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At least 199 records · Page 11

GeneLab: Multi-Omics Investigation of Rodent Research-1 Bio-Banked Tissues

NASAs Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS), it is imperative to use crew time efficiently while maximizing high-quality science return. NASAs GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics, systems biology-based approach, and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA, DNA, and protein extracted from archived RR-1 tissue samples for epigenomic, transcriptomic, and proteomic assays. During the first RR spaceflight experiment, a variety of tissue types were harvested from subjects, snap-frozen or RNAlater-preserved, and then stored at least a year at -80OC after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands, quadriceps, gastrocnemius, tibialis anterior, extensor digitorum longus, soleus, eye, and kidney. We report here protocols for and results of these tissue extractions, and thus, the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues, our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities. Support from the NASA Space Life and Physical Sciences Division and the International Space Station Program is gratefully acknowledged.

GeneLab↗

A proven knowledge-based approach to prioritizing process information

Many space-related processes are highly complex systems subject to sudden, major transients. In any complex process control system, a critical aspect is rapid analysis of the changing process information. During a disturbance, this task can overwhelm humans as well as computers. Humans deal with this by applying heuristics in determining significant information. A simple, knowledge-based approach to prioritizing information is described. The approach models those heuristics that humans would use in similar circumstances. The approach described has received two patents and was implemented in the Alarm Filtering System (AFS) at the Idaho National Engineering Laboratory (INEL). AFS was first developed for application in a nuclear reactor control room. It has since been used in chemical processing applications, where it has had a significant impact on control room environments. The approach uses knowledge-based heuristics to analyze data from process instrumentation and respond to that data according to knowledge encapsulated in objects and rules. While AFS cannot perform the complete diagnosis and control task, it has proven to be extremely effective at filtering and prioritizing information. AFS was used for over two years as a first level of analysis for human diagnosticians. Given the approach's proven track record in a wide variety of practical applications, it should be useful in both ground- and space-based systems.

Corsberg, Daniel R.↗

Selection of Next Priority IMPACT Medical Conditions Based on Available Terrestrial and Spaceflight Data

BACKGROUND: As the era of exploration class missions begins, identification of medical conditions that may occur and require management becomes essential for the modeling of medical risk. To this end, NASA has developed IMPACT (Informing Mission Planning via Analysis of Complex Tradespaces), a suite of tools to assist in assessment of medical risk analysis. It has incorporated an initial list of the 120 conditions of highest concern, labeled the IMPACT condition list 1.0 (ICL 1.0). This abstract describes a method for prioritizing the 92 conditions included on the Proposed Future Conditions List (PFCL) for inclusion in future iterations of the ICL. OVERVIEW: To construct the Prioritized Proposed Future Conditions List (P-PFCL), each condition on the PFCL was scored as “low,” “medium,” or “high” on each of four variables: incidence, likelihood of significant task impairment, diagnostic and treatment complexity, and treatment futility. Qualitative assessment using clinical judgement was utilized to score complexity, futility, and likelihood of impairment. Incidence was assessed quantitatively using spaceflight data and/or analog populations where available then assigned a score using established cutoffs. Logarithmic numerical values were assigned to each category label. A Prioritization Score was generated for each condition by taking the product of incidence and likelihood of task impairment (risk) divided by the product of complexity and futility (difficulty of care), with higher values corresponding to higher priority for future inclusion in the ICL. DISCUSSION: The described methods allow for the generation of a ranked P-PFCL to act as a decision support tool for selection of the next generation of modeled medical conditions. Some of the conditions ranked highly on the P-PFCL include EVA-related upper and lower extremity sprain/strain, iron deficiency, delirium, and hypertension, among others. While this effort does not attempt to quantify the absolute risk associated with each condition, it does attempt to semi-quantitatively estimate the risk of each condition relative to the other possible conditions. This tool in concert with subject matter expert opinion could optimize the future use of limited resources thereby producing a more accurate medical risk model, which will be essential to the upcoming exploration class missions.

Michael Pohlen↗

Weather Avoidance Using Route Optimization as a Decision Aid: An AWIN Topical Study

The aviation community is faced with reducing the fatal aircraft accident rate by 80 percent within 10 years. This must be achieved even with ever increasing, traffic and a changing National Airspace System. This is not just an altruistic goal, but a real necessity, if our growing level of commerce is to continue. Honeywell Technology Center's topical study, "Weather Avoidance Using Route Optimization as a Decision Aid", addresses these pressing needs. The goal of this program is to use route optimization and user interface technologies to develop a prototype decision aid for dispatchers and pilots. This decision aid will suggest possible diversions through single or multiple weather hazards and present weather information with a human-centered design. At the conclusion of the program, we will have a laptop prototype decision aid that will be used to demonstrate concepts to industry for integration into commercialized products for dispatchers and/or pilots. With weather a factor in 30% of aircraft accidents, our program will prevent accidents by strategically avoiding weather hazards in flight. By supplying more relevant weather information in a human-centered format along with the tools to generate flight plans around weather, aircraft exposure to weather hazards can be reduced. Our program directly addresses the NASA's five year investment areas of Strategic Weather Information and Weather Operations (simulation/hazard characterization and crew/dispatch/ATChazard monitoring, display, and decision support) (NASA Aeronautics Safety Investment Strategy: Weather Investment Recommendations, April 15, 1997). This program is comprised of two phases, Phase I concluded December 31, 1998. This first phase defined weather data requirements, lateral routing algorithms, an conceptual displays for a user-centered design. Phase II runs from January 1999 through September 1999. The second phase integrates vertical routing into the lateral optimizer and combines the user interface into a prototype software testbed. Phase II concludes with a dispatcher and pilot evaluation of the route optimizer decision aid. This document describes work completed in Phase I in contract with NASA Langley August 1998 - December 1998. This report includes: (1) Discuss how weather hazards were identified in partnership with experts, and how weather hazards were prioritized; (2) Static representations of display layouts for integrated planning function (3) Cost function for the 2D route optimizer; (4) Discussion of the method for obtaining, access to raw data of, and the results of the flight deck user information requirements definition; (5) Itemized display format requirements identified for representing weather hazards in a route planning aid.

Source record↗

Applying Registry Services to Spaceflight Technologies to Aid in the Assignment of Assigned Numbers to Disparate Systems and Their Technologies to Further Enable Interoperability

To date very little effort has been made to provide interoperability between various space agency projects. To effectively get to the Moon and beyond systems must interoperate. To provide interoperability, standardization and registries of various technologies will be required. These registries will be created as they relate to space flight. With the new NASA Moon/Mars initiative a requirement to standardize and control the naming conventions of very disparate systems and technologies are emerging. The need to provide numbering to the many processes, schemas, vehicles, robots, space suits and technologies (e.g. versions), to name a few, in the highly complex Constellation Initiative is imperative. The number of corporations, developer personnel, system interfaces, people interfaces will require standardization and registries on a scale not currently envisioned. It would only take one exception (stove piped system development) to weaken, if not, destroy interoperability. To start, a standardized registry process must be defined that allows many differing engineers, organizations and operators the ability to easily access disparate registry information across numerous technological and scientific disciplines. Once registries are standardized the need to provide registry support in terms of setup and operations, resolution of conflicts between registries and other issues will need to be addressed. Registries should not be confused with repositories. No end user data is "stored" in a registry nor is it a configuration control system. Once a registry standard is created and approved, the technologies that should be registered must be identified and prioritized. In this paper, we will identify and define a registry process that is compatible with the Constellation Initiative and other non related space activities and organizations. We will then identify and define the various technologies that should use a registry to provide interoperability. The first set of technologies will be those that are currently in need of expansion namely the assignment of satellite designations and the process which controls assignments. Second, we will analyze the technologies currently standardized under the Consultative Committee for Space Data Systems (CCSDS) banner. Third, we will analyze the current CCSDS working group and birds of a feather activities to ascertain registry requirements. Lastly, we will identify technologies that are either currently under the auspices of another

Bradford, Robert N.↗

Applying Registry Services to Spaceflight Technologies to Aid in the Assignment of Assigned Numbers to Disparate Systems and their Technologies to Further Enable Interoperability

To date very little effort has been made to provide interoperability between various space agency projects. To effectively get to the Moon and beyond systems must interoperate. To provide interoperability, standardization and registries of various technologies will be required. These registries will be created as they relate to space flight. With the new NASA Moon/Mars initiative, a requirement to standardize and control the naming conventions of very disparate systems and technologies is emerging. The need to provide numbering to the many processes, schemas, vehicles, robots, space suits and technologies (e.g. versions), to name a few, in the highly complex Constellation initiative is imperative. The number of corporations, developer personnel, system interfaces, people interfaces will require standardization and registries on a scale not currently envisioned. It would only take one exception (stove piped system development) to weaken, if not, destroy interoperability. To start, a standardized registry process must be defined that allows many differing engineers, organizations and operators the ability to easily access disparate registry information across numerous technological and scientific disciplines. Once registries are standardized the need to provide registry support in terms of setup and operations, resolution of conflicts between registries and other issues will need to be addressed. Registries should not be confused with repositories. No end user data is "stored" in a registry nor is it a configuration control system. Once a registry standard is created and approved, the technologies that should be registered must be identified and prioritized. In this paper, we will identify and define a registry process that is compatible with the Constellation initiative and other non related space activities and organizations. We will then identify and define the various technologies that should use a registry to provide interoperability. The first set of technologies will be those that are currently in need of expansion namely the assignment of satellite designations and the process which controls assignments. Second, we will analyze the technologies currently standardized under the Consultative Committee for Space Data Systems (CCSDS) banner. Third, we will analyze the current CCSDS working group and Birds of a Feather (BoF) activities to ascertain registry requirements. Lastly, we will identify technologies that are either currently under the auspices of another standards body or technologies that are currently not standardized. For activities one through three, we will provide the analysis by either discipline or technology with rationale, identification and brief description of requirements and precedence. For activity four, we will provide a list of current standards bodies e.g. IETF and a list of potential candidates.

Bradford, Robert N.↗

Wiring for space applications program

The insulation testing and analysis consists of: identifying and prioritizing NASA wiring requirements; selecting candidate wiring constructions; developing test matrix and formulating test program; managing, coordinating, and conducting tests; and analyzing and documenting data, establishing guidelines and recommendations.

Hammoud, Ahmad↗

Atomic Data in X-Ray Astrophysics

With the launches of the Chandra X-ray Observatory (CXO) and the X-ray Multimirror Mission (XMM) and the upcoming launch of the Japanese mission ASTRO-E, high resolution X-ray spectroscopy of cosmic sources has begun. Early, deep observations of three stellar coronal sources will provide not only invaluable calibration data, but will also give us benchmarks for the atomic data under collisional equilibrium conditions. Analysis of the Chandra X-ray Observatory data, and data from other telescopes taken simultaneously, for these stars is ongoing as part of the Emission Line Project. Goals of the Emission Line Project are: (1) to determine and verify accurate and robust diagnostics and (2) to identify and prioritize issues in fundamental spectroscopy which will require further theoretical and/or laboratory work. The Astrophysical Plasma Emission Database will be described in some detail, as it is introducing standardization and flexibility into X-ray spectral modeling. Spectral models of X-ray astrophysical plasmas can be generally classified as dominated by either collisional ionization or by X-ray photoionization. While the atomic data needs for spectral models under these two types of ionization are significantly different, there axe overlapping data needs, as I will describe. Early results from the Emission Line Project benchmarks are providing an invaluable starting place, but continuing work to improve the accuracy and completeness of atomic data is needed. Additionally, we consider the possibility that some sources will require that both collisional ionization and photoionization be taken into account, or that time-dependent ionization be considered. Thus plasma spectral models of general use need to be computed over a wide range of physical conditions.

Brickhouse, N. S.↗

Science Target Prioritization Framework for Remote Sensing

Behind the scenes of a remote sensing mission there are complex decision making and planning operations. Streamlining these operations, with a quantitative scientific value framework, aids efficient and optimized science data collection.While there have been previous efforts to quantify the science value for specific science scenarios, our work aims to develop a general framework which can be applied across different scenarios. We describe a pipeline of processes which combines model forecast and observation data, in computational forms, as dictated by the mission objectives set forth by subject matter experts. The framework is described with use cases involving the monitoring of nitrogen dioxide (NO2) concentrations over the Gulf of Mexico and methane concentrations over interior Alaska.

Remote Sensing↗

The Agricultural Model Intercomparison and Improvement Project: Phase I Activities by a Global Community of Science

The Agricultural Model Intercomparison and Improvement Project (AgMIP) was founded in 2010. Its mission is to improve substantially the characterization of world food security as affected by climate variability and change, and to enhance adaptation capacity in both developing and developed countries. The objectives of AgMIP are to: Incorporate state-of-the-art climate, crop/livestock, and agricultural economic model improvements into coordinated multi-model regional and global assessments of future climate impacts and adaptation and other key aspects of the food system. Utilize multiple models, scenarios, locations, crops/livestock, and participants to explore uncertainty and the impact of data and methodological choices. Collaborate with regional experts in agronomy, animal sciences, economics, and climate to build a strong basis for model applications, addressing key climate related questions and sustainable intensification farming systems. Improve scientific and adaptive capacity in modeling for major agricultural regions in the developing and developed world, with a focus on vulnerable regions. Improve agricultural data and enhance data-sharing based on their intercomparison and evaluation using best scientific practices. Develop modeling frameworks to identify and evaluate promising adaptation technologies and policies and to prioritize strategies.

farm crops↗

Northeast US Ecological Forecasting: Modeling Invasive Plant Habitat Suitability to Support Management Efforts in the American Northeast

Invasive plant species threaten environmental and economic interests when they spread into new areas, outcompete native species, and disrupt ecosystem services. If the spread is not controlled early, species can become well-established and increasingly difficult to manage. The National Park Service (NPS) Invasive Plant Management Teams (IPMTs) strive for an “early detection, rapid response” approach to reducing invasive species spread. Management teams can better prioritize their work with the help of species distribution models (SDMs), which map habitat suitability by combining species occurrences with environmental predictor variables. Scarce invaded range data for newly arrived invasive species presents a particular challenge for producing accurate models. To improve future modeling efforts, this project compared SDM methods using different spatial scales to model two plant species invasive to the Northeast US: the well-established Japanese stiltgrass (Microstegium vimineum) and newer invasive species wavyleaf basketgrass (Oplismenus undulatifolius). The team used NASA Earth observations and climate datasets to model occurrence data and predictor layers at a US-specific extent (90m2 spatial resolution) and global extent (1 km2 spatial resolution). Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper Plus (ETM+), and Landsat 8 Operational Land Imager (OLI) provided data for US Normalized Difference Moisture Indices (NDMI), while global NDMI and topographic predictor layers were derived from Shuttle Radar Topography Mission (SRTM) and Terra Moderate Resolution Imaging Spectroradiometer (MODIS). The resulting models indicated important predictor variables for each species and explored the benefits and tradeoffs of using global data to model habitat suitability for new-arrival invasive species.

Rebecca Ohman↗

Report on Workshop on Artificial Intelligence in Strategic Planning and Science Prioritization

This report details the observations from a two-day virtual workshop, held May 12-13, 2020, focused on whether, and how, artificial intelligence (AI) could assist humans in strategic planning, specifically in science and technology prioritization. The participants identified several “key challenges” that AI might tackle in this area. To further understand the value of these key challenges the workshop then developed related test cases that would demonstrate specifically how AI/machine learning (ML) could provide assistance to humans. Approximately 40 subject matter experts (SMEs), with backgrounds in AI, strategic planning for science, and scientific data, were gathered for the conference. This report collates the details of the output of the workshop. The “best” test cases include (in no particular order):Use of AI to assist in selecting Decadal Survey priorities. * Use of AI to identify new, or previously unidentified, science topics for prioritization. * Using AI to better label and increase discoverability of scientific literature and proposals. * Use of AI to enhance current observation capabilities for scientific missions. * Using AI to mitigate biases in selection of proposal reviewers and membership of advisory committees. Examination of these test cases indicates that Natural Language Processing (NLP) is a common capability found in most of the ”best” (top-rated) test cases and is a valuable, multi-purpose tool which enables ML in this area.

strategic planning↗

Streamlining Software Aspects of Certification: Report on the SSAC Survey

The aviation system now depends on information technology more than ever before to ensure safety and efficiency. To address concerns about the efficacy of software aspects of the certification process, the Federal Aviation Administration (FAA) began the Streamlining Software Aspects of Certification (SSAC) program. The SSAC technical team was commissioned to gather data, analyze results, and propose recommendations to maximize efficiency and minimize cost and delay, without compromising safety. The technical team conducted two public workshops to identify and prioritize software approval issues, and conducted a survey to validate the most urgent of those issues. The SSAC survey, containing over two hundred questions about the FAA's software approval process, reached over four hundred industry software developers, aircraft manufacturers, and FAA designated engineering representatives. Three hundred people responded. This report presents the SSAC program rationale, survey process, preliminary findings, and recommendations.

Hayhurst, Kelly J.↗

Fundamental Technology Development for Gas-Turbine Engine Health Management

Integrated vehicle health management technologies promise to dramatically improve the safety of commercial aircraft by reducing system and component failures as causal and contributing factors in aircraft accidents. To realize this promise, fundamental technology development is needed to produce reliable health management components. These components include diagnostic and prognostic algorithms, physics-based and data-driven lifing and failure models, sensors, and a sensor infrastructure including wireless communications, power scavenging, and electronics. In addition, system assessment methods are needed to effectively prioritize development efforts. Development work is needed throughout the vehicle, but particular challenges are presented by the hot, rotating environment of the propulsion system. This presentation describes current work in the field of health management technologies for propulsion systems for commercial aviation.

Mercer, Carolyn R.↗

Scheduling and Operations of the ECOSTRESS Mission

This paper describes the development and use of an automated scheduling system for the National Aeronautics and Space Administration’s (NASA) ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) mission. Key to the success of the ECOSTRESS mission has been the use of automated scheduling in mission analysis pre-launch, and in successful operations where automated scheduling was deployed to address several operational challenges. ECOSTRESS uses an adaptation of the Compressed Large-scale Activity Scheduling and Planning (CLASP) system to automatically select science observations respecting area and point target priorities as well as visibility, illumination, onboard storage, and radiation constraints to satisfy high-level prioritized science campaigns. The ECOSTRESS scheduler was used pre-launch to predict the effectiveness of alternative formulations of science campaign definitions accounting for the impact of data volume, keepout, and orbit/illumination/visibility constraints to derive the initial operational science campaign definitions and priorities. The scheduler was then used after instrument checkout for operations. ECOSTRESS has faced multiple operational challenges relating to instrument firmware and hardware, and the scheduler has been updated several times to address these challenges. The instrument Mass Storage Units (MSUs) had operational issues, requiring the scheduler to plan for and schedule commands to handle intricacies of data management. After many months of operations, both MSUs on the instrument became non-functioning and the firmware of the instrument was updated to bypass the MSUs. A further update to the ECOSTRESS scheduler enabled the scheduler to operate in this new operations mode. The ECOSTRESS scheduler has also been updated to improve handling of along-track uncertainty inherent in International Space Station operations. The flexibility and ease of updating of the automated scheduler has been a significant contributor to successful operations of the ECOSTRESS mission.

Padams, Jordan↗

Grand Valley Ecological Forecasting II: Forecasting Trends in Pinyon-Juniper and Sagebrush Habitat Relative to Wildfire, Drought, Beetle Disturbance, and Treatment Impact for Management Planning

Disturbances and landcover change in pinyon-juniper and sagebrush ecosystems are exacerbated by environmental conditions such as variability in climate characteristics. Our DEVELOP team partnered with the National Park Service (NPS) in Colorado National Monument and the Bureau of Land Management (BLM)in McInnis Canyons and Dominguez-Escalante National Conservation Areas to investigate disturbances to land cover. NPS partners were interested in identifying areas at risk of pinyon-juniper die-off or encroachment by invasive species. The BLM partners prioritized identifying areas suitable for fire reduction/prevention treatment. To address these concerns, we forecasted landcover change in the Grand Valley region of Colorado using NASA Earth observation data from Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper (ETM+), Landsat 8 Operational Land Imager (OLI), and Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Terra and Aqua. We collected and analyzed these data in conjunction with Term I of this project. We found that the primary drivers of forecasted landcover change in the study area were aspect and elevation. Our forecasted landcover change maps, created using the Idrisi TerrSet Land Change Modeler, addressed the needs of our partners by showing potential habitat suitability trends, which will inform management planning. Forecasted landcover maps indicated that by 2040, ecosystems within partner management areas will likely see tree encroachment on shrublands.

William Curtiss↗

Solutions Network Formulation Report. Landsat Data Continuity Mission Simulated Data Products for Bureau of Land Management and Environmental Protection Agency Abandoned Mine Lands Decision Support

Presently, the BLM (Bureau of Land Management) has identified a multitude of abandoned mine sites in primarily Western states for cleanup. These sites are prioritized and appropriate cleanup has been called in to reclaim the sites. The task is great in needing considerable amounts of agency resources. For instance, in Colorado alone there exists an estimated 23,000 abandoned mines. The problem is not limited to Colorado or to the United States. Cooperation for reclamation is sought at local, state, and federal agency level to aid in identification, inventory, and cleanup efforts. Dangers posed by abandoned mines are recognized widely and will tend to increase with time because some of these areas are increasingly used for recreation and, in some cases, have been or are in the process of development. In some cases, mines are often vandalized once they are closed. The perpetrators leave them open, so others can then access the mines without realizing the danger posed. Abandoned mine workings often fill with water or oxygen-deficient air and dangerous gases following mining. If the workings are accidentally entered into, water or bad air can prove fatal to those underground. Moreover, mine residue drainage negatively impacts the local watershed ecology. Some of the major hazards that might be monitored by higher-resolution satellites include acid mine drainage, clogged streams, impoundments, slides, piles, embankments, hazardous equipment or facilities, surface burning, smoke from underground fires, and mine openings.

Estep, Leland↗

Importance and Incorporation of User Feedback in Data Stewardship

Since August 1994, The National Aeronautics and Space Administration's (NASA's) Earth Observation System Data and Information System (EOSDIS) has been serving a global community of over 3 million users with Earth science data in a variety of disciplines. During the entire life of EOSDIS, various mechanisms for user feedback have been extremely important and valuable to its evolution and proven performance. Some inputs from user groups have resulted in fundamental changes in the architecture, design and operations of EOSDIS, while others have provided ideas for incremental changes. The purpose of this paper is to share this experience and the benefits that have resulted from the user feedback.In early to mid-1990s, the EOSDIS Advisory Panel (a.k.a. Data Panel) provided significant inputs for the architecture and design of EOSDIS resulting in NASA's establishment of a set of Distributed Active Archive Centers (DAACs) and development of a "working prototype with operating elements" called Version 0 EOSDIS, which went into operation in August 1994. The Data Panel also participated in many of the requirement and design reviews and influenced the design of EOSDIS through their comments.In 1995, the U.S. National Research Council's Committee on Global Change Research conducted a review of the U.S. Global Change Research Program and NASA's Mission to Planet Earth/EOS, including the plans for EOSDIS. One of this committee's recommendations was that the "Responsibility for product generation and publication and for user services should be transferred to a federation of partners selected through a competitive process open to all". In response, NASA initiated an experiment with a "self-governing" federation called the Working Prototype ESIP (WP-ESIP) Federation. This federation, with support from NASA, NOAA and USGS, has now grown into the Earth Science Information Partners (ESIP) with over 140 member organizations.The EOSDIS DAACs' User Working Groups (UWGs) represent broad user communities served by the respective DAACs. As regular users of the DAACs and experts in their scientific disciplines, the UWG members provide valuable inputs for planning and prioritizing the services as well as addition of new datasets for the benefit of the community.

Research Integrity↗