34.7%, 39.0%, 16.6%, and 9.7%, respectively. A workforce mobility tool, analysis/visualization techniques, and capabilities to understand and identify key job commute needs, new choices in access to job opportunities, and affordability aspects as levers to improve energy productivity of future integrated urban mobility systems.

ADVANCED PROPULSION SYSTEMS,ENERGY PLANNING, POLIC↗

DOE OSTI2022

An overview of the operation architectures and energy management system for multiple microgrid clusters

The emerging novel energy infrastructures, such as energy communities, smart building-based microgrids, electric vehicles enabled mobile energy storage units raise the requirements for a more interconnective and interoperable energy system. It leads to a transition from simple and isolated microgrids to relatively large-scale and complex interconnected microgrid systems named multi-microgrid clusters. In order to efficiently, optimally, and flexibly control multi-microgrid clusters, cross-disciplinary technologies such as power electronics, control theory, optimization algorithms, information and communication technologies, cyber-physical, and big-data analysis are needed. This paper introduces an overview of the relevant aspects for multi-microgrids, including the outstanding features, architectures, typical applications, existing control mechanisms, as well as the challenges.

24 POWER TRANSMISSION AND DISTRIBUTION↗

DOE OSTI2024

Security of Mobile Radiological Sources: Overview of Industry Applied Technologies

Small radiological sources used in industrial settings recurrently require transit between job sites. Securing these sources, while stationary, can be addressed with standard security approaches and equipment. Transport of these sources increases the risk and complexity of managing and maintaining control of these sources. Implementing methodologies to securely monitor and locate sources improves response and resolution of anomalous events during transit. The Mobile Source Transit Security (MSTS) system was developed to improve security and provide situational awareness of these mobile sources throughout their job cycle. The MSTS development effort focused on creating a set of systems that could be successfully implemented in industrial radiography and well-logging applications. The MSTS team worked to address source presence and location through use and storage. The MSTS system monitors radiological sources as they move from the base of operations to the job site and back. The system provides near-real-time monitoring of the mobile source location and status and early notification of source loss or theft by transmitting operational status and alerting anomalous conditions over telematic links worldwide. The MSTS system can trigger an armed response or initiation of search and recovery operations and will automatically alert management and responsible staff if a radioactive source is lost or stolen whether it is on-site, in transport, or in storage.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗

DOE OSTI2023

Atomic scale interface engineering for realizing a perpendicularly magnetized CoFeB-based skyrmion hosting material

Néel-type magnetic skyrmions in perpendicularly magnetized systems have attracted considerable interest due to their potential in fundamental research on topological objects and spintronics applications. Various systems have been explored to study Néel-type magnetic skyrmions, including repeated magnetic multilayers, two-dimensional materials, and single magnetic thin-films. Among these, single magnetic thin-films, especially a CoFeB single layer, offers multiple benefits, such as reduced defect energy, high mobility, and easy integration with existing magnetoresistive random access memory technology. However, optimizing CoFeB-based skyrmion hosting materials remains challenging and requires further systematic and comprehensive investigation. Here, in this study, we examine the effect of atomic-scale interface engineering by inserting a Ta layer between the CoFeB/MgO interface on perpendicular magnetic anisotropy, saturation magnetization, and Dzyaloshinskii–Moriya interaction. Moreover, we provide a guideline for engineering material parameters and demonstrate the validity of atomic-scale interface engineering. Our findings contribute to the development of optimized CoFeB-based skyrmion hosting materials.

36 MATERIALS SCIENCE↗

DOE OSTI2025

Synopsis of NREL's Automated Mobility District (AMD) Research Program and Associated Publications

An automated mobility district (AMD) envisions a system of integrated mobility options that serves major activity centers such as campuses, central business districts, and large medical facilities. The National Renewable Energy Laboratory (NREL) has been investigating the implementation prospects for fully automated passenger transport systems that are deployed to operate within dense urban settings. This document provides a synopsis of findings revealed over the last three phases of work, which have yielded insights into the creation and management of AMDs anticipated to use automated vehicle (AV) technology over the next decade. Phase I and Phase II tracked the deployment and lessons learned from 10 early-stage demonstrations of automated shuttle deployments, and their associated insights into the challenges for automated driving systems to achieve safe operations within district-scale deployments. Phase III began in-depth investigations of critical subsystem components, as automation, electrification, and on-demand service continue to converge within initial AMD operations. These directed studies focus on elements of electrification, curbfront/station management, the role of infrastructure sensing, and overall integration of AMD safety management in central, simultaneous coordination of multiple AMD fleets. Future research in AMDs includes systems engineering methodology (more frequently referred to as "digital twins") for planning, design, testing, and ongoing operation of AMDs; location (or co-location) of management functions; and human supervision and passenger communications for safety and security in unattended vehicles. The synopsis references the foundational research products (papers and presentations) that have been published through conference proceedings, journal articles, and NREL reports.

33 ADVANCED PROPULSION SYSTEMS↗

DOE OSTI2022

Renewable Energy and Efficiency Technologies in Scenarios of U.S. Decarbonization in Two Types of Models: Comparison of GCAM Modeling and Sector-Specific Modeling

Energy system projections from analytic models inform actions ranging from short-term and local decisions, such as technology and infrastructure deployment, to global and long-term negotiations and targets. Computational limits require the designers of these models to trade off between coverage and resolution. Some models, such as the Global Change Analysis Model (GCAM), represent all energy sources and uses but at a relatively coarse level of resolution. GCAM balances global supply and demand of all energy carriers by endogenously projecting prices for energy sources and costs of greenhouse gas mitigation while capturing interlinkages between the energy system, water, agriculture and land use, the economy, and the climate. This global model was used to frame the Long-Term Strategy released by the White House in 2021 and has been used to inform national and global economy-wide decarbonization discussions and strategy development for decades. Other models instead focus on a portion of the energy sector with greater detail and resolution. The Regional Energy Deployment System (ReEDS) electricity-sector model, for example, projects capacity expansion with an emphasis on integration of variable renewable energy into the grid of the future. The Transportation Energy and Mobility Pathway Options (TEMPO) transportation-sector model enables analysis of household choices in adoption, charging, and use of electric vehicles. The Scout buildings-sector model supports detailed consideration of the policies and markets that can accelerate the adoption of energy conservation measures in buildings. Such sector-specific models are instrumental in informing technology research, sectoral planning strategies, and sector-specific aspects of greenhouse gas (GHG) mitigation strategies in the United States. These global and sector-specific modeling approaches can complement each other. The global approach ensures consistent, endogenous energy pricing and resource allocation, which can substantially diverge from current conditions in transformative scenarios, while the sector-specific approach facilitates representation of granular details across spatial, temporal, technological, and market dimensions that enable exploration of particular interactions and trade-offs. This report presents the results of recent work to explore the differences and tradeoffs between these approaches by comparing GCAM with the sector-specific ReEDS, TEMPO, and Scout models. The report compares both model structures and results, and discusses their potential relevance and applications.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

DOE OSTI2021

Smartphone-Based Device for Colorimetric Detection of MicroRNA Biomarkers Using Nanoparticle-Based Assay

The detection of microRNAs (miRNAs) is emerging as a clinically important tool for the non-invasive detection of a wide variety of diseases ranging from cancers and cardiovascular illnesses to infectious diseases. Over the years, miRNA detection schemes have become accessible to clinicians, but they still require sophisticated and bulky laboratory equipment and trained personnel to operate. The exceptional computing ability and ease of use of modern smartphones coupled with fieldable optical detection technologies can provide a useful and portable alternative to these laboratory systems. Herein, we present the development of a smartphone-based device called Krometriks, which is capable of simple and rapid colorimetric detection of microRNA (miRNAs) using a nanoparticle-based assay. The device consists of a smartphone, a 3D printed accessory, and a custom-built dedicated mobile app. We illustrate the utility of Krometriks for the detection of an important miRNA disease biomarker, miR-21, using a nanoplasmonics-based assay developed by our group. We show that Krometriks can detect miRNA down to nanomolar concentrations with detection results comparable to a laboratory-based benchtop spectrophotometer. With slight changes to the accessory design, Krometriks can be made compatible with different types of smartphone models and specifications. Thus, the Krometriks device offers a practical colorimetric platform that has the potential to provide accessible and affordable miRNA diagnostics for point-of-care and field applications in low-resource settings.

Krishnan, Tushar (ORCID:0000000342610336)↗