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All sources NASA NTRS DOE OSTI

DOE OSTI2025

Long-Term Evaluation of Remedial Technology Performance in the Laboratory: Multi-year Experimental Test Plan

An understanding of the long-term effectiveness of remediation technologies is central to sustainable environmental cleanup. Long-term experiments are valuable for reducing uncertainty and predicting remediation outcomes at scales required for regulatory compliance. However, these types of tests can be costly and challenging to interpret. Therefore, contaminated sites often rely on short-term laboratory experiments that may not account for the potentially significant effects of gradual, time- dependent processes governing contaminant retention, release, and species transformation. For example, short-term lab experiments (from months to a year) conducted with sediments from the unsaturated and saturated zones at the Hanford Site play an important role in initial evaluations of remediation technologies but cannot capture the full extent of time-dependent reactions, leaving uncertainties in field-scale deployment. Here, long-term testing will be conducted on select technologies based on their performance in short-term testing. The overall objective is to directly address the challenges described above by generating and analyzing data on long-term (2–10 years) efficacy of selected remediation technologies, integrating this understanding into models, and providing critical input for remediation planning, monitoring, and 5-year review cycles for field-implemented remedies. Specific objectives include: 1. Evaluating long-term efficiency of promising remedies under site-specific conditions. 2. Generating robust parameters for modeling, reducing uncertainty in predictive simulations. 3. Advancing integrated monitoring by combining geochemical and geophysical observations. 4. Informing field-scale implementation by incrementally advancing technologies, identifying failure mechanisms early, and prioritizing robust, cost-effective remedies. Through systematic evaluation of technologies in laboratory-scale column experiments, integrated monitoring, and modeling support, this project is designed to bolster confidence in the long-term robustness of selected technologies. The ultimate outcome is the identification and deployment of more reliable, cost-effective remedies that safeguard human health and the environment while reducing the uncertainties that have historically hindered cleanup progress at Hanford Site. An experimental approach was developed and initiated for long-term testing potentially up to 10 years. The table below summarizes the experimental approach developed for testing select technologies and presented in this multi-year experimental test plan.

54 ENVIRONMENTAL SCIENCES↗

NASA NTRS1974

A guide for performing system safety analysis

A general guide is presented for performing system safety analyses of hardware, software, operations and human elements of an aerospace program. The guide describes a progression of activities that can be effectively applied to identify hazards to personnel and equipment during all periods of system development. The general process of performing safety analyses is described; setting forth in a logical order the information and data requirements, the analytical steps, and the results. These analyses are the technical basis of a system safety program. Although the guidance established by this document cannot replace human experience and judgement, it does provide a methodical approach to the identification of hazards and evaluation of risks to the system.

Brush, J. M.↗

NASA NTRS1983

Analysis and classification of human error

The literature on human error is reviewed with emphasis on theories of error and classification schemes. A methodology for analysis and classification of human error is then proposed which includes a general approach to classification. Identification of possible causes and factors that contribute to the occurrence of errors is also considered. An application of the methodology to the use of checklists in the aviation domain is presented for illustrative purposes.

Rouse, W. B.↗

NASA NTRS1988

An expert system based intelligent control scheme for space bioreactors

An expert system based intelligent control scheme is being developed for the effective control and full automation of bioreactor systems in space. The scheme developed will have the capability to capture information from various resources including heuristic information from process researchers and operators. The knowledge base of the expert system should contain enough expertise to perform on-line system identification and thus be able to adapt the controllers accordingly with minimal human supervision.

San, Ka-Yiu↗

NASA NTRS1993

Incorporating biologically based models into assessments of risk from chemical contaminants

The general approach to assessment of risk from chemical contaminants in drinking water involves three steps: hazard identification, exposure assessment, and dose-response assessment. Traditionally, the risks to humans associated with different levels of a chemical have been derived from the toxic responses observed in animals. It is becoming increasingly clear, however, that further information is needed if risks to humans are to be assessed accurately. Biologically based models help clarify the dose-response relationship and reduce uncertainty.

Review, Tutorial↗

NASA NTRS2009

An Effective Health and Medical Technical Authority

The NASA Governance model directed the formation of three Technical Authorities, Engineering; Safety and Mission Assurance; and Health and Medical, to ensure that risks are identified and adjudicated efficiently and transparently in concert with the spaceflight programs and projects. The Health and Medical Technical Authority (HMTA) has been implemented at the Johnson Space Center (JSC) and consists of the Chief Medical Office (CMO), the Deputy CMO, and HMTA Delegates. The JSC HMTA achieves the goals of risk identification and adjudication through the discharge of the appropriate technical expertise to human space flight programs and projects and the escalation of issues within program and technical authority boards. The JSC HMTA relies on subject matter experts (SMEs) in the Space Life Sciences Directorate at JSC as well as experts from other Centers to work crew health and performance issues at the technical level, develop requirements, oversee implementation and validation of requirements, and identify risks and non-compliances. Once a risk or potential noncompliance has been identified and reported to the programs or projects, the JSC HMTA begins to track it and closely monitor the program's or project's response. As a risk is developed or a non-compliance negotiated, positions from various levels of decision makers are sought at the program and project control boards. The HMTA may support a program or project position if it is satisfied with the decision making and vetting processes (ex. the subject matter expert voiced his/her concerns and all dissenting opinions were documented) and finds that the position both acknowledges the risk and cost of the mitigation and resolves the issue without changing NASA risk posture. The HMTA may disagree with a program or project position if the NASA risk posture has been elevated or obfuscated. If the HMTA does disagree with the program or project position, it will appeal to successively higher levels of authority so that risk acceptance and risk trades will be acknowledged and sanctioned at the highest appropriate level; this includes Program Managers, Mission Directorate Associate Administrators and the Agency Administrator.

Fogarty, Jennifer A.↗

NASA NTRS2012

A Miniature Laser Desorption/Ionization Time-of-Flight Mass Spectrometer for in Situ Analysis of Mars Surface Composition and Identification of Hazard in Advance of Future Manned Exploration

Future landed missions to Mars will be guided by two strategic directions: (1) sample return to Earth, for comprehensive compositional analyses, as recommended by the 2011 NRC Planetary Decadal Survey; and (2) preparation for human exploration in the 2030s and beyond, as laid out by US space policy. The resultant mission architecture will likely require high-fidelity in situ chemical/organic sample analyses within an extremely constrained resource envelope. Both science goals (e.g., MEPAG Goal 1, return sample selection, etc.) as well as identification of any potential toxic and biological hazards to humans, must be addressed. Over the past several years of instrument development, we have found that the adaptable, compact, and highly capable technique of laser desorption/ionization time-of-flight mass spectrometry (LD-TOF-MS) has significant potential to contribute substantially to these dual objectives. This concept thus addresses Challenge Area 1: instrumentation and Investigation Approaches.

Getty, S. A.↗

NASA NTRS2016

Some Strategic Considerations Related to the Potential Use of Water Resource Deposits on Mars by Future Human Explorers

A long-term base on Mars, at the center of an "Exploration Zone", would require substantial quantities of in-situ resources. Although water is not the only resource on Mars of potential interest, it stands out as the one that most dominates long-lead strategic planning. It is needed for multiple purposes for various human activities (including our own survival!), and in significant quantities. The absence of viable deposits could make a surface "field station" logistically unsustainable. Therefore, identification of deposits, and development of the technology needed to make use of these deposits, are an important priority in the period leading up to a human mission to Mars. Given our present understanding of Mars, ice and hydrated minerals appear to be the best potential sources for the quantity of water expected to be needed. The methods for their extraction would be different for these two classes of deposits, and at the present time it is unknown which would ultimately be an optimal solution. The deposits themselves would also ultimately have to be judged by certain economics that take into account information about geologic and engineering attributes and the "cost" of obtaining this information. Ultimately much of this information would need to come from precursor missions, which would be essential if utilization of martian is situ water resources is to become a part of human exploration of Mars.

Beaty, D.W.↗

NASA NTRS1984

Time series modeling of human operator dynamics in manual control tasks

A time-series technique is presented for identifying the dynamic characteristics of the human operator in manual control tasks from relatively short records of experimental data. Control of system excitation signals used in the identification is not required. The approach is a multi-channel identification technique for modeling multi-input/multi-output situations. The method presented includes statistical tests for validity, is designed for digital computation, and yields estimates for the frequency responses of the human operator. A comprehensive relative power analysis may also be performed for validated models. This method is applied to several sets of experimental data; the results are discussed and shown to compare favorably with previous research findings. New results are also presented for a multi-input task that has not been previously modeled to demonstrate the strengths of the method.

Biezad, D. J.↗

NASA NTRS1984

Time Series Modeling of Human Operator Dynamics in Manual Control Tasks

A time-series technique is presented for identifying the dynamic characteristics of the human operator in manual control tasks from relatively short records of experimental data. Control of system excitation signals used in the identification is not required. The approach is a multi-channel identification technique for modeling multi-input/multi-output situations. The method presented includes statistical tests for validity, is designed for digital computation, and yields estimates for the frequency response of the human operator. A comprehensive relative power analysis may also be performed for validated models. This method is applied to several sets of experimental data; the results are discussed and shown to compare favorably with previous research findings. New results are also presented for a multi-input task that was previously modeled to demonstrate the strengths of the method.

Biezad, D. J.↗

NASA NTRS2018

A Risk Analysis Tool for Estimating the Risk of Electrical Failures Due to Human Induced Defects

Aerospace electrical systems are required to withstand and adequately operate in extremely harsh environments that include, for example, high radiation exposure, temperature extremes, intense vibrational stress and drastic temperature cycling. The nature of aerospace electronics also demands high reliability since, with very few exceptions, there is no chance for hardware servicing or repairs. Common risk mitigation techniques for this type of situation are to perform a Reliability Analysis of the system throughout the development cycle, and to use electrical components that are regarded as “high reliability” because of additional controls and requirements applied in their design, manufacturing and testing. Unfortunately, studies have shown that even though these techniques are used, many systems fail to meet mission requirements well before the predicted lifetimes. This paper presents the analysis of failures of electrical parts, experienced during various stages of system development, at NASA Goddard Space Flight Center, Greenbelt MD, between the years 2001 and 2013. These components were subjected to qualification, screening and testing in which the goal was to ensure that the components would survive the stresses of the mission. The analysis categorizes failures by part type and failure mechanisms. One of the results of the analysis was the realization that a surprising proportion of failures experienced during system integration and testing were caused by human error (i.e. human induced defect). Further analysis included the determination of root failure mechanisms and any influencing factors contributing to these failures. The major causes of these defects were attributed to electrostatic damage (ESD), electrical overstress (EOS), mechanical overstress (MOS), and thermal overstress (TOS). Finally, the study proposes a risk analysis tool which incorporates these major causes for the failures, termed error-producing conditions (EPCs), and a proportionality factor representing the number of each type of failure that has occurred at the facility under study. These factors are quantified and used to communicate the risk of human induced defects for the assembly, integration and testing of space hardware based on the system’s electrical parts list. The new risk identification can trigger risk-mitigating actions more effectively, based on the presence of component categories or other hazardous conditions that have a history of failure due to human error.

Majewicz, Peter J.↗

DOE OSTI2026

A funnel approach to enable analyses of epitope-specific human CD4 T cells specific for influenza and SARS-CoV-2

Protection against pathogens relies heavily on the adaptive immune response, whose key regulators are CD4 T cells. CD4 T cells, notable for their complex repertoire and functional potential, can most easily be dissected by identifying, quantifying, characterizing, and isolating epitope-specific cells. In the study reported here, we present a systematic and unbiased strategy that has enabled the identification of highly immunogenic peptide epitopes derived from influenza virus and SARS-CoV-2, presented by human HLA-DR proteins. Coupling the use of HLA-DR transgenic mice with infection and vaccination and highly sensitive epitope-specific cytokine ELISpot assays, we have narrowed the potential epitopes from 450 to 600 peptides to 5–15 peptides for each allele by an iterative process of elimination and selection, which we have termed a funnel approach. These epitopes have been validated in HLA-DR-typed human CD4 T cells directly ex vivo and enabled the derivation and implementation of HLA-DR peptide tetramers. Tetramer staining of human PBMCs enriched for CD4 T memory populations from healthy adult subjects, highlighted this approach as a sensitive and specific method for identifying novel epitopes, and subsequent CD4 T-cell responses to human viral infections.

CD4 T cell↗

NASA NTRS2016

Some Strategic Considerations Related to the Potential Use of Water Resource Deposits on Mars by Future Human Explorers

A long-term base on Mars, at the center of an “Exploration Zone”, would require substantial quantities of in-situ resources. Although water is not the only resource on Mars of potential interest, it stands out as the one that most dominates long-lead strategic planning. It is needed for multiple aspects of various human activities (including our own survival), and in significant quantities. The absence of a viable deposits could make a surface “field station” logistically unsustainable. Therefore, identification of deposits, and development of the technology needed to make use of these deposits, are an important priority in the period leading up to a human mission to Mars. Given our present understanding of Mars, ice and hydrated minerals appear to be the best potential sources for the quantity of water expected to be needed. The methods for their extraction would be different for these two classes of deposits, and at the present time it is unknown which would ultimately be an optimal solution. The deposits themselves would ultimately have to be judged by an economic assessment that takes into account information about geologic and engineering attributes and the “cost” of obtaining this information. Ultimately, much of this information would need to come from precursor missions, which would be essential if utilization of martian is situ water resources is to become a part of human exploration of Mars.

Beaty, D. W.↗

DOE OSTI2024

An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo

Background: Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery. However, this currently requires laborious and lengthy longevity analysis. Here, we present a novel screening readout for the expedited discovery of compounds that restrain ageing of cell populations in vitro and enable extension of in vivo lifespan. Methods: Using Illumina methylation arrays, we monitored DNA methylation changes accompanying long-term passaging of adult primary human cells in culture. This enabled us to develop, test, and validate the CellPopAge Clock, an epigenetic clock with underlying algorithm, unique among existing epigenetic clocks for its design to detect anti-ageing compounds in vitro. Additionally, we measured markers of senescence and performed longevity experiments in vivo in Drosophila, to further validate our approach to discover novel anti-ageing compounds. Finally, we bench mark our epigenetic clock with other available epigenetic clocks to consolidate its usefulness and specialisation for primary cells in culture. Results: We developed a novel epigenetic clock, the CellPopAge Clock, to accurately monitor the age of a population of adult human primary cells. We find that the CellPopAge Clock can detect decelerated passage-based ageing of human primary cells treated with rapamycin or trametinib, well-established longevity drugs. We then utilise the CellPopAge Clock as a screening tool for the identification of compounds which decelerate ageing of cell populations, uncovering novel anti-ageing drugs, torin2 and dactolisib (BEZ-235). We demonstrate that delayed epigenetic ageing in human primary cells treated with anti-ageing compounds is accompanied by a reduction in senescence and ageing biomarkers. Finally, we extend our screening platform in vivo by taking advantage of a specially formulated holidic medium for increased drug bioavailability in Drosophila. We show that the novel anti-ageing drugs, torin2 and dactolisib (BEZ-235), increase longevity in vivo. Conclusions: Our method expands the scope of CpG methylation profiling to accurately and rapidly detecting anti-ageing potential of drugs using human cells in vitro, and in vivo, providing a novel accelerated discovery platform to test sought after anti-ageing compounds and geroprotectors.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1976

Portable medical status system

The hazards inherent in the Portable Medical Status System are identified, and the measures taken to reduce them to an acceptable level are described. Identification of these hazards is a prerequisite to use of the system on humans in the earth environment. One hazard which is insufficiently controlled and which is considered a constraint to use on humans is the level of current possible in the electrodes for the EEG (electroencephalograph) circuitry. It exceeds the maximum specified. A number of procedural and design recommendations for enhancement of safety are made.

Lindsey, O. C.↗

NASA NTRS1992

Microgravity effects on standardized cognitive performance measures

The purpose of this experiment, selected to fly on the International Microgravity Laboratory (IML-2) Spacelab mission, is to determine the effects of microgravity upon the cognitive skills which are critical to successful performance of many tasks on board the Space Shuttle. Six tests from the Unified Tri-service Cognitive Performance Assessment Battery (UTC-PAB) will be administered to the Mission Specialists to fulfill the goals of this experiment. These tests are based upon current theoretical models of human performance and the hypothesized effects of microgravity. The principle objective is the identification of the effects of microgravity upon specific information processing skills affecting performance from those of fatigue and shifts in work/rest cycles. Multiple measures of both short and long term fatigue will be obtained and used as a major independent variable for the analysis of these performance data. Scientific supporting studies will determine optimum practice and performance testing schedules for the astronauts. The same tests will be used post-flight to collect data on the recovery of any cognitive performance impairment compared with pre-flight, baseline levels.

Schiflett, Samuel G.↗

NASA NTRS2018

Ultra Long-Lived Autonomous Air Quality Sensing

Environmental sensing will be key to autonomous vehicle operation and crew health monitoring in tended/untended long-duration habitats for Human Space Exploration in deep space. Small wireless sensors, based on Radio Frequency Identification (RFID) technology, can provide unprecedented capacity to monitor crew/habitat health. We propose a next-generation, wireless air quality sensor capable of operating for years on a small coin-cell battery without crew-member intervention.

Wagner, Raymond S.↗

NASA NTRSDate not supplied

Dynamic Vehicle Assessment for Intelligent Contingency Management for Urban Air Mobility Vehicles

New algorithms will be required to ensure passenger and bystander safety during the expected era of autonomous urban air mobility (UAM) aircraft. This paper examines an approach for assessing the vehicle capability to fly itself and to complete a mission safely. The concepts combine elements of system identification, adaptive control, flight dynamics, envelope predictions, and handling qualities, as well as human pilot intuition. The approach is applied to a simulation of a generic distributed electric propulsion urban air mobility-type aircraft, which was developed under the NASA Transformational Tools and Technologies (TTT) project, Autonomous Systems / Intelligent Contingency Management subproject.

flight envelope prediction↗