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At least 199 records · Page 11

Protecting Neural Structures and Cognitive Function During Prolonged Space Flight by Targeting the Brain Derived Neurotrophic Factor Molecular Network

Brain derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophin in the human nervous system. BDNF is implicated in production of new neurons from dentate gyrus stem cells (hippocampal neurogenesis), synapse formation, sprouting of new axons, growth of new axons, sprouting of new dendrites, and neuron survival. Alterations in the amount or activity of BDNF can produce significant detrimental changes to cortical function and synaptic transmission in the human brain. This can result in glial and neuronal dysfunction, which may contribute to a range of clinical conditions, spanning a number of learning, behavioral, and neurological disorders. There is an extensive body of work surrounding the BDNF molecular network, including BDNF gene polymorphisms, methylated BDNF gene promoters, multiple gene transcripts, varied BDNF functional proteins, and different BDNF receptors (whose activation differentially drive the neuron to neurogenesis or apoptosis). BDNF is also closely linked to mitochondrial biogenesis through PGC-1alpha, which can influence brain and muscle metabolic efficiency. BDNF AS A HUMAN SPACE FLIGHT COUNTERMEASURE TARGET Earth-based studies reveal that BDNF is negatively impacted by many of the conditions encountered in the space environment, including oxidative stress, radiation, psychological stressors, sleep deprivation, and many others. A growing body of work suggests that the BDNF network is responsive to a range of diet, nutrition, exercise, drug, and other types of influences. This section explores the BDNF network in the context of 1) protecting the brain and nervous system in the space environment, 2) optimizing neurobehavioral performance in space, and 3) reducing the residual effects of space flight on the nervous system on return to Earth

Schmidt, M. A.↗

Hybrid simulations of the saturated Farley-Buneman instability in the ionosphere

Numerical simulations of the Farley-Buneman instability in 2-1/2 dimensions using particle ions and fluid electrons show the growth, saturation and nonlinear behavior of two-stream waves. This hybrid technique models the saturated state of the instability for a much longer period of time than the pure particle codes that preceded it. While focusing principally on modeling the topside E region equatorial electrojet, many of these results apply to the auroral two-stream instability as well. The following features are seen in all our hybrid simulations: (1) wave growth at an angle offset from the electron drift direction where the angle depends on the strength of the driving electric field, (2) nonlinear coupling to waves traveling perpendicular to the propagation direction of the principal two-stream waves, (3) a saturated wave phase velocity at or above the sound speed but well below the velocity predicted by linear theory and (4) phase velocities which remain almost constant as a simulated radar sweeps from a horizontal direction to nearly vertical. The nonlinear electron motion dominates the behavior of these waves. Further, these simulations indicate that ion kinetic effects are not essential for the saturation of the instability and that electron temperature effects have a minor impact on the final saturated state.

Oppenheim, Meers↗

Flight Planning for the International Space Station - Levitation Observation of Dendrite Evolution in Steel Ternary Alloy Rapid Solidification (LODESTARS)

During rapid solidification, a molten sample is cooled below its equilibrium solidification temperature to form a metastable liquid. Once nucleation is initiated, growth of the solid phase proceeds and can be seen as a sudden rise in temperature. The heat of fusion is rejected ahead of the growing dendrites into the undercooled liquid in a process known as recalescence. Fe-Cr-Ni alloys may form several equilibrium phases and the hypoeutectic alloys, with compositions near the commercially important 316 stainless steel alloy, are observed to solidify by way of a two-step process known as double recalescence. During double recalescence, the first temperature rise is associated with formation of the metastable ferritic solid phase with subsequent conversion to the stable austenitic phase during the second temperature rise. Selection of which phase grows into the undercooled melt during primary solidification may be accomplished by choice of the appropriate nucleation trigger material or by control of the processing parameters during rapid solidification. Due to the highly reactive nature of the molten sample material and in order to avoid contamination of the undercooled melt, a containerless electromagnetic levitation (EML) processing technique is used. In ground-based EML, the same forces that support the weight of the sample against gravity also drive convection in the liquid sample. However, in microgravity, the force required to position the sample is greatly reduced, so convection may be controlled over a wide range of internal flows. Space Shuttle experiments have shown that the double recalescence behavior of Fe-Cr-Ni alloys changes between ground and space EML experiments. This program is aimed at understanding how melt convection influences phase selection and the evolution of rapid solidification microstructures.

Flemings, Merton C.↗

Effect of Vacuum on Force Response of an Ultrasonic Penetrator

Introduction: The Apollo astronauts encountered higher than expected resistances when interacting with the lunar soil via the Apollo Lunar Surface Drill (ALSD) and the trenching tool. Reducing the force required to move tools or other mechanical components through regolith will impact many steps of the resource extraction process. Force reduction has been achieved in soil materials by imparting vibration to tooling interfaces such as a vibratory farming cultivator, a percussive scoop, and ultrasonically resonant penetrators. Vibration-assisted tools in granular media reduce interaction forces by fluidizing a volume around the tool, allowing the tool to progress through a dynamic (fluid) medium instead of a static (solid) medium. This work seeks to quantify ultrasonic vibration’s effect on the force response of a penetrator in lunar soil simulant in vacuum sufficient to be within the molecular flow regime of any disturbed gases. Methods: A custom vacuum chamber setup, CUBEvac, was designed and built to facilitate penetration testing in a high vacuum environment, for comparison to penetration behavior in ambient terrestrial environment. A two-stage pumping system (Agilent Triscroll 600 roughing pump, Agilent VHS-6 oil diffusion pump) reached chamber pressures of about 5x10-6 Torr with regolith simulant in place. Figure 1 is a schematic of the heart of the assembly (note the penetration drive mechanisms above the chamber feedthrough and the regolith simulant sample in the bottom are not shown). The penetration actuation stack was comprised of a stepper motor driving a lead screw to move the ultra-sonic probe vertically inside the chamber. Motion was coordinated with an Arduino Uno. GRC-3 lunar simulant was used for this set of experiments. Samples were prepared in a four-liter stain-less steel, cylindrical pot with an internal diameter of approximately 15.56 cm (6.125 in) and a depth of 19.37 cm (7 5/8 in) for testing. The soil was baked out prior to compaction preparation as a measure to reduce soil moisture which interfered with pump down capacity. The soil was not baked again if it was removed from the vacuum chamber, prepped, and immediately returned to the vacuum chamber for pump down. The soil was compacted using a 60 Hz vibration table with a surcharge of 34 kg place on top of the soil in the container. Prepared soil samples weighed approximately 6.5 kg (bulk density 1.895-1.934 g/cm3). Two probe end effectors were tested: A cone penetrometer (static only) with a nominal diameter of 12.7 mm (0.5 in) and a nominal height of 28.6 mm (1.125 in); and a vibrating cylindrical probe measuring 12.7 mm in diameter and 50.8 mm in effective length from the tip (Figure 2). The cylindrical probe vibrated resonantly at 20 kHz with an amplitude 23 μm. The cone penetration tests were conducted to assess potential soil behavior differences in vacuum. The cylinder probe tests were conducted as the primary subject of this investigation to assess force response in vacuum. For each test, a regolith simulant sample was load-ed and compacted in the chamber, which was then evacuated for roughly 18 hours to reach the lowest possible pressure (approximately 5x10-6 Torr for most tests). The probe was then moved to about 10 mm above the soil surface before being pushed to a depth of 50 mm for the cylinder probe tests and to a depth of 100 mm for the cone penetrometer tests, both at a speed of 2 mm/s. The simulant samples were prepared the same for all tests. Ideally, they would respond consistently to probe penetration under ambient and vacuum conditions. This was evaluated by measuring the resistance of representative prepared simulant beds with a standard cone penetrometer in both environments. Results and Discussion: The resistance of the simulant samples in the vacuum tests was consistently lower than in the ambient tests as determined by the cone penetration tests. Thus, the ambient and vacuum results cannot be compared directly; work is underway to de-confound and better correlate the data. Still, figures 3-6 show that probe penetration forces are lower overall in the vacuum environment. In both environments, resonant vibration of the probe provides two useful effects: It reduces the probe penetration force and smooths the force-depth curve, significantly reducing local maxima. These effects have implications for various potential applications, such as astronaut hand-tools, where benefits (reducing astronaut effort) outweigh the cost of the additional energy re-quired to generate vibration. These results demonstrate that resonantly vibrating tools can meaningfully reduce the penetration force required for excavation, probing, and drilling tools in simulated lunar regolith deposits under vacuum levels approaching those that will be experience on the Moon’s surface. Lunar-gravity, ambient environment tests are scheduled soon. The effects of realistic temperatures and temperature gradients and deeper vacuum remain to be tested.

E Rezich↗

Stabilization of discrete-event processes

Discrete-event processes are modeled by state-machines in the Ramadge-Wonham framework with control by a feedback event disablement mechanism. In this paper, concepts of stabilization of discrete-event processes are defined and investigated. The possibility of driving a process (under control) from arbitrary initial states to a prescribed subset of the state set and then keeping it there indefinitely is examined. This stabilization property is studied also with respect to 'open-loop' processes and their asymptotic behavior is characterized. Polynomial time algorithms are presented for verifying various types of attraction and for the synthesis of attractors.

Brave, Y.↗

Numerical and laboratory simulation of fault motion and earthquake occurrence

Simple linear rheologies were used with elastic forces driving the main events and viscoelastic forces being important for aftershock and creep occurrence. Friction and its dependence on velocity, stress, and displacement also plays a key role in determining how, when, and where fault motion occurs. The discussion of the qualitative behavior of the simulators focuses on the manner in which energy was stored in the system and released by the unstable and stable sliding processes. The numerical results emphasize the statistics of earthquake occurrence and the correlations among source parameters.

Cohen, S. C.↗

Numerical and laboratory simulation of fault motion and earthquake occurrence

This paper reviews the simulation of earthquake occurrence by numerical and laboratory mechanical block models. Simple linear rheological elements are used with elastic forces driving the main events and viscoelastic forces being important for aftershock and creep occurrence. Friction and its dependence on velocity, stress, and displacement also play a key role in determining how, when, and where fault motion occurs. The discussion of the qualitative behavior of the simulators focuses on the manner in which energy is stored in the system and released by the unstable and stable sliding processes. The numerical results emphasize the statistics of earthquake occurrence and the correlations among source parameters.

Cohen, S. C.↗

Development of the RANCOR Rotary-Percussive Coring System for Mars Sample Return

A RANCOR drill was designed to fit a Mars Exploration Rover (MER) class vehicle. The low mass of 3 kg was achieved by using the same actuator for three functions: rotation, percussions, and core break-off. Initial testing of the drill exposed an unexpected behavior of an off-the-shelf sprag clutch used to couple and decouple rotary-percussive function from the core break off function. Failure of the sprag was due to the vibration induced during percussive drilling. The sprag clutch would back drive in conditions where it was expected to hold position. Although this did not affect the performance of the drill, it nevertheless reduced the quality of the cores produced. Ultimately, the sprag clutch was replaced with a custom ratchet system that allowed for some angular displacement without advancing in either direction. Replacing the sprag with the ratchet improved the collected core quality. Also, premature failure of a 300-series stainless steel percussion spring was observed. The 300-series percussion spring was ultimately replaced with a music wire spring based on performances of previously designed rotary-percussive drill systems.

Paulsen, Gale↗

Characterization of the Biomechanical Behavior of the Optic Nerve Sheath

A major priority in current space medicine research is to characterize the mechanisms in Visual Impairment and Intracranial Pressure (VIIP) syndrome, a group of ophthalmic changes that occur in some astronauts following long-duration spaceflight [1]. It is hypothesized that microgravity-induced cephalad fluid shifts lead to increases in intracranial pressure (ICP), which drives maladaptive remodeling of the optic nerve sheath (ONS). In this study, we investigated the effects of mechanical loading on the porcine ONS to better understand the mechanical response of the ONS to increased ICP.

fluid shift (biological)↗

Tropical Diabatic Heating and the Role of Convective Processes as Represented in Several Contemporary Climate Models

One of the most fundamental properties of the global heat balance is the net heat input into the tropical atmosphere that helps drive the planetary atmospheric circulation. Although broadly understood in terms of its gross structure and balance of source / sink terms, incorporation of the relevant processes in predictive models is still rather poor. The work reported here examines the tropical radiative and water cycle behavior as produced by four contemporary climate models. Among these are the NSIPP-2 (NASA Seasonal to Interannual Prediction Project) which uses the RAS convective parameterization; the FVCCM, a code using finite volume numerics and the CCM3.6 physics; FVCCM-MCRAS again having the finite volume numerics, but MCRAS convective parameterization and a different radiation treatment; and, finally, the NCEP GSM which uses the RAS. Using multi-decadal integrations with specified SSTs we examine the statistics of radiative / convective processes and associated energy transports, and then estimate model energy flux sensitivities to SST changes. In particular the behavior of the convective parameterizations is investigated. Additional model integrations are performed specifically to assess the importance representing convective inhibition in regulating convective cloud-top structure and moisture detrainment as well as controlling surface energy fluxes. To evaluate the results of these experiments, a number of satellite retrievals are used: TRMM retrievals of vertical reflectivity structure, rainfall rate, and inferred diabatic heating are analyzed to show both seasonal and interannual variations in vertical structure of latent heat release. Top-of-atmosphere radiative fluxes from ERBS and CERES are used to examine shortwave and longwave cloud forcing and to deduce required seasonal energy transports. Retrievals of cloud properties from ISCCP and water vapor variations from SSM/T-2 are also used to understand behavior of the humidity fields. These observations are supplemented with output form the DOE Reanalysis-2.

Robertson, Franklin R.↗

Granular Flow and Dynamics of Lunar Simulants in Excavating Implements

The exploration of the lunar surface will rely on properly designed excavation equipment for surface preparations and for collection of lunar regolith in In-Situ Resource Utilization (ISRU) processes. Performance efficiency, i.e minimizing loading forces while maximizing material collection, and mass and volume reductions are major design goals. The NASA Glenn Research Center has embarked on an experimental program to determine the flow characteristics and dynamic forces produced by excavation operations using various excavator bucket designs. A new large scale soil bin facility, 2.27 m x 5.94 m x 0.76 m (nominally 8 ft. x 20 ft. x 27 in.) in size, capable of accommodating moderately large test implements was used for the simulations of lunar operations. The soil bin is filled with GRC-3simulant (a mixture of industrial sands and silt with a particle size distribution and the bulk mechanical (shear) strength representative of an average of lunar regolith from different regions) and uses motorized horizontal rails and a vertical actuator to drive the implement through the lunar simulant soil. A six-axis load cell and encoders provide well resolved measurements of the three dimensional forces and torques and motion of the bucket. In addition, simultaneous video allows for the analysis of the flow behavior and structure formation of the regolith during excavation. The data may be useful in anchoring soil mechanic models and to provide engineering data for design consideration.

Agui, Juan H.↗

The influence of engine/transmission/governor on tilting proprotor aircraft dynamics

An analytical model is developed for the dynamics of a tilting proprotor aircraft engine and drive train, including a rotor speed governor and interconnect shaft. The dynamic stability of a proprotor and cantilever wing is calculated, including the engine-transmission-governor model. It is concluded that the rotor behaves much as if windmilling as far as its dynamic behavior is concerned, with some influence of the turboshaft engine inertia and damping. The interconnect shaft has a significant influence on the antisymmetric dynamics of proprotor aircraft. The proprotor aerodynamics model is extended to include reverse flow, and a refinement on the method used to calculate the kinematic pitch-bending coupling of the blade is developed.

Johnson, W.↗

Autonomous Operations System: Development and Application

Autonomous control systems provides the ability of self-governance beyond the conventional control system. As the complexity of mechanical and electrical systems increases, there develops a natural drive for developing robust control systems to manage complicated operations. By closing the bridge between conventional automated systems to knowledge based self-awareness systems, nominal control of operations can evolve into relying on safe critical mitigation processes to support any off-nominal behavior. Current research and development efforts lead by the Autonomous Propellant Loading (APL) group at NASA Kennedy Space Center aims to improve cryogenic propellant transfer operations by developing an automated control and health monitoring system. As an integrated systems, the center aims to produce an Autonomous Operations System (AOS) capable of integrating health management operations with automated control to produce a fully autonomous system.

Autonomous Control Systems↗

COVID-19 Lockdowns Drive Decline in Active Fires in Southeastern United States

Fire is a common ecosystem process in forests and grasslands worldwide. Increasingly, ignitions are controlled by human activities either through suppression of wildfires or intentional ignition of prescribed fires. The Southeastern United States leads the nation in prescribed fire, burning ca. 80% of the countries extent annually. The COVID-19 pandemic radically changed human behavior as workplaces implemented social-distancing guidelines and provided an opportunity to evaluate relationships between humans and fire as fire management plans were postponed or cancelled. Using active fire data from satellite-based observations, we found that in the Southeastern United States, COVID-19 led to a 21% reduction in fire activity compared to the 2003-2019 average. The reduction was more pronounced for federally managed lands, up to 41% below average compared to the past 20-years (38% below average compared to the past decade). Declines in fire activity were partly affected by an unusually wet February before the COVID-19 shutdown began in mid-March 2020. Despite the wet spring, the predicted number of active fire detections was still lower than expected, confirming a COVID-19 signal on ignitions. In addition, prescribed fire management statistics, reported by US federal agencies, confirmed the satellite observations, and showed that following the wet February and before the mid-March COVID-19 shutdown, cumulative burned area was approaching record highs across the region. With fire return intervals in the Southeastern United States as frequent as 1-2 years, COVID-19 fire impacts will contribute to an increasing backlog in necessary fire management activities, affecting biodiversity and future fire danger.

Biological Sciences↗

Analysis of driver performance under reduced visibility

Mathematical models describing vehicle dynamics as well as human behavior may be useful in evaluating driver performance and in establishing design criteria for vehicles more compatible with man. In 1977, a two level model of driver steering behavior was developed, but its parameters were identified for clear visibility conditions only. Since driver performance degrades under conditions of reduced visibility, e.g., fog, the two level model should be investigated to determine its applicability to such conditions. The data analysis of a recently performed driving simulation experiment showed that the model still performed reasonably well under fog conditions, although there was a degradation in its predictive capacity during fog. Some additional parameters affecting anticipation and lag time may improve the model's performance for reduced visibility conditions.

Kaeppler, W. D.↗

Highly loaded multi-stage fan drive turbine-tandem blade configuration design

The results of the tandem blade configuration design study are reported. The three stage constant-inside-diameter turbine utilizes tandem blading in the stage two and stage three vanes and in the stage three blades. All other bladerows use plain blades. Blading detailed design is discussed, and design data are summarized. Steady-state stresses and vibratory behavior are discussed, and the results of the mechanical design analysis are presented.

Evans, D. C.↗

Petrologic Comparison of High- and Low-Titanium Basalt Clasts Derived From ANGSA Core 73001

Volatile elements and compounds significantly influence the properties and behavior of magma, including ascent and eruptive processes. Basalts record a complicated history of the volatile species inherent to their parental magma, and the processes, such as degassing, that change these volatile inventories. On the Moon, outstanding questions remain concerning the behavior of magmatic volatiles and their roles in the evolution of lunar magmas and the formation of mare basalts. As part of the Apollo Next Generation Sample Analysis (ANGSA) program, we are investigating the petrogenesis of two basalt clasts collected from the recently processed Apollo 17 drive tube, 73001. Our team is studying the petrology of the two basalt clasts in 2D and 3D. Recent work has highlighted the utility of coupling traditional 2D methods with 3D measurements to better understand the crystallization and degassing histories of lunar lava flows. We are also investigating the volatile inventory of the samples through in situ studies of volatile-bearing phases, like apatite, to understand the eruptive signatures and degassing histories of low-titanium and high-titanium lunar basalts. At the upcoming conference, we will present the first detailed study of the 2D and 3D mineralogy, textures, 3D vesiculation, and chemistry of these basalt clasts to shed light on their magmatic, volcanic, and post-eruptive histories.

Basalt↗

Gravity related behavior of the acellular slime mold Physarum polycephalum (7-IML-1)

The objective of the experiment is to investigate the effect of near weightlessness on a single cell. The test object is the acellular slime mold Physarum polycephalum. This cell is composed of a network of protoplastic strands which perform rhythmic contractions in the minute range. These contractions of the strands' ectoplastic walls generate the force to drive the vigorous shuttle streaming of fluid protoplasm inside the strands (hydrostatic pressure flow). A net transport of protoplasm in one direction determines the direction of the cell's locomotion itself. In this way, gravity modifies the contraction rhythm of the strands, the streaming velocity of protoplasm in the strands, and the direction of locomotion of the whole slime mold (geotaxis). The other parts of this experiment will address the major question of how this cell, which does not possess any specialized gravireceptors, gets the information about the direction of the gravity vector. Details of the experimental setup are given.

Block, I.↗